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소속

  • 생리학교실

직위

  • 교수

연구실 위치

  • 의과대학 신관 401호

전화/팩스

  • 02) 2228-1708 /

학력사항

  • 경북대학교 수의과대학 학사(1985)
    경북대학교 수의과대학 석사(1987)
    경북대학교 수의과대학 박사(1993)

교육 및 연구 경력

  • 1987.-1991. 연세대학교 의과대학 생리학교실
    1991.-1994. 연세대학교 의과대학 생리학교실 연구강사
    1994.-1996. 연세대학교 의과대학 생리학교실 전임강사
    1996.-2000. 연세대학교 의과대학 생리학교실 조교수
    1998.-1999. Boston Biomedical Research Institute, 교환교수
    2000.-2006 연세대학교 의과대학 생리학교실 부교수
    2007.-현재 연세대학교 의과대학 생리학교실 교수
    2014.-현재 연세대학교 의과대학 생리학교실 주임교수

기타 학술 관련 경력

  • Biophysical Society Regular member
    American Physiological Society Regular member
    대한생리학회 정회원
    한국평활근학회 이사

연구,관심분야

  • 혈관평활근 (vascular smooth muscle)
    근육의 수축기전 (Excitation-contraction coupling of muscle)
    고혈압 (hypertension)

강의분야

  • 근육생리 (muscle physiology)

