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소속

  • 소아과학교실

직위

  • 교수

연구실 위치

  • 강남세브란스병원 별관7층

전화/팩스

  • 02) 2019-3355 /

학력사항

  • 연세대학교 의과대학 의학과 학사(1984)
    연세대학교 대학원 의학과 석사(1991)
    연세대학교 대학원 의학과(소아과학) 박사 (1995)

교육 및 연구 경력

  • 1991-1993 소아내분비학 연구강사
    1993-1995 이화의대 소아과학 전임강사
    1995-1999 이화의대 소아과학 조교수
    1999-2003 미국 Oregon Health & Science University 소아과 senior researcher
    2003-2006 연세의대 소아과학교실 부교수
    2007-현재 연세의대 소아과학교실 교수

기타 학술 관련 경력

  • 1991-현재 대한소아과학회 회원
    1991-현재 대한내분비학회 회원
    1991-현재 대한당뇨병학회 회원
    1991-현재 대한소아내분비학회 회원
    1997-현재 미국 Endocrine Society 회원
    2001-현재 International Society for IGF Research 회원
    2004-현재 American Diabetes Association 회원

    *동아일보 선정 소아 질환분야 베스트 닥터(2000)

연구,관심분야

  • 저신장, 소아당뇨, 비만, 갑상선질환, 부신질환
    유방암과 소아암에서 인슐린양성장인자 결합단백질(Insulin-like growth factor binding protein)-3와 그 수용체(receptor)의 기능과 기전(apoptosis & cell signaling)
    당뇨합병증 발생에서 결합조직 성장인자(connective tissue growth factor)와 인슐린양성장인자 결합단백질 (IGFBP)의 역할
    저신장 유발 유전자의 규명

