바로가기
메인메뉴로 바로가기
콘텐츠 바로가기
하단메뉴로 바로가기
패밀리사이트 바로가기


소속

  • 약리학교실

직위

  • 교수

연구실 위치

  • 의과대학 신관 3층 302-4

전화/팩스

  • 02-2228-1738 /

학력사항

  • 연세대학교 의과대학 의학과 학사 (1995)
    연세대학교 대학원 의학과 약리학 박사 (2000)

교육 및 연구 경력

  • 1998-2000 연세의대 약리학교실 강사
    2000-2003 국군의학연구소 책임연구관
    2003-2006 미국 NIH 박사후 연구원
    2006-2010 연세의대 약리학교실 조교수
    2010-2015 연세의대 약리학교실 부교수
    2015-현재 연세의대 약리학교실 교수

연구,관심분야

  • 중추신경약리
    신경가소성
    Metabotropic glutamate receptor 신경조절 기능

강의분야

  • 중추신경약리학

논문

  • Novel biphasic effect of pyrrolidine dithiocarbamate on neuronal cell viability is mediated by the differential regulation of intracellular zinc and c
    JOURNAL OF NEUROSCIENCE RESEARCH 59/1 :117-125,2000
  • Biphasic effects of dithiocarbamates on the activity of nuclear factor-κB
    EUROPEAN JOURNAL OF PHARMACOLOGY 392/3 :133-136,2000
  • Reduced glutathione oxidation ratio and 8 ohdG accumulation by mild ischemic pretreatment
    BRAIN RESEARCH 856/1 :28-36,2000
  • IFN-gamma induces cell death in human hepatoma cells through a TRAIL/death receptor-mediated apoptotic pathway
    INTERNATIONAL JOURNAL OF CANCER 93/2 :262-268,2001
  • Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin
    EXPERIMENTAL AND MOLECULAR MEDICINE 34/2 :114-122,2002
  • Expressions of transforming growth factor (TGF)-beta1 and TGF-beta type II receptor and their relationship with apoptosis during chemical hepatocarcin
    HEPATOLOGY RESEARCH 27/3 :205-213,2003
  • Inhibition of NF-κB Activation Increases Oxygen-Glucose Deprivation-Induced Cerebral Endothelial Cell Death
    KOREAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 7/2 :65-71,2003
  • Thiol antioxidant reversal of pyrrolidine dithiocarbamate-induced reciprocal regulation of AP-1 and NF-kappaB.
    BIOLOGICAL CHEMISTRY 384/1 :143-150,2003
  • Zinc-induced NF-kappa B inhibition can be modulated by changes in the intracellular metallothionein level
    TOXICOLOGY AND APPLIED PHARMACOLOGY 190/ :189-196,2003
  • Pyrrolidine dithiocarbamate and zinc inhibit proteasome-dependent proteolysis
    EXPERIMENTAL CELL RESEARCH 298/ :229-238,2004
  • Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on serine 839 regulates Ca2+ oscillations
    JOURNAL OF BIOLOGICAL CHEMISTRY 280/27 :25409-25415,2005
  • Heparin inhibits NF-κB activation and increases cell death in cerebral endothelial cells after oxygen-glucose deprivation
    JOURNAL OF MOLECULAR NEUROSCIENCE 32/2 :145-154,2007
  • Metabotropic glutamate receptors: Phosphorylation and receptor signaling
    Journal Of Neuroscience Research 86/ :1-10,2008
  • Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats
    European Journal Of Pharmacology 579/1 :418-425,2008
  • A polymorphism in the zinc transporter gene SLC3OA8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients
    Diabetes 57/4 :1043-1047,2008
  • Inhibitory effect of zinc on hypoxic HIF-I activation in astrocytes
    Neuroreport 19/ :1063-1066,2008
  • OLETF쥐에서 Amlodipine, Losartan과 비교한 Lithospermic Acid B의 당뇨병성 신증 예방효과
    KOREAN DIABETES JOURNAL (당뇨병) 32/1 :10-20,2008
  • Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105/34 :12575-12580,2008
  • Autocrine function of erythropoietin in IGF-1-induced erythropoietin biosynthesis
    Neuroreport 19/ :1699-1703,2008
  • Heparin Attenuates the Expression of TNFα-induced Cerebral Endothelial Cell Adhesion Molecule
    Korean Journal of Physiology and Pharmacology 12/5 :231-236,2008
  • Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population
    Journal Of Human Genetics 53/ :991-998,2008
  • Microarray Analysis of Differentially Expressed Genes in the Brains of Tubby Mice
    KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 13/2 :91-97,2009
  • Zinc Inhibits Amyloid beta Production from Alzheimer's Amyloid Precursor Protein in SH-SY5Y Cells
    KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 13/ :195-200,2009
