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소속

  • 소아과학교실

보직

  • 소장

직위

  • 교수

연구실 위치

  • 세브란스 병원

전화/팩스

  • 02) 2228-2063 /

학력사항

  • 연세대학교 의학과 학사(1986)
    아주대학교 의학과 석사(1999)
    아주대학교 의학과 박사(2003)

교육 및 연구 경력

  • 1993-1996 연세대학교 의과대학 소아신경학 연구강사
    1996-1998 연세대학교 의과대학 소아과 신경학 전임강사
    1998-2002 연세대학교 의과대학 소아과 신경학 조교수
    1999-2001 미국 Wayne 대학 소아신경학 연수, PET Center research fellow
    2002-2007 연세대학교 의과대학 소아과학교실 신경학 부교수
    2002 연세대학교 장애아동연구소 소장
    2008 연세대학교 의과대학 소아과학교실 교수
    2009 세브란스병원 진료협력센터 소장
    2014 세브란스병원 연구부원장
    2016-현재 세브란스병원 진료부원장

기타 학술 관련 경력

  • 대한의사협회 회원
    대한소아과학회 회원
    대한소아신경과학회 회원
    대한소아신경학회 총무
    대한뇌전증학회 회원
    미국뇌전증학회 회원(American Epileptic Society Corresponding Member)
    대한뇌전증학회 상임이사
    대한뇌전증학회 소아청소년위원장
    2016-현재 대한소아신경학회 부회장

연구,관심분야

  • 소아간질환자, 난치성 간질환자의 진단 및 치료
    소아신경 질환의 Functional neuroimaging study (PET Study)
    소아신경, 장애아동의 원인분석, 평가, 교육, 예방, 치료
    소아 신경근 질환

