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소속

  • 신경과학교실

보직

  • 조교수

직위

  • 부교수

연구실 위치

  • 강남세브란스병원

전화/팩스

  • 02) 2019-2370 /

학력사항

  • 1996년 : 연세대학교 의과대학 의학과 졸업
    2000년 : 연세대학교 대학원 의학과 신경과학 석사
    2006년 : 연세대학교 대학원 의학과 신경과학 박사

교육 및 연구 경력

  • 1996년 3월 - 1997년 2월 : 강남세브란스병원 인턴
    1997년 3월 - 2001년 2월 : 강남세브란스병원 신경과 전공의
    2004년 5월 - 2007년 2월 : 강남세브란스병원 신경과 연구강사
    2008년 3월 - 2009년 2월: 강남세브란스병원 신경과 전임강사
    2009년 3월 - 2014년 2월: 강남세브란스병원 신경과 조교수
    2014년 3월 - : 강남세브란스병원 신경과 부교수

기타 학술 관련 경력

  • 대한 신경과 학회 회원
    대한 파킨슨 병 및 이상운동 질환 학회 회원

    [수상경력]
    * 2007년 7월 : 대한 파킨슨병 및 이상운동 질환 학회 우수 연구강사상
    * 2008년 2월 : 연세대학교 강남세브란스병원 강사학술상 최우수상

