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소속

  • 환경의생물학교실

직위

  • 교수

연구실 위치

  • 의과대학 구관 2층 257호

전화/팩스

  • 02) 2228-1844 /

학력사항

  • 한양대학교 의학과 학사 (1989)
    한양대학교 박사 (1996)

교육 및 연구 경력

  • 1995.-2002. 이화여자대학교 의과대학 기생충학교실

기타 학술 관련 경력

  • 대한기생충학회 평의원 및 편집간사
    American Association of Immunologists, 정회원

연구,관심분야

  • 호산구 (Eosinophils), 중성구 (Neutrophil)
    Protozoa (원충)
    세포고사 (apoptosis)
    신호전달 (Signal tranduction)

강의분야

  • 환경의생물학

논문

  • Han KL, Lee HJ, Shin MH, Shin HJ, Im KI, Park SJ (2004) The involvement of an integrin-like protein and protein kinase C in amoebic adhesion to fibronectin and amoebic cytotoxicity. Parasitol. Res., 94: 53-60.
  • Sohn MH, Lee YA, Jeong KY, Sim S, Kim KE, Yong TS, Shin MH (2004) German cockroach extract induces activation of human eosinophils to release cytotoxic inflammatory mediators. Int. Arch. Allergy Immunol., 134: 141-149.
  • Min DY, Lee YA, Ryu JS, Ahn MH, Chung YB, Sim S, Shin MH (2004) Caspase-3-mediated apoptosis of human eosinophils by the tissue-invding helminth Paragonimus westermani. Int. Arch. Allergy Immunol., 133: 357-364.
  • Ryu JS, Kang JH, Jung SY, Shin MH, Kim JM, Park H, Min DY (2004) Production of interleukin-8 by human neutrophils stimulated with Trichomonas vaginalis. Infection and Immunity, 72(3): 1326-1332.
  • Sim S, Lee IY, Lee KJ, Seo JH, Im KI, Shin MH, Yong TS (2003) A survey on head lice infestation in Korea (2001) and the therapeutic efficacy of oral trimethoprim/sulfamethoxazole adding to lindane shampoo. Korean J. Parasitol., 41(1): 57-61.
  • Kie JH, Yang WI, Lee MK, Kwon TJ, Min YH, Kim HO, Ahn HS, Im SA, Kim HL, Park HY, Ryu KH, Chung WS, Shin MH, Jung YJ, Woo SY, Park HK, Seoh JY (2002) Decrease in apoptosis and increase in poly-ploidization of megakaryocytes by stem cell factor during ex vivo expansion of human cord blood CD34 cells using thrombopoietin. Stem Cells, 20: 73-79.
  • 민득영, 류재숙, 안명희, 최한규, 강성인, 신명헌 (2002) 전라남도 완도군 보길도 주민의 폐흡충 및 장내기생충 감염현황. 감염, 33(4): 230-234.
  • Shin MH, Kita H, Park HY, Seoh JY (2001) Cysteine protease secreted by Paragonimus westermani attenuates effector functions of human eosinophils stimulated with immunoglobulin G. Infect. Immun., 69(3): 1599-1604.
  • Shin MH, Lee SY (2000) Proteolytic activity of cysteine proetase in excretory-secretory product of Paragonimus westermani newly excysted metacercariae pivotally regulates IL-8 production of human eosinophils. Parasite Immunol., 22(10): 529-533.
  • Shin MH (2000) Excretory-secretory product of Paragonimus westermani newly excysted metacercariae inhibits superoxide production of granulocytes stimulated with IgG. Korean J. Parasitol., 38(2): 103-106.
  • Shin MH (2000) Excretory-secretory product of newly excysted metacercariae of Paragonimus westermani directly induces eosinophil apoptosis. Korean J. Parasitol., 38(1): 17-23.
  • Cho SY, Lee NS, Shin MH, Kong Y (1999) Age-dependent infectivity of orally transferred juvenile Fasciola hepatica. J. Parasitol., 85(4): 739-742.
  • Shin MH, Min DY (1999) Infection status of Paragonimus westermani metacercariae in crayfish (Cambaroides similis) collected from Bongildo (Islet), Wando-gun, Chollanam-do, Korea. Korean J. Parasitol., 37(1): 55-57.
  • Shin MH (1997) Dermal mast cell responses in Paragonimus westermani-infected mice. Korean J. Parasitol., 35(4): 259-264.