논문

  • Effects of tegaserod on ileal of quinea pgi in vitro. JOURNAL PHARMACOLOGICAL SIENCE 94:144-152, 2004
  • Inhibition of Rho-Associated kinase reduces MLC20 phosphorylation and contractility of intact myometrium and attenuates agonist-Induced Ca2+ sensitization of force of permeabilized rat myometrium JOURNAL OF VETERINARY MEDICAL SCIENCE 65(1) : 43-50 , 2003
  • Mechanosensitive Cation Channels in Arterial Smooth Muscle Cell Are Activated by Diacylglycerol and Inhibited by Phospholipase C Inhibitor CIRCULATION RESEARCH 93 : 557-564 , 2003
  • Testosterone Causes Simultaneous Decrease of [Ca2+]i and Tension in Rabbit Coronary Arteries: by Opening Voltage Dependent Potassium Channels YONSEI MEDICAL JOURNAL 44-6 : 1027-1033 , 2003
  • Role of protein kinase C- or RhoA-induced Ca2+ sensitization in stretch-induced myogenic tone. CARDIOVASCULAR RESEARCH 53:431-438, 2002
  • Changes in myogenic tone in spontrneously hypertensive rat: role of RhoA and protein Kinase C 순환기학회지 32(3):257-267, 2002
  • 기니 픽 회장 운동 기능에 미치는 Phosphodiesterase 4형과 5형 억제제의 효과 대한소화기학회지 39-5 : 343-349 , 2002
  • Receptor-coupled contractility of uterine smooth muscle : from membrane to myofulaments Experimental Physiology 86(2) : 283-288 , 2001
  • Inhibition by clonidine of the carbachol-induced tension development and Nonselective cationic current in guinea pig ileal myocytes Japanese Journal Of Pharmacology 87 : 125-133 , 2001
  • Regulation of Vascular Smooth Muscle Tone by N-terminal Region of Caldesmon Journal Of Biological Chemistry 275(5) : 3213-3220 , 2000
  • Capsaicin-induced relaxztion in rabbit coronary artery Journal Of Veterinary Medical Science 예정 : , 2000
  • The effect of NO donor on contraction, cytosolic Ca2+ level and ionic currents in guinea-pig ileal smooth muscle Korean Journal Of Physiology Pharmacology 4 : 33-40 , 2000
  • Membrane stretch directly increases the activity of Ca activated K channels in rabbit coronary vascular smooth muscles Yonsei Medical Journal 41(2) : 266 , 2000
  • Sulfhydryl modification affects coronary artery tension by changing activity of delayed rectifier K current Yonsei Medical Journal 41(3) : 372-380 , 2000
  • Sulfhydryl modification affects coronary artery tension by changing activity of delayed rectifier K current
    YONSEI MEDICAL JOURNAL 41/3 :372-380,2000
  • Membrane stretch increases the activity if Ca2+-activated K channels in rabbit coronary vascular smooth muscle
    YONSEI MEDICAL JOURNAL 41/2 :266-272,2000
  • Mechanism of L-NAME-resistant endothelium-dependent relaxation induced by acetylcholine in rabbit renal artery
    Kor J Physiol & Pharmacol 4/6 :471-477,2000
  • The effect of NO donor on contraction, cytosolic Ca2+ level and ionic currents in guinea-pig ileal smooth muscle
    Kor J Physiol & Pharmacol 4/1 :33-40,2000
  • Regulation of vascular smooth muscle tone by N-terminal region of caldesmon: Possible role of tethering actin to myosin
    JOURNAL OF BIOLOGICAL CHEMISTRY 275/5 :3213-3220,2000
  • Inhibition by clonidine of the carbachol-induced tension development and nonselective cationic current in guinea pig ileal myocytes
    The Japanese Journal of Pharmacology 87/2 :125-133,2001
  • Receptor-coupled contractility of uterine smooth muscle: from membrane to myofilaments
    EXPERIMENTAL PHYSIOLOGY 86/2 :283-288,2001
  • Capsaicin-induced relaxation in rabbit coronary artery.
    JOURNAL OF VETERINARY MEDICAL SCIENCE 63/5 :499-503,2001
  • Changes in myogenic tone in spontaneously hypertensive rat: Role of RhoA and protein kinase C
    Kor Cir J 32/3 :257-267,2002
  • The effect of phosphodiesterase type 4 and 5 inhibitors on ileal motor function of the guinea pig
    Kor J Gastroentrology 39/5 :343-349,2002
  • Role of protein kinase C- or RhoA-induced Ca2+-sensitization in stretch-induced myogenic tone
    Cardiovas Res 53/0 :431-438,2002
  • Ca2+-sensitization mechanism in stretch-induced myogenic tone
    Kor J Physiol & Pharmacol 6/1 :33-39,2002
  • Testosterone causes simultaneous decrease of Ca and tension in rabbit coronary arteries: by opening voltage dependent potassium channels
    YONSEI MEDICAL JOURNAL 0/0 :0-0,2003
  • Mechanosensitive cation channels in arterial smooth muscle cells are activated by diacyglycerol and inhibited by phospholipase C inhibitor
    Cir Res 93/0 :557-564,2003
  • Inhibition of rho-associated kinase reduce MLC20 phosphorylation and contractility of intact myometrium and attenuates agonist-induced Ca2+-sensitizaf
    JOURNAL OF VETERINARY MEDICAL SCIENCE 65/1 :43-50,2003
  • Effects of Tegaserod on Ileal Peristalsis of Guinea Pig in Vitro
    JOURNAL OF PHARMACOLOGICAL SCIENCES 94/ :144-152,2004
  • Trinitrobenzene Sulfonic Acid로 유도한 대장염에서 대장통과시간 변화 및 장벽내 Nitric Oxide Synthase의 분포
    대한소화기학회지 44/6 :308-313,2004
  • Inhibition of carbachol-evoked oscillatory currents by the NO donor sodium nitroprusside in guinea-pig ileal myocytes
    EXPERIMENTAL PHYSIOLOGY 90/4 :577-586,2005
  • Inorganic arsenite potentiates vasoconstriction through calcium sensitization in vascular smooth muscle
    ENVIRONMENTAL HEALTH PERSPECTIVES 113/10 :1330-1335,2005
  • C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase andintracellular Ca2+ concentration
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 372/ :242-250,2005
  • Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 373/ :30-36,2006
  • Elevated contractile responses to acetylcholine in organ cultured rabbit carotid artery
    YONSEI MEDICAL JOURNAL 47/2 :249-254,2006
  • Lysophosphatidylcholine Attenuates Endothelium-dependent Relaxation Responses through Inhibition of ACh-induced Endothelial [Ca2+]i Increase
    THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 10/1 :25-30,2006
  • Enhanced stretch-induced myogenic tone in the basilar artery of spontaneously hypertensive rats
    JOURNAL OF VASCULAR RESEARCH 44/ :182-191,2007
  • Changes in stretch-induced tone induced by intracellular acidosis in rabbit basilar artery: Effects on BK
    VASCULAR PHARMACOLOGY 47/1 :74-82,2007
  • Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 34/ :1116-1120,2007
  • Vasorelaxation by Samhwangsasim-tang, an herb medicine, is associated with decreased phosphorylation of the myosin phosphatase target subunit
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 24/3 :199-205,2007
  • Lysophosphatidylcholine increases Ca2+ current via activation of protein kinase C in rabbit portal vein smooth muscle cells
    Korean Journal of Physiology & Pharmacology 12/ :31-35,2008
  • 기니 픽의 수술 후 장 폐색 모델에서 위장관 운동에 대한 Itopride Hydrochloride의 효과
    대한소화관운동학회지(Korean Journal of Gastrointestinal Motility) 14/1 :18-23,2008
  • TNBS (trinitrobenzene sulphonic acid)로 유도된 대장염에서 시간 경과에 따른 대장 통과 시간과 수축력의 변화
    대한소화관 운동학회지(Korean Journal of Neurogastroenterology and Motility) 14/2 :122-129,2008
  • Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery
    Cardiovascular Research 82/2 :324-332,2009
  • Role of T-type Ca2+ Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle
    KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 13/3 :241-249,2009
  • Potential role of HMG coA reductase inhibitor on oxidative stress induced by advanced glycation endproducts in vascular smooth muscle cells of diabetic vasculopathy.
    Experimental And Molecular Medicine 41/11 :802-811,2009
  • Urotensin II receptor antagonist attenuates monocrotaline-induced cardiac hypertrophy in rats
    American Journal of Physiology-Heart and Circulatory Physiology 299/ :H1782-H1789,2010
  • Enhanced contractility and myosin phosphorylation induced by Ca2(+)-independent MLCK activity in hypertensive rats
    CARDIOVASCULAR RESEARCH 91/1 :162-170,2011
  • Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108/26 :10750-10755,2011
  • Increase of L-type Ca2+ current by protease-activated receptor 2 activation contributes to augmentation of spontaneous uterine contractility in pregnant rats
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 418/1 :167-172,2012
  • The Role of Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in the Myogenic Tone of Posterior Cerebral Arteries
    PLOS ONE 7/4 :-,2012
  • Epithelial Na plus channel proteins are mechanotransducers of myogenic constriction in rat posterior cerebral arteries
    EXPERIMENTAL PHYSIOLOGY 97/4 :544-555,2012
  • A Direct Inhibitory Effect of Botulinum Toxin Type A on Antral Circular Muscle Contractility of Guinea Pig
    YONSEI MEDICAL JOURNAL 53/5 :968-973,2012
  • Effects of Ramosetron on Gastrointestinal Transit of Guinea Pig
    Journal of Neurogastroenterology and Motility (JNM) 19/1 :36-41,2013
  • Silencing of Atp2b1 increases blood pressure through vasoconstriction.
    JOURNAL OF HYPERTENSION 31/8 :1575-1583,2013
  • Inflammatory Responses in the Muscle Coat of Stomach and Small Bowel in the Postoperative Ileus Model of Guinea Pig
    YONSEI MEDICAL JOURNAL 54/6 :1336-1341,2013
  • Role of Endogenous ENaC and TRP Channels in the Myogenic Response of Rat Posterior Cerebral Arteries
    PLOS ONE 8/12 :e84194-,2013
  • Enhanced p22(phox) expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 306/7 :H972-H980,2014
  • Effects of GC7101, a Novel Prokinetic Agent on Gastric Motor Function: Ex Vivo Study
    JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY 20/4 :469-474,2014
  • Transient Receptor Potential Canonical Type 3 Channels Control the Vascular Contractility of Mouse Mesenteric Arteries
    PLOS ONE 9/10 :-,2014
  • Gene silencing and haploinsufficiency of Csk increase blood pressure
    PLOS ONE 11/1 :e0146841-,2016
  • Inhibition of endoplasmic reticulum stress improves coronary artery function in type 2 diabetic mice
    EXPERIMENTAL PHYSIOLOGY 101/6 :768-777,2016
  • Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats
    SCIENTIFIC REPORTS 6/ :31925 -,2016
  • Resistance to pathologic cardiac hypertrophy and reduced expression of CaV1.2 in Trpc3-depleted mice
    MOLECULAR AND CELLULAR BIOCHEMISTRY 421/1-2 :55-65,2016
  • Slitrk Missense Mutations Associated with Neuropsychiatric Disorders Distinctively Impair Slitrk Trafficking and Synapse Formation
    FRONTIERS IN MOLECULAR NEUROSCIENCE 9/Article :1-18,2016
  • Involvement of Epithelial Na+ Channel in the Elevated Myogenic Response in Posterior Cerebral Arteries from Spontaneously Hypertensive Rats
    SCIENTIFIC REPORTS 7/ :45,996-,2017
  • The effects and mechanism of action of methane on ileal motor function
    NEUROGASTROENTEROLOGY AND MOTILITY 29/9 :e13077-,2017

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