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소속

  • 약리학교실

보직

  • 주임교수

직위

  • 교수

연구실 위치

  • 의과대학 신관3층 302-1호

전화/팩스

  • 02-2228-1735 /

학력사항

  • 서울대학교 전자공학 학사(1987)
    Univ. of Southern California 의공학 박사(1994)
    연세대학교 의학과 학사(2004)

교육 및 연구 경력

  • 1995-1997 미국 USCF대학교 의과대학 Postdoctoral fellow
    1997-1998 미국 Northwestern 대학교 Research Assistant Professor
    1998-2000 미국 Northwestern 대학교 Consulting faculty
    2004-2005 연세의대 약리학교실 전임강사
    2005-2009 연세의대 약리학교실 조교수
    2009-2014 연세의대 약리학교실 부교수
    2014-현재 연세의대 약리학교실 교수

강의분야

  • 임상약리학

논문

  • Race and sex influence clearance of nifedipine: Results of a population study
    CLINICAL PHARMACOLOGY & THERAPEUTICS 68/2 :130-142,2000
  • 국내인에서의 항생제 약동학 모델링 : 아미카신의 적용예
    감염과화학요법 37/1 :S34-39,2005
  • Bispectral index does not correlate with observer assessment of alertness and sedation scores during 0.5% bupivacaine epidural anesthesia with nitrous oxide sedation
    ANESTHESIA AND ANALGESIA 103/2 :385-389,2006
  • Influence of the CYP3A5 and MDR1 genetic polymorphisms on the pharmacokinetics of tacrolimus in healthy Korean subjects
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 64/2 :185-191,2007
  • A randomized, open-label, two-period, crossover bioavailability study of two oral formulations of tacrolimus in healthy Korean adults
    CLINICAL THERAPEUTICS 29/1 :154-162,2007
  • Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans
    Clinical Pharmacology & Therapeutics 83/ :251-257,2008
  • Phase II Study of Transarterial Holmium-166-Chitosan Complex Treatment in Patients with a Single, Large Hepatocellular Carcinoma
    Oncology 76/1 :1-9,2009
  • Pharmacokinetic properties and tissue storage of FITC conjugated SA-MnMEIO nanoparticles in mice
    Current Applied Physics 9/0 :e304-e307,2009
  • Nerve growth factor and expression of its receptors in patients with diabetic neuropathy
    Diabetic Medicine 26/12 :1228-1234,2009
  • Pharmacokinetic Comparison of Controlled-Release and Immediate-Release Oral Formulations of Simvastatin in Healthy Korean Subjects: A Randomized, Open-Label, Parallel-Group, Single- and Multiple-Dose Study
    Clinical Therapeutics 32/ :206-216,2010
  • A phase I pharmacokinetic and pharmacodynamic study of CKD-732, an antiangiogenic agent, in patients with refractory solid cancer
    Investigational New Drugs 28/5 :650-658,2010
  • Modeling the Effect of Sevoflurane on Corrected QT Prolongation A Pharmacodynamic Analysis
    Anesthesiology 113/ :806-811,2010
  • Prognostic Factors in Small Cell Lung Cancer: A New Prognostic Index in Korean Patients
    Oncology 79/3-4 :293-300,2010
  • PEG-인터페론 알파-2a 제제 DA-3021의 안전성 및 약동력학적 특성 연구
    Journal Of Korean Society For Clinical Pharmacology And Therapeutics 18/2 :117-126,2010
  • Effect of CYP2B6 Genotype on the Pharmacokinetics of Sibutramine and Active Metabolites in Healthy Subjects
    JOURNAL OF CLINICAL PHARMACOLOGY 51/1 :53-59,2011
  • Rifampin Enhances the Glucose-Lowering Effect of Metformin and Increases OCT1 mRNA Levels in Healthy Participants
    CLINICAL PHARMACOLOGY & THERAPEUTICS 89/3 :416-421,2011
  • The effect of beta1-adrenergic receptor gene polymorphism on prolongation of corrected QT interval during endotracheal intubation under sevoflurane anesthesia
    Korean Journal of Anesthesiology 61/2 :117-121,2011
  • Population pharmacokinetics of amikacin in a Korean clinical population
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 49/6 :371-381,2011
  • The T2-Shortening Effect of Gadolinium and the Optimal Conditions for Maximizing the CNR for Evaluating the Biliary System: a Phantom Study
    KOREAN JOURNAL OF RADIOLOGY 12/3 :358-364,2011
  • Pharmacokinetic Comparison of Sustained- and Immediate-Release Oral Formulations of Cilostazol in Healthy Korean Subjects: A Randomized, Open-Label, 3-Part, Sequential, 2-Period, Crossover, Single-Dose, Food-Effect, and Multiple-Dose Study
    CLINICAL THERAPEUTICS 33/12 :2038-2053,2011
  • A Phase Ib pharmacokinetic study of the anti-angiogenic agent CKD-732 used in combination with capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer patients who progressed on irinotecan-based chemotherapy
