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소속

  • 신경외과학교실

보직

  • 세브란스병원 병원장

직위

  • 교수

연구실 위치

  • 의과대학 본관 512호

전화/팩스

  • 02) 2228-2157 /

학력사항

  • 1980 연세대학교 의과대학 의학사
    1984 연세대학교 대학원 의학석사
    1991 연세대학교 대학원 의학박사

교육 및 연구 경력

  • 1993-1995 New York University Medical Center 연구원
    1997-2004 연세의대 신경외과 부교수
    2004- 연세의대 신경외과 교수
    2007.3-2010.8 연세의대 신경외과 주임교수겸 신경외과 과장
    2010.9 세브란스병원 제1진료부원장
    2012.10-2014.8 의료원 건설사업단 암병원 개원사업본부 부본부장
    2014.8-2016.7 세브란스병원 병원장
    2016.8~ 의무부총장 겸 의료원장

기타 학술 관련 경력

  • 대한신경외과학회 정회원
    대한신경외과학회 학술위원
    대한신경외과학회 고시위원
    대한신경외과학회 간행위원
    대한척추신경외과학회 학술이사,보험이사
    신경손상학회 총무

연구,관심분야

  • 척추신경외과
    경추질환
    척수 및 척추종양
    척수손상에 대한 신경재생치료
    퇴행성 척추질환

강의분야

  • 신경외과
    척추신경외과
    척추신경외과학

논문

  • 요통의 수술적 치료
    대한통증학회지(J Korean Pain Soc) 10/0 :30-37,2000
  • 대공부와 상위 경추부 종양에 대한 수술적 치료
    대한신경외과학회지(JOURNAL OF KOREAN NEUROSURGICAL SOCIETY) 30/0 :463-471,2001
  • Oncocytoma of the spinal cord - Case report
    JOURNAL OF NEUROSURGERY-SPINE 94/2 :310-312,2001
  • Thoracoscopic limited T3 sympathicotomy for primary hyperhidrosis: prevention for compensatory hyperhidrosis
    Jounal of neurosurgury 99/1 :39-43,2003
  • Intermediate filament nestin expressions in human cord blood monocytes(HCMNCs)
    ACTA NEUROCHIRURGICA 0/0 :0-0,2003
  • 척수손상백서에서 인간 제대혈 세포이식에 의한 신경기능의 회복
    대한신경외과학회지(JOURNAL OF KOREAN NEUROSURGICAL SOCIETY) 35/3 :302-308,2004
  • 급성 청수손상 환자의 치료 - 최근의 세포치료 연구 결과를 중심으로 -
    KOREAN JOURNAL OF SPINE 1/ :16-26,2004
  • A Case of Thoracic Vertebral Chondroblastoma, Treated with 3-D Image Guided Resection and Reconstruction
    대한신경외과학회지(JOURNAL OF KOREAN NEUROSURGICAL SOCIETY) 37/2 :154-156,2005
  • Effects of methylprednisolone on the neural conduction of the motor evoked potentials in spinal cord injured rats
    JOURNAL OF KOREAN MEDICAL SCIENCE 20/1 :132-138,2005
  • Effects of glial transplantation on functional recovery following acute spinal cord injury
    JOURNAL OF NEUROTRAUMA 22/5 :575-589,2005
  • Thoracic myelomeningocele in spondylocostal dysostosis
    JOURNAL OF NEUROSURGERY / :-,2005
  • Surgical management of spinal disease in renal recipients
    CLINICAL TRANSPLANTATION 19/5 :632-637,2005
  • Functional recovery after human umbilical cord blood cells transplantation with brain-derived neutrophic factor into the spinal cord injured rat
    ACTA NEUROCHIRURGICA 147/ :985-992,2005
  • 후측방 접근법을 이용한 흉요추부 척추체 성형술
    Korean Journal of Neurotraumatology 1/1 :123-127,2005
  • 척추 수술 후 발생한 척추 경막외 혈종
    Korean Journal of Neurotraumatology 1/1 :103-109,2005
  • Real-time CT fluoroscopy (CTF)-guided vertebroplasty in osteoporotic spine fractures
    YONSEI MEDICAL JOURNAL 46/5 :635-642,2005
  • Effect of human mesenchymal stem cell transplantation combined with growth factor infusion in the repair of injured spinal cord.
    ACTA NEUROCHIRURGICA SUPPLEMENT 99/ :133-136,2006
  • 척추성형술 후 발생한 자발성 방출성 압박골절
    KOREAN JOURNAL OF NEUROTRAUMATOLOGY 2/1 :76-80,2006
  • Postoperative spinal epidural hematoma: Risk factor and clinical outcome
    YONSEI MEDICAL JOURNAL 47/3 :326-332,2006
  • Clinical and radiological results following cervical arthroplasty
    ACTA NEUROCHIRURGICA 148/9 :943-950,2006
  • Posterior lumbar interbody fusion via a unilateral approach
    YONSEI MEDICAL JOURNAL 47/3 :319-325,2006