연구,관심분야

  • 퇴행성 신경계 질환 (치매, 파킨슨병)의 영상 진단과 분석
    유전성 신경병

논문

  • 류철형, 장진우, 이명식. 파킨슨병에 대한 시상하핵 심부뇌자극술. 대한신경과학회지 2006;24:191-203.
  • 류철형, 이승엽, 유영훈, 이명식. 파킨슨병과 다계통위축증 감별 진단에 정량적 18-fluorodeoxyglucose PET의 유용성. 대한신경과학회지 2006;24:31-37.
  • 이기욱, 류철형, 이명식. 젊은 나이에 산발성 파킨슨병이 생긴 한국인 환자의 Parkin 유전자 변이. 대한신경과학회지 2006;24:26-30.
  • 류철형, 장진우, 이명식. 파킨슨병 환자에서 전극선의 부분 손상으로 인한 심부뇌자극 효과 소실. 대한신경과학회지 2005;23:820-822.
  • 오승헌, 김현숙, 류철형, 이진구, 이명식. 한 가족에서 나타난 간대성근경련-이긴장증. 대한신경과학회지 2002;20:509-514.
  • 김원찬, 오승헌, 김현숙, 류철형, 이진구, 장진우, 이명식. 진행된 특발성 파킨슨병에서 시상하핵 자극의 효과. 대한신경과학회지 2002;20:234-242.
  • 류철형, 김현숙, 김용덕, 김진호, 이명식. 한국인 가족성 파킨슨병과 α-synuclein유전자 돌연변이의 무관성. 대한신경과학회지 1999;17:534-540.
  • 김용덕, 양진우, 이현정, 류철형, 김원찬, 이명식. 치료받은 적이 없는 원발성 파킨슨병과 다계통 위축증 환자들의 Single Oral Levodopa Challenge Test. 대한신경과학회지 1999;17:53-62.
  • 김원주, 김선곤, 류철형, 김원찬, 김용덕, 최영철, 이명식. 현훈 환자 neuron specific enolase의 임상적 의의. 대한신경과학회지 1998;16:506-509.
  • 류철형, 허경, 최영철, 이성철, Stevanin G, David G, Brice A, 이명식. 제 2형 상염색체 우성 유전성 소뇌 실조증에 합당한 임상 소견을 보인 한국인 가족들에서 유전자 검사로 확인된 SCA7의 과도한 CAG 반복. 대한신경과학회지 1998;16:341-352.
  • 류철형, 김용덕, 이명식. 유전자 검사로 확진된 Machado-Joseph disease 가족. 대한신경과학회지 1997;15:403-412.
  • 류철형, 이명식. 유전자 검사와 부검으로 확진된 헌팅톤씨 병. 대한신경과학회지 1996;14:725-737.
  • Lyoo CH, Jeong Y, Ryu YH, et al. Effects of disease duration on the clinical features and brain glucose metabolism in patients with mixed type multiple system atrophy. Brain 2008;131:438-446.
  • Baik JS, Lyoo CH, Lee JH, Lee MS. Drug-induced and psychogenic resting suprahyoid neck and tongue tremors. Mov Disord 2008 (in press).
  • Lyoo CH, Prokisch H, Meitinger T, Lee SY, Kim DH, Lee MS. Anticholinergic-responsive gait freezing in a patient with pantothenate kinase-associated neurodegeneration. Mov Disord 2007;23:283-284.
  • Lyoo CH, Lee SY, Song TJ, Lee MS. Abnormal temporal discrimination threshold in patients with multiple system atrophy. Mov Disord 2007;22:556-559.
  • Lyoo CH, Kim DJ, Chang H, Lee MS. Moyamoya disease presenting with paroxysmal exercise-induced dyskinesia. Parkinsonism Relat Disord 2007;13:446-448.
  • Lyoo CH, Aalto S, Rinne JO, et al. Different cerebral cortical areas influence the effect of subthalamic nucleus stimulation on parkinsonian motor deficits and freezing of gait. Mov Disord 2007;22:2176-2182.
  • Kang SY, Sohn YH, Kim HS, Lyoo CH, Lee MS. Corticospinal disinhibition in paroxysmal kinesigenic dyskinesia. Clin Neurophysiol 2006;117:57-60.
  • Lee MS, Kim YD, Lyoo CH. Oculogyric crisis as an initial manifestation of Wilson's disease. Neurology 1999;52:1714-1715.
  • Lee MS, Kim YD, Kim WC, Lyoo CH. Slow rhythmic dyskinesia of the shoulder: one idopathic and two symptomatic cases. Mov Disord 1999;14:1049-1051.
  • Lee MS, Kim WC, Lyoo CH, Lee HJ. Reciprocal inhibition between the forearm muscles in patients with paroxysmal kinesigenic dyskinesia. J Neurol Sci 1999;168:57-61.
  • Lee MS, Kim YD, Kim JT, Lyoo CH. Abrupt onset of transient pseudochoreoathetosis associated with proprioceptive sensory loss as a result of a thalamic infarction. Mov Disord 1998;13:184-186.
  • Lee MS, Lyoo CH, Kim WC, Kang HJ. Periodic bursts of rhythmic dyskinesia associated with spinal anesthesia. Mov Disord 1997;12:816-817.
  • 파킨슨병 환자에서 전극선의 부분 손상으로 인한 시상하핵 자극 효과 소실
    대한신경과학회지(JournalOfTheKoreanNeurologicalAssociation) 23/6 :820-822,2005
  • "Off" gait freezing and temporal discrimination threshold in patients with Parkinson disease
    NEUROLOGY 64/ :670-674,2005
  • Abnormal temporal discrimination threshold in patients with multiple system atrophy
    MOVEMENT DISORDERS 22/4 :556-559,2007
  • Moyamoya disease presenting with paroxysmal exercise-induced dyskinesia
    PARKINSONISM & RELATED DISORDERS 13/ :446-448,2007
  • Different cerebral cortical areas influence the effect of subthalamic nucleus stimulation on Parkinsonian motor deficits and freezing of gait
    MOVEMENT DISORDERS 22/15 :2176-2182,2007
  • Effects of disease duration on the clinical features and brain glucose metabolism in patients with mixed type multiple system atrophy
    Brain 131/ :438-446,2008
  • Anticholinergic-responsive gait freezing in a patient with pantothenate kinase-associated neurodegeneration
    Movement Disorders 23/ :283-284,2008
  • 전형적, 비전형적 임상 양상을 보인 Neurodegeneration With Brain Iron Accumulation 환자
    대한신경과학회지(Journal Of The Korean Neurological Association) 26/3 :243-246,2008
  • Drug-induced and psychogenic resting suprahyoid neck and tongue tremors
    Movement Disorders 23/ :746-748,2008
