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소속

  • 정신과학교실

직위

  • 교수

연구실 위치

  • 세브란스병원

전화/팩스

  • 02-2228-1627 /

학력사항

  • 연세대학교 의학과 의학사(1994)
    연세대학교 대학원 의학석사(1998)
    연세대학교 대학원 의학박사(2004)

교육 및 연구 경력

  • 2005.03~2009.02 연세대학교 의과대학 정신과학교실 조교수
    2008.09~2010.08 UCLA 신경행동유전학연구소 방문연구원
    2009.03~2014.02 연세대학교 의과대학 정신과학교실 부교수
    2014.03~현재 연세대학교 의과대학 정신과학교실 교수

연구,관심분야

  • 강박장애 유전연구
    난치성 강박장애 치료
    기분장애 약물치료
    경두개자기자극술

논문

  • 급성기 뇌졸중 환자의 우울 및 불안 증상
    대한뇌졸중학회지 2/1 :40-47,2000
  • 공황장애 환자의 삶의 질
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 40/3 :407-415,2001
  • 청소년기 문제행동과 부모 양육행동에 관한 연구
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 40/4 :605-615,2001
  • 초등학생에서 집단따돌림의 유병률과 이와 관련된 정신병리현상
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 40/5 :876-884,2001
  • 급성기 뇌졸중 환자의 자살 사고
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 40/2 :243-252,2001
  • 좌측 정중 전두엽과 양측 기저절 경색 후 과잉성욕 증상과 강박 증상을 보인 환자 1례(증례)
    생물정신의학(Journal Of The Korean Society Of Biological Psychiatry) 8/6 :271-275,2001
  • 급성기 뇌졸중 환자의 삶의 질
    정신신체의학 10/1 :27-36,2002
  • 뇌졸중 후 삶의 질에 관한 추적연구
    신경정신의학 41/6 :-,2002
  • 한국어판 Conners 부모 및 교사용 평가 척도의 신뢰도와 타당도에 대한 예비적 연구
    소아청소년정신의학 14/2 :183-196,2003
  • 뇌졸중 후 삶의 질에 영향을 미치는 요인
    노인정신의학(J KOREAN GERIATR PSYCHIATRY) 7/1 :67-75,2003
  • 어머니의 우울, 불안과 자녀 행동 평가
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 42/6 :-,2003
  • 정신분열병과 강박장애
    정신분열병클리닉(J Schinophrenia Clinics) 6/2 :100-109,2003
  • 정신지체와 자폐장애를 보이는 Cornellia De Lange 증후군 1예
    소아청소년정신의학 14/1 :123-127,2003
  • 급성 뇌졸중 환자에서 우울 및 불안 증상에 영향을 미치는 요인
    노인병학회지 7/3 :230-242,2003
  • 한국어판 부모 및 교사용 ADHD 평가 척도(K-ARS)의 규준연구
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 42/6 :-,2003
  • Correlates of quality of life after stroke
    JOURNAL OF THE NEUROLOGICAL SCIENCES 224/ :37-41,2004
  • Serotonin transporter gene polymorphism and personality traits in a Korean population
    NEUROPSYCHOBIOLOGY 51/ :243-247,2005
  • 한국인에서 5-HT1Dβ 유전자다형성과 성격 특성
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 44/2 :185-190,2005
  • 강박장애의 약물치료 전략
    대한정신약물학회지(Korean J Psychopharmacol) 16/3 :197-207,2005
  • Serotonin transporter gene polymorphism and migraine in the Korean population
    HEADACHE 45/ :1056-1060,2005
  • Family-based association study of DAT1 and DRD4 polymorphism in Korean children with ADHD
    NEUROSCIENCE LETTERS 390/3 :176-181,2005
  • Obsessive-compulsive disorder, factor-analyzed symptom dimensions and serotonin transporter polymorphism
    NEUROPSYCHOBIOLOGY 52/ :176-182,2005
  • 뇌졸중 후 우울증
    우울조울병 3/2 :81-87,2005
  • 불안의 생물학적 근원
    ANXIETY AND MOOD 1/1 :7-13,2005
  • 강박장애와 도파민 D4 수용체 유전자형과의 연관성
    대한정신약물학회지(Korean J Psychopharmacol) 16/6 :513-520,2005
  • 지난 4년간의 학회지 "신경정신의학" 심사 평가보고
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 44/5 :537-544,2005
  • Family-based association study of the serotonin transporter gene polymorphisms in Korean ADHD trios
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 139B/ :14-18,2005
  • 세로토닌 수송체와 약물치료
    대한정신약물학회지(Korean J Psychopharmacol) 17/3 :263-272,2006
  • 한국인에서 조기-발병 및 후기-발병 강박장애 간의Catechol-O-Methyltransferase 유전자 다형성 차이
    대한정신약물학회지(Korean J Psychopharmacol) 17/2 :197-202,2006
