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소속

  • 소아과학교실

직위

  • 교수

연구실 위치

전화/팩스

  • 82056 /

학력사항

  • 연세대학교 의학과 학사(1992)
    연세대학교 대학원 의학석사(2001)
    연세대학교 대학원 의학박사(2006)

교육 및 연구 경력

  • 1993년 연세대학교 세브란스병원 인턴 수료
    2001년 연세대학교 세브란스병원 소아과 전공의 수료
    2002년 연세대학교 세브란스병원 소아과 연구강사 수료
    2002년-2008년 인제대학교 상계백병원 소아과, 간질센터 조교수
    2006년 Observership in MEG Lab., The Hospital for Sick Children,Toronto University
    2007년-2008년 Research Fellow in Molecular Neurobiology Lab.,
    McLean Hospital, Harvard Medical School
    2009년-2013년 연세대학교 세브란스병원 소아신경과 임상부교수
    2014년-2015년 Visiting Professor at Lab. of Pediatric Brain Disease, Rockefeller University
    2013년-현재 연세대학교 세브란스병원 소아신경과 교수

기타 학술 관련 경력

  • International League Against Epilepsy (Member of Neurobiology Commission)
    Journal of Korean Medical Science (Editorial)
    International Child Neurology Association
    Asian & Oceanian Society of Child Neurology
    American society of human genetics
    International Society of Stem Cell Research
    대한소아신경과학회(간행위원장)
    대한뇌전증학회(총무위원장)
    대한소아과학회
    대한의학유전학회
    대한두통학회
    대한유전대사질환학회