  • Total Body Replacement wlth an Expandable Cage after en Bloc Lumber Spondylectomy
    대한신경외과학회지(JOURNAL OF KOREAN NEUROSURGICAL SOCIETY) 40/6 :471-475,2006
  • A thoracic myelomeningocele in a patient with spondylocostal dysostosis - Case report
    JOURNAL OF NEUROSURGERY 104 (1 su :37-40,2006
  • Cervical arthroplasty in a patient with Klippel-Feil syndrome
    ACTA NEUROCHIRURGICA 149/8 :805-809,2007
  • Human mesenchymal stem cell transplantation promotes functional recovery following acute spinal cord injury in rats
    ACTA NEUROBIOLOGIAE EXPERIMENTALIS 67/ :13-22,2007
  • Early results from posterior cervical fusion with a screw-rod system
    YONSEI MEDICAL JOURNAL 48/3 :440-448,2007
  • Early clinical experience with the Mobi-C disc prosthesis
    YONSEI MEDICAL JOURNAL 48/3 :457-464,2007
  • Modified techniques to prevent sagittal imbalance after cervical arthroplasty
    SPINE 32/18 :1986-1991,2007
  • surgical management of Paraspinal tumors
    Korean Journal of Spine 4/3 :134-139,2007
  • Clinical and kinematic Analysis in patients with cervical Disc Herniation at the C3-4 Single Level
    Korean Journal of Spine 4/3 :101-105,2007
  • Thoracolumbar junction Disc Herniations: Clinical Features and surgical Approaches
    Korean Journal of Spine 4/3 :129-133,2007
  • Outcome of surgery for a symptomatic herniated thoracic disc in relation to preoperative characteristics of the disc
    ACTA NEUROCHIRURGICA 149/11 :1139-1145,2007
  • Spinal cord tumors of the thoracolumbar junction requiring surgery: A retrospective review of clinical features and surgical outcome
    YONSEI MEDICAL JOURNAL 48/6 :988-993,2007
  • Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients - Comparison with ondansetron
    Spine 33/17 :602-606,2008
  • Progressive collapse of PMMA-augmented vertebra: A report of three cases
    Zentralblatt Fur Neurochirurgie 69/ :43-46,2008
  • The efficacy of microendoscopic discectomy in reducing iatrogenic muscle injury
    Journal of Neurosurgery-Spine 8/ :39-43,2008
  • Interspinous Implantation for Degenerative Lumbar Spine: Clinical and Radiological Outcome at 3-yr Follow up
    Korean Journal Of Spine 5/3 :130-135,2008
  • 척추 후만성형술에서 Polymethylmethacrylate와 Calcium Phosphate 골양시멘트질 주입에 대한 임상적인 평가
    Korean Journal Of Spine 5/3 :167-172,2008
  • Surgical management of spinal cord haemangioblastoma
    Acta Neurochirurgica 150/ :215-220,2008
  • Cervical artificial disc replacement - Part 2: Clinical experience with the cervical artificial disc
    Neurosurgery Quarterly 18/2 :89-92,2008
  • Cervical artificial disc replacement - Part 1: History, design, and overview of the cervical artificial disc
    Neurosurgery Quarterly 18/2 :89-95,2008
  • A dumbbell-shaped solitary fibrous tumor of the cervical spinal cord
    Yonsei Medical Journal 49/1 :167-170,2008
  • Radiologically documented adjacent-segment degeneration after cervical arthroplasty: characteristics and review of cases
    Surgical Neurology 72/4 :325-329,2009
  • 척주와 흉곽을 침범한 악성 종양에 대한 흉곽절제술과 일괄 척추제 절제술
    Korea Journal Of Spine 6/3 :221-224,2009
  • clinical and radiological outcome of an interspinous dynamic stabilization system in degenerative lumbar disease: 24 cases with over 24 months of follow-up
    Korea Journal Of Spine 6/3 :175-180,2009
