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소속

  • 미생물학교실

보직

  • 주임교수

직위

  • 교수

연구실 위치

  • 의과대학 신관 246-11

전화/팩스

  • 02) 2228-1814 /

학력사항

  • 서울대학교 자연과학대학 화학과 학사(1986)
    서울대학교 자연과학대학 화학과 석사(1988)
    미국 California Institute of Technology Ph.D.(1993)

교육 및 연구 경력

  • 1993.-1995. Harvard University, post Doc.
    1995.-2000. 연세대학교 의과대학, 조교수
    2000.-2005. 연세대학교 의과대학, 부교수
    2005.-현재 연세대학교 의과대학, 교수

기타 학술 관련 경력

  • 한국생화학회 뉴스지 편집위원
    한국분자생물학회 뉴스지 편집위원

연구,관심분야

  • 단백질공학 (Protein engineering),
    치료용 단백질의 구조와 기능 ( Structure and function of therapeutic proteins), 면역세포에서의 신호전달(Signal transduction in immune system),
    NK 세포 및 NK 세포 수용체의 면역학적 기능(Immunological function of NK cells and NK cell receptors)

강의분야

  • 분자면역학, 종양면역학, 단백질의 구조와 기능

논문

  • Expression Patterns of α-Synuclein in Human Hematopoietic Cells and in Drosophila at Different Developmental Stages. Molecules and Cells 10:65-70, 2000
  • Diversity of the p70 Killer Cell Inhibitory Receptor(KIR3DL) Family Members in a Single Individual. Molecules and Cells 10:54-60, 2000
  • Structural changes in alpha-synuclein affect its chaperone-like activity in vitro. Protein Science 9(12):2489-2496, 2000
  • Thermal Behavior of Proteins: Heat-Resistant Proteins and Their Heat-induced Secondary Structural Changes. Biochemistry 39:14839-14846, 2000
  • Analysis of FcgRIII and IgG Fc Polymorphism Reveals Functional and Evolutionary Implications of Protein-Protein Interaction. Journal of Molecular Evolution 53:1-9, 2001
  • Sreuctural basis for inhibition of protein tyrosine phosphatases by Keggin compounds phosphomolybdate and phosphotungstate. Experimental Molecular Medicine 34:211-223, 2002
  • Stress-Induced Aggregation Profiles of GST-a-synuclein Fusion Proteins: Role of the Cterminal Acidic Tail of α-synuclein in Protein Thermosolubility and Stability. Biochemistry 41:4137-4146, 2002
  • Distinct roles of the N-terminal-binding domain and the C-terminal-solubilizing domain of α-synuclein, a molecular chaperone. Journal of Biological Chemistry 277:28512-28520, 2002
  • Molecular mechanism of the activation-induced cell death inhibition mediated by a p70 inhibitory killer cell Ig-like receptor in Jurkat T cells. Journal of Immunology 169:3726-3735, 2002
  • Evidence that alpha-synuclein functions as a negative regulator of Ca2+-dependent -granule release from human platelets. Blood 100:2506-2514, 2002
  • Effects of novel peptides derived from the acidic tail of synuclein(ATS) on the aggregation and stability of fusion proteins. Protein Engineering, Design & Selection 17:251-260, 2004
  • Structural changes in alpha-synuclein affect its chaperone-like activity in vitro
    PROTEIN SCIENCE 9/ :2489-2496,2000
  • Expression patterns of alpha-synuclein in human hematopoietic cells and in Drosophila at different developmental stages
    MOLECULES AND CELLS 10/1 :65-70,2000
  • Diversity of the p70 killer inhibitory receptor (KIR3D) family members in a single individual
    MOLECULES AND CELLS 10/0 :54-60,2000
  • Thermal behavior of proteins: Heat-resistant proteins and their heat-induced secondary structural changes
    BIOCHEMISTRY 39/48 :14839-14846,2000
  • Induction of neuronal cell death by Rab5A-dependent endocytosis of α-synuclein
    JOURNAL OF BIOLOGICAL CHEMISTRY 276/29 :27441-27448,2001
  • Multiple ligand interaction of alpha-synuclein produced various forms of protein aggregates in the presence of Ab25-35, copper, and eosin
    BRAIN RESEARCH 908/ :93-98,2001
  • Analysis of FcrRIII and IgG Fc polymorphism reveals functional and evolutional implications of protein-protein interaction
    JOURNAL OF MOLECULAR EVOLUTION 53/ :1-9,2001
  • Distinct roles of the N-terminal-binding domain and the C-terminal-solubilizing domain of alpha-synuclein, a molecular chaperone
    JOURNAL OF BIOLOGICAL CHEMISTRY 277/32 :28512-28520,2002
  • Molecular mechanism of the activation-induced cell death inhibition mediated p70 inhibitory killer cell Ig-like receptor in Jurkat T cells
    JOURNAL OF IMMUNOLOGY 169/0 :3726-3735,2002
  • Structural basis for inhibition of protein tyrosine phosphatases by Keggin compounds phosphomolybdate and phosphotungstate
    TECHNIQUES IN COLOPROCTOLOGY 34/3 :211-223,2002
  • Lipid interaction of a-synuclein during the metal-catalyzed oxidation in the presence of Cu++ and H2O2
    JOURNAL OF NEUROCHEMISTRY 84/0 :1128-1142,2003
  • Effects of novel peptides derived from-the acidic tail of synuclein (ATS) on the aggregation and stability of fusion proteins
    PROTEIN ENGINEERING DESIGN & SELECTION 17/ :251-260,2004
  • Characteristics of the killing mechanism of human natural killer cells against hepatocellular carcinoma cell lines HepG2 and Hep3B