강의분야

  • 소아신경질환
    소아의 발달
    소아 정신 질환
    소아 간질
    소아 신경근 질환

논문

  • 급성 파종성 뇌척수염(Acute disseminated encephalomyelitis)의 임상양상 및 예후에 관한 연구. 대한소아신경학회지. 6(2):372-376, 1999
  • 측두엽 및 전두엽 간질 환아의 발작 양상 비교. 대한소아과학회지. 41(6);769-774, 1998
  • Sturge-Weber syndrome : Correlation between clinical course and FDG PET findings
    NEUROLOGY 57/0 :189-195,2001
  • Patterns of Cerebral Glucose Metabolism in Early and Late Stages of Rasmussen's Syndrome
    JOURNAL OF CHILD NEUROLOGY 16/0 :798-805,2001
  • Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability
    BRITISH JOURNAL OF CANCER 85/8 :1147-1152,2001
  • Alpha[11C] methyl-L-typtophan positron emission tomography in patients
    J Child Neurol 17/4 :253-260,2002
  • Altered regional brain glucose metabolism in Duchenne muscualr dystrophy: a PET study.
    MUSCLE & NERVE 26/4 :506-512,2002
  • Quantitative analysis of gray and white matter volumes and glucose metabolism in
    J Child Neurol 18/2 :119-126,2003
  • General supportive treatmet for genetic/metabolic disorders
    장애아동연구소논문집 17/ :75-90,2004
  • 소아 급성 파종성 뇌척수염의 임상양상 및 치료 결과
    대한소아신경학회지(Journal of the Korean Child Neurology Society) 11/2 :343-350,2004
  • 단순포진상 뇌염환자에서 연속적으로 시행한 MRI, SPECT, FDG-PET 분석
    대한간질학회지(Journal of Korean Epilepsy Society) 9/1 :94-96,2005
  • Prognostic factors of status epilepticus in children
    YONSEI MEDICAL JOURNAL 46/1 :27-33,2005
  • 이소성 신장을 동반한 신경섬유종 1례
    소아과(Korean Journal Of Pediatrics) 48/4 :448-452,2005
  • 영아 연축을 동반한 난치성 간질에 대한 수술 치료에 대한 고찰
    대한소아신경학회지(Journal of the Korean Child Neurology Society) 13/2 :166-171,2005
  • Clinical Characteristics of Mitochondrial Respiratory Chain Defect with Neurological Manifestations
    대한소아신경학회지(Journal of the Korean Child Neurology Society) 14/2 :-,2006
  • 영아 연축 환아에서의 발달 평가 결과
    대한소아신경학회지(Journal of the Korean Child Neurology Society) 14/2 :286-294,2006
  • Neurologic manifestations and treatment of Henoch-Scho?nlein purpura
    BRAIN & DEVELOPMENT 28/ :547-,2006
  • A Case of Cogential Fiber Type Disproportion With Multiple Anomalies
    대한소아신경학회지(Journal of the Korean Child Neurology Society) 14/2 :328-332,2006
  • The effects on cognitive function and behavioral problems of topiramate compared to carbamazepine as monotherapy for children with benign rolandic epilepsy
    EPILEPSIA 48/9 :1716-1723,2007
  • 대뇌피질 이형성증과 미세발생이상; 난치성 소아 간질로 뇌엽절제술을 받은 환자에서의 임상소견, 뇌파 및 영상학적 비교
    대한소아신경학회지(Journal of the Korean Child Neurology Society) 15/1 :45-57,2007
  • Safe and effective use of the ketogenic diet in children with epilepsy and mitochondrial respiratory chain complex defects
    EPILEPSIA 48/1 :82-88,2007
  • Efficacy and tolerability of the ketogenic diet according to lipid:nonlipid ratios - Comparison of 3:1 with 4:1 diet
    EPILEPSIA 48/4 :801-805,2007
  • Mitochondrial respiratory chain defects: Underlying etiology in various epileptic conditions
    Epilepsia 49/ :685-690,2008
  • 레녹스 가스토 증후군에서 뇌량절제술
    대한간질학회지(Journal of Korean Epilepsy Society) 12/1 :41-45,2008
  • Changing the paradigm of 1-stage total callosotomy for the treatment of pediatric generalized epilepsy
    Journal of Neurosurgery-Pediatrics 2/ :29-36,2008
  • 소아 간질 환아에서 뇌파와 PET과의 연관성에 대한 분석
    대한소아과학회지(Journal of the Korean Pediatric Society) 51/3 :286-292,2008
  • 피질 이형성증과 미세이형성의 영상 의학적, 전기생리적 및 임상적 차이
    대한소아신경외과학회지(The Korean Journal of Pediatric Neurosurgery) 5/1 :30-36,2008
  • 소아 만성 두통 환자에서의 Magnetic Resonance Angiography 결과 분석
    대한소아신경학회지(Journal of the Korean Child Neurology Society) 16/2 :175-181,2008
  • 반구절단술 시행받은 난치성 소아간질환자들의 임상적 고찰 및 술후 성적
    대한소아신경학회지(Journal of the Korean Child Neurology Society) 16/2 :156-162,2008
  • 소아 청소년 간질에서 토피라메이트와 관련된 인지 기능 장애
    대한간질학회지(Journal of Korean Epilepsy Society) 12/s1 :67-70,2008
  • 비측두엽 소아 간질 환자의 수술 결과
    대한소아신경학회지(Journal of the Korean Child Neurology Society) 16/2 :146-155,2008