  • Shin MH, Min HK (1997) Effects of anti-IgE on serum IgE, Fc epsilon RII/CD23 expression on splenic B cells and worm burden in mice infected with Paragonimus westermani. Korean J. Parasitol., 35(1): 47-54.
  • Min DY, Ryu JS, Shin MH (1993) Changes of IgE production, splenic helper and suppressor T lymphocytes in mice infected with Paragnoimus westermani. Korean J. Parasitol., 31(3): 231-238.
  • Min DY, Shin MH, Choi R (1992) Blastogenesis of splenic lymphocytes to specific antigens and PHA in Paragonimus westermani infected mice. Korean J. Parasitol., 30(1): 43-48.
  • Shin MH, Ryu JS, Min DY (1991) Serum IgE levels in rats infected with Paragonimus westermani. Korean J. Parasitol., 29(4): 397-401.
  • Proteolytic activity of cysteine protease in excretory-secretory product of Paragonimus westermani newly excysted metacercariae pivotally regulates IL-8 production of human eosinophils
    PARASITE IMMUNOLOGY 22/10 :529-533,2000
  • Excretory-secretory product of newly excysted metacercariae of Paragonimus westermani directly induces eosinophil apoptosis
    THE KOREAN JOURNAL OF PARASITOLOGY 38/1 :17-23,2000
  • Excretory-secretory product of Paragonimus westermani newly excysted metacercariae inhibits superoxide production of granulocytes stimulated with IgG
    THE KOREAN JOURNAL OF PARASITOLOGY 38/3 :103-106,2000
  • In vitro activites of 2,2'-Dipyridyl aganist Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 11/1 :124-130,2001
  • Apoptosis and megakaryocytic differentiation during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin
    BRITISH JOURNAL OF HAEMATOLOGY 113/0 :470-478,2001
  • Cysteine protease secreted by Paragonimus westermani attenuates effector functions of human eosinophils stimulated with immunoglobulin G
    INFECTION AND IMMUNITY 69/3 :1599-1604,2001
  • Complestatin antagonizee the AMPA/Kainate-induced neurotoxicity in cultured chick telencephalic neurons
    NEUROCHEMICAL RESEARCH 27/4 :337-343,2002
  • 전라남도 완도군 보길도 주민의 폐흡충 및 장내기생충 감염현황
    감염 33/4 :230-234,2002
  • Excretory-secretory products secreted by Paragonimus westermani delay the spontaneous cell death of human eosinophils through autocrine production of GM-SCF
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 132/1 :48-57,2003
  • Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hyperpyrexia
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 68/1 :102-106,2003
  • Caspase-3-mediated apoptosis of human eosinophils by the tissue-invading helminth Paragonimus westermani
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 133/ :357-364,2004
  • German cockroach extract induces activation of human eosinophils to release cytotoxic inflammatory mediators
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 134/ :141-149,2004
  • Production of interleukin-8 by human neutrophils stimulated with Trichomonas vaginalis
    INFECTION AND IMMUNITY 72/ :1326-1332,2004
  • The involvement of an integrin-like protein and protein kinase C in amoebic adhesion to fibronectin and amoebic cytotoxicity
    PARASITOLOGY RESEARCH 94/ :53-60,2004
  • Ultrastructural observation of human neutrophils during apoptotic cell death triggered by Entamoeba histolytica (Brief Communication)
    KOREAN JOURNAL OF PARASITOLOGY 42/4 :205-208,2004
  • NADPH oxidase-derived reactive oxygen species-mediated activation of ERK1/2 is required for apoptosis of human neutrophils induced by Entamoeba histolytica
