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소속

  • 약리학교실

직위

  • 부교수

연구실 위치

  • 에비슨의생명연구센터 222호

전화/팩스

  • 02-2228-1736 /

학력사항

  • 연세대학교 이과대학 생물학과 이학사
    연세대학교 이과대학 생물학과 이학석사: 생물학 전공
    연세대학교 의과대학 약리학교실 이학박사: 약리학 및 세포생물학
    University of Texas Southwestern medical center at Dallas, Department of Physiology

교육 및 연구 경력

  • 1998-2000: 연세대학교 이과대학, 생물학 실습조교
    2000-2004: 연세대학교 의과대학, 약리학 실습조교
    2004-2006: Postdoctoral Fellow - Department of Physiology, University of Texas Southwestern medical center at Dallas, USA
    2006-2007: 연세대학교 의과대학 약리학교실 연구강사
    2007-2009: 연세대학교 의과대학 약리학교실 전임강사
    2009-2015: 연세대학교 의과대학 약리학교실 조교수
    2015-현재: 연세대학교 의과대학 약리학교실 부교수

연구,관심분야

  • 상피세포학, 칼슘신호전달, 세포막단백활성조절

강의분야

  • 조혈장기에 작용하는 약물

논문

  • Regulatory interaction between the cystic fibrosis transmembrane conductance regulator and HCO3- salvage mechanisms in model systems and the mouse pancreatic duct
    JOURNAL OF BIOLOGICAL CHEMISTRY 276/ :17236-17243,2001
  • A molecular mechanism for aberrant CFTR-dependent HCO3- transport in cystic fibrosis
    EUROPEAN MOLECULAR BIOLOGY ORGANIZATION JOURNAL 21/ :5662-5672,2002
  • Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells
    GASTROENTEROLOGY 122/7 :1941-1953,2002
  • The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3
    JOURNAL OF BIOLOGICAL CHEMISTRY 277/ :50503-50509,2002
  • The cystic fibrosis transmembrane conductance regulator (CFTR) interacts with and regulates the activity of the HCO3- salvage transporter hNBC3
    JOURNAL OF BIOLOGICAL CHEMISTRY 277/52 :50503-50509,2002
  • Pancreatitis from bile reflux-again? - Reply
    GASTROENTEROLOGY 124/ :864-865,2003
  • Inhibitory regulation of cystic fibrosis transmembrane conductance regulator anion-transporting activities by Shank2
    JOURNAL OF BIOLOGICAL CHEMISTRY 279/11 :10389-10396,2004
  • protein-protein interaction and function TRPC channels
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 451/ :116-124,2005
  • Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane
    JOURNAL OF BIOLOGICAL CHEMISTRY 281/ :32540-32549,2006
  • STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels
    NATURE CELL BIOLOGY 8/9 :1003-1010,2006
  • Homer proteins in Ca2+ signaling by excitable and non-excitable cells
    CELL CALCIUM 42/ :363-371,2007
  • TRPC channels as STIM1-regulated store-operated channels
    CELL CALCIUM 42/ :205-211,2007
  • Synaptic Scaffolding Molecule Binds to and Regulates Vasoactive Intestinal Polypeptide Type-1 Receptor in Epithelial Cells
    Gastroenterology 137/2 :607-617,2009
  • The role of translation elongation factor eEF1A in intracellular alkalinization-induced tumor cell growth
    Laboratory Investigation 89/ :867-874,2009
  • beta Pix Up-regulates Na+/H+ Exchanger 3 through a Shank2-mediated Protein-Protein Interaction
    The Journal of biological chemistry 285/11 :8104-8113,2010
  • Dynamic Regulation of CFTR Bicarbonate Permeability by [Cl-](i) and Its Role in Pancreatic Bicarbonate Secretion
    Gastroenterology 139/2 :620-631,2010
  • WNK4 kinase negatively regulates the surface expression of Muscarinic M3 receptor
    CELLULAR SIGNALLING 23/3 :566-571,2011
  • Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108/26 :10750-10755,2011
  • Unlocking SOAR releases STIM
    EMBO JOURNAL 30/9 :1673-1675,2011
  • Opposite regulatory effects of TRPC1 and TRPC5 on neurite outgrowth in PC12 cells
    CELLULAR SIGNALLING 24/ :899-906,2012
  • Regulation of SLC26A3 activity by NHERF4 PDZ-mediated interaction
    CELLULAR SIGNALLING 24/9 :1821-1830,2012
  • Impaired autophagy and delayed autophagic clearance of transforming growth factor beta-induced protein (TGFBI) in granular corneal dystrophy type 2
    AUTOPHAGY 8/ :1782-1797,2012
  • WNK4 inhibits plasma membrane targeting of NCC through regulation of syntaxin13 SNARE formation.
    CELLULAR SIGNALLING 25/12 :2469-2477,2013
  • Transient Receptor Potential Canonical Type 3 Channels Control the Vascular Contractility of Mouse Mesenteric Arteries
    PLOS ONE 9/10 :-,2014
  • Regulation of phagocytosis and cytokine secretion by store-operated calcium entry in primary isolated murine microglia
    CELLULAR SIGNALLING 27/1 :177-186,2015
  • Analysis of conventional and unconventional trafficking of CFTR and other membrane proteins.
    Methods in molecular biology (Clifton, N.J.) 1270/ :137-154,2015
  • Monomerization and ER Relocalization of GRASP Is a Requisite for Unconventional Secretion of CFTR
    TRAFFIC 17/7 :733-753,2016
  • Generation of Delta F508-CFTR T84 cell lines by CRISPR/Cas9-mediated genome editing
    BIOTECHNOLOGY LETTERS 38/12 :2023-2034,2016
  • Resistance to pathologic cardiac hypertrophy and reduced expression of CaV1.2 in Trpc3-depleted mice
    MOLECULAR AND CELLULAR BIOCHEMISTRY 421/1-2 :55-65,2016
  • Sec16A is critical for both conventional and unconventional secretion of CFTR
    SCIENTIFIC REPORTS 7/39887 :1-17,2017
  • UDP-Induced Phagocytosis and ATP-Stimulated Chemotactic Migration Are Impaired in STIM1(-/-) Microglia In Vitro and In Vivo
    MEDIATORS OF INFLAMMATION 2017/Arti :1-13,2017

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