강의분야

  • 소아내분비학

논문

  • Insulin-like growth factor-binding protein 3 induces caspase-dependent apoptosis through a death receptor-mediated pathway in MCF-7 human breast cancer cells. Cancer Res 64:2229-2237, 2004
  • Effect of intense exercise on inflammatory cytokines and growth mediators in adolescent boys. Pediatrics 110:681-689, 2002
  • Connective tissue growth factor/IGF-binding protein-related protein-2 is a mediator in the induction of fibronectin by advanced glycosylation end-products in human dermal fibroblasts. Endocrinol 143:1260-1269, 2002.
  • Effects of sodium butyrates on expression of members of the insulin-like growth factor binding protein superfamily in human mammary epithelial cells. J Endocrinol 169:97-110, 2001
  • Advanced glycosylation end-products up-regulate connective tissue growth factor (IGFBP-rP2) in human fibroblast.; a potential mechanism for expansion of extracellular matrix in diabetes mellitus. Endocrinol 142:1760-1769, 2001
  • Serum levels of insulin-like growth factor (IGF)-I, free IGF-I, IGF binding protein (IGFBP)-1, IGFBP-3 and insulin in obese children. J Pediatr Endocrinol Metab 12:139-144, 1999
  • Identification of glycosylated 38-kDa connective tissue growth factor (IGFBP-related protein 2) and proteolytic fragments in human biological fluids, and up-regulation of IGFBP-rP2 expression by TGF in Hs 578T human breast cancer cells. J Clin Endocr Metab 83:2593-2596, 1998
  • Identification of low-affinity insulin-like growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily. Proc Natl Acad Sci USA 94: 12981-12986, 1997
  • Biological roles of insulin-like growth factor binding proteins (IGFBPs). Exp Mol Med 29:85-96, 1997
  • Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. J Biol Chem 271: 30322-30325, 1996
  • 성장호르몬 결핍증과 특발성 저신장증 환아에서 성장호르몬의 치료 효과
    KOREAN JOURNAL OF PEDIATRICS 47/3 :310-316,2004
  • 소아비만증에서 대사 증후군의 유병률
    KOREAN JOURNAL OF PEDIATRICS 47/11 :1149-1156,2004
  • 소아 제 2형 당뇨병 환아에서 Maturity Onset Diabetes of the Young(MODY) 3의 유병률에 관한 연구
    KOREAN JOURNAL OF PEDIATRICS 47/6 :641-,2004
  • 소아기 후천성 갑상선질환
    소아과(Korean Journal of Pediatrics) 47/9 :926-932,2004
  • Insulin-LIke Growth Factor-Binding Protein 3 Induces Caspase-Dependent Apoptosis through a Death Receptor-Mediated pathway in MCF-7 Human Breast Caner Cells
    CANCER RESEARCH 64/ :2229-2237,2004
  • The abnormalities of carbohydrate metabolism in Turner syndrome: Analysis of risk factors associated with impaired glucose tolerance
    EUROPEAN JOURNAL OF PEDIATRICS 164/ :442-447,2005
  • 소아 및 청소년 비만증에서 인슐린 저항성의 성별 차이
    대한소아내분비학회지(Journal Of Korean Society Of Pediatric Endocrinology) 10/1 :84-89,2005
  • 정상변이 염색체 다형현상과 동반된 저신장증
    대한소아내분비학회지(Journal Of Korean Society Of Pediatric Endocrinology) 10/1 :95-99,2005
  • 소아 및 청소년 비만증에서 인슐린 저항성에 미치는 요인
    소아과(Korean Journal Of Pediatrics) 48/10 :1076-1081,2005
  • 소아 비만증에서 비알코올성 지방간염의 유병률
    Korean Journal of Pediatrics 48/1 :13-20,2005
  • 한국인 선천성 부신피질과형성증의 임상적 특성
    대한소아내분비학회지(Journal Of Korean Society Of Pediatric Endocrinology) 10/2 :132-137,2005
  • 단순비만아에서 비만이 혈중 성장인자와 인슐린양성인자결합단백질-3의 단백분해에 미치는 영향
    대한소아내분비학회지(Journal Of Korean Society Of Pediatric Endocrinology) 10/2 :1995-203,2005
  • Obesity and cardiovascular risk factors in Korean children and adolescents aged 10-18 years from the Korean National Health and Nutrition Examination Survey, 1998 and 2001
    AMERICAN JOURNAL OF EPIDEMIOLOGY 164/8 :787-793,2006
  • 특발성 저신장증 환자에서 성장 호르몬 투여가 당 대사에 미치는 영향
    대한소아내분비학회지(Journal Of Korean Society Of Pediatric Endocrinology) 49/6 :665-671,2006
  • Association of Henoch-Scho?nlein purpura and Graves' disease [12]
    NEPHROLOGY DIALYSIS TRANSPLANTATION 21/ :2997-,2006
  • 조기 사춘기 여아에서 성선자극호르몬 분비호르몬 유도체가 성장과 성호르몬에 미치는 효과
    대한소아내분비학회지(Journal Of Korean Society Of Pediatric Endocrinology) 11/2 :162-169,2006
  • 소아에서 혈중 아연 농도가 성장에 미치는 영향
    대한소아내분비학회지(Journal Of Korean Society Of Pediatric Endocrinology) 11/2 :155-161,2006
  • Prevalence of the metabolic syndrome in Korean adolescents aged 12-19 years from the Korean National Health and Nutrition Examination Survey 1998 and 2001
    DIABETES RESEARCH AND CLINICAL PRACTICE 75/ :111-114,2007
  • 1형 당뇨병을 가진 소아과 청소년에서 란투스 치료의 혈당 조절에 대한 효과
    소아과(Korean Journal Of Pediatrics) 50/6 :565-569,2007
  • 뇌종양 환아에서 성장호르몬 치료 후 뇌종양 재발증가에 관한 연구
    대한소아내분비학회지(Journal Of Korean Society Of Pediatric Endocrinology) 12/2 :99-103,2007
  • 성조숙증 아동의 임상 및 내분비 검사의 특징
