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소속

  • 정신과학교실

직위

  • 부교수

연구실 위치

  • 의과대학 정신과학교실(office), 에비슨의생명연구원(lab)

전화/팩스

  • 02-2228-1623 /

학력사항

  • 연세대학교 이과대학 생화학과
    연세대학교 의과대학 의학과
    연세대학교 의과대학원 의학석사
    연세대학교 의학대학원 의학박사

교육 및 연구 경력

  • 2003-2007 연세대학교 의과대학 세브란스정신건강병원 전공의
    2007-2008 연세대학교 의과대학 세브란스정신건강병원 강사 및 노인전임의
    2008-2009 연세대학교 의과대학 세브란스정신건강병원 임상연구조교수
    2009-2010 연세대학교 의과대학 세브란스병원 임상조교수
    2010-2016 연세대학교 의과대학 세브란스병원 조교수
    2016-현재 연세대학교 의과대학 세브란스병원 부교수
    2015-현재 케임브리지대학교 행동인지신경과학센터 객원연구원

    <보직>
    2009-2015 서대문구치매지원센터장

기타 학술 관련 경력

  • 대한신경정신의학회- 정회원
    대한노인정신의학회-총무간사
    대한 치매학회-회원
    국립공주병원 치매예방사업 자문위원
    질병관리본부 노인우울증 전문분과 위원
    복지부 미래의료원정단 생애맞춤분과 위원

연구,관심분야

  • 알츠하이머병의 분자정신의학 (Molecular Psychiatry of Alzheimer's Disease) 및 신약개발
    행동 내분비학 (Behavioural Psychoneuroendocrinology) 및 호르몬 영향 분석
    행동인지신경과학 (Behavioural and Cognitive Neuroscience) 및 질환 모델 인지행동 표현형 분석 (phenotyping)