  • Association of Common Type 2 Diabetes Risk Gene Variants and Posttransplantation Diabetes Mellitus in Renal Allograft Recipients in Korea
    Transplantation 88/5 :693-698,2009
  • Pharmacokinetic properties and tissue storage of FITC conjugated SA-MnMEIO nanoparticles in mice
    Current Applied Physics 9/0 :e304-e307,2009
  • Agonist-induced internalization of mGluR1α is mediated by caveolin
    Journal Of Neurochemistry 111/1 :61-71,2009
  • The effect of nicotine on the production of soluble fms-like tyrosine kinase-1 and soluble endoglin in human umbilical vein endothelial cells and trophoblasts
    Acta Obstetricia Et Gynecologica Scandinavica 89/4 :565-571,2010
  • 17-베타 에스트라디올이 OLETF 쥐의 지방세포 Lipin-1 발현에 미치는 영향
    Journal Of The Korean Society Of Endocrinology(대한내분비학회지) 25/3 :199-205,2010
  • An efficient synthesis of trans-N-{2-[4-(2-Methoxyphenyl)piperazinyl]ethyl} -N-(2-pyridyl)-N-(4-tosyloxymethylcyclohexane)carboxamide, A precursor of [ 18F]mefway for imaging 5-HT1A receptor
    Bulletin of the Korean Chemical Society 31/8 :2371-2374,2010
  • Motor pathway injury in patients with periventricular leucomalacia and spastic diplegia
    BRAIN 134/4 :1199-1210,2011
  • Regulation of DREAM Expression by Group I mGluR
    KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 15/2 :95-100,2011
  • A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion
    PHARMACOGENOMICS JOURNAL 11/3 :191-198,2011
  • Reversible SUMOylation of TBL1-TBLR1 Regulates beta-Catenin-Mediated Wnt Signaling
    MOLECULAR CELL 43/2 :203-216,2011
  • Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway
    NEUROREPORT 22/16 :839-844,2011
  • Gap junctions contribute to astrocytic resistance against zinc toxicity
    BRAIN RESEARCH BULLETIN 86/ :314-318,2011
  • A facile approach for the delivery of inorganic nanoparticles into the brain by passing through the blood-brain barrier (BBB)
    CHEMICAL COMMUNICATIONS 48/1 :61-63,2012
  • Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress
    NEUROSCIENCE LETTERS 519/1 :62-66,2012
  • Effective MicroPET imaging of brain 5-HT1A receptors in rats with [18F]MeFWAY by suppression of radioligand defluorination
    SYNAPSE 66/12 :1015-1023,2012
  • Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F] FPCIT and [18F] fallypride
    APPLIED RADIATION AND ISOTOPES 70/12 :2689-2694,2012
  • PKC Phosphorylation Regulates mGluR5 Trafficking by Enhancing Binding of Siah-1A
    JOURNAL OF NEUROSCIENCE 32/46 :16391-16401,2012
  • Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110/10 :4057-4062,2013
  • Alteration of Synaptic Activity-Regulating Genes Underlying Functional Improvement by Long-term Exposure to an Enriched Environment in the Adult Brain
    NEUROREHABILITATION AND NEURAL REPAIR 27/6 :561-574,2013
  • An Odorant-Binding Protein Required for Suppression of Sweet Taste by Bitter Chemicals
    NEURON 79/4 :725-737,2013
  • Increased GABA-A Receptor Binding and Reduced Connectivity at the Motor Cortex in Children with Hemiplegic Cerebral Palsy: A Multimodal Investigation Using 18F-Fluoroflumazenil PET, Immunohistochemistry, and MR Imaging
    JOURNAL OF NUCLEAR MEDICINE 54/8 :1263-1269,2013
  • dTULP, the Drosophila melanogaster Homolog of Tubby, Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia.
    PLOS GENETICS 9/9 :e1003814-e1003814,2013
  • Environmental Enrichment Synergistically Improves Functional Recovery by Transplanted Adipose Stem Cells in Chronic Hypoxic-Ischemic Brain Injury
    CELL TRANSPLANTATION 22/9 :1553-1568,2013
  • Estrogen-related genome-based expression profiling study of uterosacral ligaments in women with pelvic organ prolapse
    INTERNATIONAL UROGYNECOLOGY JOURNAL 24/ :1961-1967,2013
  • Optimization of the radiosynthesis of [F-18]MEFWAY for imaging brain serotonin 1A receptors by using the GE TracerLab FXFN-Pro module
