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소속

  • 미생물학교실

직위

  • 교수

연구실 위치

  • 의과대학 신관 248-1

전화/팩스

  • 02) 2228-1815 /

학력사항

  • 연세대학교 의과대학 의학과 의학사 (1980)
    연세대학교 대학원 의학과 의학석사 (1985)
    연세대학교 대학원 의학과 의학박사 (1988)

교육 및 연구 경력

  • 1987 -1988 연세대학교 의과대학 미생물학교실 연구강사
    1988 -1992 Laboratory of Biochemical Immunogenetics Sloan-Kettering Institute for Cancer Research New York, NY, USA Postdoctoral Research Fellow
    1992 -1993 연세대학교 의과대학 미생물학교실 연구강사
    1993 - 1994 연세대학교 의과대학 미생물학교실 조교수 대우
    1994 - 2000 연세대학교 의과대학 미생물학교실 부교수
    2000 - 현재 연세대학교 의과대학 미생물학교실 교수

기타 학술 관련 경력

  • 대한미생물학회 회원
    대한미생물학회 평의원
    대한면역학회 학술부 위원
    대한의학협회 협회지 편집자문·실무위원
    대한미생물학회 학술부장
    대한미생물학회지 편집위원장
    Journal of Microbiology & Virology Associate Editor
    Cell Death Society Member
    AACR Member

연구,관심분야

  • 간암발생 기전,
    세포고사,
    암세포의 면역방어 회피 HBx와 상호작용하는 단백질과 기능,
    Photodynamic therapy
    면역세포수용체 (NK receptor),
    면역유전자 발현 조절