  • Neuroradiologic findings in children with mitochondrial disorder: correlation with mitochondrial respiratory chain defects
    European Radiology 18/ :1741-1748,2008
  • Newly observed thalamic involvement and mutations of the HEXA gene in a Korean patient with juvenile GM2 gangliosidosis
    Metabolic Brain Disease 23/3 :235-242,2008
  • Advanced treatment of intractable childgood epilepsy.
    epilepsy & seizure 1/1 :1-10,2008
  • Comparison of various imaging modalities in localization of epileptogenic lesion using epilepsy surgery outcome in pediatric patients
    Seizure-European Journal Of Epilepsy 18/7 :504-510,2009
  • Insular epilepsy surgery under neuronavigation guidance using depth electrode
    Childs Nervous System 25/5 :591-597,2009
  • Evaluation of renal function in children with mitochondrial respiratory chain complex defect: usefulness of cystatin C
    Acta Paediatrica 98/6 :1014-1018,2009
  • Clinical characteristics of patients with non-specific and non-categorized mitochondrial diseases
    Acta Paediatrica 98/11 :1825-1829,2009
  • 소아 사립체 질환에서 시각 유발전위검사의 유용성
    Korean Journal of Pediatrics 52/4 :471-475,2009
  • Outcome of surgical treatment in non-lesional intractable childhood epilepsy
    Seizure-European Journal Of Epilepsy 18/9 :625-629,2009
  • Ictal single-photon emission computed tomography with slow dye injection for determining primary epileptic foci in infantile spasms
    Korean Journal of Pediatrics 52/7 :804-810,2009
  • Endoscopic disconnection of hypothalamic astrocytoma causing gelastic epilepsy: Case report
    Journal of Neurosurgery-Pediatrics 4/2 :151-155,2009
  • 소아 뇌갈림증의 신경영상학적 소견 및 임상 양상
    Korean Journal of Pediatrics 52/4 :458-463,2009
  • Resective Pediatric Epilepsy Surgery in Lennox-Gastaut Syndrome
    Pediatrics 125/1 :E58-E66,2010
  • Comparison of temporal lobectomies of children and adults with intractable temporal lobe epilepsy
    CHILDS NERVOUS SYSTEM 26/ :177-183,2010
  • Efficacy and Safety of Adjunctive Levetiracetam Therapy in Pediatric Intractable Epilepsy
    Pediatric Neurology 42/2 :86-92,2010
  • Efficacy and tolerability of adjunctive therapy with zonisamide in childhood intractable epilepsy
    Brain & Development 32/2 :208-212,2010
  • Caregiver's Burden and Quality of Life in Mitochondrial Disease
    Pediatric Neurology 42/4 :271-276,2010
  • A case of Ohtahara syndrome with mitochondrial respiratory chain complex I deficiency
    Brain & Development 32/3 :253-257,2010
  • Initial Experiences with Proton MR Spectroscopy in Treatment Monitoring of Mitochondrial Encephalopathy
    YONSEI MEDICAL JOURNAL 51/5 :672-675,2010
  • 외측두엽 간질의 수술적 결과
    대한소아신경외과학회지 7/1 :31-40,2010
  • Iron deficiency in children with mitochondrial disease
    Metabolic Brain Disease 25/2 :185-189,2010
  • A case of hippocampal sclerosis diagnosed as cortical dysplasia due to preoperative brain MRI finding
    Korean Journal of Pediatrics 53/1 :106-110,2010
  • Electrocardiography as an early cardiac screening test in children with mitochondrial disease
    Korean Journal of Pediatrics 54/5 :644-647,2010
  • Multimodal neuroimaging in presurgical evaluation of childhood epilepsy
    Korean Journal of Pediatrics 53/8 :779-785,2010
  • Electroencephalography Features of Primary Epileptogenic Regions in Surgically Treated MRI-Negative Infantile Spasms
    Pediatric Neurosurgery 46/3 :182-187,2010
  • Surgical Outcomes and Prognostic Factors after Epilepsy Surgery in Children with Extratemporal Lobe Epilepsy
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/1 :20-32,2010
  • 소아청소년기 수면 장애의 임상적 연구
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/2 :187-196,2010
  • 중심-측두엽 극파 동반 양성 간질에서의 인지 행동 관찰 및 topiramate 1일 1회 투약 효과
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/2 :206-213,2010
  • Usefulness of liquid ketogenic milk for intractable childhood epilepsy
