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소속

  • 신경과학교실

직위

  • 임상조교수

연구실 위치

전화/팩스

  • /

학력사항

  • 1999.3 ~ 2005. 2 연세대학교 의과대학 졸업

교육 및 연구 경력

  • 2005.3 ~ 2006.2 신촌세브란스 인턴
    2007.3 ~ 2011.2 강남세브란스 신경과 전공의
    2011.3. 신경과 전문의 취득
    2011.3 ~ 2012.2 삼성의료원 신경과 치매분야 임상강사
    2012.3~ 2014.2 삼성의료원 신경과 치매분야 연구강사
    2011.3~ 2012.2 보건복지부 임상의과학자 양성과제 주관책임자
    2011.3 ~ 2013.12 강남구 치매지원센터 촉탁의
    2012.3 ~ 2014.2 보건복지부 노인요양건강보험 등급판정 위원

기타 학술 관련 경력

  • 국제학술대회 강연: 2012년 AAIC (Alzheimer's Association International Conference) Symposium Lecture : ‘Amyloid burden in Early onset vs Late onset Alzheimer's disease’

연구,관심분야

  • 조발형 알츠하이머 치매, 혈관성 치매, 경도인지장애, 주관적 기억장애, 치매 예방, 치매 예측 시스템

강의분야

  • 인지신경학, 조발형 알츠하이머 치매

논문

  • 1 .Shape Changes of the Basal Ganglia and Thalamus in Alzheimer's Disease: A Three-Year Longitudinal Study.
  • 2. Amyloid deposition in early onset versus late onset Alzheimer's disease.
  • 3. Changes in subcortical structures in early- versus late-onset Alzheimer's disease.
  • 4. Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease.
  • 5. Blood Viscosity in Subcortical Vascular Mild Cognitive Impairment with versus without Cerebral Amyloid Burden.
  • 6. White Matter Hyperintensities are associated with Amyloid Burden in APOE4 Non-Carriers.
  • 7. Synergistic Effects of Ischemia and β-Amyloid Burden on Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment.
  • 8. A Case of GNE Myopathy Presenting a Rapid Deterioration during Pregnancy.
  • 9. Individual subject classification of mixed dementia from pure subcortical vascular dementia based on subcortical shape analysis.
  • 10. Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment.
  • 11. Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment.
  • 12. A New Classification System for Ischemia Using a Combination of Deep and Periventricular White Matter Hyperintensities.
  • 13. Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions: a study among patients with subcortical vascular cognitive impairment.
  • 14. Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment.
  • 15. The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments.
  • 16. Cognitive deficits of pure subcortical vascular dementia vs. Alzheimer disease: PiB-PET-based study.
  • 17. Effects of education on the progression of early- versus late-stage mild cognitive impairment.
  • 18. Effect of kidney dysfunction on cortical thinning in patients with probable Alzheimer's disease dementia.
  • 19. Cortical thinning in subcortical vascular dementia with negative 11C-PiB PET.
  • 확장형심근병증과 뇌경색증을 동반한 듀센 근육이영양증 환자
    Journal Of The Korean Neurological Association(대한신경과학회지) 27/1 :82-84,2009
  • 저산소뇌증 환자에서 혈청 Neuron-Specific Enolase 수치와 예후
    Journal of Neurocritical Care 2/ :6-11,2009
  • Multiplex Ligation-dependent Probe Amplification (MLPA) 방법에 의한 디스트로핀 유전자 돌연변이 분자학적 진단의 유용성
    Journal Of The Korean Neurological Association(대한신경과학회지) 28/1 :22-26,2010
  • 독시라민 과량 복용 후 발작이 발생한 환자들의 임상양상
    Journal of Korean Epilepsy Society(대한간질학회지) 14/1 :6-10,2010
  • Impaired finger dexterity in patients with parkinson's disease correlates with discriminative cutaneous sensory dysfunction
    Movement Disorders 25/15 :2531-2535,2010
  • Claude's Syndrome Associated with Neurocysticercosis
    YONSEI MEDICAL JOURNAL 51/6 :978-979,2010
  • Insulinoma Presenting as a Parasomnia Mimic Symptoms