  • 급성기 조증에서 Quetiapine 단독요법의 효능과 안전성: 다기관 개방연구
    대한정신약물학회지(Korean J Psychopharmacol) 17/4 :374-383,2006
  • An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans
    NEUROSCIENCE LETTERS 401/ :154-158,2006
  • The genetic studies of obsessive-compulsive disorder and its future directions
    YONSEI MEDICAL JOURNAL 47/4 :443-454,2006
  • An interaction between the serotonin transporter promoter region and dopamine transporter polymorphisms contributes to harm avoidance and reward dependence traits in normal healthy subjects
    JOURNAL OF NEURAL TRANSMISSION 113/ :877-886,2006
  • 한국인 강박장애와 Val-158-Met Catechol-O-Methyltransferase 유전자 다형성 간의 상관성 연구
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 45/5 :444-452,2006
  • 안정기 양극성 장애 I형 환자에서 정신병적 증상에 따른 기질과 성격
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 45/5 :427-431,2006
  • Association between Obessive-Compulsive Disorder and Dopamine Transporter Gene Polymorphism
    PSYCHIATR INVEST 3/1 :72-77,2006
  • 한국판 Mini International Neuropsychiatric Interview 타당도 연구
    ANXIETY AND MOOD 2/1 :50-55,2006
  • 강박장애와 공황장애 환자의 삶의 질
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 45/5 :438-443,2006
  • Lack of association between polymorphisms of the dopamine receptor D4 and dopamine transporter genes and personality traits in a Korean population
    YONSEI MEDICAL JOURNAL 47/6 :787-792,2006
  • 양극성 장애 환자에서 정신병적 증상의 과거력 유무에 따른 얼굴 자극의 지속적 주의력에 차이가 있는가?
    우울조울병 4/1 :20-25,2006
  • 알츠하이머형 치매환자의 발화특성
    언어청각장애연구 11/3 :82-98,2006
  • 한국형 강박장애 치료 알고리듬 2007(Ⅱ) : 초기 치료와 치료 저항성 강박장애
    대한정신약물학회지(Korean J Psychopharmacol) 18/5 :347-357,2007
  • 한국형 강박장애 약물치료 알고리듬 2007(Ⅰ) : 개발과정과 개요
    대한정신약물학회지(Korean J Psychopharmacol) 18/5 :338-346,2007
  • 안정기 양극성 장애환자의 얼굴자극에 대한 주의력 유지과제에서의 결핍 특성
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 46/3 :229-236,2007
  • 양극성 장애 환자의 첫 삽화에 따른 임상적 특징
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 46/4 :352-356,2007
  • 양극성 장애 환자의 의학적 공존질환: 후향적 챠트 조사
    우울조울병 5/ :30-33,2007
  • 4개 병원에서 양극성 장애 입원 환자의 최근 5년간 약물 처방 경향
    대한정신약물학회지(Korean J Psychopharmacol) 18/5 :308-317,2007
  • 한국형 강박장애 치료 알고리듬 2007 (Ⅲ) : 인지행동치료 적용을 위한 예비 조사
    대한정신약물학회지(Korean J Psychopharmacol) 18/6 :408-413,2007
  • 한국형 강박장애 치료 알고리듬 2007 (IV) : 공존질환이 동반된 경우
    대한정신약물학회지(Korean J Psychopharmacol) 18/6 :414-422,2007
  • 주요우울증이 근로자의 생산성에 미치는 영향: WHO-HPQ(Health and Work Performance Questionnaire)를 이용한 예비연구
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 46/6 :587-595,2007
  • 첫 입원 양극성장애에서 정신병적 증상의 유무에 따른 임상 특성
    우울조울병 5/2 :114-118,2007
  • Different hemispheric specializations for pitch and audioverbal working memory
    Neuroreport 19/ :99-103,2008
  • 한국판 대칭 및 정리정돈 성향 척도(K-SOAQ)의 표준화 연구
    신경정신의학(J Korean Neuropsychiatr Assoc) 47/3 :263-268,2008
  • 한국인 강박장애와 단가아민 산화효소 A 유전자 다형성과의 관련성
    대한정신약물학회지(Korean J Psychopharmacol) 19/4 :226-232,2008
  • The association of 5-HTTLPR and DRD4 VNTR polymorphisms with affective temperamental traits in healthy volunteers
    Journal Of Affective Disorders 109/ :157-163,2008
  • The relationship between online game addiction and aggression, self-control and narcissistic personality traits
    European Psychiatry 23/ :212-218,2008