    e-SPEN, the European e-journal of Clinical Nutrition and Metabolism 5/5 :203-207,2010
  • Risk factors of ocular involvement in children with mitochondrial respiratory chain complex defect
    Korean Journal of Pediatrics 53/12 :994-999,2010
  • Leigh 증후군 환아에서의 안과적 이상 소견
    Korean Journal of Pediatrics 53/2 :163-166,2010
  • Comparison of short-versus long-term ketogenic diet for intractable infantile spasms
    EPILEPSIA 52/4 :781-787,2011
  • Neuroimaging in identifying focal cortical dysplasia and prognostic factors in pediatric and adolescent epilepsy surgery
    EPILEPSIA 52/4 :722-727,2011
  • Uncovered primary seizure foci in Lennox-Gastaut syndrome after corpus callosotomy
    BRAIN & DEVELOPMENT 33/8 :672-677,2011
  • Comparative trial of low- and high-dose zonisamide as monotherapy for childhood epilepsy
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 20/7 :558-563,2011
  • Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 20/6 :449-457,2011
  • A Case of Metachromatic Leukodystrophy Confirmed by Molecular Genetic Analysis
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/3 :272-276,2011
  • A Case of Early Onset MELAS Patient with Wolff-Parkinson-White Syndrome
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/3 :266-271,2011
  • A1 Segment Hypoplasia/aplasia Detected by Magnetic Resonance Angiography in Neuropediatric Patients
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/3 :231-239,2011
  • Various indications for a modified Atkins diet in intractable childhood epilepsy
    BRAIN & DEVELOPMENT 34/ :570-575,2012
  • Rufinamide as an adjuvant treatment in children with Lennox-Gastaut syndrome
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 21/4 :288-291,2012
  • Genetic and Epileptic Features in Rett Syndrome
    YONSEI MEDICAL JOURNAL 53/3 :495-500,2012
  • Effects of lamotrigine on cognition and behavior compared to carbamazepine as monotherapy for children with partial epilepsy
    BRAIN & DEVELOPMENT 34/10 :818-823,2012
  • Safety and role of ketogenic parenteral nutrition for intractable childhood epilepsy
    BRAIN & DEVELOPMENT 34/8 :620-624,2012
  • Early cardiac evaluation in children with non-specific mitochondrial disease with isolated mitochondrial respiratory chain complex i defect
    JOURNAL OF PAEDIATRICS AND CHILD HEALTH 48/11 :1016-1020,2012
  • A multicenter trial of oxcarbazepine oral suspension monotherapy in children newly diagnosed with partial seizures: A clinical and cognitive evaluation
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 21/9 :679-684,2012
  • Epilepsy in Korean patients with Angelman syndrome
    Korean Journal of Pediatrics 55/5 :171-176,2012
  • Usefulness of Diffusion Tensor Tractography in Pediatric Epilepsy Surgery
    YONSEI MEDICAL JOURNAL 54/1 :21-27,2013
  • Catch-up growth after long-term implementation and weaning from ketogenic diet in pediatric epileptic patients
    CLINICAL NUTRITION 32/1 :98-103,2013
  • Seizure outcome of infantile spasms with focal cortical dysplasia
    BRAIN & DEVELOPMENT 35/35 :816-820,2013
  • Interferon beta-1b Treatment in a Korean Girl with Multiple Sclerosis
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 21/1 :28-32,2013
  • Clinical Presentations and the Bacterial Meningitis Score in Children with Cerebrospinal Fluid (CSF) Pleocytosis
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 21/2 :46-52,2013
  • The Usefulness of Diffusion Tensor Image-integrated Neuronavigation in Pediatric Epilepsy Surgery
    대한소아신경외과학회지 10/1 :15-21,2013
  • Schilder's disease in a young child with tumefactive demyelinating brain lesion
    NEUROLOGY ASIA 18/4 :419-421,2013
  • Quantitative Analysis of Simultaneous EEG Features during PET Studies for Childhood Partial Epilepsy
    YONSEI MEDICAL JOURNAL 54/3 :572-577,2013
  • The Significance of Insular Hypometabolism in Temporal Lobe Epilepsy in Children