    CANCER IMMUNOLOGY IMMUNOTHERAPY 53/ :461-470,2004
  • Stabilizing peptide fusion for solving the stability and solubility problems of therapeutic proteins
    PHARMACEUTICAL RESEARCH 22/ :1735-1746,2005
  • Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein
    JOURNAL OF NEUROCHEMISTRY 97/ :265-279,2006
  • Adiponectin protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity
    BIOCHEMICAL PHARMACOLOGY 72/72 :616-623,2006
  • Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 343/343 :564-570,2006
  • Dequalinium-induced protofibril formation of alpha-synuclein
    JOURNAL OF BIOLOGICAL CHEMISTRY 281/6 :3463-3472,2006
  • Association of Killer Cell Ig-like Receptor (KIR) with an Adaptor Protein Shc
    IMMUNE NETWORK 6/3 :-,2006
  • Calpain-resistant fragment(s) of alpha-synuclein regulates the synuclein-cleaving activity of 20S proteasome
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 455/ :40-47,2006
  • Parkin ubiquitinates and promotes the degradation of RanBP2
    JOURNAL OF BIOLOGICAL CHEMISTRY 281/ :3595-3603,2006
  • Crystallization and preliminary crystallographic analysis of the fourth FAS1 domain of human BigH3
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 63/10 :893-895,2007
  • Activation-induced upregulation of inhibitory killer Ig-like receptors is regulated by protein kinase C
    IMMUNOLOGY AND CELL BIOLOGY 85/ :220-228,2007
  • Amino-acid sequence motifs for PKC-mediated membrane trafficking of the inhibitory killer Ig-like receptor
    Immunology And Cell Biology 86/ :372-380,2008
  • A soluble and heat-resistant form of hantavirus nucleocapsid protein for the serodiagnosis of HFRS
    Journal Of Virological Methods 147/ :1-9,2008
  • Inhibition of casein kinase 2 enhances the death ligand- and natural killer cell-induced hepatocellular carcinoma cell death
    Clinical And Experimental Immunology 152/ :336-344,2008
  • Identification of the amino acid sequence motif of α-synuclein responsible for macrophage activation
    Biochemical And Biophysical Research Communications 381/1 :39-43,2009
  • Expression of human interferon alpha-1 with enhanced stability via the tagging system of a stabilizing peptide
    PROTEIN EXPRESSION AND PURIFICATION 63/ :140-146,2009
  • Anti-cancer activity and mechanistic features of a NK cell activating molecule
    Cancer Immunology Immunotherapy 58/ :1691-1700,2009
  • On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft
    Journal Of Neurochemistry 110/ :400-411,2009
  • Enzymatic properties of the N- and C-terminal halves of human hexokinase II
    BMB REPORTS 42/6 :350-355,2009
  • Identification of the amino acid sequence motif for conventional PKC-mediated regulation of NKP46 surface expression
    Scandinavian Journal Of Immunology 71/6 :413-419,2010
  • The gene expression profile of matrix metalloproteinases and their inhibitors in children with Henoch-Schonlein purpura
    BRITISH JOURNAL OF DERMATOLOGY 164/6 :1348-1355,2011
  • Metabolic Effects of a stabilizing peptide fusion protein of leptin in normal mice
    HORMONE AND METABOLIC RESEARCH 44/6 :422-428,2012
  • The chaperone activity of a-synuclein: Utilizing deletion mutants to map its interaction with target proteins
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 80/5 :1316-1325,2012
  • Susceptibility of CD24+ ovarian cancer cells to anti-cancer drugs and natural killer cells
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 427/2 :373-378,2012
  • The Effects of Recombinant Synucleins and Insulin-like Growth Factor 1 on Cancer Cell Migration
    Journal of Bacteriology and Virology 42/2 :133-151,2012
  • Evaluation of the Bioefficacy of a Stabilized Form of Human Growth Hormone (SP-hGH)
    HORMONE AND METABOLIC RESEARCH 45/10 :722-727,2013
  • A high-throughput assay of NK cell activity in whole blood and its clinical application
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 445/3 :584-590,2014
  • A comparative study of the effects of inhibitory cytokines on human natural killer cells and the mechanistic features of transforming growth factor-beta
    CELLULAR IMMUNOLOGY 290/1 :52-61,2014
  • Protection of Mice Against Pandemic H1N1 Influenza virus challenge after Immunization with Baculovirus-expressed stabilizing peptide fusion hemagglutinin protein
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 25/2 :280-287,2015
  • Effect of major histocompatibility complex haplotype matching by C4 and MICA genotyping on acute graft versus host disease in unrelated hematopoietic stem cell transplantation
    HUMAN IMMUNOLOGY 77/2 :176-183,2016

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