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소속

  • 미생물학교실

직위

  • 교수

연구실 위치

  • 의과대학 신관 248-2

전화/팩스

  • 02) 2228-1821 /

학력사항

  • 연세대학교 의학과 학사 (1980)
    연세대학교 대학원 의학과 박사 (1986)

교육 및 연구 경력

  • 1991.-1993. 미국 New York, North Shore University Hospital (방문연구원)
    2000.-2000. 호주 Melbourne, the Walter and Eliza Hall Institute (방문연구원)
    2000.-현재 연세대학교 의과대학 미생물학교실 교수

기타 학술 관련 경력

  • 대한면역학회 이사
    AAI member

연구,관심분야

  • 감염면역학 (Infection and immunity),
    자가면역질환 (autoimmunity)

강의분야

  • 면역학

논문

  • 한국 IgA 신병증 환아에서 MHC Class II 유전자형과 예후와의 관계 분석. 대한소아신장학회지 4:33-39, 2000
  • Diversity of the p70 killer cell inhibitory receptor (KIR3DL) family members in a single individual. Molecules and Cells 10:54-60, 2000
  • Restoration of P-glycoprotein function if involved in the increase of natural killer activity with exogenous interleukin-15 in human immunodeficiency virus-inftected indiciduals. Yonsei Medical Journal 41(5):600-606, 2000
  • 뇌종양에 의한 신경세포의 세포고사. 대한신경과학회지 19:266-277, 2001
  • 류마티스양 관절염 환자 활막 T 세포의 T 세포수용체 특성. Immune Network 1:70-76, 2001
  • Hydrogen peroxide triggers the expression of Fas/FasL in astrocytoma cell lines and augments apoptosis. Journal of Neuroimmunology 113:1-9, 2001
  • Ceramide increases Fas-mediated apoptosis in glioblastoma cells through FLIP down-regulation. Journal of Neuro-Oncology 60:135-141, 2002
  • p38 Mitogen-activated Protein Kinase Modulates Expression of TRAIL Induced by IFN-in Human Brain Astrocytes. Journal of Neuroscience Research 74:884-90, 2003
  • Two novel mutations of Wiskott-Aldrich syndrome: the molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling. Biochimica et Biophysica Acta(BBA)-Molecular Basis of Disease 1690:134-144, 2004
  • Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae. FEMS Immunology and Medical Microbiology 41:51-57, 2004
  • Overexpression of S100b protein in children with cerebral palsy or delayed development. Brain & Development 26:190-196, 2004
  • Expression of novel secreted splice variant of the receptor for advanced glycation end products(RAGE) in human brain astrocytes and peripheral blood mononuclear cells. Molecular Immunology 40:1203-1211, 2004
  • Induction of chemokines in human astrocytes by picornavirus infection requires activation of both AP-1 and NF-kappaB. Glia 45:287-296, 2004
  • Cloning of a TLR3 isoform. Yonsei Medical Journal 45:359-361, 2004
  • Over-expression of LIM kinase 1 renders reistance to apoptosis in PC12 cells by inhibition of caspase activation. Cellular and Molecular Neurobiology, 24:181-192, 2004
  • Restoration of P-glycoprotein function is involved in the increase of Natural Killer activity with exogenous interleukin-15 in human immunodeficiency virus-infected individuals
    YONSEI MEDICAL JOURNAL 41/5 :600-606,2000
  • Diversity of the p70 killer inhibitory receptor (KIR3D) family members in a single individual
    MOLECULES AND CELLS 10/0 :54-60,2000
  • Hydrogen peroxide triggers the expression of Fas/FasL in astrocytoma cell lines and augments apoptosis
    JOURNAL OF NEUROIMMUNOLOGY 113/0 :1-9,2001
  • 류마티스양 관절염 환자 활막 T 세포의 T 세포수용체 특성.
    IMMUNE NETWORK 1/1 :70-76,2001
  • Ceramide increases Fas-mediated apoptosis in glioblastoma cells through FLIP down-regulation.
    JOURNAL OF NEURO-ONCOLOGY 60/2 :135-141,2002
  • P38 mitogen-activated protein kinase modulates expression of tumor necrosis factor-related apoptosis-inducing ligand induced by interferon-gamma in fetal brain astrocytes
    JOURNAL OF NEUROSCIENCE RESEARCH 74/ :884-890,2003
  • p38 Mitogen-activated Protein Kinase Modulates Expression of TRAIL Induced by IFN- in Human Brain Astrocytes
    JOURNAL OF NEUROSCIENCE RESEARCH 74/6 :884-890,2003
  • Expression of a novel secreted splice variant of the receptor for advanced glycation end products (RAGE) in human brain astrocytes and peripheral blood mononuclear cells
    MOLECULAR IMMUNOLOGY 40/ :1203-1211,2004
  • Overexpression of LIM kinase 1 renders resistance to apoptosis in PC12 cells by inhibition of caspase activation
    CELLULAR AND MOLECULAR NEUROBIOLOGY 24/ :181-192,2004
  • Over-expression of S100B protein in children with cerebral palsy or delayed development
    BRAIN & DEVELOPMENT 26/ :190-196,2004
  • Peptide mimotopes of Neisseria meningitidis group B capsular polysaccharide
    YONSEI MEDICAL JOURNAL 45/4 :755-758,2004
  • Two novel mutations of Wiskott - Aldrich syndrome: The molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling
    BIOCHIMICA ET BIOPHYSICA ACTA 1690/ :134-140,2004
  • Induction of chemokines in human astrocytes by picornavirus infection requires activation of both AP-1 and NF-kappa B
    GLIA 45/ :287-296,2004
  • Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae
    FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 41/ :51-57,2004