    Journal of Epilepsy Research 3/2 :54-62,2013
  • Outcomes of epilepsy surgery in childhood-onset epileptic encephalopathy
    BRAIN & DEVELOPMENT 36/6 :496-504,2014
  • Primary central nervous system anaplastic large cell lymphoma presenting initially with meningitis
    NEUROLOGY ASIA 19/ :231-234,2014
  • The impact of an exercise therapy on psychosocial health of children with benign epilepsy: A pilot study
    EPILEPSY & BEHAVIOR 37/ :151-156,2014
  • Epilepsy-related clinical factors and psychosocial functions in pediatric epilepsy
    EPILEPSY & BEHAVIOR 37c/- :43-48,2014
  • Adjunctive levetiracetam treatment in pediatric lennox-gastaut syndrome
    PEDIATRIC NEUROLOGY 51/4 :527-531,2014
  • Congenital muscular dystrophy type 1A with residual merosin expression
    Korean Journal of Pediatrics 57/3 :149-152,2014
  • EPILEPSY SURGERY IN PEDIATRIC INTRACTABLE EPILEPSY WITH DESTRUCTIVE ENCEPHALOPATHY
    Journal of Epilepsy Research 54/Specia :281-282,2014
  • Tract-based spatial statistics of diffusion tensor imaging after corpus callosotomy in relation to seizure recurrence
    CHILDS NERVOUS SYSTEM 30/12 :2043-2049,2014
  • Psychological Problems and Clinical Outcomes of Children with Psychogenic Non-Epileptic Seizures
    YONSEI MEDICAL JOURNAL 55/6 :1556-1561,2014
  • Neurocognitive function in children after anterior temporal lobectomy with amygdalohippocampectomy
    PEDIATRIC NEUROLOGY 52/1 :88-93,2015
  • Long-term prognosis of patients with Lennox-Gastaut syndrome in recent decades
    EPILEPSY RESEARCH 110/- :10-19,2015
  • Screening for depression and anxiety disorder in children with headache
    Korean Journal of Pediatrics 58/2 :64-68,2015
  • Pandemic influenza A vaccination and incidence of Guillain-Barre syndrome in Korea
    VACCINE 33/15 :1815-1823,2015
  • Neuropsychological effects of levetiracetam and carbamazepine in children with focal epilepsy
    NEUROLOGY 84/23 :2312-2319,2015
  • 결절성 경화증 (Tuberous sclerosis) 환자에서 뇌실막밑 거대세포 별아교세포종의 (Subependymal giant cell astrocytoma) 치료
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 23/1 :1-6,2015
  • Applying the bacterial meningitis score in children with cerebrospinal fluid pleocytosis: a single center’s experience
    Korean Journal of Pediatrics 58/7 :251-255,2015
  • Chronic inflammatory demyelinating polyneuropathy in children: a report of four patients with variable relapsing courses
    Korean Journal of Pediatrics 58/5 :194-198,2015
  • Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy
    EPILEPSIA 57/1 :51-58,2016
  • The Impact of a 35-Week Long-Term Exercise Therapy on Psychosocial Health of Children With Benign Epilepsy
    JOURNAL OF CHILD NEUROLOGY 31/8 :985-990,2016
  • Surgical treatment of pediatric focal cortical dysplasia: Clinical spectrum and surgical outcome
    NEUROLOGY 30;87/9 :945-951,2016
  • 미토콘드리아 호흡연쇄 복합체 결함이 동반된 난치성 소아 뇌전증에서의 Zonisamide 부가 요법
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 24/3 :89-94,2016
  • Juvenile Myasthenia Gravis in Korea: Subgroup Analysis According to Sex and Onset Age
    JOURNAL OF CHILD NEUROLOGY 31/14 :1561-4568,2016
  • Epilepsy Characteristics and Clinical Outcome in Patients With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS)
    PEDIATRIC NEUROLOGY 64/- :59-65,2016
  • Type I Chiari malformation presenting orthostatic syncope who treated with decompressive surgery
    Korean Journal of Pediatrics 59/Suppl :S149-S151,2016
  • Cause of Death in Children With Mitochondrial Diseases
    PEDIATRIC NEUROLOGY 66/ :82-88,2017
  • Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia
    AMERICAN JOURNAL OF HUMAN GENETICS 100/3 :454-472,2017
  • Gastroesophageal Reflux in Neurologically Impaired Children: What Are the Risk Factors?
    GUT AND LIVER 11/2 :232-236,2017

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