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소속

  • 약리학교실

직위

  • 부교수

연구실 위치

  • 에비슨의생명연구센터 504호

전화/팩스

  • 02-2228-0879 /

학력사항

  • 연세대학교 의과대학 의학사(2001)
    연세대학교 의과대학 의학석사(2003)
    연세대학교 나노과학기술협동과정 이학박사(2006)

교육 및 연구 경력

  • 2007-2008 CSEMC/Tufts Univ. 박사후연구원
    2008-2010 Emory Univ. Sch. Med. 박사후연구원
    2010-2011 차의과학대학원 조교수
    2011-2014 한양대학교 조교수/부교수
    2015-2016 연세의대 약리학교실 조교수
    2016-현재 연세의대 약리학교실 부교수

기타 학술 관련 경력

  • 2013 분쉬의학상 (젊은의과학자상)
    2014 젊은과학자상 (대통령상)
    2015 아산의학상 (젊은의과학자상)

연구,관심분야

  • 유전체 교정
    차세대 유전자 치료법 개발
    줄기세포생물학

강의분야

  • 심장약리학

논문

  • 최근 주요 논문
  • 1. Ramakrishna S, Dad A-B D, Beloor J, Gopalappa R, Lee S-K, Kim H? (?Corresponding author). Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA. Genome Res., 2014 June. 24: 1020-1027 (Featured on the cover; http://genome.cshlp.org/content/24/6.cover-expansion).
  • 2. Kim H, Kim JS. A guide to genome engineering with programmable nucleases. Nat. Rev. Genet., 2014 May;15(5):321-34.
  • 3. Ramakrishna S, Cho SW, Kim S, Song M, Gopalappa R, Kim JS?, Kim H? (?Corresponding authors). Surrogate reporter-based enrichment of cells containing RNA-guided Cas9 nuclease-induced mutations. Nat. Commun., 2014 Feb 26; 5: 3378.
  • 4. Kim H, Um E, Cho SR, Jung C, Kim H?, and Kim JS? (?Corresponding authors). Surrogate reporters for enrichment of cells with nuclease-induced mutations. Nat. Methods, 2011 Oct 9;8:941-3. (Featured in Chemical & Engineering News, http://pubs.acs.org/cen/news/89/i42/8942notw4.html)
  • Hepatitis C Virus Entry Is Impaired by Claudin-1 Downregulation in Diacylglycerol Acyltransferase-1-Deficient Cells
    JOURNAL OF VIROLOGY 88/16 :9233-9244,2014
  • Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells
    STEM CELL REPORTS 3/2 :353-364,2014
  • Rh D blood group conversion using transcription activator-like effector nucleases
    NATURE COMMUNICATIONS 6/- :7451-,2015
  • Recent developments and clinical studies utilizing engineered zinc finger nuclease technology
    CELLULAR AND MOLECULAR LIFE SCIENCES 72/20 :3819-3830,2015
  • Diabetic Mesenchymal Stem Cells Are Ineffective for Improving Limb Ischemia Due to Their Impaired Angiogenic Capability
    CELL TRANSPLANTATION 24/8 :1571-1584,2015
  • Effective Gene Delivery into Human Stem Cells with a Cell-Targeting Peptide-Modified Bioreducible Polymer
    SMALL 11/17 :2069-2079,2015
  • CRISPR/Cas9 system as an innovative genetic engineering tool:Enhancements in sequence specificity and delivery methods
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1856/2 :234-243,2015
  • Environmental enrichment enhances synaptic plasticity by internalization of striatal dopamine transporters
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 36/12 :2122-2133,2016
  • Designed nucleases for targeted genome editing
    PLANT BIOTECHNOLOGY JOURNAL 14/2 :448-462,2016
  • Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice
    SCIENTIFIC REPORTS 6/20242 :1-12,2016
  • Regulation of pluripotency and differentiation by deubiquitinating enzymes.
    CELL DEATH AND DIFFERENTIATION 23/- :1257-1264,2016
  • Generation of Delta F508-CFTR T84 cell lines by CRISPR/Cas9-mediated genome editing
    BIOTECHNOLOGY LETTERS 38/12 :2023-2034,2016
  • Astroglial Activation by an Enriched Environment after Transplantation of Mesenchymal Stem Cells Enhances Angiogenesis after Hypoxic-Ischemic Brain Injury
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17/9 :1-15,2016
  • In Situ Pluripotency Factor Expression Promotes Functional Recovery From Cerebral Ischemia
    MOLECULAR THERAPY 24/9 :1,538-1,549,2016
  • Elucidation of Relevant Neuroinflammation Mechanisms Using Gene Expression Profiling in Patients with Amyotrophic Lateral Sclerosis
    PLOS ONE 11/11 :e0165290-,2016
  • Heroes of peer review: Hyongbum (Henry) Kim
    GENOME BIOLOGY 17/200 :1-3,2016
  • Cell-Penetrating Peptide-Mediated Delivery of Cas9 Protein and Guide RNA for Genome Editing.
    Methods in molecular biology (Clifton, N.J.) 1507/- :81-94,2017
  • In vivo high-throughput profiling of CRISPR-Cpf1 activity.
    NATURE METHODS 14/2 :153-159,2017
  • Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes
    STEM CELLS 35/1 :9-16,2017
  • Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia
    AMERICAN JOURNAL OF HUMAN GENETICS 100/3 :454-472,2017
  • Contriction of the mitochondrial inner compartment is a priming event for mitochondrial division
    NATURE COMMUNICATIONS 8/15754 :1-17,2017

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