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소속

  • 약리학교실

직위

  • 부교수

연구실 위치

  • 에비슨의생명연구센터 504호

전화/팩스

  • 02-2228-0879 /

학력사항

  • 연세대학교 의과대학 의학사(2001)
    연세대학교 의과대학 의학석사(2003)
    연세대학교 나노과학기술협동과정 이학박사(2006)

교육 및 연구 경력

  • 2007-2008 CSEMC/Tufts Univ. 박사후연구원
    2008-2010 Emory Univ. Sch. Med. 박사후연구원
    2010-2011 차의과학대학원 조교수
    2011-2014 한양대학교 조교수/부교수
    2015-2016 연세의대 약리학교실 조교수
    2016-현재 연세의대 약리학교실 부교수

기타 학술 관련 경력

  • 2013 분쉬의학상 (젊은의과학자상)
    2014 젊은과학자상 (대통령상)
    2015 아산의학상 (젊은의과학자상)
    2017 화이자의학상 (기초의학상)

연구,관심분야

  • 유전체 교정
    차세대 유전자 치료법 개발
    줄기세포생물학

강의분야

  • 심장약리학

논문

  • 주요 논문 list
  • 1. Kim HK, Min S, Song M, Jung S, Choi JW, Kim Y, Lee S, Yoon S+, Kim H+ (+Corresponding authors). Deep learning improves prediction of CRISPR?Cpf1 guide RNA activity. Nat. Biotechnol. 2018.
  • 2. Kim W, Lee S, Kim HS, Song M, Cha YH, Kim YH, Shin J, Lee ES, Joo Y, Song JJ, Choi EJ, Choi JW, Lee J, Kang M, Yook JI, Lee MG, Kim YS, Paik S, Kim H+ (+Corresponding author). Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth. Genome Res. 2018.
  • 3. Lim JS, Gopalappa R, Kim SH, Ramakrishna S, Lee M, Kim W, Kim J, Park SM, Lee J, Oh JH, Kim HD, Park CH, Lee JS, Kim S, Kim SD, Han JM, Kang HC+, Kim H+, Lee JH+ (+Corresponding authors). Somatic Mutations in TSC1 and TSC2 cause focal cortical dysplasia. Am. J. Hum. Genet. 2017 ;100(3) :454-472
  • 4. Kim HK, Song M, Lee J, Menon AV, Jung S, Kang YM, Choi JW, Woo E, Koh HC, Nam JW, Kim H+ (+Corresponding author). In vivo high-throughput profiling of CRISPR-Cpf1 activity. Nat. Methods. 2017; 14(2):153-159.
  • 5. Kim YH, Kim HO, Baek EJ, Kurita R, Cha HJ, Nakamura Y, Kim H+ (+Corresponding author). Rh D blood group conversion using transcription activator-like effector nucleases. Nat. Commun., 2015; 6:7451.
  • 6. Ramakrishna S, Dad A-B D, Beloor J, Gopalappa R, Lee S-K, Kim H+ (+Corresponding author). Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA. Genome Res., 2014; 24(6):1020-7. (Featured on the cover)
  • 7. Kim H, Kim JS. A guide to genome engineering with programmable nucleases. Nat. Rev. Genet., 2014; 15 (5): 321-334.
  • 8. Ramakrishna S, Cho SW, Kim S, Song M, Gopalappa R, Kim JS+, Kim H+ (+Corresponding authors). Surrogate reporter-based enrichment of cells containing RNA-guided Cas9 nuclease-induced mutations. Nat. Commun., 2014; 5: 3378.
  • 9. Kim H, Um E, Cho SR, Jung C, Kim H+, and Kim JS+ (+Corresponding authors). Surrogate reporters for enrichment of cells with nuclease-induced mutations. Nat. Methods, 2011;8:941-3.
  • Hepatitis C Virus Entry Is Impaired by Claudin-1 Downregulation in Diacylglycerol Acyltransferase-1-Deficient Cells
    JOURNAL OF VIROLOGY 88/16 :9233-9244,2014
  • Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells
    STEM CELL REPORTS 3/2 :353-364,2014
  • Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA
    GENOME RESEARCH 24/ :1,020-1,027,2014
  • Rh D blood group conversion using transcription activator-like effector nucleases
    NATURE COMMUNICATIONS 6/- :7451-,2015