  • Cloning of TLR3 isoform
    YONSEI MEDICAL JOURNAL 45/ :359-361,2004
  • Induction of proinflammatory mediators requires activation of the TRAF, NIK, IKK and NF-κB signal transduction pathway in astrocytes infected with Escherichia coli
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY 140/ :450-460,2005
  • Anti-idiotypic antibody as a potential candidate vaccine for Neisseria meningitidis serogroup B
    INFECTION AND IMMUNITY 73/10 :6399-6406,2005
  • Human brain astrocytes mediate TRAIL-mediated apoptosis after treatment with IFN-gamma
    YONSEI MEDICAL JOURNAL 47/3 :354-358,2006
  • Hydrogen peroxide upregulates TNF-related apoptosis-inducing ligand (TRAIL) expression in human astroglial cells, and augments apoptosis of T cells
    YONSEI MEDICAL JOURNAL 47/4 :551-557,2006
  • Apoptosis of macrophages induced by Trichomonas vaginalis through the phosphorylation of p38 mitogen-activated protein kinase that locates at downstream of mitochondria-dependent caspase activation
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 38/ :638-647,2006
  • 결핵균 단백항원 자극에 의한 대식세포의 TNF - α 및 IL -6 생성과 ERK 활성화
    Immune Network 7/1 :26-30,2007
  • Development of Water-Soluble Single-Crystalline TiO2 Nanoparticles for Photocatalytic Cancer-Cell Treatment
    SMALL 3/5 :850-853,2007
  • Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes
    Immunology 124/ :480-488,2008
  • Multifunctional nanoparticles for combined doxorubicin and photothermal treatments
    Acs Nano 3/10 :2919-2926,2009
  • An Introduction to the New Web Site of the Journal of the Korean Medical Association
    대한의사협회지(Journal Of The Korean Medical Association) 53/8 :648-652,2010
  • The Impact of Nanomaterials in Immune System
    Immune Network 10/3 :85-91,2010
  • Size dependent macrophage responses and toxicological effects of Ag nanoparticles
    CHEMICAL COMMUNICATIONS 47/15 :4382-4384,2011
  • CKD712, (S)-1-(alpha-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C
    INTERNATIONAL IMMUNOPHARMACOLOGY 11/ :1160-1165,2011
  • Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles
    TOXICOLOGY LETTERS 205/3 :227-234,2011
  • Ribosomal Protein L19 and L22 Modulate TLR3 Signaling
    IMMUNE NETWORK 11/3 :155-162,2011
  • CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling
    IMMUNE NETWORK 11/6 :420-423,2011
  • Mass imaging of iron oxide nanoparticles inside cells for in vitro cytotoxicity
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 11/1 :638-641,2011
  • The effects of sub-lethal concentrations of silver nanoparticles on inflammatory and stress genes in human macrophages using cDNA microarray analysis
    BIOMATERIALS 33/18 :4690-4699,2012
  • Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages
    YONSEI MEDICAL JOURNAL 53/3 :654-657,2012
  • Inflammasome formation and IL-1 beta release by human blood monocytes in response to silver nanoparticles
    BIOMATERIALS 33/ :6858-6867,2012
  • Capacitance-based assay for real-time monitoring of endocytosis and cell viability
    Lab on a Chip 12/13 :2377-2384,2012
  • Silver Nanoparticles as a Smart Antimicrobial Agent
    Journal of Bacteriology and Virology 42/2 :177-179,2012
  • The Effects of Silica Nanoparticles in Macrophage Cells
    IMMUNE NETWORK 12/6 :296-300,2012
  • Immunostimulatory Effects of Silica Nanoparticles in Human Monocytes
    IMMUNE NETWORK 13/3 :94-101,2013
  • Contrasting Roles of Different Endoglin Forms in Atherosclerosis
    Immune Network 14/5 :237-240,2014
  • Acute exposure to silica nanoparticles aggravate airway inflammation: different effects according to surface characteristics
    EXPERIMENTAL AND MOLECULAR MEDICINE (Korean journal of biochemistry) 47/ :e173-,2015
  • Macrophage Differentiation from Monocytes Is Influenced by
    MEDIATORS OF INFLAMMATION 2015/ :235797-1-235797-10,2015
  • An inhibitory alternative splice isoform of Toll-like receptor 3 is induced by type I interferons in human astrocyte cell lines
    BMB REPORTS 48/12 :696-701,2015
  • Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species
    INTERNATIONAL JOURNAL OF NANOMEDICINE 11/- :55-68,2016
  • Real-time monitoring of 3D cell culture using a 3D capacitance biosensor
    BIOSENSORS & BIOELECTRONICS 77/- :56-61,2016
  • Immunotoxicity of metal oxide and metal nanoparticles and animal models to evaluate immunotoxicity of nanoparticles
    Current Bionanotechnology 2/2 :84-90,2016
  • Do Helper T Cell Subtypes in Lymphocytic Thyroiditis Play a Role in the Antitumor Effect?
    Journal of Pathology and Translational Medicine 50/5 :377-384,2016
  • 5 nm Silver Nanoparticles Amplify Clinical Features of Atopic Dermatitis in Mice by Activating Mast Cells
    SMALL 13/9 :1602363-,2017

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