  • Artificial disc replacement combined with fusion versus two-level fusion in cervical two-level disc disease
    Spine 34/11 :1153-1159,2009
  • Role of the oxygen-dependent degradation degradation domain in a hypoxia-inducible gene expression system in vascular endothelial growth factor gene therapy.
    Spine 34/26 :e952-e958,2009
  • Comparison of anterior cervical foraminotomy vs arthroplasty for unilateral cervical radiculopathy
    Surgical Neurology 71/6 :677-680,2009
  • Hypoxia-preconditioned adipose tissue-derived mesenchymal stem cell increase the survival and gene expression of engineered neural stem cells in a spinal cord injury model
    Neuroscience Letters 472/3 :215-219,2010
  • Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords
    Neuroscience Research 67/1 :59-64,2010
  • Robot-assisted anterior lumbar interbody fusion (ALIF) using retroperitoneal approach
    Acta Neurochirurgica 152/4 :675-679,2010
  • Cervical Spondylolysis Three Cases and a Review of the Current Literature
    Spine 35/3 :E80-E83,2010
  • Pediatric cervical chordoma: report of two cases and a review of the current literature
    CHILDS NERVOUS SYSTEM 26/6 :835-840,2010
  • Difference in Occurrence of Heterotopic Ossification According to Prosthesis Type in the Cervical Artificial Disc Replacement
    Spine 35/16 :1556-1561,2010
  • Effect of primate bone marrow stromal cells on survival and neurite outgrowth
    Neuroreport 21/13 :877-881,2010
  • Controlled nonviral gene delivery and expression using stable neural stem cell line transfected with a hypoxia-inducible gene expression system
    Journal Of Gene Medicine 12/12 :990-1001,2010
  • Neuroprotective effect of combined hypoxia-induced VEGF and bone marrow-derived mesenchymal stem cell treatment
    CHILDS NERVOUS SYSTEM 26/3 :323-331,2010
  • Primary spinal cord melanoma
    JOURNAL OF KOREAN NEUROSURGICAL SOCIETY(대한신경외과학회지) 48/2 :157-161,2010
  • Robot-Assisted Transoral Odontoidectomy : Experiment in New Minimally Invasive Technology, a Cadaveric Study
    JOURNAL OF KOREAN NEUROSURGICAL SOCIETY 49/4 :248-251,2011
  • The clinical features and surgical outcomes of patients with intramedullary spinal cord cavernous malformations
    ACTA NEUROCHIRURGICA 153/8 :1677-1685,2011
  • Neurotrophin-3-Over-Expressing Mesenchymal Stem Cell Transplantation Improves Functional Recovery and Axonal Outgrowth in a Rat Model of Spinal Cord Injury
    TISSUE ENGINEERING AND REGENERATIVE MEDICINE 8/5 :477-481,2011
  • Neural Stem Cells Modified by a Hypoxia-Inducible VEGF Gene Expression System Improve Cell Viability under Hypoxic Conditions and Spinal Cord Injury
    SPINE 36/11 :857-864,2011
  • Hypoxia-induced expression of VEGF in the organotypic spinal cord slice culture
    NEUROREPORT 22/2 :55-60,2011
  • Sugical Outcomes of Spine Disorders in Patients with Parkinson's Disease
    Korean Journal of Spine 8/3 :208-214,2011
  • Cotransplantation of Mouse Neural Stem Cells (mNSCs) With Adipose Tissue-Derived Mesenchymal Stem Cells Improves mNSC Survival in a Rat Spinal Cord Injury Model
    CELL TRANSPLANTATION 20/6 :837-849,2011
  • Robot-Assisted Anterior Lumbar Interbody Fusion in a Swine Model In Vivo Test of the da Vinci Surgical-Assisted Spinal Surgery System
    SPINE 36/2 :139-143,2011
  • Intraoperative Indocyanine Green Video-Angiography Spinal Dural Arteriovenous Fistula
