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소속

  • 진단검사의학교실

보직

  • 과장

직위

  • 교수

연구실 위치

  • 용인세브란스병원

전화/팩스

  • 031)5189-8694 /

학력사항

  • 연세대학교 의학과 학사(1983)
    연세대학교 의학과 석사(1986)
    연세대학교 의학과 박사(1995)

교육 및 연구 경력

  • ㆍ1992-1995 연세의대 임상병리학교실 전임강사대우
    ㆍ1992-1995 연세의대 용인세브란스병원 임상병리과 과장
    ㆍ1995-1997 미국 워싱턴의과대학 지질대사연구소 연구원
    ㆍ1995-1999 연세의대 임상병리과 조교수
    ㆍ1999-2004 연세의대 임상병리과 (진단검사의학과) 부교수
    ㆍ2004-현재, 연세의대 진단검사의학교실 교수
    ㆍ2004-2012, 연세의대 강남세브란스병원 진단검사의학과장
    ㆍ2013-2017, 연세의대 세브란스병원 진단검사의학과장 겸 진단검사의학교실 주임교수
    ㆍ2017-2020, 연세의대 연세암병원 진단검사의학과장
    ㆍ2019-현재, 연세의대 (신축)용인세브란스병원 진단검사의학과장

기타 학술 관련 경력

  • ㆍ 1994~현재 American Association of Clinical Chemistry 정회원
    ㆍ 2000-2012 대한임상검사정도관리협회 TDM분과위원장
    ㆍ 2005-2016 대한진단검사의학회 이사
    ㆍ 2008-2010 아시아태평양 임상생화학회 (APFCB) 2010 학술위원장
    ㆍ 2011~2013 대한의학학술지편집인회의 교육연수위원장
    ㆍ 2013~현재 대한임상검사정도관리협회 이사
    ㆍ 2013~2015 대한진단검사의학회 이사장
    ㆍ 2013~2016 (재)진단검사의학재단 이사장
    ㆍ 2014~2015 대한유전자검사평가원 원장
    ㆍ 2014~2018 대한의학회 임상진료지침평가위원
    ㆍ 2017~2020 대한임상화학회 회장

연구,관심분야

  • 임상화학 (clinical chemistry)
    Dyslipoproteinemia
    약물유전체학(pharmacogenomics)