연구,관심분야

  • 소아신경질환
    소아뇌전증
    소아운동질환
    발달
    소아두통
    소아수면
    소아신경퇴행성질환

논문

  • Factors Influencing the Evolution of West Syndrome to Lennox-Gastaut Syndrome
    Pediatric Neurology 41/2 :111-113,2009
  • Clinical characteristics of patients with non-specific and non-categorized mitochondrial diseases
    Acta Paediatrica 98/11 :1825-1829,2009
  • Outcome of surgical treatment in non-lesional intractable childhood epilepsy
    Seizure-European Journal Of Epilepsy 18/9 :625-629,2009
  • 편두통의 전 단계인 소아기주기성증후군의 다기관 임상 연구 : 국제두통질환분류 제2판 제1차 수정판 적용
    Korean Journal of Pediatrics 52/5 :557-566,2009
  • 저산소 허혈 뇌 손상을 유발시킨 미성숙 흰쥐에서 마우스 골수 기원 중간엽 줄기 세포 이식 후 기능 회복
    Korean Journal of Pediatrics 52/7 :824-831,2009
  • Ictal single-photon emission computed tomography with slow dye injection for determining primary epileptic foci in infantile spasms
    Korean Journal of Pediatrics 52/7 :804-810,2009
  • Resective Pediatric Epilepsy Surgery in Lennox-Gastaut Syndrome
    Pediatrics 125/1 :E58-E66,2010
  • Comparison of temporal lobectomies of children and adults with intractable temporal lobe epilepsy
    CHILDS NERVOUS SYSTEM 26/ :177-183,2010
  • Efficacy and Safety of Adjunctive Levetiracetam Therapy in Pediatric Intractable Epilepsy
    Pediatric Neurology 42/2 :86-92,2010
  • Efficacy and tolerability of adjunctive therapy with zonisamide in childhood intractable epilepsy
    Brain & Development 32/2 :208-212,2010
  • Behavioral improvement after transplantation of neural precursors derived from embryonic stem cells into the globally ischemic brain of adolescent rats
    Brain & Development 32/8 :658-668,2010
  • 외측두엽 간질의 수술적 결과
    대한소아신경외과학회지 7/1 :31-40,2010
  • Iron deficiency in children with mitochondrial disease
    Metabolic Brain Disease 25/2 :185-189,2010
  • Electrocardiography as an early cardiac screening test in children with mitochondrial disease
    Korean Journal of Pediatrics 54/5 :644-647,2010
  • Surgical Outcomes and Prognostic Factors after Epilepsy Surgery in Children with Extratemporal Lobe Epilepsy
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/1 :20-32,2010
  • 소아청소년기 수면 장애의 임상적 연구
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/2 :187-196,2010
  • 중심-측두엽 극파 동반 양성 간질에서의 인지 행동 관찰 및 topiramate 1일 1회 투약 효과
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/2 :206-213,2010
  • Usefulness of liquid ketogenic milk for intractable childhood epilepsy
    e-SPEN, the European e-journal of Clinical Nutrition and Metabolism 5/5 :203-207,2010
  • Risk factors of ocular involvement in children with mitochondrial respiratory chain complex defect
    Korean Journal of Pediatrics 53/12 :994-999,2010
  • Leigh 증후군 환아에서의 안과적 이상 소견
    Korean Journal of Pediatrics 53/2 :163-166,2010
  • Comparison of short-versus long-term ketogenic diet for intractable infantile spasms
    EPILEPSIA 52/4 :781-787,2011
  • Neuroimaging in identifying focal cortical dysplasia and prognostic factors in pediatric and adolescent epilepsy surgery
    EPILEPSIA 52/4 :722-727,2011
  • Uncovered primary seizure foci in Lennox-Gastaut syndrome after corpus callosotomy
    BRAIN & DEVELOPMENT 33/8 :672-677,2011
  • Comparative trial of low- and high-dose zonisamide as monotherapy for childhood epilepsy
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 20/7 :558-563,2011
  • Induced Pluripotent Stem Cell Models from X-linked Adrenoleukodystrophy Patients
    ANNALS OF NEUROLOGY 70/3 :402-409,2011
  • Evaluation of Algorithms for Intracranial EEG (iEEG) Source Imaging of Extended Sources: Feasibility of Using iEEG Source Imaging for Localizing Epileptogenic Zones in Secondary Generalized Epilepsy
    BRAIN TOPOGRAPHY 24/ :91-104,2011
  • Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 20/6 :449-457,2011
  • A Case of Metachromatic Leukodystrophy Confirmed by Molecular Genetic Analysis
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/3 :272-276,2011
  • A Case of Early Onset MELAS Patient with Wolff-Parkinson-White Syndrome
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/3 :266-271,2011
  • A1 Segment Hypoplasia/aplasia Detected by Magnetic Resonance Angiography in Neuropediatric Patients
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 18/3 :231-239,2011
  • Various indications for a modified Atkins diet in intractable childhood epilepsy
    BRAIN & DEVELOPMENT 34/ :570-575,2012
  • Highly pure and expandable PSA-NCAM-positive neural precursors from human ESC and iPSC-derived neural rosettes
    PLOS ONE 7/7 :e39715-e39715,2012
  • Rufinamide as an adjuvant treatment in children with Lennox-Gastaut syndrome
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 21/4 :288-291,2012
  • Genetic and Epileptic Features in Rett Syndrome
    YONSEI MEDICAL JOURNAL 53/3 :495-500,2012
  • Localization of ictal onset zones in Lennox-Gastaut syndrome (LGS) based on information theoretical time delay analysis of intracranial electroencephalography (iEEG)
    EPILEPSY RESEARCH 99/1-2 :78-86,2012
