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소속

  • 신경과학교실

직위

  • 교수

연구실 위치

  • 의과대학 본관516호

전화/팩스

  • 02) 2228-1607 /

학력사항

  • 연세대학교 의과대학 졸업(1985)
    연세대학교 의학과 석사학위 취득(1990)
    경희대학교 의학과 박사학위 취득(1999)

교육 및 연구 경력

  • 1991 인제대학교 부산백병원 임상강사
    1992 閨 의과대학 전임강사
    1993-1994 미국 예일대학교 병원 연수(간질학, 방문교수)
    1995-1998 인제대학교 의과대학 조교수
    1998-2000 포천중문의과대학교 조교수
    2000-2005 세브란스병원 신경과 조교수
    2005-2010 세브란스병원 신경과 부교수
    2010-현재 세브란스병원 신경과 교수
    2011-현재 세브란스병원 신경과 과장
    2015-현재 세브란스병원 신경과 주임교수

기타 학술 관련 경력

  • 대한신경과학회
    대한간질학회 정회원
    대한간질학회 총무간사
    대한수면연구학회 회장

연구,관심분야

  • 간질(epilepsy)

강의분야

  • 간질 환자의 약물 및 수술 치료 참여
    대한간질학회 학술대회 강의 참여

논문

  • Transient induction of neuronal nitric oxide synthase in neurons of rat cerebral cortex after status epilepticus
    NEUROSCIENCE LETTERS 281/1 :49-52,2000
  • 열성 경련과 측두엽 간질의 관계 : 열성 경련을 경험한 성인 간질 환자에서 측두엽 간질이 호발하는가?
    대한신경과학회지(JournalOfTheKoreanNeurologicalAssociation) 18/4 :409-413,2000
  • 항경련제의 다약물치료의 합리적인 방볍
    대한간질학회지(Journal of Korean Epilepsy Society) 4/2 :124-128,2000
  • Localization of Claude's syndrome
    NEUROLOGY 57/12 :2304-2307,2001
  • Ictal automatisms with preserved responsiveness in a patient with left mesial temporal lobe epilepsy
    EPILEPSIA 42/8 :1078-1081,2001
  • Coma probably induced by lorazepam-valproate interaction
    Seizure 11/2 :124-125,2002
  • Interictal epileptiform discharges related to H-MRS-detected metabolic abnormalities in mesial temporal lobe epilepsy
    EPILEPSIA 43/11 :1385-1389,2002
  • Syndromic diagnosis at the epilepsy clinic: role of MRI in lobar epilepsies
    EPILEPSIA 43/5 :496-504,2002
  • 측두엽경화증을 가진 측두엽 환자에서 시상의 손상
    대한간질학회지 6/2 :110-116,2002
  • Low dose and slow titration of topiramate as adjunctive therapy in refractory partial epilepsies: a multicentre open clinical trial
    Seizure 11/4 :255-260,2002
  • Ictal electrocorticographic findings related with surgical outcomes in nonlesional neocortical epilepsy
    EPILEPSY RESEARCH 48/3 :199-206,2002
  • Post-transfusion posterior leukoencephalopathy with cytotoxic and vasogenic edema precipitated by vasospasm
    CEREBROVASCULAR DISEASES 15/3 :220-223,2003
  • 경동맥 협착증에서 일과성뇌허혈발작으로 인한 지떨림
    대한신경과학회지(JournalOfTheKoreanNeurologicalAssociation) 22/1 :84-86,2004
  • 내측두엽간질 환자에서 일측성과 양측성 발작간 간질양파 간의 발작중 두피뇌파의 측위화 비교
    JOURNAL OF THE KOREAN NEUROLOGICAL ASSOCIATION 22/5 :459-464,2004
  • Kainate 유발 간질모델에서 Aqurinic/Apyrimidinic Endonuclease의 빠른 소실과 이에 따른 세포고사
    대한간질학회지(Journal of Korean Epilepsy Society) 8/2 :108-115,2004
  • Diffusion tensor MRI visualizes decreased subcortical fiber connectivity in focal cortical dysplasia
    NEUROIMAGE 22/ :1826-1829,2004
  • Single-photon emission computed tomography in a patient with ictal metamorphopsia
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 13/4 :250-253,2004
  • Antiepileptic drug withdrawal after successful surgery for intractable temporal lobe epilepsy
    EPILEPSIA 46/2 :251-257,2005
  • 부분 간질 중첩증 환자에서의 혈관성 부종
    대한간질학회지(Journal of Korean Epilepsy Society) 9/1 :86-89,2005
  • Factors contributing to the stigma of epilepsy
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 14/ :157-163,2005
  • 생쥐 Pilocarpine 모델에서 중첩경련으로 유발한 해마신경세포 사멸과 이끼섬유발아에 대한 MMP-9의 역할