강의분야

  • 임상화학검사의 원리와 해석
    치료약물모니터링
    지질대 관련 검사
    심장혈관 관련 생화학 검사
    요체액검사

논문

  • 가족성 고콜레스테롤 혈증 우전자 진단에서 저밀도 지단백 수용체 유전자 및 인접 유전 표식자의 유용성
    대한내과학회지(korean Journal of medcine) 58/3 :283-292,2000
  • Amanita virosa induced toxic hepatitis: report of three cases.
    YONSEI MEDICAL JOURNAL 41/3 :416-421,2000
  • 한국의 Amatoxins 중독증
    대한간학회지 6/3 :340-350,2000
  • 선천성 대사질환검사 신빙도조사 결과 보고(1999)
    임상병리와 정도관리 22/1 :139-152,2000
  • Comparison of tear secretion and tear film instability after photorefractive keratectomy and laser in situ keratomileusis(1).
    J Cataract Refract Surg 26/9 :1326-1331,2000
  • 급성 식도정맥류 출혈 환자에서 Somatostatin과 Vasopressin의 치료효과 비교: A Prospective Randomized Trial.
    대한간학회지 6/4 :468-473,2000
  • 요검사 신빙도조사 결과보고
    임상병리와 정도관리 23/1 :87-104,2001
  • 인슐린 저항성과 고감도 C-반응성 단백의 연관성
    대한임상병리학회지 21/6 :465-470,2001
  • The apolipoproten(a) size, pentanucleotide repeat, C/T(+93) polymorphism of apolipoprotein(a) gene, serum lipoprotein(a) concentrations and their relationship in a Koream population
    CLINICA CHIMICA ACTA 314/ :113-123,2001
  • 뇌혈관 질환에서 혈장 호모시스틴 측정
    한국혈전지혈학회지 8/1 :27-31,2001
  • 선천성 대사질환검사 신빙도조사 결과보고(2000)
    임상병리와 정도관리 23/1 :157-174,2001
  • TDM검사 신빙도 조사 결과 보고(2001)
    임상병리와 정도관리 24/1 :95-115,2002
  • 저베타지단백혈증을 보이는 한국인에서의 Apolipoprotein B 및 Apolipoprotein E 다형성 양상.
    대한진단검사의학회지(Korean Journal Of Legal Medicine) 22/4 :388-394,2002
  • Autoantibody against, Malondialdehyde-Modified Low Density Lipoprotein in Patients with Non-Diabetic Unstable Angina: A Potential Role in Immunologic Reaction of Plaque Instability
    YONSEI MEDICAL JOURNAL 43/2 :203-210,2002
  • Morpenem 동시 사용으로 인한 Valproic acid의 혈중농도 감소 3예.
    대한화학요법학회지 20/4 :333-341,2002
  • 화학발광자동면역분석기 Vitros ECi를 이용한 TSH, Free Triiodothyronine, Free Thyroxine 및 Estradiol 검사 평가.
    임상병리학회지 22/2 :95-100,2002
  • 선천성 대사 질환 검사 신빙도 조사 결과 보고(2001)
    임상병리와 정도관리 24/1 :117-126,2002
  • Evaluation of Denka-Seiken Turbidimetric High-Sensitivity C-Reactive Protein Assay
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE 40/8 :840-845,2002
  • BSCCO(2223)단심 초전도 선재를 이용한 다심 초전도 선재의 접합 공정 연구
    한국 전기 전자 재료 학회 16/10 :923-930,2003
  • ICG 청정검사에 있어서 고식적 정맥채혈 방법과 Finger monitoring 방법 간의 비교
    대한진단검사의학회지(Korean Journal Of Legal Medicine) 23/2 :88-91,2003
  • B-Type Natriuretic Peptide Predicts Clinical Presentations and Ventricular Overloading in Patients with Heart Failure
    YONSEI MEDICAL JOURNAL 44/4 :623-634,2003
  • 혈중 N-Terminal Pro-Brain Type Natriuretic Peptide 농도와 심초음파 검사 지표와의 상관관계
    대한진단검사의학회지(Korean Journal Of Legal Medicine) 23/2 :82-87,2003
  • TDM검사 신빙도조사 결과보고(2002)
    임상검사와 정도관리 25/1 :117-144,2003
  • 선천성 대사질환검사 신빙도 조사 결과보고
    임상검사와 정도관리 26/1 :137-146,2004
  • 임상화학검사 신빙도조사 결과보고(2003)
    임상검사와 정도관리 26/1 :1-10,2004
  • 한국인에서 Vancomycin의 치료적 약물농도 평가
    감염과화학요법 36/5 :311-318,2004
  • TDM검사 신빙도조사 결과보고
    임상검사와 정도관리 26/ :123-136,2004
  • Cystic fibrosis in Korean children: A case report identified by a quantitative pilocarpine iontophoresis sweat test and genetic analysis
    JOURNAL OF KOREAN MEDICAL SCIENCE 20/1 :153-157,2005
  • Effect of long-term hormone therapy on telomere length in postmenopausal women
    YONSEI MEDICAL JOURNAL 46/4 :471-479,2005
  • 비당뇨병성인에서 LDL 입자크기와 내중막 두께 및 인슐린저항성과의 연관성
    당뇨병학회지(J Korean Diabetes Assoc) 29/4 :333-343,2005
  • 선천성 대사질환검사 신빙도조사 결과보고(2004)
    임상검사와 정도관리 27/1 :125-40,2005
  • TDM검사 신빙도조사 결과보고(2004)
    임상검사와 정도관리 27/1 :111-124,2005
  • 요검사 신빙도조사 결과보고(2004)
    임상검사와 정도관리 27/1 :59-83,2005
  • 임상화학검사 신빙도 조사 결과보고
    임상검사와 정도관리 27/1 :1-10,2005
  • Significance of small dense low-density lipoprotein as a risk factor for coronary artery disease and acute coronary syndrome
    YONSEI MEDICAL JOURNAL 47/ :405-414,2006
  • Report of a Korean patient with cystic fibrosis, carrying Q98R and Q220X mutations in the CFTR gene
    JOURNAL OF KOREAN MEDICAL SCIENCE 21/ :563-566,2006