    대한소아내분비학회지(Journal Of Korean Society Of Pediatric Endocrinology) 12/2 :119-126,2007
  • 성조숙증의 진단과 최신 치료 경향
    대한내분비학회지(Journal Of The Korean Society Of Endocrinology) 23/3 :165-173,2008
  • 당뇨병성 신증의 조기 예측 인자로서의 혈중 cystatin C 및 β2-microglobulin의 유용성
    대한소아내분비학회지(Journal Of Korean Society Of Pediatric Endocrinology) 13/2 :177-183,2008
  • 소아 뇌종양 수술 후 수분대사 및 전해질 장애
    Journal Of Korean Society Of Pediatric Endocrinology(대한소아내분비학회지) 14/2 :124-131,2009
  • 1형 당뇨병 환자에서 생리주기 이상
    Journal Of Korean Society Of Pediatric Endocrinology(대한소아내분비학회지) 14/2 :116-123,2009
  • Determination of Serum Di-(2-ethylhexyl) phthalate and Bisphenol A Level in Children with Idiopathic Central Precocious Puberty
    Journal Of Korean Society Of Pediatric Endocrinology(대한소아내분비학회지) 14/2 :154-162,2009
  • Clinical application of gonadotropin-releasing hormone analogs in children and adolescents
    Korean Journal of Pediatrics 53/3 :294-299,2010
  • Insulin-like Growth Factor Binding Protein-3 Induces G1 Cell Cycle Arrest with Inhibition of Cyclin-dependent Kinase 2 and 4 in MCF-7 Human Breast Cancer Cells
    Hormone And Metabolic Research 42/3 :165-172,2010
  • 터너증후군에서 성장호르몬과 성호르몬 치료에 따른 인슐린 저항성의 변화
    Journal Of Korean Society Of Pediatric Endocrinology(대한소아내분비학회지) 15/1 :44-50,2010
  • An SRY-Deleted XXY Female Resulting from a Paternally Inherited t(Y;22)
    Annals of Clinical and Laboratory Science 40/3 :295-299,2010
  • Two Cases of Multiple Endocrine Neoplasia Type 2B, Early Diagnosis by Genetic Analysis and Prophylactic Total Thyroidectomy
    Journal Of Korean Society Of Pediatric Endocrinology(대한소아내분비학회지) 15/2 :138-144,2010
  • 소아청소년 연령에서 발생한 2형 당뇨병의 항췌도 자가항체 유무에 따른 임상적 특성
    Journal Of Korean Society Of Pediatric Endocrinology(대한소아내분비학회지) 15/2 :93-99,2010
  • Identification of a Novel Cell Death Receptor Mediating IGFBP-3-induced Anti-tumor Effects in Breast and Prostate Cancer
    The Journal of biological chemistry 285/39 :30233-30246,2010
  • Effects of a Structured Exercise Program on Insulin Resistance, Inflammatory Markers and Physical Fitness in Obese Korean Children
    Journal of Pediatric Endocrinology & Metabolism 23/10 :1065-1072,2010
  • 부갑상샘저하증과 거짓 부갑상샘저하증의 임상적 특성
    Journal Of Korean Society Of Pediatric Endocrinology(대한소아내분비학회지) 15/3 :181-186,2010
  • 1형 당뇨병 소아환자에서 발생한 원발성 국소분절사구체경화증 1례
    Journal Of Korean Society Of Pediatric Endocrinology(대한소아내분비학회지) 15/3 :203-206,2010
  • Effects of Body Composition, Leptin, and Adiponectin on Bone Mineral Density in Prepubertal Girls
    JOURNAL OF KOREAN MEDICAL SCIENCE 25/8 :1187-1190,2010
  • Noonan 증후군과 성장호르몬결핍증 환아에서 성장호르몬 치료 효과
    대한소아내분비학회지 16/2 :100-105,2011
  • Serum Kisspeptin Levels in Korean Girls with Central Precocious Puberty
    JOURNAL OF KOREAN MEDICAL SCIENCE 26/7 :927-931,2011
  • Insulin-Like Growth Factor-Binding Protein-3 Mediates High Glucose-Induced Apoptosis by Increasing Oxidative Stress in Proximal Tubular Epithelial Cells
    ENDOCRINOLOGY 152/8 :3135-3142,2011
  • Frequencies and Related Factors for Microvascular Complications in Patients with Type 1 Diabetes
    Annals of Pediatric Endocrinology & Metabolism 17/1 :16-26,2012
  • Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents
    CLINICAL BIOCHEMISTRY 45/1-2 :16-21,2012
  • Spot urine albumin to creatinine ratio and serum cystatin C are effective for detection of diabetic nephropathy in childhood diabetic patients
    JOURNAL OF KOREAN MEDICAL SCIENCE 27/7 :784-787,2012
  • Hypodipsic hypernatremia leading to reversible renal failure following surgery for craniopharyngioma
    JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 25/9-10 :1027-1030,2012
  • Proton-Pump Inhibitor-Induced Hypocalcemia and Hypomagnesemia
    대한소아내분비학회지 17/4 :249-252,2012
  • IGFBP-3 Inhibits Cytokine-Induced Insulin Resistance and Early Manifestations of Atherosclerosis
    PLOS ONE 8/1 :e55084-e55084,2013
  • Longitudinal Standards for Height and Height Velocity in Korean Children and Adolescents: the Kangwha Cohort Study
    JOURNAL OF KOREAN MEDICAL SCIENCE 28/10 :1512-1517,2013
  • The Clinical Measures Associated with C-peptide Decline in Patients with Type 1 Diabetes over 15 Years
    JOURNAL OF KOREAN MEDICAL SCIENCE 28/9 :1340-1344,2013
  • Final height and insulin-like growth factor-1 in children with medulloblastoma treated with growth hormone
    CHILDS NERVOUS SYSTEM 29/10 :1859-1863,2013
  • Efficacy and safety of LB03002, a once-weekly sustained-release human GH for 12-month treatment in Korean children with GH deficiency