강의분야

  • 면역학,
    미생물학,
    바이러스학,
    종양학

논문

  • Influence of the sequence variations of the HLA-DR promoters derived from human melanoma cell lines on nuclear protein binding and promoter activity. Yonsei Med J 41(5):593-599, 2000
  • IFN-γ induces cells death in human hepatoma cells through a TRAIL/death receptor-mediated apoptotic pathway. Int J Cancer 93:262-268, 2001
  • Effective local control of malignant melanoma by intratumoral injection of a beta-emitting radionucleotide. 29(20):221-230 Eur J Nucl Med, 2001
  • Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability. br J Cancer 85(8):1147-1152, 2001
  • Apoptosis if chondrocytes and its regulation in pathogenesis of osteoarthritis. 대한류마치스학회지 8(2):104- 117, 2001
  • Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis and the resistance is abolished by cisplatin. Exp Mol Med 34(2):114-122, May 2002
  • Expression patterns of cytokines and chemokines genes in human hepatoma cells. Yonsei Med J 2002 Oct 31;43(5):657-64
  • Characteristics of the killing mechanism of human natural killer cells against hepatocellular carcinoma cell lines HepG2 and Hep3B. Cancer Immunol Immunother. 53:461-470, 2004
  • Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein-protein interaction. FEBS Letters 557:73-80, 2004
  • Cisplatin-induced apoptosis in Hep3B cells: mitochondria-dependent and independent pathways. Biochem Pharmacol 67:1459-1468, 2004
  • Effects of nevel peptides derived from the acidic tail of synuclein(ATS) on the aggregation and stability of fusion proteins. Protein Engineering, Design & Selection 17(3):251-260, 2004
  • Role of caspase-3 in apoptosis of colon cancer cells induced by nonsteroid anti-inflammatory drugs
    IEEE Trans Fuzzy Systems 15/0 :105-111,2000
  • Differential effects of retinoids on the growth and apoptosis in human colon cancer cell lines associated with the induction of RARβ
    INTERNATIONAL JOURNAL FOR PARASITOLOGY 59/5 :485-496,2000
  • Restoration of P-glycoprotein function is involved in the increase of Natural Killer activity with exogenous interleukin-15 in human immunodeficiency virus-infected individuals
    YONSEI MEDICAL JOURNAL 41/5 :600-606,2000
  • Expression patterns of alpha-synuclein in human hematopoietic cells and in Drosophila at different developmental stages
    MOLECULES AND CELLS 10/1 :65-70,2000
  • Influence of the sequence variation of the HLA-DR promoters derived from human melanoma cell lines on nuclear protein binding and promoter activity
    YONSEI MEDICAL JOURNAL 41/5 :593-599,2000
  • P16 is a major inactivation target in hepatocellular carcinoma
    CANCER 89/0 :60-68,2000
  • Diversity of the p70 killer inhibitory receptor (KIR3D) family members in a single individual
    MOLECULES AND CELLS 10/0 :54-60,2000
  • Role of caspase-3 in apoptosis of colon cancer cells induced by nonsteroidal anti-inflammatory drugs
    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 15/ :105-111,2000
  • Induction of neuronal cell death by Rab5A-dependent endocytosis of α-synuclein
    JOURNAL OF BIOLOGICAL CHEMISTRY 276/29 :27441-27448,2001
  • Polymerase chain reaction을 이용한 감염성 안내염의 진단
    대한안과학회지(J Korean Ophthalmol Soc) 42/4 :600-606,2001
  • Effect of interferon-gamma on the susceptibility to Fas (CD95/APO-1) mediated cell death in human hepatoma cells
    JOURNAL OF NEUROLINGUISTICS 50/0 :23-30,2001
  • IFN-gamma induces cell death in human hepatoma cells through a TRAIL/death receptor-mediated apoptotic pathway
    INTERNATIONAL JOURNAL OF CANCER 93/2 :262-268,2001
  • Hepatitis B virus X protein induced expression of the Nur77 Gene
    INTERNATIONAL GEOLOGY REVIEW 288/0 :1162-1168,2001
  • Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability
    BRITISH JOURNAL OF CANCER 85/8 :1147-1152,2001
  • Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin
    EXPERIMENTAL AND MOLECULAR MEDICINE 34/2 :114-122,2002
  • Effective local control of malignant melanoma by intratumoural injection of a beta=emitting radionuclide
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 29/2 :221-230,2002
  • 규칙적인 수영훈련이 마우스 비장세포의 ROS 생성과 림프구 증식에 미치는 영향
    IMMUNE NETWORK 2/2 :96-101,2002
  • Hepatitis B virus X protein induced expression of interleukin 18: a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection
    JOURNAL OF HEPATOLOGY 37/0 :380-386,2002
  • PREPARATION AND CHARACTERISTICS OF CERAMIC COMPOSITE POWDERS COATED WITH AL2O3 (I) HYDROLYSIS OF MIX
    한국 세라믹 학회지 22/2 :277-284,2002
  • Distinct roles of the N-terminal-binding domain and the C-terminal-solubilizing domain of alpha-synuclein, a molecular chaperone
    JOURNAL OF BIOLOGICAL CHEMISTRY 277/32 :28512-28520,2002
  • Expression patterns of cytokines and chemokines genes in human hepatoma cells
    YONSEI MEDICAL JOURNAL 43/0 :657-664,2002
  • Structural basis for inhibition of protein tyrosine phosphatases by Keggin compounds phosphomolybdate and phosphotungstate
    TECHNIQUES IN COLOPROCTOLOGY 34/3 :211-223,2002
  • Effects of novel peptides derived from-the acidic tail of synuclein (ATS) on the aggregation and stability of fusion proteins
    PROTEIN ENGINEERING DESIGN & SELECTION 17/ :251-260,2004
  • Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor gamma through protein-protein interaction