  • Recent developments and clinical studies utilizing engineered zinc finger nuclease technology
    CELLULAR AND MOLECULAR LIFE SCIENCES 72/20 :3819-3830,2015
  • Diabetic Mesenchymal Stem Cells Are Ineffective for Improving Limb Ischemia Due to Their Impaired Angiogenic Capability
    CELL TRANSPLANTATION 24/8 :1571-1584,2015
  • Effective Gene Delivery into Human Stem Cells with a Cell-Targeting Peptide-Modified Bioreducible Polymer
    SMALL 11/17 :2069-2079,2015
  • CRISPR/Cas9 system as an innovative genetic engineering tool:Enhancements in sequence specificity and delivery methods
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1856/2 :234-243,2015
  • Environmental enrichment enhances synaptic plasticity by internalization of striatal dopamine transporters
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 36/12 :2122-2133,2016
  • Designed nucleases for targeted genome editing
    PLANT BIOTECHNOLOGY JOURNAL 14/2 :448-462,2016
  • Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice
    SCIENTIFIC REPORTS 6/20242 :1-12,2016
  • Regulation of pluripotency and differentiation by deubiquitinating enzymes.
    CELL DEATH AND DIFFERENTIATION 23/- :1257-1264,2016
  • Generation of Delta F508-CFTR T84 cell lines by CRISPR/Cas9-mediated genome editing
    BIOTECHNOLOGY LETTERS 38/12 :2023-2034,2016
  • Astroglial Activation by an Enriched Environment after Transplantation of Mesenchymal Stem Cells Enhances Angiogenesis after Hypoxic-Ischemic Brain Injury
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17/9 :1-15,2016
  • In Situ Pluripotency Factor Expression Promotes Functional Recovery From Cerebral Ischemia
    MOLECULAR THERAPY 24/9 :1,538-1,549,2016
  • Elucidation of Relevant Neuroinflammation Mechanisms Using Gene Expression Profiling in Patients with Amyotrophic Lateral Sclerosis
    PLOS ONE 11/11 :e0165290-,2016
  • Heroes of peer review: Hyongbum (Henry) Kim
    GENOME BIOLOGY 17/200 :1-3,2016
  • Cell-Penetrating Peptide-Mediated Delivery of Cas9 Protein and Guide RNA for Genome Editing.
    Methods in molecular biology (Clifton, N.J.) 1507/- :81-94,2017
  • In vivo high-throughput profiling of CRISPR-Cpf1 activity.
    NATURE METHODS 14/2 :153-159,2017
  • Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes
    STEM CELLS 35/1 :9-16,2017
  • Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia
    AMERICAN JOURNAL OF HUMAN GENETICS 100/3 :454-472,2017
  • Contriction of the mitochondrial inner compartment is a priming event for mitochondrial division
    NATURE COMMUNICATIONS 8/15754 :1-17,2017
  • RanBPM: a potential therapeutic target for modulating diverse physiological disorders.
    DRUG DISCOVERY TODAY 22/12 :1816-1824,2017
  • Targeted Genome Engineering to Control VEGF Expression in Human Umbilical Cord Blood?Derived Mesenchymal Stem Cells: Potential Implications for the Treatment of Myocardial Infarction.
    STEM CELLS TRANSLATIONAL MEDICINE 6/3 :1,040-1,051,2017
  • Deep-learning improves prediction of CRISPR-Cpf1 guide RNA activity
    NATURE BIOTECHNOLOGY 36/3 :239-241,2018

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