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소속

  • 약리학교실

직위

  • 교수

연구실 위치

  • 의과대학 신관 303-2호

전화/팩스

  • 02) 2228-1733 /

학력사항

  • 연세대학교 의과대학 학사(1979)
    연세대학교 약리학 석사(1982)
    연세대학교 약리학 박사(1988)
    University of Minnesota 행동약리학 박사(1992)

교육 및 연구 경력

  • 1986.- 현재. 연세대학교 의과대학 약리학교실 강사, 조교수, 부교수, 교수
    1988.- 1992. University of Minnesota
    1999. Cold Spring Harbor Lab. " Biology of Memory: From Molecules to Behavior"
    1999. 서강대 경영대학원 최고경영자 과정
    2004. Enneagram Institute. Ennesgram Workshop & Training
    2004.-2012. 약리학교실 주임교수

기타 학술 관련 경력

  • 대한약리학회 이사장
    한국뇌신경과학회 이사장
    한국뇌학회 이사
    산업표준심의회 의료장치의 생물학적평가(ISO/TC194) 전문위원회 위원장
    대한스트레스학회 상임이사
    한국통합의학학회 상임이사

연구,관심분야

  • 발달장애(developmental disability)
    스트레스(stress)
    학습과 기억(learning and memory)
    행동신경과학(behavioral neuroscience)