    FEBS LETTERS 557/ :73-80,2004
  • F-Fluorodeoxyglucose Uptake Pattern on Positron Emission Tomography
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING / :-,2004
  • Characteristics of the killing mechanism of human natural killer cells against hepatocellular carcinoma cell lines HepG2 and Hep3B
    CANCER IMMUNOLOGY IMMUNOTHERAPY 53/ :461-470,2004
  • Cisplatin-induced apoptosis in Hep3B cells: Mitochondria-dependent and -independent pathways
    BIOCHEMICAL PHARMACOLOGY 67/ :1459-1468,2004
  • Analysis of gene expression profiles of hepatocellular carcinomas with regard to F-18-fluorodeoxyglucose uptake pattern on positron emission tomography
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 31/12 :1621-1630,2004
  • EBNA2 is required for protection of latently Epstein-Barr virus-infected B cells against specific apoptotic stimuli
    JOURNAL OF VIROLOGY 78/22 :12694-12697,2004
  • Induction of cell death by photodynamic therapy with a new synthetic photosensitizer DH-I-180-3 in undifferentiated and differentiated 3T3-L1 cells
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 337/ :1059-1064,2005
  • 유방암에서 감시림프절 파라핀 포매조직 RT-PCR법을 이용한 미세전이 분석
    한국유방암학회지(Journal Of Korean Breast Cancer Society) 8/2 :31-39,2005
  • Different glucose uptake and glycolytic mechanisms between hepatocellular carcinoma and intrahepatic mass-forming cholangiocarcinoma with increased
    JOURNAL OF NUCLEAR MEDICINE 46/10 :1753-1759,2005
  • Combined effects of swim training and ginseng supplementation on exercise performance time, ROS, lymphocyte proliferation, and DNA damage following exhaustive exercise stress
    INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH / :-,2006
  • The interaction of hepatitis B virus X protein and protein phosphatase type 2 C alpha and its effect on IL-6
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 351/ :253-258,2006
  • Raf-1 and protein kinase B regulate cell survival through the activation of NF-kappa B in hepatitis B virus X-expressing cells
    VIRUS RESEARCH 125/ :1-8,2007
  • Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells - ROS-mediated cell death by 3-BrPA
    Journal Of Bioenergetics And Biomembranes / :1-12,2008
  • Characteristics of B-Cell-Specific Growth Substance Produced by Bacillus licheniformis E1
    Journal Of Microbiology And Biotechnology 19/1 :55-64,2009
  • Enzymatic properties of the N- and C-terminal halves of human hexokinase II
    BMB REPORTS 42/6 :350-355,2009
  • Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines
    Journal Of Nuclear Medicine 50/9 :1525-1532,2009
  • 기본의학 교육과정 개선 방안 - 연세의대 광혜교육과정을 중심으로 -
    의학교육논단 11/2 :15-24,2009
  • Impact of Hepatitis B Virus (HBV) X Gene Mutations on Hepatocellular Carcinoma Development in Chronic HBV Infection
    CLINICAL AND VACCINE IMMUNOLOGY 18/6 :914-921,2011
  • Expression of Epstein-Barr Virus Gene and Clonality of Infiltrated T Lymphocytes in Epstein-Barr Virus-associated Gastric Carcinoma
    IMMUNE NETWORK 11/1 :50-58,2011
  • Cell-to-Cell Contact with Hepatitis C Virus-Infected Cells Reduces Functional Capacity of Natural Killer Cells
    JOURNAL OF VIROLOGY 85/23 :12557-12569,2011
  • Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway
    CELL COMMUNICATION AND SIGNALING 11/ :-,2013
  • Pre-S mutations of hepatitis B virus affect genome replication and expression of surface antigens
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 29/4 :843-850,2014
  • Loop-mediated isothermal amplification of vanA gene enables a rapid and naked-eye detection of vancomycin-resistant enterococci infection
    JOURNAL OF MICROBIOLOGICAL METHODS 103/ :61-66,2014
  • Inhibition of tumour angiogenesis and growth by small hairpin HIF-1a and IL-8 in hepatocellular carcinoma
    LIVER INTERNATIONAL 34/4 :632-642,2014
  • Hypermethylation of the interferon regulatory factor 5 promoter in Epstein-Barr virus-associated gastric carcinoma
    JOURNAL OF MICROBIOLOGY 53/1 :70-76,2015
  • Efficacy of perifosine alone and in combination with sorafenib in an HrasG12V plus shp53 transgenic mouse model of hepatocellular carcinoma
    CANCER CHEMOTHERAPY AND PHARMACOLOGY 76/2 :257-267,2015
  • Serum Dickkopf-1 as a Biomarker for the Diagnosis of Hepatocellular Carcinoma
    YONSEI MEDICAL JOURNAL 56/5 :1296-1306,2015
  • Targeted therapy for Epstein-Barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation
    ONCOTARGET 6/31 :31018-31029,2015
  • Clonal evolution of multidrug resistant hepatitis B virus during entecavir rescue therapy
    LIVER INTERNATIONAL 35/11 :2370-2383,2015
  • Pandemic influenza virus, pH1N1, induces asthmatic symptoms via activation of innate lymphoid cells
    PEDIATRIC ALLERGY AND IMMUNOLOGY 26/8 :780-788,2015
  • Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1
    EUROPEAN JOURNAL OF CANCER PREVENTION 25/1 :54-64,2016
  • Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma
    ONCOTARGET 7/27 :41718-41810,2016
  • Troglitazone enhaces the apoptotic response of DLD-1 colon cancer cells to photodynamic therapy
    YONSEI MEDICAL JOURNAL 57/6 :1,494-1,499,2016
  • Hepatitis C virus impairs natural killer cell activity via viral serine protease NS3
    PLOS ONE 12/4 :e0175793-,2017

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