    SPINE 36/24 :1578-1580,2011
  • A histopathological diagnostic marker for human spinal astrocytoma: expression of glial fibrillary acidic protein-δ
    JOURNAL OF NEURO-ONCOLOGY 108/1 :45-52,2012
  • Initial Clinical Outcomes of Minimally Invasive Lateral Lumbar Interbody Fusion in Degenerative Lumbar Disease: A Preliminary Report on the Experience of a Single Institution with 30 Cases
    대한척추신경외과학회지 9/3 :187-192,2012
  • Rapid recovery of tissue hypoxia by cotransplantation of endothelial cells
    NEUROREPORT 23/11 :658-662,2012
  • Transplantation of an adipose stem cell cluster in a spinal cord injury
    NEUROREPORT 23/5 :277-282,2012
  • Hypoxia-specific VEGF-expressing neural stem cells in spinal cord injury model
    NEUROREPORT 23/3 :174-178,2012
  • Thoracolumbar extradural arachnoid cysts: a study of 14 consecutive cases
    ACTA NEUROCHIRURGICA 154/2 :341-348,2012
  • Correction of Coronal Imbalance in Degenerative Lumbar Spine Disease Following Direct Lateral Interbody Fusion (DLIF)
    대한척추신경외과학회지 9/3 :176-180,2012
  • Spinal Cord Hemangioblastomas in von Hippel-Lindau Disease: Management of Asymptomatic and Symptomatic Tumors
    YONSEI MEDICAL JOURNAL 53/6 :1073-1080,2012
  • Hypoxia-specific GM-CSF-overexpressing neural stem cells improve graft survival and functional recovery in spinal cord injury
    GENE THERAPY 19/5 :513-521,2012
  • Chitosan/TPP-Hyaluronic Acid Nanoparticles: A New Vehicle for Gene Delivery to the Spinal Cord
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 23/- :1437-1450,2012
  • Radiofrequency ablation of spine: an experimental study in an ex vivo bovine and in vivo Swine model for feasibility in spine tumor
    SPINE 38/18 :E1121-E1127,2013
  • Clinical features and surgical outcomes of primary cauda equina tumours
    ACTA NEUROCHIRURGICA 155/10 :1911-1916,2013
  • The predisposing factors for the heterotopic ossification after cervical artificial disc replacement
    SPINE JOURNAL 13/9 :1048-1054,2013
  • Association between low-back pain and lumbar spine bone density: a population-based cross-sectional study
    JOURNAL OF NEUROSURGERY-SPINE 19/3 :307-313,2013
  • Stand-alone Cervical Cages Versus Anterior Cervical Plate in 2-Level Cervical Anterior Interbody Fusion Patients
    JOURNAL OF SPINAL DISORDERS & TECHNIQUES 26/8 :415-420,2013
  • Long-term surgical outcomes of cervical myelopathy with athetoid cerebral palsy
    EUROPEAN SPINE JOURNAL 23/7 :1464-1471,2014
  • Effect of Combined Bevacizumab and Temozolomide Treatment on Intramedullary Spinal Cord Tumor
    SPINE 39/2 :E65-E73,2014
  • Association Between Urine Cotinine Levels and Bone Mineral Density in Lumbar Spine and Femoral Neck Among Adult Males
    SPINE 39/4 :311-317,2014
  • Co-transplantation of bone marrow-derived mesenchymal stem cells and nanospheres containing FGF-2 improve cell survival and neurological function in the injured rat spinal cord
    ACTA NEUROCHIRURGICA 156/2 :297-303,2014
  • Robotic Resection of Huge Presacral Tumors - Case Series and Comparison With an Open Resection
    JOURNAL OF SPINAL DISORDERS & TECHNIQUES 27/4 :E151-E154,2014
  • The fate of heterotopic ossification associated with cervical artificial disc replacement
    SPINE 39/25 :2078-2083,2014
  • Rosai-Dorfman Disease in Thoracic Spine: A Rare Case of Compression Fracture