    대한간질학회지(Journal of Korean Epilepsy Society) 9/2 :119-128,2005
  • Relationship between bilateral temporal hypometabolism and EEG findings for mesial temporal lobe epilepsy: Analysis of
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 15/ :56-63,2006
  • Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice
    NEUROSCIENCE LETTERS 398/ :195-200,2006
  • 안와의 종양성 병변으로 인한 단안의 반복적인 시력저하
    대한신경과학회지(JournalOfTheKoreanNeurologicalAssociation) 24/4 :402-404,2006
  • 우측내경동맥 폐쇄를 지닌 환자에서 식후 저혈압으로 유발된 반복적인 일과성 뇌허혈증
    대한신경과학회지(JournalOfTheKoreanNeurologicalAssociation) 24/4 :356-358,2006
  • Kainic Acid 유발 마우스 간질모델에서 Minocycline에 의한 Caspase 의존성 세포고사 억제
    대한간질학회지(Journal of Korean Epilepsy Society) 10/1 :3-10,2006
  • Patient awareness of complex partial seizures
    EPILEPSIA 47/11 :1931-1935,2006
  • Efficacy and safety of levetiracetam as adjunctive treatment of refractory partial seizures in a multicentre open-label single-arm trial in Korean patients
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 16/ :402-409,2007
  • 간질중첩증 후 가역적 팽대병변을 보인 환자에서 나타난 장기간의 전두엽장애
    대한간질학회지(Journal of Korean Epilepsy Society) 11/1 :54-58,2007
  • 다기관, 공개 임상, 단일군 시험을 통한 난치성 부분 간질을 가진 한국인에서 부가요법으로 사용된 레비티라세탐의유효성 및 안전성: 1년 이상의 추적
    대한간질학회지(Journal of Korean Epilepsy Society) 11/1 :25-32,2007
  • 항간질약물과 선천성 기형 및 임신 중 발작 조절
    대한간질학회지(Journal of Korean Epilepsy Society) 11/2 :85-90,2007
  • 측두엽 간질 환자에서 발작 중 코 문지르기
    대한간질학회지(Journal of Korean Epilepsy Society) 11/2 :109-112,2007
  • Carbamazepine에 의한 만성적, 반복적 담관염
    대한간질학회지(Journal of Korean Epilepsy Society) 11/2 :106-108,2007
  • 수면 무호흡과 대사성 기능 부전(대사성 증후군)
    대한수면연구학회지 4/1 :17-22,2007
  • Balloon cells and dysmorphic neurons in the hippocampus associated with epileptic amnesic syndrome: A case report
    Epilepsia 49/5 :905-909,2008
  • 장기 추적 관찰한 Rasmussen 뇌염 1예
    대한간질학회지(Journal of Korean Epilepsy Society) 12/1 :55-58,2008
  • 일차단독요법에서의 라모트리진과 카바마제핀의 비교: 다기관 개방형 임상연구
    대한간질학회지(Journal of Korean Epilepsy Society) 12/1 :27-34,2008
  • 신경근 통증으로 발현된 척수 내 해면혈관종
    대한신경과학회지(Journal Of The Korean Neurological Association) 26/4 :387-389,2008
  • Neurocutaneous Melanosis Presenting as Chronic Partial Epilepsy
    Journal Of Clinical Neurology 4/ :134-137,2008
  • Pregabalin add-on therapy using a flexible, optimized dose schedule in refractory partial epilepsies: A double-blind, randomized, placebo-controlled, multicenter trial
    Epilepsia 50/3 :464-474,2009
  • Long-term efficacy and tolerability of topiramate as add-on therapy in refractory partial epilepsy: An observational study
    Epilepsia 50/8 :1910-1919,2009
  • Palilalia, echolalia, and echopraxia-palipraxia as ictal manifestations in a patient with left frontal lobe epilepsy
    Epilepsia 50/6 :1616-1619,2009
  • Surgery for intractable non-lesional partial epilepsy
    Advances In Clinical Neuroscience & Rehabilitation : Acnr 40/1 :40-42,2009
  • A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy
    Pharmacogenetics And Genomics 20/ :249-256,2010
  • Clinical feasibility of immediate overnight switching from slow-release carbamazepine to oxcarbazepine in Korean patients with refractory partial epilepsy
    Seizure-European Journal Of Epilepsy 19/6 :356-358,2010
  • Determination of lamotrigine in human serum by high-performance liquid chromatography-tandem mass spectrometry