  • 발작과 뇌전증에 대한 개정된 용어 및 개념: ILAE의 분류 및 용어 관련 보고(2005-2009) 한글판
    Journal of Korean Epilepsy Society 16/1 :1-8,2012
  • Safety and role of ketogenic parenteral nutrition for intractable childhood epilepsy
    BRAIN & DEVELOPMENT 34/8 :620-624,2012
  • Disease-specific induced pluripotent stem cells: a platform for human disease modeling and drug discovery.
    EXPERIMENTAL AND MOLECULAR MEDICINE 44/3 :202-213,2012
  • Early cardiac evaluation in children with non-specific mitochondrial disease with isolated mitochondrial respiratory chain complex i defect
    JOURNAL OF PAEDIATRICS AND CHILD HEALTH 48/11 :1016-1020,2012
  • Is the ketogenic diet effective in specific epilepsy syndromes?
    EPILEPSY RESEARCH 100/3 :252-257,2012
  • A multicenter trial of oxcarbazepine oral suspension monotherapy in children newly diagnosed with partial seizures: A clinical and cognitive evaluation
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 21/9 :679-684,2012
  • New Classification of Focal Cortical Dysplasia: Application to Practical Diagnosis
    Journal of Epilepsy Research 2/2 :38-42,2012
  • Epilepsy in Korean patients with Angelman syndrome
    Korean Journal of Pediatrics 55/5 :171-176,2012
  • Catch-up growth after long-term implementation and weaning from ketogenic diet in pediatric epileptic patients
    CLINICAL NUTRITION 32/1 :98-103,2013
  • Mitochondrial disease and epilepsy
    BRAIN & DEVELOPMENT 35/35 :757-761,2013
  • The Genetically Modified Polysialylated Form of Neural Cell Adhesion Molecule-Positive Cells for Potential Treatment of X-Linked Adrenoleukodystrophy
    YONSEI MEDICAL JOURNAL 54/1 :246-252,2013
  • Seizure outcome of infantile spasms with focal cortical dysplasia
    BRAIN & DEVELOPMENT 35/35 :816-820,2013
  • Clinical analysis of catastrophic epilepsy in infancy and early childhood: Results of the Far-East Asia Catastrophic Epilepsy (FACE) study group
    BRAIN & DEVELOPMENT 35/1 :786-792,2013
  • Localization of epileptogenic zones in Lennox-Gastaut syndrome using frequency domain source imaging of intracranial electroencephalography: a preliminary investigation
    PHYSIOLOGICAL MEASUREMENT 34/1 :247-263,2013
  • Lower fat and better quality diet therapy for children with pharmacoresistant epilepsy
    Korean Journal of Pediatrics 56/8 :327-331,2013
  • Interferon beta-1b Treatment in a Korean Girl with Multiple Sclerosis
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 21/1 :28-32,2013
  • Clinical Presentations and the Bacterial Meningitis Score in Children with Cerebrospinal Fluid (CSF) Pleocytosis
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 21/2 :46-52,2013
  • Schilder's disease in a young child with tumefactive demyelinating brain lesion
    NEUROLOGY ASIA 18/4 :419-421,2013
  • The Significance of Insular Hypometabolism in Temporal Lobe Epilepsy in Children
    Journal of Epilepsy Research 3/2 :54-62,2013
  • Epilepsy surgery in pediatric intractable epilepsy with destructive encephalopathy.
    Journal of Epilepsy Research 3/2 :48-53,2013
  • Localization of epileptogenic zones in Lennox-Gastaut syndrome using frequency domain source imaging of intracranial electroencephalography: a preliminary investigation.
    PHYSIOLOGICAL MEASUREMENT 34/2 :247-263,2013
  • Polyunsaturated fatty acid-enriched diet therapy for a child with epilepsy
    BRAIN & DEVELOPMENT 36/Issue2 :163-166,2014
  • Changing name of epilepsy in Korea; cerebroelectric disorder(noi-jeon-jeung,뇌전증,): my epilepsy story.
    EPILEPSIA 55/3 :384-386,2014
  • Clinical and Genetic Aspects in Twelve Korean Patients with Adrenomyeloneuropathy
    YONSEI MEDICAL JOURNAL 55/3 :676-682,2014
  • Outcomes of epilepsy surgery in childhood-onset epileptic encephalopathy
    BRAIN & DEVELOPMENT 36/6 :496-504,2014
  • Primary central nervous system anaplastic large cell lymphoma presenting initially with meningitis
    NEUROLOGY ASIA 19/ :231-234,2014
  • Combined Use of Multiple Computational Intracranial EEG Analysis Techniques for the Localization of Epileptogenic Zones in Lennox-Gastaut Syndrome
    CLINICAL EEG AND NEUROSCIENCE 45/3 :169-178,2014
  • The impact of an exercise therapy on psychosocial health of children with benign epilepsy: A pilot study
    EPILEPSY & BEHAVIOR 37/ :151-156,2014
  • Epilepsy-related clinical factors and psychosocial functions in pediatric epilepsy
    EPILEPSY & BEHAVIOR 37c/- :43-48,2014
  • Adjunctive levetiracetam treatment in pediatric lennox-gastaut syndrome
    PEDIATRIC NEUROLOGY 51/4 :527-531,2014
  • A modified Atkin's diet for an infant with pyruvate dehydrogenase complex deficiency confirmed by PDHA1 gene mutation
    NEUROLOGY ASIA 19/3 :327-329,2014
  • Congenital muscular dystrophy type 1A with residual merosin expression
    Korean Journal of Pediatrics 57/3 :149-152,2014
  • Induced pluripotent stem cells for modeling of pediatric neurological disorders
    BIOTECHNOLOGY JOURNAL 9/7 :871-881,2014