  • Helicobacter pylori 감염에서 새로운 저용량 13C-요소캡슐과 기존의 정제형13C-요소제제를 이용한 요소호기검사간 비교
    대한진단검사의학회지(Korean Journal Of Legal Medicine) 26/2 :81-85,2006
  • Liquid heparin anticoagulant produces more negative bias in the determination of ionized magnesium than ionized calcium
    YONSEI MEDICAL JOURNAL 47/2 :191-195,2006
  • TDM검사 신빙도조사 결과보고(2005)
    임상검사와 정도관리 28/1 :121-134,2006
  • Relationship of low-density lipoprotein particle size to insulin resistance and intima-media thickness in nondiabetic Koreans
    METABOLISM-CLINICAL AND EXPERIMENTAL 55/ :1610-1615,2006
  • 늑막삼출과 주변 림프절 침범이 동반된 다발성골수종 1예
    대한혈액학회지 41/1 :6-6,2006
  • 선천성 대사질환검사 신빙도조사 결과보고(2006)
    임상검사와 정도관리 29/1 :137-152,2007
  • 임상화학검사 신빙도 조사 결과보고(2006)
    임상검사와 정도관리 29/1 :1-12,2007
  • Carbapenem계 항생제에 의한 Valproic Acid 혈중 농도 감소 7예 보고
    대한진단검사의학회지(The Korean Journal of Laboratory Medicine) 27/5 :338-343,2007
  • 요검사 신빙도 조사 결과보고(2006)
    임상검사와 정도관리 29/1 :65-90,2007
  • TDM검사 신빙도조사 결과보고(2006)
    임상검사와 정도관리 29/1 :121-135,2007
  • TDM 및 약물남용검사 신빙도조사 결과보고(2007)
    임상검사와 정도관리(Journal of Laboratory Medicine and Quality Assurance) 30/1 :133-149,2008
  • Cytokine Profile of Peripheral Blood in Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy
    Annals Of Clinical And Laboratory Science 38/ :361-367,2008
  • Effects of increasing particle size of low-density lipoprotein on restenosis after coronary stent implantation
    Circulation Journal 72/7 :1059-1064,2008
  • 임상화학검사 신빙도조사 결과보고(2007)
    임상검사와 정도관리(Journal of Laboratory Medicine and Quality Assurance) 30/1 :1-12,2008
  • Clinical Performance Evaluation of Four Automated Chemiluminescence Immunoassays for Hepatitis C Virus Antibody Detection
    Journal Of Clinical Microbiology 46/ :3919-3923,2008
  • 한국인 낭성 섬유증 진단을 위한 표준화된 땀 유발 염소 농도 분석
    대한진단검사의학회지(The Korean Journal of Laboratory Medicine) 28/4 :274-281,2008
  • Comparison of 10% coefficient of variation and 99th percentile cutoff of troponin I in serum and heparinized plasma using Access 2 and DxI 800
    Clinica Chimica Acta 399/ :117-118,2009
  • TDM 및 남용약물검사 신빙도검사 결과보고(2008)
    Journal of Laboratory Medicine and Quality Assurance 31/1 :125-141,2009
  • 대사질환검사 신빙도 조사 결과보고(2008)
    Journal of Laboratory Medicine and Quality Assurance 31/1 :143-159,2009
  • 임상화학검사 신빙도조사 결과보고(2008)
    Journal of Laboratory Medicine and Quality Assurance 31/1 :1-12,2009
  • The L441P Mutation of Cystic Fibrosis Transmembrane conductance Regulator and its Molecular Pathogenic Mechanisms in a Korean Patient with Cystic Fibrosis
    JOURNAL OF KOREAN MEDICAL SCIENCE 25/1 :166-171,2010
  • Evaluation of three automated enzyme immunoassays for detection of anti-cyclic citrullinated peptide antibodies in qualitative and quantitative aspects
    Rheumatology 49/ :450-457,2010
  • Performance Characteristics of the UniCel DxI 800 Immunoassay for the Maternal Serum Quadruple Test, Including Median Values for Each Week of Gestation, in Korean Women
    KOREAN JOURNAL OF LABORATORY MEDICINE 30/ :126-132,2010
  • Serum neuron-specific enolase level as a biomarker in differential diagnosis of seizure and syncope
    Journal of Neurology 257/ :1708-1712,2010
  • Determination of lamotrigine in human serum by high-performance liquid chromatography-tandem mass spectrometry
    Neurological Sciences 31/6 :717-720,2010
  • TDM 및 남용약물조사 신빙도조사 결과보고(2009)
    Journal of Laboratory Medicine and Quality Assurance 32/1 :115-130,2010
  • Population pharmacokinetics of amikacin in a Korean clinical population
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 49/6 :371-381,2011
  • Heterogeneous Spectrum of CFTR Gene Mutations in Korean Patients with Cystic Fibrosis
    KOREAN JOURNAL OF LABORATORY MEDICINE 31/3 :219-224,2011
  • 콩팥기능이상의 신속 정확한 진단을 위하여 Roche 효소법 검사와 일치시킨 Nova CCX 혈액가스분석기를 이용한 크레아티닌 검사 평가
    Laboratory Medicine Online 1/4 :179-183,2011