    JOURNAL OF IMMUNOLOGY 174/4 :4279-4288,2005
  • The synthetic chemoattractant peptide WKYMVm induces superoxide production by human eosinophils via the phosphoinositide 3-kinase-mediated activation of ERK1/2
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 137/ :21-26,2005
  • Degranulation of human eosinophils induced by Paragonimus westermani-secreted protease
    THE KOREAN JOURNAL OF PARASITOLOGY 43/1 :1-11,2005
  • 고삼투압 자극이 호산구의 활성화에 미치는 영향
    Korean Journal of Pediatrics 48/8 :881-885,2005
  • Trichomonas vaginalis promotes apoptosis of human neutrophils by activating caspase-3 and reducing Mcl-1 expression
    PARASITE IMMUNOLOGY 28/ :439-446,2006
  • Macrophageal/microglial cell activation and cerebral injury induced by excretory-secretory products secreted by Paragonimus westermani
    NEUROSCIENCE RESEARCH 54/ :133-139,2006
  • Excretory-secretory products produced by Paragonimus westermani differentially regulate the nitric oxide production and viability of microglial cells
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 139/ :16-24,2006
  • Involvement of beta2-integrin in ROS-mediated neutrophil
    MICROBES AND INFECTION 9/ :1368-1375,2007
  • House dust mite induces expression of intercellular adhesion molecule-1 in EoL-1 human eosinophilic leukemic cells
    JOURNAL OF KOREAN MEDICAL SCIENCE 22/ :815-819,2007
  • Calpain-dependent calpastatin cleavage regulates caspase-3 activation during apoptosis of Jurkat T cells induced by Entamoeba histolytica
    INTERNATIONAL JOURNAL FOR PARASITOLOGY 37/ :1209-1219,2007
  • A 27 kDa cysteine protease secreted by newly excysted Paragonimus westermani metacercariae induces superoxide anion production and degranulation of human eosinophils
    Korean Journal Of Parasitology 46/ :95-99,2008
  • Trichomonas vaginalis: Reactive oxygen species mediates caspase-3 dependent apoptosis of human neutrophils
    Experimental Parasitology 118/ :59-65,2008
  • Vibrio vulnificus-induced death of Jurkat T-cells requires activation of p38 mitogen-activated protein kinase by NADPH oxidase-derived reactive oxygen species
    Cellular Immunology 253/ :81-91,2008
  • Mitochondrial respiration is required for activation of ERK1/2 and caspase-3 in human eosinophils stimulated with hydrogen peroxide
    Journal Of Investigational Allergology And Clinical Immunology 19/3 :188-194,2009
  • Evaluation of alpha-Tubulin as an Antigenic and Molecular Probe to Detect Giardia lamblia
    Korean Journal Of Parasitology 47/3 :287-291,2009
  • Eosinophil-mediated tissue inflammatory responses in helminthic infections
    Korean Journal Of Parasitology 47/1 :S125-S131,2009
  • Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of jurkat T cells induced by entamoeba histolytica
    Parasite Immunology 31/ :1-8,2009
  • The Nf-actin gene is an important factor for food-cup formation and cytotoxicity of pathogenic Naegleria fowleri
    Parasitology Research 106/4 :917-924,2010
  • 호산구와 조직침습 기생연충
    Hanyang Medical Reviews 30/3 :238-245,2010
  • Prevalence of pediculosis capitis among Korean children
    Parasitology Research 107/6 :1415-1419,2010
  • Involvement of Src Family Tyrosine Kinase in Apoptosis of Human Neutrophils Induced by Protozoan Parasite Entamoeba histolytica
    Korean Journal of Parasitology 48/4 :285-290,2010
  • Calpain mediates degradation of cytoskeletal proteins during Jurkat T-cell death induced by Entamoeba histolytica