    INVESTIGATIONAL NEW DRUGS 30/ :672-680,2012
  • The views of patients and healthy volunteers on participation in clinical trials: An exploratory survey study
    CONTEMPORARY CLINICAL TRIALS 33/ :611-619,2012
  • Modeling of the LDL cholesterol-lowering effect of atorvastatin in Korean dyslipidemic patients and non-patient volunteers.
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 50/9 :647-656,2012
  • The UGT1A3*2 polymorphism affects atorvastatin lactonization and lipid-lowering effect in healthy volunteers
    PHARMACOGENETICS AND GENOMICS 22/8 :598-605,2012
  • Pharmacokinetic Comparison of an Orally Disintegrating Film Formulation With a Film-Coated Tablet Formulation of Sildenafil in Healthy Korean Subjects: A Randomized, Open-Label, Single-Dose, 2-Period Crossover Study
    CLINICAL THERAPEUTICS 35/3 :205-214,2013
  • Pharmacokinetics of Rosuvastatin/Olmesartan Fixed-Dose Combination: A Single-Dose, Randomized, Open-Label, 2-Period Crossover Study in Healthy Korean Subjects
    CLINICAL THERAPEUTICS 35/7 :915-922,2013
  • Pharmacokinetic Comparison of 2 Fixed-Dose Combination Tablets of Amlodipine and Valsartan in Healthy Male Korean Volunteers: A Randomized, Open-Label, 2-Period, Single-Dose, Crossover Study
    CLINICAL THERAPEUTICS 35/7 :934-940,2013
  • Development of a Pharmacokinetic Interaction Model for Co-administration of Simvastatin and Amlodipine
    DRUG METABOLISM AND PHARMACOKINETICS 29/2 :120-128,2014
  • Pharmacokinetic Interaction between Rosuvastatin and Telmisartan in Healthy Korean Male Volunteers: A Randomized, Open-label, Two-period, Crossover, Multiple-dose Study
    CLINICAL THERAPEUTICS 36/8 :1147-1158,2014
  • Pharmacokinetic Interaction between Rosuvastatin and Olmesartan: A Randomized, Open-label, 3-period, Multiple-dose Crossover Study in Healthy Korean Male Subjects
    CLINICAL THERAPEUTICS 36/8 :1159-1170,2014
  • Pharmacokinetic Interaction between Rosuvastatin and Metformin in Healthy Korean Male Volunteers: A Randomized, Open-label, 3-period, Crossover, Multiple-dose Study
    CLINICAL THERAPEUTICS 36/8 :1171-1181,2014
  • Population pharmacokinetic analysis of diurnal and seasonal variations of plasma concentrations of cilostazol in healthy volunteers
    THERAPEUTIC DRUG MONITORING 36/6 :771-780,2014
  • Pharmacokinetics of a telmisartan/rosuvastatin fixed-dose combination: a single-dose, randomized, open-label, 2-period crossover study in healthy Korean subjects
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 53/10 :883-889,2015
  • Modelling of the Effect of End-Tidal Carbon Dioxide on Cerebral Oxygen Saturation in Beach Chair Position under General Anaesthesia
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 119/1 :85-92,2016
  • Pore dilatation increases the bicarbonate permeability of CFTR, ANO1 and glycine receptor anion channels
    JOURNAL OF PHYSIOLOGY-LONDON 594/11 :2929-2955,2016
  • Pharmacokinetic Interaction Between Rosuvastatin and Metformin in Healthy Korean Male Volunteers: A Randomized, Open-label, 3-period, Crossover, Multiple-dose Study
    CLINICAL THERAPEUTICS 38/8 :1845-1857,2016
  • Pharmacokinetics of a nanocrystal-containing megestrol acetate formulation: A Single-Dose, Randomized, Open-Label, 2-Part, 2-Period Crossover Study in Healthy Korean Subjects
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 54/9 :698-704,2016
  • Quantitative Model for the Blood Pressure Lowering Interaction of Valsartan and Amlodipine
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 82/6 :1,557-1,567,2016
  • Quantitative assessment of food effect on the pharmacokinetics of nano-crystallized megestrol acetate
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 120/3 :270-277,2017
  • Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures
    Korean Journal of Pediatrics 60/2 :50-54,2017
  • A Review of Modeling Approaches to Predict Drug Response in Clinical Oncology
    YONSEI MEDICAL JOURNAL 58/1 :1-8,2017

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