  • Evaluation of automated serum des-gamma-carboxyprothrombin (DCP) assays for detecting hepatocellular carcinoma
    CLINICAL BIOCHEMISTRY 44/ :1464-1468,2011
  • Evaluation of revisited fucosylated alpha-fetoprotein (AFP-L3) with an autoanalyzer mu TAS in a clinical laboratory
    CLINICA CHIMICA ACTA 413/1-2 :170-174,2012
  • Urinary iodine and sodium status of urban Korean subjects: A pilot study
    CLINICAL BIOCHEMISTRY 45/0 :596-598,2012
  • Gender-specific reference intervals for serum total bilirubin in healthy Korean adults
    CLINICAL BIOCHEMISTRY 45/15 :1257-1259,2012
  • Editorial Announcement Regarding Title Change of the Korean Journal of Laboratory Medicine to Annals of Laboratory Medicine
    ANNALS OF LABORATORY MEDICINE 32/1 :1-2,2012
  • The Plasma Small Dense LDL-Cholesterol Calculation Formula Proposed by Srisawasdi et al Is Not Applicable to Koreans Who Are Healthy or Have Metabolic Syndrome
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY 138/5 :754-758,2012
  • Detection and genotyping of human papillomavirus by five assays according to cytologic results
    JOURNAL OF VIROLOGICAL METHODS 187/1 :79-84,2013
  • Association of urinary sodium/creatinine ratio and urinary sodium/specific gravity unit ratio with blood pressure and hypertension: KNHANES 2009-2010
    CLINICA CHIMICA ACTA 424/ :168-173,2013
  • The Asian project for collaborative derivation of reference intervals: (1) strategy and major results of standardized analytes
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE 51/7 :1429-1442,2013
  • Additive association of vitamin D insufficiency and sarcopenia with low femoral bone mineral density in noninstitutionalized elderly population: the Korea National Health and Nutrition Examination Surveys 2009-2010
    OSTEOPOROSIS INTERNATIONAL 24/ :2789-2799,2013
  • Serum cholesterol concentration and prevalence, awareness, treatment, and control of high LDL cholesterol in the Korea National Health and Nutrition Examination Surveys 2008―2010: Beyond the tip of the iceberg
    JOURNAL OF THE AMERICAN HEART ASSOCIATION 3/1 :446-,2014
  • Differences in clinical chemistry values according to the use of two laxatives for colonoscopy
    CLINICAL BIOCHEMISTRY 47/12 :1047-1051,2014
  • Establishing pediatric reference intervals for 13 biochemical analytes derived from normal subjects in a pediatric endocrinology clinic in Korea
    CLINICAL BIOCHEMISTRY 47/18 :268-271,2014
  • Evaluation of Random Urine Sodium and Potassium Compensated by Creatinine as Possible Alternative Markers for 24 Hours Urinary Sodium and Potassium Excretion
    ANNALS OF LABORATORY MEDICINE 35/2 :238-241,2014
  • Annual Report on the External Quality Assessment of Therapeutic Drug Monitoring and Testing for Drugs of Abuse in Korea (2013)
    Journal of Laboratory Medicine and Quality Assurance 36/ :12-22,2014
  • Association of hemoglobin levels with blood pressure and hypertension in a large population-based study: the Korea National Health and Nutrition Examination Surveys 2008-2011
    CLINICA CHIMICA ACTA 438/ :12-18,2015
  • Annual Report on the External Quality Assessment Scheme for Therapeutic Drug Monitoring and Testing for Drugs of Abuse in Korea (2014)
    Journal of Laboratory Medicine and Quality Assurance 37/ :12-22,2015
  • Central obesity is an independent risk factor for microalbuminuria in both the general Korean women and nondiabetic nonhypertensive subpopulation: Association of microalbuminuria and metabolic syndrome from the Korea National Health and Nutrition Ex
    CLINICA CHIMICA ACTA -/488 :74-79,2015
  • Hypertriglyceridemia is a Major Factor Associated With Elevated Levels of Small Dense LDL Cholesterol in Patients With Metabolic Syndrome
    ANNALS OF LABORATORY MEDICINE 35/6 :586-594,2015
  • Ascorbate Oxidase Minimizes Interference by High-Concentration Ascorbic Acid in Total Cholesterol Assays