    EUROPEAN JOURNAL OF ENDOCRINOLOGY 169/2 :179-185,2013
  • Sex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious puberty
    Annals of Pediatric Endocrinology & Metabolism 18/2 :81-84,2013
  • Factors that predict a positive response on gonadotropin-releasing hormone stimulation test for diagnosing central precocious puberty in girls
    Annals of Pediatric Endocrinology & Metabolism 18/4 :202-207,2013
  • Role of insulin-like growth factor binding protein-3 in glucose and lipid metabolism
    Annals of Pediatric Endocrinology & Metabolism 18/1 :9-12,2013
  • Efficacy of Short-Term Growth Hormone Treatment in Prepubertal Children with Idiopathic Short Stature
    YONSEI MEDICAL JOURNAL 55/1 :53-60,2014
  • Establishing pediatric reference intervals for 13 biochemical analytes derived from normal subjects in a pediatric endocrinology clinic in Korea
    CLINICAL BIOCHEMISTRY 47/18 :268-271,2014
  • KISS1 Gene Polymorphisms in Korean Girls with Central Precocious Puberty
    JOURNAL OF KOREAN MEDICAL SCIENCE 29/8 :1120-1125,2014
  • A case of thyrotoxic periodic paralysis as initial manifestation of Graves' disease in a 16-year-old Korean adolescent
    Annals of Pediatric Endocrinology & Metabolism 19/3 :169-173,2014
  • Adult height in girls with central precocious puberty treated with gonadotropin-releasing hormone agonist with or without growth hormone
    Annals of Pediatric Endocrinology & Metabolism 19/4 :214-219,2014
  • Growth hormone treatment and risk of malignancy
    Korean Journal of Pediatrics 58/2 :41-46,2015
  • Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus
    Annals of Pediatric Endocrinology & Metabolism 20/1 :13-20,2015
  • Etiologies and characteristics of children with chief complaint of short stature
    Annals of Pediatric Endocrinology & Metabolism 20/1 :34-39,2015
  • Relationship between serum 25-hydroxyvitamin D concentration and risks of metabolic syndrome in children and adolescents from Korean National Health and Nutrition Examination survey 2008?2010
    Annals of Pediatric Endocrinology & Metabolism 20/1 :46-52,2015
  • Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia
    Annals of Pediatric Endocrinology & Metabolism 20/3 :155-161,2015
  • Hypotonic hyponatremia by primary polydipsia caused brain death in a 10-year-old boy
    Annals of Pediatric Endocrinology & Metabolism 20/3 :166-169,2015
  • XYY syndrome: a 13-year-old boy with tall stature
    Annals of Pediatric Endocrinology & Metabolism 20/3 :170-173,2015
  • Turner syndrome with spinal hemorrhage due to vascular malformation
    Annals of Pediatirc Endocrinology & Metabolism 20/4 :235-237,2015
  • Burkholderia Sepsis in Children as a Hospital-Acquired Infection
    YONSEI MEDICAL JOURNAL 57/1 :97-102,2016
  • Ultrasound measurement of pediatric visceral fat thickness: correlations with metabolic and liver profiles
    Annals of Pediatirc Endocrinology & Metabolism 21/2 :75-80,2016
  • Male patients presenting with rapidly progressive puberty associated with malignant tumors.
    Annals of Pediatric Endocrinology & Metabolism 21/1 :51-55,2016
  • A patient with Cushing disease lateralizing a pituitary adenoma by inferior petrosal sinus sampling using desmopressin
    Annals of Pediatric Endocrinology & Metabolism 21/1 :43-46,2016
  • Human Coronavirus in the 2014 Winter Season as a Cause of Lower Respiratory Tract Infection
    YONSEI MEDICAL JOURNAL 58/1 :174-179,2017
  • Elevated serum YKL-40 levels in patients with Kawasaki disease
    BIOMARKERS 22/3-4 :326-330,2017
  • Diabetes mellitus due to agenesis of the dorsal pancreas in a patient with heterotaxy syndrome
    Annals of Pediatirc Endocrinology & Metabolism 22/2 :125-128,2017
  • Risk of Gonadoblastoma Development in Patients with Turner Syndrome with Cryptic Y Chromosome Material
    HORMONES & CANCER 8/3 :166-173,2017
  • Clinical manifestations of Rathke’s cleft cysts and their natural progression during 2 years in children and adolescents
    Annals of Pediatirc Endocrinology & Metabolism 22/3 :164-169,2017
  • A 1-month-old infant with chylomicronemia due to GPIHBP1 gene mutation treated by plasmapheresis
    Annals of Pediatirc Endocrinology & Metabolism 22/1 :68-71,2017
  • Insulin resistance and bone age advancement in girls with central precocious puberty
    Annals of Pediatirc Endocrinology & Metabolism 22/3 :176-182,2017

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