  • Association of DRD4 and COMT polymorphisms with anger and forgiveness traits in healthy volunteers
    Neuroscience Letters 430/ :252-257,2008
  • Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population
    European Neuropsychopharmacology 18/ :820-825,2008
  • Reliability and Validity of the Korean Version of Obsessive-Compulsive Inventory - Revised in a Non-clinical Sample
    Yonsei Medical Journal 49/ :909-916,2008
  • Standardization of the Korean version of Mini-Mental Adjustment to Cancer (K-Mini-MAC) scale: factor structure, reliability and validity
    Psycho-Oncology 17/ :592-597,2008
  • Interaction between serotonin transporter promoter and dopamine receptor D4 polymorphisms on decision making
    Progress In Neuro-Psychopharmacology & Biological Psychiatry 33/7 :1217-1222,2009
  • Association of a 5-HT1Dβ receptor gene polymorphism with obsessive-compulsive disorder in Korean male subjects
    Neuropsychobiology 59/2 :96-99,2009
  • A Randomized controlled study of sequentially applied repetitive transcranial magnetic stimulation in obsessive-compulsive disorder
    Journal Of Clinical Psychiatry 70/12 :1645-1651,2009
  • Temperament and character in subjects with obsessive-compulsive disorder
    Comprehensive Psychiatry 50/6 :567-572,2009
  • 강박장애의 임상적 특징과 충동성의 관련성
    신경정신의학(Journal of the Korean Neuropsychiatric Association) 48/5 :336-343,2009
  • 트립토판 가수분해 효소 및 세로토닌-2A 수용체 유전자 다형성과 정서기질의 관련성
    우울조울병 7/2 :126-130,2009
  • Association of DRD4 and COMT Polymorphisms with Disgust Sensitivity in Healthy Volunteers
    NEUROPSYCHOBIOLOGY 61/2 :105-112,2010
  • MRP1 Polymorphisms Associated With Citalopram Response in Patients With Major Depression
    Journal Of Clinical Psychopharmacology 30/2 :116-125,2010
  • Proxy and patients ratings on quality of life in patients with schizophrenia and bipolar disorder in Korea
    Quality Of Life Research 19/4 :521-529,2010
  • Interaction effects between COMT and BDNF polymorphisms on boredom susceptibility of sensation seeking traits
    Psychiatry Research 178/1 :132-136,2010
  • Perception bias of disgust in ambiguous facial expressions in obsessive-compulsive disorder
    Psychiatry Research 178/1 :126-131,2010
  • Serotonin Transporter Gene Polymorphism Associated with Short-Term Treatment Response to Venlafaxine
    NEUROPSYCHOBIOLOGY 62/3 :198-206,2010
  • Initial Depressive Episodes Affect the Risk of Suicide Attempts in Korean Patients with Bipolar Disorder
    YONSEI MEDICAL JOURNAL 51/5 :641-647,2010
  • Influence of BDNF and COMT polymorphisms on emotional decision making
    Neuropharmacology 58/7 :1109-1113,2010
  • 양극성 장애에서 Longitudinal Interval Follow-up Evaluation-Range of Impaired Functioning Tool(LIFE-RIFT)의 신뢰도 및 타당도
    우울조울병 8/2 :138-144,2010
  • 양극성장애와 Catechol O-Methyltransferase 및 Monoamine Oxidase A 유전자 다형성의 연관성
    우울조울병 8/1 :24-30,2010
  • Prestimulus top-down reflection of obsessive-compulsive disorder in EEG frontal theta and occipital alpha oscillations
    NEUROSCIENCE LETTERS 496/3 :181-185,2011
  • Impact of depression on work productivity and its improvement after outpatient treatment with antidepressants
    VALUE IN HEALTH 14/4 :475-482,2011
  • 정신과 질환에서의 광범위 유전체 연합연구
    신경정신의학 50/1 :20-38,2011
