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소속

  • 미생물학교실

보직

  • 연구정책개발부장, 학생연구력개발위원회, BK 간사

직위

  • 부교수

연구실 위치

  • 의과대학 신관 248-3

전화/팩스

  • 02) 2228-1824 /

학력사항

  • 1998, 학사, 한양대학교 생명화학공학과
    2000, 석사, KAIST 생명화학공학과
    2004, 박사, University of Cincinnati College of Medicine
    2007, 박사후연구원, Harvard Medical School

교육 및 연구 경력

  • 2009.-2014.연세대학교 의과대학 미생물학교실 조교수
    2014.- 현재 연세대학교 의과대학 미생물학교실 부교수

연구,관심분야

  • 미생물 병인론
    미생물-숙주 상호작용
    장내미생물
    C. elegans Biology

강의분야

  • 감염학 총론

논문

  • Proteome analysis of metabolically engineered Escherichia coli producing poly(3-hydroxybutyrate)
    JOURNAL OF BACTERIOLOGY 183/ :301-308,2001
  • Pseudomonas aeruginosa anaerobic respiration in biofilms: Relationships to cystic fibrosis pathogenesis
    DEVELOPMENTAL CELL 3/4 :593-603,2002
  • Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets
    ADVANCED DRUG DELIVERY REVIEWS 54/11 :1425-1443,2002
  • MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101/12 :4246-4249,2004
  • Chronic Pseudomonas aeruginosa infection in cystic fibrosis airway disease: Metabolic changes that unravel novel drug targets
    EXPERT REVIEW OF ANTI-INFECTIVE THERAPY 2/4 :611-623,2004
  • 2,3-Butanediol synthesis and the emergence of the Vibrio cholerae El Tor biotype
    INFECTION AND IMMUNITY 74/12 :6547-6556,2006
  • Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions
    JOURNAL OF CLINICAL INVESTIGATION 116/2 :436-446,2006
  • Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration
    EMBO JOURNAL 26/15 :3662-3672,2007
  • Decreased potency of the Vibrio cholerae sheathed flagellum to trigger host innate immunity
    Infection And Immunity 76/3 :1282-1288,2008
  • Production and sequence validation of a complete full length ORF collection for the pathogenic bacterium Vibrio cholerae
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105/11 :4364-4369,2008
  • Vibrio cholerae proteome-wide screen for immunostimulatory proteins identifies phosphatidylserine decarboxylase as a novel toll-like receptor 4 agonist
    Plos Pathogens 5/8 :1-11,2009
  • Anaerobiosis of Pseudomonas aeruginosa: Implications for Treatments of Airway Infection
    Journal Of Bacteriology And Virology 40/2 :59-66,2010
  • Heterogeneous Virulence Potential and High Antibiotic Resistance of Pseudomonas aeruginosa Strains Isolated from Korean Pneumonia Patients
    Journal Of Microbiology 48/4 :518-525,2010
  • Contribution of cell elongation to the biofilm formation of Pseudomonas aeruginosa during anaerobic respiration
    PLOS ONE 6/1 :e16105- ,2011
  • Suppressed Induction of Proinflammatory Cytokines by a Unique Metabolite Produced by Vibrio cholerae O1 El Tor Biotype in Cultured Host Cells
    INFECTION AND IMMUNITY 79/8 :3149-3158,2011
  • Anaerobiosis-Induced Loss of Cytotoxicity Is Due to Inactivation of Quorum Sensing in Pseudomonas aeruginosa
    INFECTION AND IMMUNITY 79/7 :2792-2800,2011
  • Inhibitory effects of broccoli extract on Escherichia coli O157:H7 quorum sensing and in vivo virulence
    FEMS MICROBIOLOGY LETTERS 321/1 :67-74,2011
  • Vitamin B-12-Mediated Restoration of Defective Anaerobic Growth Leads to Reduced Biofilm Formation in Pseudomonas aeruginosa
    INFECTION AND IMMUNITY 80/ :1639-1649,2012
  • Pseudomonas aeruginosa Bacteriophage PA1Ø Requires Type IV Pili for Infection and Shows Broad Bactericidal and Biofilm Removal Activities
    Applied and Environmental Microbiology 78/17 :6380-6385,2012
  • Structural and Functional Importance of Outer Membrane Proteins in Vibrio cholerae Flagellum
    JOURNAL OF MICROBIOLOGY 50/4 :631-637,2012
  • Activation of Cholera Toxin Production by Anaerobic Respiration of Trimethylamine N-oxide in Vibrio cholerae
    JOURNAL OF BIOLOGICAL CHEMISTRY 287/47 :-,2012
  • Functional Screening of a Metagenomic Library Reveals Operons Responsible for Enhanced Intestinal Colonization by Gut Commensal Microbes
    Applied and Environmental Microbiology 79/12 :3829-3838,2013
