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소속

  • 신경과학교실

직위

  • 부교수

연구실 위치

전화/팩스

  • 02)2228-1602 /

학력사항

  • 연세대학교 의학과학사 (1987)
    연세대학교 의학과 석사 (1990)
    연세대학교 의학과 박사 (1997)

교육 및 연구 경력

  • 연세대학교 세브란스 병원 인턴
    연세대학교 세브란스 병원 신경과 레지던트
    연세대학교 세브란스 병원 뇌졸중 전임의, 강사
    1997-2001 Post-doc Fellow in Neurology, Neurosurgery and Neuroscience, UC San Francisco, Stanford University, U.S.A.
    2001 Visiting Professor in Neurocritical care, Geneva University, Switzerland
    2001- 현재 연세대학교 의과대학 부교수
    2004-2005 Clinicall Fellow in Stroke and Neurocritical care, University of Southern California, U.S.A.

기타 학술 관련 경력

  • American Society of Neurology: Regular member
    American Society of Stroke: Regular member
    American Society of Neuroscience: Regular member
    American Society of Neurocritical Care: Regular member대한혈관신경의학회: 회장
    대한치매학회: 정회원 (보건복지부 치매 판정의)
    대한신경과학회: 정회원 대한뇌졸중학회: 정회원 대한신경집중치료학회: 정회원
    한국혈전지혈학회: 정회원
    한국혈관학회: 정회원
    대한신경초음파학회: 정회원
    대한초음파학회: 정회원