  • 조기 발현 파킨슨병 환자에서 SCA2, SCA3과SCA17 유전자 내의 삼염기 반복수 변화
    대한신경과학회지(Journal Of The Korean Neurological Association) 26/1 :23-27,2008
  • 파킨슨병 환자들에서 넘어짐과 신체 손상
    대한 파킨슨병 및 이상운동질환학회 1/1 :13-18,2008
  • Relationship between the striatal and cerebellar glucose metabolism and the response to levodopa treatment in patients with multiple system atrophy
    대한 파킨슨병 및 이상운동질환학회 1/1 :26-32,2008
  • Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease
    Neurogenetics 9/4 :263-269,2008
  • 편측무도증으로 발현하여 처음 진단된 제2형 당뇨병 1예
    임상당뇨병학회지(Clinical Diabetes) 9/3 :213-218,2008
  • Functional peak dose dyskinesia in patients with Parkinson's disease
    Parkinsonism & Related Disorders 15/6 :475-476,2009
  • Oculogyric crisis associated with disulfiram-induced pallidonigral lesion
    Journal of Movement Disorders 2/ :48-49,2009
  • giant somatosensory evoked potential in a patient with shaking TIA
    Movement Disorders 24/15 :2301-2303,2009
  • Topographical distribution of cerebral cortical thinning in patients with mild Parkinson's disease without dementia
    Movement Disorders 25/4 :496-499,2010
  • Primary Progressive Freezing Gait in a Patient with CO-Induced Parkinsonism
    Movement Disorders 25/10 :1513-1515,2010
  • Cerebral glucose metabolism of Parkinson's disease patients with mild cognitive impairment
    European Neurology 64/2 :65-73,2010
  • Levodopa responsive hemidystonia associated with contralateral nigral lesion
    Journal of Neurology 257/5 :856-857,2010
  • Impaired finger dexterity in patients with parkinson's disease correlates with discriminative cutaneous sensory dysfunction
    Movement Disorders 25/15 :2531-2535,2010
  • 근긴장이상증이나 무도증의 임상적 특징과 감별진단
    대한임상신경생리학회지(Journal of the Korean Society for Clinical Neurophysiology) 12/1 :230-234,2010
  • Imaging Evidence of Nigral Damage in Dystonia Secondary to Disulfiram Intoxication
    MOVEMENT DISORDERS 26/4 :763-764,2011
  • The effect of age on motor deficits and cerebral glucose metabolism of Parkinson's disease
    ACTA NEUROLOGICA SCANDINAVICA 124/3 :196-201,2011
  • Rhabdomyolysis induced by severe levodopa induced dyskinesia in a patient with Parkinson's disease
    JOURNAL OF NEUROLOGY 258/0 :1893-1894,2011
  • Cerebral cortical areas in which thickness correlates with severity of motor deficits of Parkinson's disease
    JOURNAL OF NEUROLOGY 258/10 :1871-1876,2011
  • A patient with genetically confirmed myoclonus-dystonia responded to anticholinergic treatment and improved spontaneously
    JOURNAL OF CLINICAL NEUROLOGY 7/4 :231-232,2011
  • Neuroleptic Malignant Syndrome in a Patient with Corticobasal Degeneration
    Journal of Movement Disorders 4/ :73-74,2011
  • Association of mutations in the glucocerebrosidase gene with Parkinson disease in a Korean population.
    NEUROSCIENCE LETTERS 514/1 :12-15,2012
  • Striatal dopamine loss and discriminative sensory dysfunction in Parkinson's disease
    ACTA NEUROLOGICA SCANDINAVICA 126/5 :344-349,2012
  • 원발성 가역적뇌혈관수축증후군에 의한 가역적후뇌병증
    Journal of Neurocritical Care 5/2 :61-64,2012
  • A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 33/1 :53-58,2013
  • Population-Based Input Function Modeling for [(18)F]FMPEP-d 2, an Inverse Agonist Radioligand for Cannabinoid CB1 Receptors: Validation in Clinical Studies
    PLOS ONE 8/4 :e60231-e60231,2013
  • In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease
    BRAIN 136/Pt 7 :2228-2238,2013
  • Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography
    MOLECULAR PSYCHIATRY 18/8 :916-921,2013
  • Image-Derived Input Function Derived from a Supervised Clustering Algorithm: Methodology and Validation in a Clinical Protocol Using [11C](R)-Rolipram
    PLOS ONE 9/Issue 2 :e89101-,2014
  • Fluoxetine administered to juvenile monkeys: Effects on the serotonin transporter and behavior
    AMERICAN JOURNAL OF PSYCHIATRY 171/3 :323-331,2014
  • Kinematic Analysis in Patients with Parkinson's Disease and SWEDD
    JOURNAL OF PARKINSONS DISEASE 4/3 :421-430,2014
  • Application of calibrated image-derived input function to a clinical protocol
    NUCLEAR MEDICINE COMMUNICATIONS 35/11 :1188-1189,2014
  • Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[18F]Mefway
    APPLIED RADIATION AND ISOTOPES 94/0 :30-34,2014
  • A Computed Tomography-Based Spatial Normalization for the Analysis of [18F] Fluorodeoxyglucose Positron Emission Tomography of the Brain
    KOREAN JOURNAL OF RADIOLOGY 15/6 :862-870,2014