  • The Effects of Serotonin Transporter Promoter and Monoamine Oxidase A Gene Polymorphisms on Trait Emotional Intelligence
    NEUROPSYCHOBIOLOGY 64/4 :224-230,2011
  • Clinical Case Conference 수학 문제가 떠올라 머리가 아프고 힘이 빠지는 고등학생
    신경정신의학 50/6 :419-427,2011
  • 우울증 화자 음성의 음향음성학적 특성
    말소리와 음성과학 4/1 :91-98,2012
  • Psychometric analysis of the Korean version of the Disgust Scale-Revised
    COMPREHENSIVE PSYCHIATRY 53/ :648-655,2012
  • Body image, sexual function and depression in Korean patients with breast cancer: modification by 5-HTT polymorphism
    SUPPORTIVE CARE IN CANCER 20/ :2177-2182,2012
  • FKBP5 polymorphisms as vulnerability to anxiety and depression in patients with advanced gastric cancer: A controlled and prospective study
    PSYCHONEUROENDOCRINOLOGY 37/ :1569-1576,2012
  • Abnormalities of emotional awareness and perception in patients with obsessive-compulsive disorder
    JOURNAL OF AFFECTIVE DISORDERS 141/2-3 :286-293,2012
  • Association of the Brain-derived Neurotrophic Factor Gene and Clinical Features of Bipolar Disorder in Korea
    Clinical Psychopharmacology and Neuroscience 10/3 :163-167,2012
  • Alpha amplitude and phase locking in obsessive-compulsive disorder during working memory
    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY 83/1 :1-7,2012
  • Is the GABA System Related to the Social Competence Improvement Effect of Aripiprazole? An 18F-FluoroflumazenilPET Study
    PSYCHIATRY INVESTIGATION 10/1 :75-80,2013
  • Reevaluation of Patients With Bipolar Disorder on Manic Episode : Improving the Diagnosing of Mixed Episode
    JOURNAL OF NERVOUS AND MENTAL DISEASE 201/8 :686-690,2013
  • 한글판 차원적 강박척도의 표준화 연구
    신경정신의학 52/3 :130-142,2013
  • Genetic Influence of COMT and BDNF Gene Polymorphisms on Resilience in Healthy College Students
    NEUROPSYCHOBIOLOGY 68/3 :174-180,2013
  • Temperament and character in individuals at ultra-high risk for psychosis and with first-episode schizophrenia: Associations with psychopathology, psychosocial functioning, and aspects of psychological health
    COMPREHENSIVE PSYCHIATRY 54/8 :1161-1168,2013
  • APOLIPOPROTEIN E GENE POLYMORPHISM, ALCOHOLUSE, AND THEIR INTERACTIONS IN COMBAT-RELATEDPOSTTRAUMATIC STRESS DISORDER
    DEPRESSION AND ANXIETY 30/12 :1194-1201,2013
  • 자살 시도자들에 대한 응급 중재 후 정신과 치료 연계와 관련된 요인
    우울조울병(Journal of Korean Society for Depressive and Bipolar Disorders) 11/3 :130-137,2013
  • Prevalence of bipolar spectrum disorder in Korean college students according to the K-MDQ
    Neuropsychiatric Disease and Treatment 9/ :869-874,2013
  • Reduced Binding Potential of GABA-A/Benzodiazepine Receptors in Individuals at Ultra-high Risk for Psychosis:An [18F]-Fluroflumazenil Positron Emission Tomography Study
    SCHIZOPHRENIA BULLETIN 40/3 :548-557,2014
  • Distinct functional connectivity of limbic network in the washing type obsessive-compulsive disorder
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 53C/ :149-155,2014
  • Is it useful to use the Korean version of the mood disorder questionnaire for assessing bipolar spectrum disorder among Korean college students?
    ASIA-PACIFIC PSYCHIATRY 6/2 :170-178,2014