    PARASITE IMMUNOLOGY 33/6 :349-356,2011
  • Reactive oxygen species-dependent necroptosis in Jurkat T cells induced by pathogenic free-living Naegleria fowleri
    PARASITE IMMUNOLOGY 33/7 :390-400,2011
  • NOX1 participates in ROS-dependent cell death of colon epithelial Caco2 cells induced by Entamoeba histolytica
    MICROBES AND INFECTION 13/12-13 :1052-1061,2011
  • NF-κB and CREB Are Involved in IL-8 Production of Human Neutrophils Induced by Trichomonas vaginalis-Derived Secretory Products
    KOREAN JOURNAL OF PARASITOLOGY 49/3 :291-294,2011
  • Identification of Antigenic Proteins in Trichomonas vaginalis
    KOREAN JOURNAL OF PARASITOLOGY 49/1 :79-83,2011
  • Accessible chromatin structure permits factors Sp1 and Sp3 to regulate human TGFBI gene expression
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 409/2 :222-228,2011
  • Calpains are Involved in Entamoeba histolytica-Induced Death of HT-29 Colonic Epithelial Cells
    KOREAN JOURNAL OF PARASITOLOGY 49/2 :177-180,2011
  • Leukotriene B(4) receptor BLT-mediated phosphorylation of NF-kappa B and CREB is involved in IL-8 production in human mast cells induced by Trichomonas vaginalis-derived secretory products
    MICROBES AND INFECTION 13/ :1211-1220,2011
  • NF-kB and CREB are involved in IL-8 production of human neutrophils induced by Trichomonas vaginalis-derived secretory products
    KOREAN JOURNAL OF PARASITOLOGY 49/3 :291-294,2011
  • Identification of antigenic proteins in Trichomonas vaginalis
    KOREAN JOURNAL OF PARASITOLOGY 49/1 :79-83,2011
  • Leukotriene B-4 receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products
    INFLAMMATION RESEARCH 61/2 :97-102,2012
  • Entamoeba histolytica induces cell death of HT29 colonic epithelial cells via NOX1-derived ROS
    KOREAN JOURNAL OF PARASITOLOGY 51/1 :61-68,2013
  • Entamoeba histolytica-secreted cysteine proteases induce IL-8 production in human mast cells via a PAR2-independent mechanism
    PARASITE 21/1 :1-9,2014
  • Amoebic PI3K and PKC is required for Jurkat T cell death induced by Entamoeba histolytica
    KOREAN JOURNAL OF PARASITOLOGY 52/4 :355-366,2014
  • Degradation of the Transcription Factors NF-kappa B, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells
    KOREAN JOURNAL OF PARASITOLOGY 52/5 :459-469,2014
  • NOX2-derived ROS-mediated surface translocation of BLT1 is essential for exocytosis in human eosinophils induced by LTB 4
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 165/1 :40-51,2014
  • Modulation of endogenous Cysteine Protease Inhibitor (ICP) 1 expression in Entamoeba histolytica affects amoebic adhesion to Extracellular Matrix proteins
    EXPERIMENTAL PARASITOLOGY 149/0 :7-15,2015
  • Modulation of dendritic cell function by Trichomonas vaginalis-derived secretory products
    BMB REPORTS 48/2 :103-108,2015
  • Activation of MAPK is required for ROS generation and exocytosis in HMC-1 cells induced by Trichomonas vaginalis-derived secretory products
    KOREAN JOURNAL OF PARASITOLOGY 53/5 :1-7,2015
  • Thymic stromal lymphopoietin regulates eosinophil migration via phosphorylation of l-plastin in atopic dermatitis
    EXPERIMENTAL DERMATOLOGY 25/11 :880-886,2016
  • SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4
    INFECTION AND IMMUNITY 85/ :e00526-16-,2017

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