    수면(Journal of Korean Sleeping Society) 7/2 :57-60,2010
  • Three Cases of Manifesting Female Carriers in Patients with Duchenne Muscular Dystrophy
    YONSEI MEDICAL JOURNAL 52/1 :192-195,2011
  • Cortical Thinning in Subcortical Vascular Dementia with Negative C-11-PiB PET
    JOURNAL OF ALZHEIMERS DISEASE 31/2 :315-323,2012
  • Pathogenesis of Cerebral Microbleeds: In Vivo Imaging of Amyloid and Subcortical Ischemic Small Vessel Disease in 226 Individuals with Cognitive Impairment
    ANNALS OF NEUROLOGY 73/5 :584-593,2013
  • Changes in subcortical structures in early- versus late-onset Alzheimer’s disease
    NEUROBIOLOGY OF AGING 34/7 :1740-1747,2013
  • A Case of GNE Myopathy Presenting a Rapid Deterioration during Pregnancy
    JOURNAL OF CLINICAL NEUROLOGY 9/4 :280-282,2013
  • Effects of education on the progression of early-versus late-stage mild cognitive impairment
    INTERNATIONAL PSYCHOGERIATRICS 25/4 :597-606,2013
  • Effect of Kidney Dysfunction on Cortical Thinning in Patients with Probable Alzheimer's Disease Dementia
    JOURNAL OF ALZHEIMERS DISEASE 33/4 :961-968,2013
  • Cerebellar Atrophy in Patients with Subcortical-Type Vascular Cognitive Impairment
    CEREBELLUM 12/ :35-42,2013
  • Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease
    NEUROBIOLOGY OF AGING 34/7 :e9-1921-,2013
  • Amyloid Deposition in Early Onset versus Late Onset Alzheimer's Disease
    JOURNAL OF ALZHEIMERS DISEASE 35/4 :813-821,2013
  • Individual Subject Classification of Mixed Dementia from Pure Subcortical Vascular Dementia Based on Subcortical Shape Analysis
    PLOS ONE 8/10 :e75602-,2013
  • Cognitive deficits of pure subcortical vascular dementia vs Alzheimer disease
    NEUROLOGY 80/6 :569-573,2013
  • Shape Changes of the Basal Ganglia and Thalamus in Alzheimer’s Disease: A Three-Year Longitudinal Study
    JOURNAL OF ALZHEIMERS DISEASE 40/2 :285-295,2014
  • Synergistic Effects of Ischemia and β-Amyloid Burden on Cognitive Decline in PatientsWith Subcortical Vascular Mild Cognitive Impairment
    JAMA PSYCHIATRY 71/4 :412-422,2014
  • White Matter Hyperintensities are associated with Amyloid Burden in APOE4 Non-Carriers
    JOURNAL OF ALZHEIMERS DISEASE 40/4 :877-886,2014
  • A Computed Tomography-Based Spatial Normalization for the Analysis of [18F] Fluorodeoxyglucose Positron Emission Tomography of the Brain
    KOREAN JOURNAL OF RADIOLOGY 15/6 :862-870,2014
  • Anatomical heterogeneity of Alzheimer disease Based on cortical thickness on MRIs
    NEUROLOGY 83/21 :1936-1944,2014
  • A New Classification System for Ischemia Using a Combination of Deep and Periventricular White Matter Hyperintensities
    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 23/4 :636-642,2014
  • Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment
    NEUROBIOLOGY OF AGING 35/2 :291-300,2014
  • Seoul criteria for PiB(-) subcortical vascular dementia based on clinical and MRI variables
    NEUROLOGY 82/17 :1529-1535,2014
  • Association between body mass index and cortical thickness: Among elderly cognitively normal men and women
    INTERNATIONAL PSYCHOGERIATRICS 27/1 :121-130,2015
  • Higher education affects accelerated cortical thinning in Alzheimer’s disease: a 5-year preliminary longitudinal study
    INTERNATIONAL PSYCHOGERIATRICS 27/1 :111-20,2015