  • Prenatal maternal depression is associated with low birth weight through shorter gestational age in term infants in Korea
    EARLY HUMAN DEVELOPMENT 90/1 :15-20,2014
  • Multidimensional Measures of Impulsivity in Obsessive-Compulsive Disorder: Cannot Wait and Stop
    PLOS ONE 9/11 :e111739-,2014
  • 위험감수와 충동성 및 불확실성에 대한 인내력 부족의 관련성
    생물정신의학 21/3 :87-92,2014
  • 젊은 성인에서 일주기유형과 기질 및 성격의 관련성
    생물정신의학 21/3 :93-98,2014
  • Further evidence of a dissociation between decision-making under ambiguity and decision-making under risk in obsessive-compulsive disorder
    JOURNAL OF AFFECTIVE DISORDERS 176/- :118-124,2015
  • Circadian preference and trait impulsivity, sensation-seeking and response inhibition in healthy young adults
    CHRONOBIOLOGY INTERNATIONAL 32/2 :235-241,2015
  • Associations between polymorphisms in the NR1D1 gene encoding for nuclear receptor REV-ERBa and circadian typologies
    CHRONOBIOLOGY INTERNATIONAL 32/4 :568-572,2015
  • Relationships between chronotypes and affective temperaments in healthy young adults
    JOURNAL OF AFFECTIVE DISORDERS 175/- :256-259,2015
  • 강박장애 환자의 반응억제 결함
    대한불안의학회지 11/1 :33-37,2015
  • Extending a structural model of somatization to South Koreans: Cultural values, somatization tendency, and the presentation of depressive symptoms
    JOURNAL OF AFFECTIVE DISORDERS 176/ :151-154,2015
  • Bilateral thermal capsulotomy with MR-guided focused ultrasound for patients with treatment-refractory obsessive-compulsive disorder: a proof-of-concept study
    MOLECULAR PSYCHIATRY 20/10 :1205-1211,2015
  • Lack of Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Alexithymia: Evidence from Patients with Obsessive-Compulsive Disorder
    PLOS ONE 10/11 :e0143168-,2015
  • 젊은 여성의 정서기질 특성과 관련된 우울 취약성
    여성정신의학 13/1 :12-18,2015
  • The Impact of Coping Styles on Psychological Distress and Quality of Life in Korean Patients with Cancer
    Korean Journal of Psycho-Oncology(정신종양학회지) 1/1 :36-42,2015
  • Alexithymia and perfectionism traits are associated with suicidal risk in patients with obsessive-compulsive disorder
    JOURNAL OF AFFECTIVE DISORDERS 192/- :50-55,2016
  • Association between the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Alexithymia in Patients with Obsessive-Compulsive Disorder
    YONSEI MEDICAL JOURNAL 57/3 :721-727,2016
  • Review of Cohort Studies for Mood Disorders
    PSYCHIATRY INVESTIGATION 13/3 :265-276,2016
  • Common variants of HTR3 genes are associated with obsessive-compulsive disorder and its phenotypic expression
    SCIENTIFIC REPORTS 6/32564 :1-8,2016
  • 한국어판 완벽주의 구성 척도의 표준화 연구
    대한불안의학회지 12/2 :103-112,2016
  • Social network types among older Korean adults: Associations with subjective health
    SOCIAL SCIENCE & MEDICINE 173/ :88-95,2017
  • Epigenetic alterations of the BDNF gene in combat-related post-traumatic stress disorder
    ACTA PSYCHIATRICA SCANDINAVICA 135/2 :170-179,2017
  • Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study
    PSYCHIATRY INVESTIGATION 14/1 :100-106,2017

저서

  • 정신분열병의 세로토닌 가설
  • 정신분열병 클리닉 “정신분열병의 병인론과 약물치료”(ISSN 1598-6624)
  • 출판사 : 중앙문화사 2002년 9월 6일
  • 사회 인지와 정신분열병 조기 정신병의 인지 지향 정신치료: 이론, 실행, 결과들, 그리고 과제들(번역서)
  • 중앙문화사 2004.9

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