    Neurological Sciences 31/6 :717-720,2010
  • The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy
    EPILEPSIA 52/10 :1884-1889,2011
  • Cognitive and behavioral effects of lamotrigine and carbamazepine monotherapy in patients with newly diagnosed or untreated partial epilepsy
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 20/1 :49-54,2011
  • Simple Partial Status of Forced Thinking Originated in the Mesial Temporal Region: Intracranial Foramen Ovale Electrode Recording and Ictal PET
    Journal of Epilepsy Research 1/2 :77-80,2011
  • The Localizing and Lateralizing Value of Auras in Lesional Partial Epilepsy Patients
    YONSEI MEDICAL JOURNAL 53/3 :477-485,2012
  • 인슐린종으로 인한 과다수면과 무의식배회
    대한신경과학회지 30/1 :54-56,2012
  • 새로운 항뇌전증약물
    JOURNAL OF THE KOREAN MEDICAL ASSOCIATION 55/2 :155-173,2012
  • Reflex epilepsy induced by playing Go-stop or Baduk games
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 21/10 :770-774,2012
  • Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: A multicenter open-label single-arm trial in Korean patients
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 21/3 :188-193,2012
  • Epilepsy: New genes, new technologies, new insights
    LANCET NEUROLOGY 13/1 :7-9,2014
  • A newly discovered LGI1 mutation in Korean family with autosomal dominant lateral temporal lobe epilepsy
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 23/1 :69-73,2014
  • Nonconvulsive status epilepticus manifesting as full-blown psychosis during pregnancy
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 23/5 :402-404,2014
  • Prophylactic effect of erythropoietin injection to prevent acute mountain sickness: an open-label randomized controlled trial.
    JOURNAL OF KOREAN MEDICAL SCIENCE 29/3 :416-422,2014
  • Effects of botulinum toxin on jaw motor events during sleep in sleep bruxism patients: a polysomnographic evaluation
    JOURNAL OF CLINICAL SLEEP MEDICINE 10/3 :291-298,2014
  • Effect of Androsterone after Pilocarpine-induced Status Epilepticus in Mice
    Journal of Epilepsy Research 4/1 :7-13,2014
  • Long-term prognosis of patients with Lennox-Gastaut syndrome in recent decades
    EPILEPSY RESEARCH 110/- :10-19,2015
  • GWAS identifies two susceptibility loci for lamotrigine-induced skin rash in patients with epilepsy
    EPILEPSY RESEARCH 115/ :88-94,2015
  • Development of epilepsy after posterior reversible encephalopathy syndrome
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 34/ :90-94,2016
  • Atrophy of the pedunculopontine nucleus region in patients with sleep-predominant seizures: A voxel-based morphometry study
    EPILEPSIA 57/8 :e151-e154,2016
  • Clinical Utility of Bone Marrow Study in Gaucher Disease: A Case Report of Gaucher Disease Type 3 With Intractable Myoclonic Seizures
    ANNALS OF LABORATORY MEDICINE 36/2 :177-179,2016
  • Simple partial seizures aggravated or induced by benzodiazepine injection.
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 41/ :6-8,2016
  • Trafficking patterns of NMDA and GABAA receptors in a Mg2+-free cultured hippocampal neuron model of status epilepticus.
    EPILEPSY RESEARCH 136/ :143-148,2017

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