  • Neuroimaging studies and whole exome sequencing of PLA2G6-associated neurodegeneration in a family with intrafamilial phenotypic heterogeneity
    PARKINSONISM & RELATED DISORDERS 21/4 :402-406,2015
  • Current Status of Huntington's Disease in Korea: A Nationwide Survey and National Registry Analysis
    Journal of Movement Disorders 8/1 :14-20,2015
  • 18F-Mefway PET imaging of serotonin 1A receptors in humans: A comparison with 18F-FCWAY
    PLOS ONE 10/4 :0-0,2015
  • 대뇌피질 대사저하가 관찰된안구간대경련-근간대경련증후군
    대한신경과학회지 33/2 :103-105,2015
  • Impact of regional striatal dopaminergic function on kinematic parameters of Parkinson’s disease
    JOURNAL OF NEURAL TRANSMISSION 122/5 :669-677,2015
  • Cerebellum can serve as a pseudo-reference region in Alzheimer disease to detect neuroinflammation measured with PET radioligand binding to translocator protein
    JOURNAL OF NUCLEAR MEDICINE 56/5 :701-706,2015
  • [18F]FPEB and [18F]FDEGPECO comparative study of mGlu5 quantification in rodent brain
    APPLIED RADIATION AND ISOTOPES 98/0 :103-107,2015
  • Parkinsonism and Dementia Associated with Giant Virchow-Robin Spaces
    Journal of Movement Disorders 8/2 :106-107,2015
  • Feasibility of Computed Tomography-Guided Methods for Spatial Normalization of Dopamine Transporter Positron Emission Tomography Image
    PLOS ONE 10/7 :e0132585-,2015
  • Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system
    SYNAPSE 69/9 :453-460,2015
  • [(18)F] FP-CIT PET study in parkinsonian patients with leukoaraiosis.
    PARKINSONISM & RELATED DISORDERS 21/7 :704-708,2015
  • 기억상실형경도인지장애로 나타난 항LGI1항체변연뇌염
    대한신경과학회지 34/1 :71-73,2016
  • Optimal timing of [18F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects
    APPLIED RADIATION AND ISOTOPES 107/0 :127-132,2016
  • P-Glycoprotein, not BCRP, Limits the Brain Uptake of [(18)F]Mefway in Rodent Brain
    MOLECULAR IMAGING AND BIOLOGY 18/2 :267-73,2016
  • Prevalence and treatment pattern of Parkinson's disease dementia in Korea
    GERIATRICS & GERONTOLOGY INTERNATIONAL 16/2 :230-236,2016
  • Tau Accumulation in Primary Motor Cortex of Variant Alzheimer's Disease with Spastic Paraparesis
    JOURNAL OF ALZHEIMERS DISEASE 51/3 :671-675,2016
  • Clinical Heterogeneity of Atypical Pantothenate Kinase-Associated Neurodegeneration in Koreans
    Journal of Movement Disorders 9/1 :20-27,2016
  • Tau PET in Alzheimer disease and mild cognitive impairment
    NEUROLOGY 87/4 :375-383,2016
  • In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum
    ANNALS OF NEUROLOGY 80/2 :247-258,2016
  • 11C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease
    NEUROBIOLOGY OF AGING 44/ :53-61,2016
  • A Dextral Primary Progressive Aphasia Patient with Right Dominant Hypometabolism and Tau Accumulation and Left Dominant Amyloid Accumulation
    Case Reports in Neurology 8/1 :78-86,2016
  • Human Radiation Dosimetry of [F-18]AV-1451(T807) to Detect Tau Pathology
    MOLECULAR IMAGING AND BIOLOGY 18/4 :479-482,2016
  • Deleayed iron deposit and atrophy of the putamen in a case with osmotic demyelination syndrome
    JOURNAL OF THE NEUROLOGICAL SCIENCES 369/ :131-133,2016
  • Impact of prolonged temporal discrimination threshold on finger movements of Parkinson’s disease.
    PLOS ONE 11/11 :e0167034-,2016
  • A prognostic factor in focal hand dystonia: typist's cramp cases and literature review
    JOURNAL OF THE NEUROLOGICAL SCIENCES 371/12 :85-87,2016
  • Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans
    MOLECULAR IMAGING AND BIOLOGY 18/6 :803-806,2016
  • Subcortical 18F-AV-1451 Binding Patterns in Progressive Supranuclear Palsy
    MOVEMENT DISORDERS 32/1 :134-140,2017
  • Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease
    JOURNAL OF CLINICAL NEUROSCIENCE 36/ :108-113,2017
  • 18F-AV-1451 Binds to Putamen in Multiple System Atrophy
    MOVEMENT DISORDERS 32/1 :171-173,2017
  • Clinical features indicating reduced nigrostriatal dopaminergic innervation in patients with drug-induced parkinsonism.
    Journal of Movement Disorders 10/1 :35-39,2017
  • Excessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer's disease
    NEUROBIOLOGY OF AGING 53/ :103-111,2017
  • 18F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy
    JOURNAL OF ALZHEIMERS DISEASE 57/3 :711-716,2017
  • Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer ' s disease
    NEUROBIOLOGY OF AGING 51/ :132-140,2017

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