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 56/12 :589-594,2013
  • Discovery of DiPeptidyl Peptidase-4 Gene Variants and the Associations with Efficacy of Vildagliptin in Patients with Type 2 Diabetes - A Pilot Study
    JOURNAL OF DIABETES & METABOLISM S13/006 :1-6,2013
  • Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[18F]Mefway
    APPLIED RADIATION AND ISOTOPES 94/0 :30-34,2014
  • GPR30 mediates anorectic estrogen-induced STAT3 signaling in the hypothalamus
    METABOLISM-CLINICAL AND EXPERIMENTAL 63/11 :1455-1461,2014
  • Effect of Endogenous Bone Marrow Derived Stem Cells Induced by AMD-3100 on Expanded Ischemic Flap
    JOURNAL OF KOREAN MEDICAL SCIENCE 29/ :237-248,2014
  • Translational possibility of [18F]Mefway to image serotonin 1A receptors in humans: Comparison with [18F]FCWAY in rodents
    SYNAPSE 68/12 :595-603,2014
  • Acute Physical Stress Induces the Alteration of the Serotonin 1A Receptor Density in the Hippocampus
    SYNAPSE 68/8 :363-368,2014
  • The role of orexin in post-stroke inflammation, cognitive decline, and depression
    MOLECULAR BRAIN 8/ :16-,2015
  • The antibody atliximab attenuates collagen-induced arthritis by neutralizing AIMP1, an inflammatory cytokine that enhances osteoclastogenesis
    BIOMATERIALS 44/0 :45-54,2015
  • [18F]FPEB and [18F]FDEGPECO comparative study of mGlu5 quantification in rodent brain
    APPLIED RADIATION AND ISOTOPES 98/0 :103-107,2015
  • Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death
    NEUROSCIENCE 301/- :26-38,2015
  • mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress
    NATURE NEUROSCIENCE 18/7 :1017-1024,2015
  • Adiponectin receptor 1-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study.
    CELL DEATH & DISEASE 6/- :e1844-,2015
  • Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system
    SYNAPSE 69/9 :453-460,2015
  • Chronic HMGCR/HMG-CoA Reductase Inhibitor Treatment Contributes to Dysglycemia by Upregulating Hepatic Gluconeogenesis through Autophagy Induction.
    AUTOPHAGY 11/11 :2089-2101,2015
  • Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila
    CELL REPORTS 13/13 :2808-2816,2015
  • Environmental enrichment enhances synaptic plasticity by internalization of striatal dopamine transporters
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 36/12 :2122-2133,2016
  • P-Glycoprotein, not BCRP, Limits the Brain Uptake of [(18)F]Mefway in Rodent Brain
    MOLECULAR IMAGING AND BIOLOGY 18/2 :267-73,2016
  • Overexpression of SOX2 Is Associated with Better Overall Survival in Squamous Cell Lung Cancer Patients Treated with Adjuvant Radiotherapy
    CANCER RESEARCH AND TREATMENT 48/2 :473-482,2016
  • Pore dilatation increases the bicarbonate permeability of CFTR, ANO1 and glycine receptor anion channels
    JOURNAL OF PHYSIOLOGY-LONDON 594/11 :2929-2955,2016
  • Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling
    Experimental Neurobiology 25/1 :24-32,2016
  • Blunted response of hippocampal AMPK associated with reduced neurogenesis in older versus younger mice
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 71/ :57-65,2016
  • Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1
    MOLECULAR BRAIN 9/81 :1-10,2016
  • A genetic variant in GLP1R is associated with response to DPP-4 inhibitors in patients with type 2 diabetes
    MEDICINE 95/44 :e5155-,2016
  • Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling
    NEUROPHARMACOLOGY 113/Pt A :467-479,2017
  • Tubby domain superfamily protein is required for the formation of the 7S SNARE complex in Drosophila
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 482/4 :814-820,2017
  • Suppression of AIMP1 protects cognition in Alzheimer's disease model mice 3xTg-AD
    NEUROREPORT 28/2 :82-86,2017

김철훈

콘텐츠 처음으로 이동

네크워크 링크안내/사이트 정보