강의분야

  • 치매
    노년기 우울증
    분자정신의학

논문

  • 뇌척수액과 말초혈액 내 알츠하이머병의 생화학적 생체표지자. 노인정신의학. 16:17-23. 2012
  • 몰입적 가상 환경에서 니코틴이 정신분열병 환자의 대인거리에 미치는 영향:예비연구
    대한정신약물학회지 17/6 :517-527,2006
  • A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia
    Journal Of Clinical Psychopharmacology 28/ :138-146,2008
  • Interactive effect of central obesity and hypertension on cognitive function in older out-patients with Type 2 diabetes
    Diabetic Medicine 25/ :1440-1446,2008
  • Nonverbal Social Behaviors of Patients With Bipolar Mania During Interactions With Virtual Humans
    Journal Of Nervous And Mental Disease 197/6 :412-418,2009
  • Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy
    Brain 132/2 :369-376,2009
  • Reduced activation in the mirror neuron system during a virtual social cognition task in euthymic bipolar disorder
    Progress In Neuro-Psychopharmacology & Biological Psychiatry 33/8 :1409-1416,2009
  • Restoration of mammillothalamic functional connectivity through thiamine replacement therapy in Wernicke's encephalopathy
    Neuroscience Letters 479/3 :257-261,2010
  • Deficits in Eye Gaze During Negative Social Interactions in Patients With Schizophrenia
    Journal Of Nervous And Mental Disease 198/ :829-835,2010
  • Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women
    ARCHIVES OF GERONTOLOGY AND GERIATRICS 53/ :E218-E221,2011
  • Emotional Priming With Facial Exposures in Euthymic Patients With Bipolar Disorder
    JOURNAL OF NERVOUS AND MENTAL DISEASE 199/ :971-977,2011
  • 일 대학병원에 입원하는 알코올 의존 환자에서 동반되는 베르니케 뇌병증의 선별 및 치료
    신경정신의학 50/4 :323-328,2011
  • AMPK gamma 2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age
    PSYCHONEUROENDOCRINOLOGY 37/3 :358-365,2012
  • 조현병에서 긍정 정서가 인지적 갈등 해결에 미치는 영향과 사회적 무쾌감증과의 관계
    대한조현병학회지 15/1 :27-33,2012
  • 혈관성 치매
    노인정신의학 16/2 :82-88,2012
  • 뇌척수액과 말초혈액 내 알츠하이머병의 생화학적 생체표지자
    노인정신의학 16/1 :17-23,2012
  • Is the GABA System Related to the Social Competence Improvement Effect of Aripiprazole? An 18F-FluoroflumazenilPET Study
    PSYCHIATRY INVESTIGATION 10/1 :75-80,2013
  • A carbon nanotube metal semiconductor field effect transistor-based biosensor for detection of amyloid-beta in human serum
    BIOSENSORS & BIOELECTRONICS 50/0 :345-350,2013
  • ILLUMINATION INFLUENCES WORKING MEMORY: AN EEG STUDY
    NEUROSCIENCE 247/ :386-394,2013
  • Bright illumination reduces parietal EEG alpha activity during a sustained attention task
    BRAIN RESEARCH 1538/- :83-92,2013
  • Effects of Color Temperature and Brightness on Electroencephalogram Alpha Activity in a Polychromatic Light-emitting Diode
    Clinical Psychopharmacology and Neuroscience 11/3 :126-131,2013
  • Organotypic hippocampal slice culture from the adult mouse brain: A versatile tool for translational neuropsychopharmacology
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 41/- :36-43,2013
  • HIV-associated neurocognitive disorder in HIV-infected Koreans: The Korean NeuroAIDS Project
    HIV MEDICINE 15/8 :470-477,2014
  • Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine
    PSYCHOPHARMACOLOGY 231/20 :4059-4069,2014
  • Metabolomic Signatures in Peripheral Blood Associated with Alzheimer's Disease Amyloid-beta-Induced Neuroinflammation
    JOURNAL OF ALZHEIMERS DISEASE 42/2 :421-433,2014
  • Effect of hypertension on the resting-state functional connectivity in patients with Alzheimer's disease (AD)
    ARCHIVES OF GERONTOLOGY AND GERIATRICS 60/1 :210-216,2015
  • The role of orexin in post-stroke inflammation, cognitive decline, and depression
    MOLECULAR BRAIN 8/ :16-,2015
  • Altered Neural Basis of the Reality Processing and Its Relation to Cognitive Insight in Schizophrenia
    PLOS ONE 10/3 :e012478-,2015
  • Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death
    NEUROSCIENCE 301/- :26-38,2015
  • Adiponectin receptor 1-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study.
    CELL DEATH & DISEASE 6/- :e1844-,2015
  • Requirement of AMPK activation for neuronal metabolic-enhancing effects of antidepressant paroxetine
    NEUROREPORT 26/ :424-428,2015
  • Technical and clinical aspects of cortisol as a biochemical marker of chronic stress
    BMB REPORTS 48/4 :209-216,2015
  • Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling
    Experimental Neurobiology 25/1 :24-32,2016
  • The relationship between self-referential processing-related brain activity and anhedonia in patients with schizophrenia
    PSYCHIATRY RESEARCH-NEUROIMAGING 23/254 :112-118,2016
  • Hair sterol signatures coupled to multivariate data analysis reveal an increased 7 beta-hydroxycholesterol production in cognitive impairment
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 155/Pt A :9-17,2016
  • Utility of the Montreal Cognitive Assessment (MoCA) and its subset in HIV-associated neurocognitive disorder (HAND) screening
    JOURNAL OF PSYCHOSOMATIC RESEARCH 80/ :53-57,2016
  • Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway
    ONCOTARGET 7/21 :30831-30844,2016
  • Blunted response of hippocampal AMPK associated with reduced neurogenesis in older versus younger mice
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 71/ :57-65,2016
  • Cholinesterase Inhibitor Donepezil Increases Mitochondrial Biogenesis through AMP-Activated Protein Kinase in the Hippocampus
    NEUROPSYCHOBIOLOGY 73/2 :81-91,2016
  • Adjunctive alpha-lipoic acid reduces weight gain compared with placebo at 12 weeks in schizophrenic patients treated with atypical antipsychotics: a double-blind randomized placebo-controlled study
    INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY 31/5 :265-274,2016
  • Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling
    NEUROPHARMACOLOGY 113/Pt A :467-479,2017
  • Suppression of AIMP1 protects cognition in Alzheimer's disease model mice 3xTg-AD
    NEUROREPORT 28/2 :82-86,2017
  • Contribution of fronto-striatal regions to emotional valence and repetition under cognitive conflict
    BRAIN RESEARCH 1666/ :48-57,2017

저서

  • 치매, 정신행동문제 개입전략 (공저), 중앙문화사 2008.
  • 노인치과학(공저), (주)신흥인터내셔날 2008.

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