강의분야

  • 중추신경 약리학,
    학습과 기억
    신경행동약리, 행동기형, 약물남용

논문

  • 동물실험기법 및 결과분석.
    Medical POSTGRADUATES 28/6 :392-397,2000
  • 실험적 중뇌동맥 폐색 후 Matrix Metalloproteinases의 시간적 변화
    대한신경과학회지(JournalOfTheKoreanNeurologicalAssociation) 19/3 :278-284,2001
  • Subdiaphragmatic vagotomy induces NADPH diaphorase in the rat dorsal motor nucleus of the vagus.
    YONSEI MEDICAL JOURNAL 42/2 :215-219,2001
  • Effects of dextromethorphan on nocturnal behavior and brain c-Fos expression in adolescent rats.
    STOCHASTIC ENVIRONMENTAL RESEARCH AND RISK ASSESSMENT 431/0 :47-52,2001
  • Dextromethorphan increases tyrosine hydroxylase mRNA in the mesencephalon of adolescent rats.
    NEUROSCIENCE LETTERS 309/0 :85-88,2001
  • 랫드에서 생애초기 스트레스가 청소년기 약물남용에 미치는 영향.
    The Korean Journal of Stress Research 10/2 :41-50,2002
  • Neuroprotective effect of 8-OH-DPAT on long-term sequelae from prenatal ischemia in rats.
    THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 6/0 :293-297,2002
  • 한국의과대학인정평가위원회 발전방안 연구: 한국의과대학인정평가의 과제
    한국의학교육학회지 (Korean Journal of Medical Education) 14/1 :73-83,2002
  • Evaluation of the cytotoxicity of polyetherurethane(PU) film containing zink diethyldithiocarbamate (ZDEC) on various cell lines.
    YONSEI MEDICAL JOURNAL 43/4 :518-526,2002
  • Systemic 5-hydroxy-L-tryptophan down-regulates the arcuate CART mRNA level in rats.
    REGULATORY PEPTIDES 115/0 :73-80,2003
  • Dexamethasone blocks the refeeding-induced phosphorylation of cAMP response element-binding protein in the rat hypothalamus
    NEUROSCIENCE LETTERS 344/0 :107-111,2003
  • Orphanin FQ/nociceptin blocks methamphetamine place preference in rats.
    NEUROREPORT 14/18 :2383-2385,2003
  • Central N-nitro-L-arginine methyl ester does not influence lithium-induced c-Fos and conditioned tasted aversion.
    YONSEI MEDICAL JOURNAL 44/5 :869-874,2003
  • Sweet preference in tumor bearing mouse and pCREB in its taste receptor cells
    Exp Neurobiol 12/0 :43-49,2003
  • Nω-NITRO-L-arginine methy1 ester attenuates lithium-induced c-Fos, but not conditioned taste aversion, in rats
    NEUROSCIENCE RESEARCH 50/ :485-492,2004
  • RU486 blocks fasting-induced decrease of neuronal nitric oxide synthase in the rat paraventricular nucleus
    BRAIN RESEARCH 1018/ :221-226,2004
  • N-w-nitro-L-arginine methyl ester attenuates lithium-induced c-Fos, but not conditioned taste aversion, in rats
    NEUROSCIENCE RESEARCH 50/ :485-492,2004
  • Neuropeptide Y immunoreactivity and corticotropin-releasing hormone mRNA level are increased in the hypothalamus of mouse bearing a human oral squamous cell carcinoma
    NEUROPEPTIDES 38/ :345-350,2004
  • Nitric oxide is involved in lithium-induced immediate early gene expressions in the adrenal medulla
    EUROPEAN JOURNAL OF PHARMACOLOGY 489/ :111-116,2004
  • Fasting-induced down-regulation of NADPH-diaphorase in the magnocellular PVN of rats
    YONSEI MEDICAL JOURNAL 45/ :917-922,2004
  • Adrenalectomy abolishes fasting-induced down-regulation of NADPH-diaphorase in the Rat paraventricular nucleus
    YONSEI MEDICAL JOURNAL 45/ :123-128,2004
  • Neurofeedback: 원리와 임상응용
    대한스트레스학회지 13/2 :93-98,2005
  • Adaptive Response of Stress Hormones and Neuronal Activity of the Paraventricular Nucleus to the Same Repeated Stressor in Rats
    Experimental Neurobiology 14/ :59-65,2005
  • Enneagram: 성격유형의 이해
    대한스트레스학회지 14/1 :1-7,2006
  • G-CSF Mobilized Peripheral Blood Human Hematopoietic CD34+ Stem Cells Therapy for Acute Stroke: Preliminary Results
    대한뇌혈관외과학회지(Korean Journal of Cerebrovascular Surgery) 8/4 :235-240,2006
  • 헌팅톤 병 동물 모델에서 치료효과 판정을 위한 운동기능 평가
    대한재활의학회지(Journal Of The Korean Academy Of Rehabilitation Medicine) 31/5 :503-511,2007
  • Assessment of regional GABA(A) receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy.
    NEUROIMAGE 34/1 :19-25,2007
  • Development of animal model for cerebral palsy based on impairment of neonatal gamma-aminobutyric acid (GABA)
    Experimental Neurobiology 16/1 :1-8,2007
  • Diphenyleneiodonium suppresses apoptosis in cerulein-stimulated pancreatic acinar cells
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 39/ :2063-2075,2007
  • Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function
    Korean Journal of Physiology and Pharmacology 11/ :113-119,2007
  • Inhibitory effect of zinc on hypoxic HIF-I activation in astrocytes
    Neuroreport 19/ :1063-1066,2008
  • Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105/34 :12575-12580,2008
  • Differences in Neuropsychiatric Symptoms according to Mild Cognitive Impairment Subtypes in the Community
    Dementia And Geriatric Cognitive Disorders 26/ :212-217,2008
  • Heparin Attenuates the Expression of TNFα-induced Cerebral Endothelial Cell Adhesion Molecule
    Korean Journal of Physiology and Pharmacology 12/5 :231-236,2008
  • Microarray Analysis of Differentially Expressed Genes in the Brains of Tubby Mice
    KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 13/2 :91-97,2009
  • Zinc Inhibits Amyloid beta Production from Alzheimer's Amyloid Precursor Protein in SH-SY5Y Cells
    KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 13/ :195-200,2009
  • Pharmacokinetic properties and tissue storage of FITC conjugated SA-MnMEIO nanoparticles in mice
    Current Applied Physics 9/0 :e304-e307,2009
  • Down-regulation of Bcl-2 is mediated by NF-kappa B activation in Helicobacter pylori-induced apoptosis of gastric epithelial cells
    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 46/2 :148-155,2011
  • Motor pathway injury in patients with periventricular leucomalacia and spastic diplegia
    BRAIN 134/4 :1199-1210,2011
  • Regulation of DREAM Expression by Group I mGluR
    KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 15/2 :95-100,2011
  • Gap junctions contribute to astrocytic resistance against zinc toxicity
    BRAIN RESEARCH BULLETIN 86/ :314-318,2011
  • A facile approach for the delivery of inorganic nanoparticles into the brain by passing through the blood-brain barrier (BBB)
    CHEMICAL COMMUNICATIONS 48/1 :61-63,2012
  • TSL Family Therapy Followed by Improved Marital Quality and Reduced Oxidative Stress
    RESEARCH ON SOCIAL WORK PRACTICE 22/4 :389-399,2012
  • Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress
    NEUROSCIENCE LETTERS 519/1 :62-66,2012
  • Effective MicroPET imaging of brain 5-HT1A receptors in rats with [18F]MeFWAY by suppression of radioligand defluorination
    SYNAPSE 66/12 :1015-1023,2012
  • Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F] FPCIT and [18F] fallypride
    APPLIED RADIATION AND ISOTOPES 70/12 :2689-2694,2012
  • PKC Phosphorylation Regulates mGluR5 Trafficking by Enhancing Binding of Siah-1A
    JOURNAL OF NEUROSCIENCE 32/46 :16391-16401,2012
  • Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110/10 :4057-4062,2013
  • Optimization of the radiosynthesis of [F-18]MEFWAY for imaging brain serotonin 1A receptors by using the GE TracerLab FXFN-Pro module
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 56/12 :589-594,2013
  • Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[18F]Mefway
    APPLIED RADIATION AND ISOTOPES 94/0 :30-34,2014
  • Translational possibility of [18F]Mefway to image serotonin 1A receptors in humans: Comparison with [18F]FCWAY in rodents
    SYNAPSE 68/12 :595-603,2014
  • Acute Physical Stress Induces the Alteration of the Serotonin 1A Receptor Density in the Hippocampus
    SYNAPSE 68/8 :363-368,2014
  • mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress
    NATURE NEUROSCIENCE 18/7 :1017-1024,2015
  • Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system
    SYNAPSE 69/9 :453-460,2015
  • "Thank You, Sorry, Love" (TSL) Therapy With North Korean Refugee Women: A Pilot Study
    RESEARCH ON SOCIAL WORK PRACTICE 26/7 :816-824,2016
  • Relationships between psychosocial difficulties and oxidative stress biomarkers in women subject to intimate partner violence
    HEALTH & SOCIAL WORK 42/1 :41-47,2017

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