  • Feasibility of Computed Tomography-Guided Methods for Spatial Normalization of Dopamine Transporter Positron Emission Tomography Image
    PLOS ONE 10/7 :e0132585-,2015
  • Clinical effect of white matter network disruption related to amyloid and small vessel disease
    NEUROLOGY 85/1 :63-70,2015
  • Association of body fat percentage and waist-hip ratio with brain cortical thickness: A study among 1777 cognitively normal subjects
    ALZHEIMER DISEASE & ASSOCIATED DISORDERS 29/4 :279-286,2015
  • Effects of education on aging-related cortical thinning among cognitively normal individuals
    NEUROLOGY 85/9 :806-812,2015
  • Structural Brain Changes after Traditional and Robot-Assisted Multi-Domain Cognitive Training in Community-Dwelling Healthy Elderly
    PLOS ONE 10/e01232 :1-19,2015
  • Hippocampal volume and shape in pure subcortical vascular dementia
    NEUROBIOLOGY OF AGING 36/1 :485-491,2015
  • Apolipoprotein E4 Affects Topographical Changes in Hippocampal and Cortical Atrophy in Alzheimer's Disease Dementia: A Five-Year Longitudinal Study
    JOURNAL OF ALZHEIMERS DISEASE 44/4 :1075-1085,2015
  • Effects of Amyloid and Small Vessel Disease on White Matter Network Disruption
    JOURNAL OF ALZHEIMERS DISEASE 44/3 :963-975,2015
  • Effects of amyloid and vascular markers on cognitive decline in subcortical vascular dementia
    NEUROLOGY 85/19 :1687-1693,2015
  • Postmorbid learning of saxophone playing in a patient with frontotemporal dementia
    NEUROCASE 21/6 :767-772,2015
  • Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients
    ALZHEIMERS & DEMENTIA 11/5 :494-503,2015
  • Impact of smoking on neurodegeneration and cerebrovascular disease markers in cognitively normal men
    EUROPEAN JOURNAL OF NEUROLOGY 23/1 :110-119,2016
  • 기억상실형경도인지장애로 나타난 항LGI1항체변연뇌염
    대한신경과학회지 34/1 :71-73,2016
  • Tau Accumulation in Primary Motor Cortex of Variant Alzheimer's Disease with Spastic Paraparesis
    JOURNAL OF ALZHEIMERS DISEASE 51/3 :671-675,2016
  • Tau PET in Alzheimer disease and mild cognitive impairment
    NEUROLOGY 87/4 :375-383,2016
  • In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum
    ANNALS OF NEUROLOGY 80/2 :247-258,2016
  • A Dextral Primary Progressive Aphasia Patient with Right Dominant Hypometabolism and Tau Accumulation and Left Dominant Amyloid Accumulation
    Case Reports in Neurology 8/1 :78-86,2016
  • Human Radiation Dosimetry of [F-18]AV-1451(T807) to Detect Tau Pathology
    MOLECULAR IMAGING AND BIOLOGY 18/4 :479-482,2016
  • Subcortical 18F-AV-1451 Binding Patterns in Progressive Supranuclear Palsy
    MOVEMENT DISORDERS 32/1 :134-140,2017
  • 18F-AV-1451 Binds to Putamen in Multiple System Atrophy
    MOVEMENT DISORDERS 32/1 :171-173,2017
  • Excessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer's disease
    NEUROBIOLOGY OF AGING 53/ :103-111,2017
  • 18F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy
    JOURNAL OF ALZHEIMERS DISEASE 57/3 :711-716,2017
  • Parkinsonian Patients with Striatal Cribriform State Present Rapidly Progressive Axial Parkinsonism
    EUROPEAN NEUROLOGY 78/ :119-124,2017
  • 18F-AV-1451 binds to motor-related subcortical gray and white matter in corticobasal syndrome
    NEUROLOGY 89/11 :1,170-1,178,2017

저서

  • 알츠하이머 병의 최신지견 2012.4. 대한신경과학회지
  • 화학요법 이후의 인지기능 2013.5. 암생존자 관리 핸드북

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