  • Psychological Problems and Clinical Outcomes of Children with Psychogenic Non-Epileptic Seizures
    YONSEI MEDICAL JOURNAL 55/6 :1556-1561,2014
  • Isolated Cerebellar Variant of Adrenoleukodystrophy with a de novo Adenosine Triphosphate-Binding Cassette D1 (ABCD1) Gene Mutation
    YONSEI MEDICAL JOURNAL 55/4 :1157-1160,2014
  • Localization of epileptogenic zones in Lennox-Gastaut syndrome (LGS) using graph theoretical analysis of ictal intracranial EEG: A preliminary investigation
    BRAIN & DEVELOPMENT 37/1 :29-36,2015
  • Neurocognitive function in children after anterior temporal lobectomy with amygdalohippocampectomy
    PEDIATRIC NEUROLOGY 52/1 :88-93,2015
  • Long-term prognosis of patients with Lennox-Gastaut syndrome in recent decades
    EPILEPSY RESEARCH 110/- :10-19,2015
  • Screening for depression and anxiety disorder in children with headache
    Korean Journal of Pediatrics 58/2 :64-68,2015
  • Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy
    NATURE MEDICINE 21/4 :395-400,2015
  • Neuropsychological effects of levetiracetam and carbamazepine in children with focal epilepsy
    NEUROLOGY 84/23 :2312-2319,2015
  • 결절성 경화증 (Tuberous sclerosis) 환자에서 뇌실막밑 거대세포 별아교세포종의 (Subependymal giant cell astrocytoma) 치료
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 23/1 :1-6,2015
  • Applying the bacterial meningitis score in children with cerebrospinal fluid pleocytosis: a single center’s experience
    Korean Journal of Pediatrics 58/7 :251-255,2015
  • Chronic inflammatory demyelinating polyneuropathy in children: a report of four patients with variable relapsing courses
    Korean Journal of Pediatrics 58/5 :194-198,2015
  • 부신백질형성장애증 섬유모세포에서 발프로산의 항산화능
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 23/2 :45-50,2015
  • Clinical and Genetic Aspects of the Segmental Overgrowth Spectrum Due to Somatic Mutations in PIK3CA
    JOURNAL OF PEDIATRICS 167/5 :957-962,2015
  • An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development
    NATURE MEDICINE 21/12 :1445-1456,2015
  • Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy
    EPILEPSIA 57/1 :51-58,2016
  • The Impact of a 35-Week Long-Term Exercise Therapy on Psychosocial Health of Children With Benign Epilepsy
    JOURNAL OF CHILD NEUROLOGY 31/8 :985-990,2016
  • Surgical treatment of pediatric focal cortical dysplasia: Clinical spectrum and surgical outcome
    NEUROLOGY 30;87/9 :945-951,2016
  • 미토콘드리아 호흡연쇄 복합체 결함이 동반된 난치성 소아 뇌전증에서의 Zonisamide 부가 요법
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 24/3 :89-94,2016
  • 25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
    NATURE COMMUNICATIONS 7/ :13,129-,2016
  • X연관 부신백질이영양증의 분류, 진단 및 치료의 최신 지견
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 24/3 :71-84,2016
  • Juvenile Myasthenia Gravis in Korea: Subgroup Analysis According to Sex and Onset Age
    JOURNAL OF CHILD NEUROLOGY 31/14 :1561-4568,2016
  • Epilepsy Characteristics and Clinical Outcome in Patients With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS)
    PEDIATRIC NEUROLOGY 64/- :59-65,2016
  • Ketogenic Diet for Children with Epilepsy : A Practical Meal Plan in a Hospital
    Clinical nutrition research 5/1 :60-63,2016
  • Automatic Identification of Interictal Epileptiform Discharges in Secondary Generalized Epilepsy.
    COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE 2016/Arti :1-10,2016
  • Estimating the Prevalence of Treated Epilepsy Using Administrative Health Data and Its Validity: ESSENCE Study
    JOURNAL OF CLINICAL NEUROLOGY 12/4 :434-440,2016
  • Cause of Death in Children With Mitochondrial Diseases
    PEDIATRIC NEUROLOGY 66/ :82-88,2017
  • Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia
    AMERICAN JOURNAL OF HUMAN GENETICS 100/3 :454-472,2017
  • Ketogenic Diet for the Management of Epilepsy Associated with Tuberous Sclerosis Complex in Children
    Journal of Epilepsy Research 7/1 :45-49,2017
  • Could Cannabidiol be a Treatment Option for Intractable Childhood and Adolescent Epilepsy?
    Journal of Epilepsy Research 7/1 :16-20,2017
  • Long-term epilepsy-associated tumor in the amygdala of a 16-year-old boy: report of a rare case having intranuclear filaments
    BRAIN TUMOR PATHOLOGY 34/4 :172-178,2017
  • 드라베 증후군의 SCN1A 유전자 변이 양상
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 25/1 :9-12,2017
  • A Patient Diagnosed with Spinocerebellar Ataxia Type 5 associated with SPTBN2: Case Repor
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 25/3 :200-203,2017
  • Quinidine Trial in a Patient with Epilepsy of Infancy with Migrating Focal Seizure and KCNT1 Mutation
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 25/3 :169-173,2017
  • Discontinuing Antiepileptic Drugs after Pediatric Epilepsy Surgery for Focal Cortical Dysplasia
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 25/3 :127-132,2017
  • Low glycemic index treatment in patients with drug-resistant epilepsy
    BRAIN & DEVELOPMENT 39/8 :687-692,2017

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