  • Dissemination of metallo-B-lactamase-producing Pseudomonas aeruginosa of sequence type 235 in Asian countries
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 68/ :2820-2824,2013
  • Evaluation of humoral immune response to nosocomial pathogen and functional status in elderly patients with sepsis.
    ARCHIVES OF GERONTOLOGY AND GERIATRICS 58/1 :10-14,2014
  • Cholera toxin production during anaerobic trimethylamine N-oxide respiration is mediated by stringent response in Vibrio cholerae
    JOURNAL OF BIOLOGICAL CHEMISTRY 289/19 :13232-13242,2014
  • Loop-mediated isothermal amplification of vanA gene enables a rapid and naked-eye detection of vancomycin-resistant enterococci infection
    JOURNAL OF MICROBIOLOGICAL METHODS 103/ :61-66,2014
  • Risk factors for mortality in patients with bloodstream infections caused by carbapenem-resistant Pseudomonas aeruginosa: clinical impact of bacterial virulence and strains on outcome
    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 80/2 :130-135,2014
  • A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent for suppressing the elastase-mediated virulence of Pseudomonas aeruginosa
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 58/12 :7205-7214,2014
  • Nonmucoid conversion of mucoid Pseudomonas aeruginosa induced by sulfate-stimulated growth
    FEMS MICROBIOLOGY LETTERS 360/2 :157-166,2014
  • Extended longevity and robust early-stage development of Caenorhabditis elegans by a soil microbe, Lysinibacillus sphaericus
    ENVIRONMENTAL MICROBIOLOGY REPORTS 6/6 :730-737,2014
  • Protective Role of Gut Commensal Microbes against Intestinal Infections
    JOURNAL OF MICROBIOLOGY 52/12 :983-989,2014
  • Functional genomic and metagenomic approaches to understanding gut microbiota-animal mutualism
    CURRENT OPINION IN MICROBIOLOGY 24/0 :38-46,2015
  • (p)ppGpp, a Small Nucleotide Regulator, Directs the Metabolic Fate of Glucose in Vibrio cholerae
    JOURNAL OF BIOLOGICAL CHEMISTRY 290/21 :13178-13190,2015
  • A novel siderophore system is essential for the growth of Pseudomonas aeruginosa in airway mucus
    SCIENTIFIC REPORTS 5/- :14644-,2015
  • Rapid Detection of Pseudomonas aeruginosa and Acinetobacter baumannii Harboring blaVIM-2, blaIMP-1 and blaOXA-23 Genes by Using Loop-Mediated Isothermal Amplification Methods
    ANNALS OF LABORATORY MEDICINE 36/1 :15-22,2016
  • Cholera Toxin Production Induced upon Anaerobic Respiration is Suppressed by Glucose Fermentation in Vibrio cholerae
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 26/3 :627-636,2016
  • A single gene of a commensal microbe affects host susceptibility to enteric infection
    NATURE COMMUNICATIONS 7/ :11606-,2016
  • The ferrichrome receptor A as a new target for Pseudomonas aeruginosa virulence attenuation
    FEMS MICROBIOLOGY LETTERS 363/11 :1-8,2016
  • Network-assisted investigation of virulence and antibiotic-resistance systems in Pseudomonas aeruginosa
    SCIENTIFIC REPORTS 6/ :26223-1-26223-11,2016
  • The Resistance Mechanism and Clonal Distribution of Tigecycline-Nonsusceptible Klebsiella pneumoniae Isolates in Korea
    YONSEI MEDICAL JOURNAL 57/3 :641-646,2016
  • Selective and Efficient Elimination of Vibrio cholerae with a Chemical Modulator that Targets Glucose Metabolism
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 6/Article :1-12,2016
  • Identification of essential genes of Pseudomonas aeruginosa for its growth in airway mucus
    JOURNAL OF MICROBIOLOGY 55/1 :68-74,2017
  • A Genetic Screen Reveals Novel Targets to Render Pseudomonas aeruginosa Sensitive to Lysozyme and Cell Wall-Targeting Antibiotics
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 7/Article :1-11,2017
  • Bacterial secretant from Pseudomonas aeruginosa Dampens inflammasome activation in a Quorum sensing-Dependent Manner
    FRONTIERS IN IMMUNOLOGY 8/Article :1-16,2017

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