    대한척추신경외과학회지 11/3 :198-201,2014
  • A morphometric analysis of contralateral neural foramen in TLIF
    EUROPEAN SPINE JOURNAL 24/4 :783-790,2015
  • Human adipose stem cells improve mechanical allodynia and enhance functional recovery in a rat model of neuropathic pain
    TISSUE ENGINEERING PART A 21/13 :1-9,2015
  • The Use of Magnetic Resonance Imaging in Predicting the Clinical Outcome of Spinal Arteriovenous Fistula
    YONSEI MEDICAL JOURNAL 56/2 :397-402,2015
  • Surgical outcome and prognostic factors of anterior decompression and fusion for cervical compressive myelopathy due to ossificaiton of the posterior longitudinal ligament
    SPINE JOURNAL 15/5 :875-884,2015
  • A Gene and Neural Stem Cell Therapy Platform Based on Neuronal Cell Type?Inducible Gene Overexpression
    YONSEI MEDICAL JOURNAL 56/4 :1036-1043,2015
  • Multifunctional nanoparticles for gene delivery and spinal cord injury
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 103/11 :3474-3482,2015
  • Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury
    STEM CELL RESEARCH & THERAPY 6/ :125-1-125-14,2015
  • Experimental Evaluation of Percutaneous Lumbar Laser Disc Decompression Using a 1414 nm Nd:YAG Laser
    PAIN PHYSICIAN 18/6 :E1091-E1099,2015
  • Three Cases of Spine Fractures after an Airplane Crash.
    Korean Journal of Neurotrauma (대한신경손상학회지) 2/. :195-200,2015
  • Relationship between T1 slope and loss of lordosis after laminoplasty in patients with cervical ossification of the posterior longitudinal ligament
    SPINE JOURNAL 16/2 :219-225,2016
  • Paradoxical Radiographic Changes of Coflex Interspinous Device with Minimum 2-Year Follow-Up in Lumbar Spinal Stenosis
    WORLD NEUROSURGERY 85/ :177-184,2016
  • Compression Angle of Ossification of the Posterior Longitudinal Ligament and Its Clinical Significance in Cervical Myelopathy
    JOURNAL OF KOREAN NEUROSURGICAL SOCIETY 59/5 :471-477,2016
  • Therapeutic Use of 3 beta-[N-(N ',N '-Dimethylaminoethane) Carbamoyl] Cholesterol-Modified PLGA Nanospheres as Gene Delivery Vehicles for Spinal Cord Injury
    PLOS ONE 11/e0147, :1-14,2016
  • Correlation between cervical spine sagittal alignment and clinical outcome after cervical laminoplasty for ossification of the posterior longitudinal ligament
    JOURNAL OF NEUROSURGERY-SPINE 24/. :100-107,2016
  • Clinical Characteristics and Surgical Outcome of Revision Surgery in Patients with Cervical Ossification of the Posterior Longitudinal Ligament
    WORLD NEUROSURGERY 90/. :164-171,2016
  • Progression of Coronal Cobb Angle After Short-Segment Lumbar Interbody Fusion in Patients with Degenerative Lumbar Stenosis
    WORLD NEUROSURGERY 89/. :510-516,2016
  • Finite Element Analysis of the Effect of Epidural Adhesions
    PAIN PHYSICIAN 19/5 :E787-E793,2016
  • Clinical outcomes of correcting cervical deformity in cerebral palsy patients
    WORLD NEUROSURGERY 96/0 :500-509,2016
  • Sacral Reconstruction with a 3D-Printed Implant after Hemisacrectomy in a Patient with Sacral Osteosarcoma: 1-Year Follow-Up Result
    YONSEI MEDICAL JOURNAL 58/2 :453-457,2017
  • Automated pressure-controlled discography in patients undergoing anterior lumbar interbody fusion for discogenic back pain.
    WORLD NEUROSURGERY 97/ :8-15,2017

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