    ANNALS OF LABORATORY MEDICINE 36/26 :188-190,2016
  • Survey of Clinical Laboratory Practices for 2015 Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea
    ANNALS OF LABORATORY MEDICINE 36/2 :154-161,2016
  • Evaluation of bilirubin interference and accuracy of six creatinine assays compared with isotope dilution-liquid chromatography mass spectrometry.
    CLINICAL BIOCHEMISTRY 49/3 :274-281,2016
  • Influence of Vitamin C and Maltose on the Accuracy of Three Models of Glucose Meters
    ANNALS OF LABORATORY MEDICINE 36/ :271-274,2016
  • Validation of a liquid chromatography tandem mass spectrometrymethod to measure oxidized and reduced forms of glutathione inwhole blood and verification in a mouse model as an indicator ofoxidative stress
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 1019/ :45-50,2016
  • Comparison and Validation of 10 Equations Including a Novel Method for Estimation of LDL-cholesterol in a 168,212 Asian Population
    MEDICINE 95/14 :e3230-,2016
  • Characterization of circulating antibodies with affinity to an epitope used in antibody-conjugated magnetic immunoassays from a case of falsely elevated cyclosporine A
    CLINICA CHIMICA ACTA 458/ :35-39,2016
  • Evaluation of an automated urinary iodine measurement using AU5800 analyzer with AutoLab Iodine reagent
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE 54/11 :e339-e341,2016
  • Urinary N-acetyl-β-D-glucosaminidase, an early marker of diabetic kidney disease, might reflect glucose excursion in patients with type 2 diabetes
    MEDICINE 95/27 :e4114-,2016
  • 자동 요분석기 CLINITEK Novus의 성능 평가
    Laboratory Medicine Online 6/3 :147-151,2016
  • Guidelines for the Laboratory Diagnosis of Middle East Respiratory Syndrome Coronavirus in Korea
    Infection and Chemotherapy 48/1 :61-69,2016
  • Korean Society for Laboratory Medicine Practice Guidelines for the Molecular Diagnosis of Middle East Respiratory Syndrome During an Outbreak in Korea in 2015
    ANNALS OF LABORATORY MEDICINE 36/3 :203-208,2016
  • Morning Spot Urine Glucose-to-Creatinine Ratios Predict Overnight Urinary Glucose Excretion in Patients With Type 2 Diabetes.
    ANNALS OF LABORATORY MEDICINE 37/1 :9-17,2017
  • Homeostasis model assessment of insulin resistance in a general adult population in Korea: additive association of sarcopenia and obesity with insulin resistance
    CLINICAL ENDOCRINOLOGY 86/1 :44-51,2017
  • Effect of Accreditation on Accuracy of Diagnostic Tests in Medical Laboratories
    ANNALS OF LABORATORY MEDICINE 37/3 :213-222,2017
  • Calibration of High-Density Lipoprotein Cholesterol Values From the Korea National Health and Nutrition Examination Survey Data, 2008 to 2015
    ANNALS OF LABORATORY MEDICINE 37/1 :1-8,2017
  • Neutropenia is independently associated with sub-therapeutic serum concentration of vancomycin
    CLINICA CHIMICA ACTA 465/ :106-111,2017
  • Fecal Occult Blood Test Results of the National Colorectal Cancer Screening Program in South Korea(2006-2013)
    SCIENTIFIC REPORTS 7/1 :2804-,2017
  • A practical way to overcome ascorbate interference in total cholesterol and triglyceride measurement by exploiting the autoxidation property of ascorbate
    CLINICAL BIOCHEMISTRY 50/6 :350-351,2017
  • Effects of two types of medical contrast media on routine chemistry results by three automated chemistry analyzers
    CLINICAL BIOCHEMISTRY 50/12 :719-725,2017
  • Stability of lyophilized pooled sera as quality control materials for tumor marker assays in external quality assessment
    CLINICA CHIMICA ACTA 471/ :233-242,2017
  • Lipoprotein X Detected in a Case of Hypercholesterolemia Associated With Chronic Cholangiohepatitis
    ANNALS OF LABORATORY MEDICINE 37/6 :550-552,2017
  • Fasting serum amino acids concentration is associated with insulin resistance and pro-inflammatory cytokines
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