BS: Department of Veterinary Medicine, Kyppok National University(1985)
MS: Department of Veterinary Medicine, Kyppok National University(1987)
Ph.D.: Department of Veterinary Medicine, Kyppok National University(1993)
Education and research career
1987.-1991. Assitant/Departement of Physiology, College of Medicine, Yonsei University
1991.-1994. Istructor/Assitant/Departement of Physiology, College of Medicine, Yonsei University
1996.-2000. Assitant Professor/Departement of Physiology, College of Medicine, Yonsei University
1998.-1999. Visiting Professor/Boston Biomedical Research Institute
2000.-2006. Associate Professor/Departement of Physiology, College of Medicine, Yonsei University
2007.-현 재. Professor/Departement of Physiology, College of Medicine, Yonsei University
2014.-2019. Head of Department/Departement of Physiology, College of Medicine, Yonsei University
Academic career
Biophysical Society. Regular member
American Physiological Society. Regular member
Korean Physiological Society. Member of board of directors
Korean Smooth muscle Society. Member of board of directors
Research Interests
Research topics
1. Excitation-Contraction coupling in vascular smooth muscle
2. Ca2+ signaling
3. Relationship between change of vascular excitability and vascular disease
Research Interest
The focus of the laboratory is to study mechanisms that regulate the diameter of small arteries and arterioles that modulate systemic blood pressure and organ blood flow. Smooth muscle cells within the vascular wall determine arterial diameter. Thus, our major focus is to investigate the functional significance of arterial smooth muscle cell plasma membrane and intracellular ion channels and local and global calcium signals in regulating arterial smooth muscle cell contractility. Research in the laboratory involves a multi-faceted approach, studying events at molecular, cellular and intact artery levels. Techniques include patch clamp electrophysiology, rapid confocal calcium imaging, conventional calcium imaging, diameter measurement of pressurized arteries, use of knockout models, and molecular biology. Please click on My Laboratory for more detailed information.
Major achievements
1. Vasodilatory effect of Phellinus linteus extract in rat mesenteric arteries. Kwon Y, Haam CE, Byeon S, Choi SJ, Shin DH, Choi SK, Lee YH. Molecules. 2020 Jul 10;25(14):3160. (IF 4.41)
2. AdipoRon, adiponectin receptor agonist, improves vascular function in the mesenteric arteries of type 2 diabetic mice. Plos One. Choi SK, Kwon Y, Byeon S, Haam CE, Lee YH. PLoS One. 2020 Mar 17;15(3):e0230227 (IF 3.24)
3. Stimulation of autophagy improves vascular function in the mesenteric arteries of type 2 diabetic mice. Experimental Physiology 2020 Jan;105(1):192-200. doi: 10.1113/EP087737. ISSN: 0958-0670. (IF 2.96)
4. Involvement of inhibitor kappa B kinase 2 (IKK2) in the regulation of vascular tone. Kwon YI, Choi SK, Byeon SH, Lee YH. Laboratory Investigation. 2018;98(10): 1311~1319. ISSN:0023-6837 (IF 5.66)
5. Involvement of epithelial Na+ channel in the elevated myogenic response in posterior cerebral arteries from spontaneously hypertensive rats. Scientific Reports. 2017;7:45996~. ISSN: 2045-2322 (IF 4.259)
6. Resistance to pathologic cardiac hypertrophy and reduced expression of CaV1.2 in Trpc3-depleted mice. Jung Woo Han, Young Ho Lee, Su-In Yoen, Joel Abramowitz, Lutz Birnbaumer, Min Goo Lee, Joo Young Kim. Molecular and Cellular Biochemistry. 2016;421(1-2):55~65. ISSN: 0300-8177 (IF 2.613)
7. Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats. Soo-Kyoung Choi, Mihwa Lim, Seon-Hee Byeon, Young-Ho Lee. Scientific Reports. 2016;6:31925~. ISSN: 2045-2322 (IF 5.228)
8. Inhibition of endoplasmic reticulum stress improves coronary artery function in type 2 diabetic mice. Soo-Kyoung Choi, Mihwa Lim, Soo-In Yeon, Young-Ho Lee. Exp Physiol. 2016;101.6:pp 768~777. ISSN: 0958-0670. (IF 2.828)
9. Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure Hyeon-Ju Lee, Ji-One Kang, Sung-Moon Kim, Su-Min Ji, So-Yon Park, Marina E. Kim, Baigalmaa Jigden, Ji Eun Lim, Sue-Yun Hwang, Young-Ho Lee, Bermseok Oh. PLoS ONE. 2016;11(1): e0146841. ISSN: 1932-6203 (IF 3.057)
10. Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries. PLoS ONE. 2014;9(10): e110413. ISSN 1932-6203 (IF 3.534)
11. Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP-kinase- dependent mechanisms in type 2 diabetic mice. Am J Physiol. 2014;306(7):H972-980. ISSN: 0363-6135 (IF 4.012)
12. Role of Endogenous ENaC and TRP Channels in the Myogenic Response of Rat Posterior Cerebral Arteries. Eok-Cheon Kim, Soo-Kyoung Choi, Mihwa Lim, Soo-In Yeon, Young-Ho Lee. PLoS ONE. 2013;8(12): e84194 ISSN: 1932-6203 (IF 3.73)
13. Silencing of Atp2b1 increases blood pressure through vasoconstriction. Shin YB, Lim JE, Ji SM, Lee HJ, Park SY, Hong KW, Lim M, McCarthy MI, Lee YH, Oh B. J Hypertens. 2013;31(8):1575-1583. ISSN: 0263-6352 (IF 4.021)
14. The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries. Lim M, Choi S-K, Cho Y-E, Yeon S-I, Kim E-C, Ahn D-S, Lee Y-H. PLoS ONE. 2012;7(4):e35177. ISSN: 1932-6203 (IF 4.411)
15. Increase of L-type Ca2+ current by protease-activated receptor 2 activation contributes to augmentation of spontaneous uterine contractility in pregnant rats. Kim Y-H, Chung S, Lee Y-H, Kim E-C, Ahn D-S. Biochem Biophys Res Commun. 2012;418:167-172. ISSN: 0006-291X (IF 2.595)
16. Epithelial Na+ channel proteins are mechanotransducers of myogenic constriction in rat posterior cerebral arteries. Eok-Cheon Kim, Duck-Sun Ahn, Soo-In Yeon, Mihwa Lim and Young-Ho Lee. Exp Physiol. 2012;947.4:544-555. ISSN: 0958-0670 (IF 3.35)
17. Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature. Hyun Woo Park, Joo Young Kim, Soo-Kyoung Choi, Young-Ho Lee, Weizhong Zeng, Kyung Hwan Kim, Shmuel Muallem, and Min Goo Lee. PNAS. 2011;108(26):10750-10755. ISSN: 0027-8424 (IF 9.771)
18. Enhanced contractility and myosin phosphorylation induced by Ca2+-independent MLCK activity in hypertensive rats. Cho Y-E, Ahn D-S, Morgan KG, Lee Y-H. Cardiovasc Res. 2011;91:162-170. ISSN: 0008-6363 (IF 6.051)
