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소속

  • 미생물학교실

직위

  • 부교수

연구실 위치

  • ABMRC 303호

전화/팩스

  • 02) 2228-1817 /

학력사항

  • 연세대학교 공학사 (1994)
    연세대학교 대학원 공학석사 (1996)
    연세대학교 대학원 공학박사 (2002)

교육 및 연구 경력

  • 2002 - 2004 고려대학교 세포사멸연구센터 선임연구원
    2004 - 2009 Thomas Jefferson University Postdoctoral Research Fellow
    2009 - 2010 Thomas Jeferson University Research Associate
    2010 - 2012 명지대학교 생명과학정보학부 조교수
    2012 - 2016 연세대학교 의과대학 미생물학교실 조교수
    2016 - 현재 연세대학교 의과대학 미생물학교실 부교수

연구,관심분야

  • - Elucidation of pattern-recognition receptor-mediated signaling mechanism
    - Identification of a novel modulator for inflammasome signaling pathway
    - Molecular pathogenesis of inflammatory / neurodegenerative diseases

강의분야

  • 기초면역학

논문

  • Iron chlorin e(6) scavenges hydroxyl radical and protects human endothelial cells against hydrogen peroxide toxicity
    BIOLOGICAL & PHARMACEUTICAL BULLETIN 24/6 :1053-1059,2001
  • Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism
    JOURNAL OF BIOLOGICAL CHEMISTRY 279/9 :7584-7590,2004
  • Cryopyrin and pyrin activate caspase-1, but not NF-kappa B, via ASC oligomerization
    CELL DEATH AND DIFFERENTIATION 13/2 :236-249,2006
  • Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants
    MOLECULAR CELL 28/2 :214-227,2007
  • The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
    CELL DEATH AND DIFFERENTIATION 14/9 :1590-1604,2007
  • Mutations in NALP12 cause hereditary periodic fever syndromes
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105/5 :1614-1619,2008
  • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    Nature 458/7237 :509-513,2009
  • Differential cytoprotective effect of copper- and iron-containing chlorophyllins against oxidative stress-mediated cell death
    Free Radical Research 44/6 :655-667,2010
  • The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
    Nature Immunology 11/5 :385-394,2010
  • CIIA Is a Novel Regulator of Detachment-Induced Cell Death
    Cancer Research 70/15 :6352-6358,2010
  • Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome
    The Journal of biological chemistry 285/13 :9792-9802,2010
  • TRADD is critical for resistance to TRAIL-induced cell death through NF-kappa B activation
    FEBS LETTERS 585/14 :2144-2150,2011
  • Pyrin Domain (PYD)-containing Inflammasome in Innate Immunity
    Journal of Bacteriology and Virology 41/3 :133-146,2011
  • Salmonella Promotes ASC Oligomerization-dependent Caspase-1 Activation
    IMMUNE NETWORK 12/6 :284-290,2012
  • Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death
    CANCER LETTERS 331/2 :183-191,2013
  • Ribotoxic stress through p38 mitogen-activated protein kinase activates in Vitro the human pyrin inflammasome
    JOURNAL OF BIOLOGICAL CHEMISTRY 288/16 :11378-11383,2013
  • The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity
    JOURNAL OF IMMUNOLOGY 191/8 :4358-4366,2013
  • Cobalt Chloride-induced Hypoxia Ameliorates NLRP3-Mediated Caspase-1 Activation in Mixed Glial Cultures
    IMMUNE NETWORK 13/4 :141-147,2013
  • Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4
    IMMUNOLOGY AND CELL BIOLOGY 93/6 :591-599,2015
  • Defective mitochondrial fission augments NLRP3 inflammasome activation
    SCIENTIFIC REPORTS 5/15489 :1-14,2015
  • Rotenone-induced impairment of mitochondrial electron transport chain confers a selective priming signal for NLRP3 inflammasome activation
    JOURNAL OF BIOLOGICAL CHEMISTRY 290/45 :27425-27437,2015
  • Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 467/4 :973-978,2015
  • Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113/6 :E762-E771,2016
  • Inflammasome activation by cell volume regulation and inflammation associated hyponatremia: A vicious cycle
    MEDICAL HYPOTHESES 93/ :117-121,2016
  • 25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
    NATURE COMMUNICATIONS 7/ :13,129-,2016
  • Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance
    ARCHIVES OF PHARMACAL RESEARCH 39/99 :1503-1518,2016
  • Immunomodulatory/anti-inflammatory effect of ZOE-based dental materials
    DENTAL MATERIALS 33/1 :e1-e12,2017
  • Bacterial secretant from Pseudomonas aeruginosa Dampens inflammasome activation in a Quorum sensing-Dependent Manner
    FRONTIERS IN IMMUNOLOGY 8/Article :1-16,2017

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