연구,관심분야

  • 뇌혈관 질환, 경동맥 질환, 혈관질환, 뇌졸중, 혈관치매, 경도 인지 장애

논문

  • Early Decrease in DNA Repair Proteins, Ku70 and Ku86, and Subsequent DNA Fragmentation After Transient Focal Cerebral Ischemia in Mice
  • Stroke 32: 1401-1407, 2001
  • Oxidative Stress and Neuronal DNA Fragmentation Mediate Age-Dependent Vulnerability to the Mitochondrial Toxin, 3-Nitropropionic Acid, in the Mouse Striatum Neurobiology of Disease 8: 114-126, 2001
  • Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice
  • Stroke 33: 809-815, 2002
  • Involvement of Superoxide in Excitotoxicity and DNA Fragmentation in Striatal Vulnerability in Mice After Treatment With the Mitochondrial Toxin, 3-Nitropropionic Acid
  • Journal of Cerebral Blood Flow & Metabolism 22: 798-809, 2002
  • Neurodegeneration in Striatum Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Role of Matrix Metalloproteinase-9 in Early Blood-Brain Barrier Disruption?
  • The Journal of Neuroscience 232:8733-8742, 2003
  • Neuronal Death/Survival Signaling Pathways in Cerebral Ischemia
  • The Journal of the American Society for Experimental NeuroTherapeutics 1: 17-25, 2004
  • Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-indcing factor andthe subsequent DNA fragmentation after permanent focalcerebral ischemia in mice
  • Stroke 36:2712-2717, 2005
  • Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age-dependent vulnerability to 3-nitropropionc acid in the mouse striatum
  • Neuroscience Letters 430: 142-146, 2008
  • Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20/0 :119-129,2000
  • Involvement of oxidative stress and caspase-3 in cortical infarction after photothrombotic ischemia in mice.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20/0 :1690-1701,2000
  • Arterial pulsatility as an index of cerebral microangiopathy in diabetes.
    STROKE 31/0 :1111-1115,2000
  • The Cytosolic Antioxidant, Copper/Zinc-Superoxide Dismutase Attenuates Blood-Brain Barrier Disruption and Oxidative Cellular Injury After Photothrombotic Cortical Ischemia in Mice.
    NEUROSCIENCE 105/4 :1007-1018,2001
  • Oxidative Stress and Neuronal DNA Fragmentation Mediate Age-Dependent Vulnerability to the Mitochondrial Toxin, 3-Nitropropionic Acid, in the Mouse Striatum.
    NEUROBIOLOGY OF DISEASE 8/0 :114-126,2001
  • Neuronal expression of the DNA repair protein Ku 70 after ischemic preconditioning corresponds to tolerance to global cerebral ischemia.
    STROKE 32/0 :2388-2393,2001
  • Early decrease in DNA repair proteins, Ku70 and Ku86, and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
    STROKE 32/6 :1401-1407,2001
  • Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice Implications for the Production and Role of Superoxide Radicals
    STROKE 33/0 :809-815,2002
  • Involvement of superoxide in excitotoxicity & DNA fragmentation in straiatal vulnerability in mice after treatment with the mitochondrial toxin, 3-NP
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 22/0 :798-809,2002
  • Neurodegeneration in stratum induced by the mitochondrial toxin 3-NP: role of matrix metalloproteinase-9 in darly blood-brain barrier disruption?
    JOURNAL OF NEUROSCIENCE 23/25 :8733-8742,2003
  • 3-nitropropionic Acid 투여 후 마우스 선조체에서 Apurinic/Apyrimidinic Endonuclease의 발현과 신경세포고사
    JOURNAL OF THE KOREAN NEUROLOGICAL ASSOCIATION 23/4 :510-518,2005
  • Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
    NATURE 435/435 :347-353,2005
  • Early nuclear translocation of endonuclease G and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
    NEUROSCIENCE LETTERS 386/ :23-27,2005
  • Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-inducing factor and the subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
    STROKE 36/ :2712-2717,2005
  • 영구적 국소 대뇌 허혈 생쥐 모델에서 활성 산소종에 의한 세포고사 유도인자의 핵내 이동과 세포고사
    대한뇌졸중학회지 7/2 :214-223,2005
  • 생쥐 Pilocarpine 모델에서 중첩경련으로 유발한 해마신경세포 사멸과 이끼섬유발아에 대한 MMP-9의 역할
    대한간질학회지(Journal of Korean Epilepsy Society) 9/2 :119-128,2005
  • Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice
    NEUROSCIENCE LETTERS 398/ :195-200,2006
  • Kainic Acid 유발 마우스 간질모델에서 Minocycline에 의한 Caspase 의존성 세포고사 억제
    대한간질학회지(Journal of Korean Epilepsy Society) 10/1 :3-10,2006
  • 국소 대뇌 허혈 및 재관류 후 생쥐 모델에서 활성 산소 제거제(MnTBAP)에 의한 Endonuclease G의 조기 핵 내 이동방지 및 뇌경색 감소
    대한신경과학회지(JournalOfTheKoreanNeurologicalAssociation) 25/4 :535-543,2007
  • Preconditioning with chronic cerebral hypoperfusion reduces a focal cerebral ischemic injury and increases apurinic/apyrimidinic endonuclease/redox factor-1 and matrix metalloproteinase-2 expression
    CURRENT NEUROVASCULAR RESEARCH 4/2 :89-97,2007
  • Tracing of Noradrenergic Neuronal Circuitry and Functional Recovery after Permanent Focal Cerebral Ischemia in Mice
    Journal of Neurocritical Care 1/ :31-42,2008
  • Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age-dependent vulnerability to 3-nitropropionic acid in the mouse striatum
    Neuroscience Letters 430/ :142-146,2008
  • 후뇌동맥박리에 의한 후뇌동맥경색증 1예
    Journal of Neurocritical Care 1/ :59-61,2008
  • 급성기 허혈성 뇌졸중에서 혈소판과 백혈구의 상호작용
    Journal of Neurocritical Care 1/ :43-49,2008
  • 급성 허혈성 뇌졸중치료 패러다임의 전환
    Journal of Neurocritical Care 1/ :1-11,2008
  • 일과성 국소 대뇌 허혈 생쥐 모델에서 Apoptosis Signal-Regulating Kinase 1의 증가 및 Ask1 표적 siRNA 처치에 의한 대뇌 허혈 감소
    Journal of Neurocritical Care 1/2 :143-149,2008
  • 일과성 국소 대뇌 허혈 생쥐 모델에서 APE/Ref-1 융합 아데노바이러스 처치에 의한 APE/Ref-1의 과발현 및 신경세포고사 감소
    Journal of Neurocritical Care 1/2 :150-156,2008
  • 콜린분해효소 억제제의 사용 유무에 따른소혈관성 치매 환자의 임상 경과
    대한신경과학회지(Journal Of The Korean Neurological Association) 26/3 :209-215,2008
  • The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice
    Brain Research 1274/ :1-10,2009
  • Post-ischemic administration of peptide with apurinic/apyrimidinic endonuclease activity inhibits induction of cell death after focal cerebral ischemia/reperfusion in mice
    Neuroscience Letters 460/2 :166-169,2009
  • The role of MMP-9 in integrin-mediated hippocampal cell death after pilocarpine-induced status epilepticus
    Neurobiology Of Disease 36/1 :169-180,2009
  • 근거중심의학의 관점에서 급성 허혈성 뇌졸중에서의 혈전용해제 투여 지침에 대한 고찰
    대한혈관신경의학회 1/1 :27-32,2009
  • Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease
    Neuroscience 163/4 :1128-1134,2009
  • Oxidative Stress-Induced Necrotic Cell Death via Mitochondira-Dependent Burst of Reactive Oxygen Species
    Current Neurovascular Research 6/4 :213-222,2009
  • INDUCTION OF STRIATAL NEUROGENESIS ENHANCES FUNCTIONAL RECOVERY IN AN ADULT ANIMAL MODEL OF NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY
    NEUROSCIENCE 169/1 :259-268,2010
  • The Korean Addenbrooke's Cognitive Examination revised for differential diagnosis of Alzheimer's disease and subcortical ischaemic vascular dementia
    Journal of Neurology 257/ :P179-,2010
  • Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death
    Molecular And Cellular Neuroscience 45/3 :267-276,2010
  • 알츠하이머성 치매와 혈관성 치매의 특징비교
    Vascular Neurology 2/1 :18-25,2010
  • Current Strategies for the Treatment of Atherosclerotic Plaques
    Vascular Neurology 2/1 :14-17,2010
  • Apoptosis signal-regulating kinase 1 (Ask1) targeted small interfering RNA on ischemic neuronal cell death
    BRAIN RESEARCH 1412/0 :73-78,2011
  • 뇌졸중 치료 패러다임의 현재와 미래
    Vascular Neurology 3/1 :13-19,2011
  • Cerebroprotective effects of red ginseng extract pretreatment against ischemia-induced oxidative stress and apoptosis
    INTERNATIONAL JOURNAL OF NEUROSCIENCE 123/4 :269-277,2013
  • Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 441/2 :280-285,2013
  • The Therapeutic Potential of Apoptosis Signal-Regulating
    Vascular Neurology 5/- :3-6,2013
  • Differential caspase activity in the cortex and striatum with chronic infusion of 3-nitropropionic acid
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 465/3 :631-637,2015
  • Statins promote long-term recovery after ischemic stroke by reconnecting noradrenergic neuronal circuitry
    NEURAL PLASTICITY 2015/Arti :1-10,2015
  • Knockdown of apoptosis signal-regulating kinase 1 affects ischaemia-induced astrocyte activation and glial scar formation
    EUROPEAN JOURNAL OF NEUROSCIENCE 43/7 :912-922,2016
  • Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q
    SCIENTIFIC REPORTS 6/ :18840-,2016

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