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소속

  • 미생물학교실

직위

  • 교수

연구실 위치

  • 의과대학 신관 249-2

전화/팩스

  • 02) 2228-1822 /

학력사항

  • 연세대학교 의학과 학사 (1991)
    연세대학교 의학과 석사 (1993)
    연세대학교 의학과 박사 (1999)

교육 및 연구 경력

  • Johns Hopkins University Oncology Centre, 2003-2004, Instructor
    Johns Hopkins University Dept. of Pharmacology, 1999-2003, Postdoctoral fellow
    연세대학교 의과대학 미생물학교실, 1998-1999, 연구강사
    보건의료기술연구기획평가단, 1995-1998, 의과학 책임연구원
    2012.- 현재 연세대학교 의과대학 미생물학교실 교수

기타 학술 관련 경력

  • The International Association for Research on Epstein-Barr virus and associated diseases.
    대한미생물학회, 대한면역학회

연구,관심분야

  • Tumor associated Herpes virus (Epstein-Barr virus, Kaposi's Sarcom Associated Herpes virus), Interferon regulatory factor 5, Nur77
    Molecular Imaging of cancer
    Tumor development and cytokine promoter polymorphism
    miRNA and siRNA

강의분야

  • 의학바이러스학,
    종양바이러스학,
    molecular imaging

논문

  • Molecular analysis of HLA-DR gene expression induced by IFN-gamma in malignant melanoma cell lines. Yonsei Med J. 40:30-39, 1999
  • The Epsteinvirus latency Qp promoter is positively regulated by STATs and Zta interference with JAK activation leads to loss of Qp activity. Proc. Natl. Acad. Sci. USA 96:9339, 1999
  • A linkage between STAT regulation and Epsteinvirus gene expression in tumors. J. Virol. 75:2929, 2001
  • Epstein Barr virus EBNA2 blocks Nur77 mediated apoptosis. Proc. Natl. Acad. Sci. USA 99, 11878-11883, 2002
  • Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide. Proc. Natl. Acad. Sci. USA 101:4625-4630, 2004
  • EBNA2 Is Required for Protection of Latently Epstein-Barr Virus-Infected B Cells against Specific Apoptotic Stimuli. J. Virology 78, 22, 2004
  • Cisplatin-induced apoptosis in Hep3B cells: mitochondria-dependent and-independent pathway. Biochem Pharmacol. 15;67(8):1459-68, 2004
  • Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor gamma through protein-protein interaction. FEBS Lett. 557:73-80, 2004
  • Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors.
    JOURNAL OF VIROLOGY 75/6 :2929-2937,2001
  • Epstein-Barr virus EBNA2 blocks Nur77-mediated apoptosis.
    PNAS 99/18 :11878-11883,2002
  • Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor gamma through protein-protein interaction
    FEBS LETTERS 557/ :73-80,2004
  • Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101/13 :4625-4630,2004
  • Cisplatin-induced apoptosis in Hep3B cells: Mitochondria-dependent and -independent pathways
    BIOCHEMICAL PHARMACOLOGY 67/ :1459-1468,2004
  • Analysis of gene expression profiles of hepatocellular carcinomas with regard to F-18-fluorodeoxyglucose uptake pattern on positron emission tomography
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 31/12 :1621-1630,2004
  • EBNA2 is required for protection of latently Epstein-Barr virus-infected B cells against specific apoptotic stimuli
    JOURNAL OF VIROLOGY 78/22 :12694-12697,2004
  • Induction of cell death by photodynamic therapy with a new synthetic photosensitizer DH-I-180-3 in undifferentiated and differentiated 3T3-L1 cells
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 337/ :1059-1064,2005
  • Stabilizing peptide fusion for solving the stability and solubility problems of therapeutic proteins
    PHARMACEUTICAL RESEARCH 22/ :1735-1746,2005
  • RASSF1A hypermethylation and its inverse correlation with BRAF and/or KRAS mutations in MSI-associated endometrial carcinoma
    INTERNATIONAL JOURNAL OF CANCER 119/ :1316-1321,2006
  • The interaction of hepatitis B virus X protein and protein phosphatase type 2 C alpha and its effect on IL-6
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 351/ :253-258,2006
  • Manipulation of the toll-like receptor 7 signaling pathway by Epstein-Barr virus
    JOURNAL OF VIROLOGY 81/18 :9748-9758,2007
  • Expression of viral microRNAs in Epstein-Barr virus-associated gastric carcinoma
    JOURNAL OF VIROLOGY 81/2 :1033-1036,2007
  • Activation-induced upregulation of inhibitory killer Ig-like receptors is regulated by protein kinase C
    IMMUNOLOGY AND CELL BIOLOGY 85/ :220-228,2007
  • Association of interleukin-10 gene promoter polymorphism in children with atopic dermatitis
    JOURNAL OF PEDIATRICS 150/1 :106-108,2007
  • Amino-acid sequence motifs for PKC-mediated membrane trafficking of the inhibitory killer Ig-like receptor
    Immunology And Cell Biology 86/ :372-380,2008
  • Development of Monoclonal Antibodies Against Human IRF-5 and Their Use in Identifying the Binding of IRF-5 to Nuclear Import Proteins Karyopherin-alpha l and -beta 1
    Yonsei Medical Journal 49/ :1023-1031,2008
  • Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells - ROS-mediated cell death by 3-BrPA
    Journal Of Bioenergetics And Biomembranes / :1-12,2008
  • Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of ReIA Acetylation
    Cancer Research 69/ :583-592,2009
  • In vivo magnetic resonance imaging of injected mesenchymal stem cells in rat myocardial infarction; simultaneous cell tracking and left ventricular function measurement
    International Journal Of Cardiovascular Imaging 25/1 :99-109,2009
  • Gallic acid suppresses lipopolysaccharide-induced nuclear factor-kB signaling by preventing relA acetlylation in A549 lung cancer cells
    Molecular Cancer Research 7/12 :2011-2021,2009
  • MRP1 Polymorphisms Associated With Citalopram Response in Patients With Major Depression
    Journal Of Clinical Psychopharmacology 30/2 :116-125,2010
  • Impact of Hepatitis B Virus (HBV) X Gene Mutations on Hepatocellular Carcinoma Development in Chronic HBV Infection
    CLINICAL AND VACCINE IMMUNOLOGY 18/6 :914-921,2011
  • The humoral immune response to the inactivated influenzaA (H1N1) 2009 monovalent vaccine in patients with Type2 diabetes mellitus in Korea
    DIABETIC MEDICINE 28/7 :815-817,2011
  • Expression of Epstein-Barr Virus Gene and Clonality of Infiltrated T Lymphocytes in Epstein-Barr Virus-associated Gastric Carcinoma
    IMMUNE NETWORK 11/1 :50-58,2011
  • Cell-to-Cell Contact with Hepatitis C Virus-Infected Cells Reduces Functional Capacity of Natural Killer Cells
    JOURNAL OF VIROLOGY 85/23 :12557-12569,2011
  • MicroRNA-494 Downregulates KIT and Inhibits Gastrointestinal Stromal Tumor Cell Proliferation
    CLINICAL CANCER RESEARCH 17/ :7584-7594,2011
  • The humoral immune response to the inactivated influenza A (H1N1) 2009 monovalent vaccine in patients with Type 2 diabetes mellitus in Korea (vol 28, pg 815, 2011)
    DIABETIC MEDICINE 28/12 :815-817,2011
  • Risk factors affecting seroconversion after influenza A/H1N1 vaccination in hemodialysis patients
    BMC NEPHROLOGY 13/165 :165</div>-165</div>,2012
  • Usefulness of impulse oscillometry in children with eosinophilic bronchitis
    PEDIATRIC PULMONOLOGY 48/3 :221-228,2013
  • LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients.
    BREAST CANCER RESEARCH AND TREATMENT 141/1 :89-99,2013
  • Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway
    CELL COMMUNICATION AND SIGNALING 11/ :-,2013
  • Reactive Oxygen Species Induce Antiviral Innate Immune Response through IFN-λ Regulation in Human Nasal Epithelial Cells
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 49/5 :855-865,2013
  • Reduction of the CD16(-)CD56(bright) NK Cell Subset Precedes NK Cell Dysfunction in Prostate Cancer
    PLOS ONE 8/11 :e78049-e78049,2013
  • A high-throughput assay of NK cell activity in whole blood and its clinical application
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 445/3 :584-590,2014
  • Loop-mediated isothermal amplification of vanA gene enables a rapid and naked-eye detection of vancomycin-resistant enterococci infection
    JOURNAL OF MICROBIOLOGICAL METHODS 103/ :61-66,2014
  • Hypermethylation of the interferon regulatory factor 5 promoter in Epstein-Barr virus-associated gastric carcinoma
    JOURNAL OF MICROBIOLOGY 53/1 :70-76,2015
  • Protection of Mice Against Pandemic H1N1 Influenza virus challenge after Immunization with Baculovirus-expressed stabilizing peptide fusion hemagglutinin protein
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 25/2 :280-287,2015
  • CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts
    JOURNAL OF EXPERIMENTAL MEDICINE 212/8 :1283-1301,2015
  • Serum Dickkopf-1 as a Biomarker for the Diagnosis of Hepatocellular Carcinoma
    YONSEI MEDICAL JOURNAL 56/5 :1296-1306,2015
  • Targeted therapy for Epstein-Barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation
    ONCOTARGET 6/31 :31018-31029,2015
  • Pandemic influenza virus, pH1N1, induces asthmatic symptoms via activation of innate lymphoid cells
    PEDIATRIC ALLERGY AND IMMUNOLOGY 26/8 :780-788,2015
  • Rapid Detection of Pseudomonas aeruginosa and Acinetobacter baumannii Harboring blaVIM-2, blaIMP-1 and blaOXA-23 Genes by Using Loop-Mediated Isothermal Amplification Methods
    ANNALS OF LABORATORY MEDICINE 36/1 :15-22,2016
  • Natural killer cells in hepatitis C: Current progress
    WORLD JOURNAL OF GASTROENTEROLOGY 22/4 :1449-1460,2016
  • Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma
    ONCOTARGET 7/27 :41718-41810,2016
  • Hepatitis C virus impairs natural killer cell activity via viral serine protease NS3
    PLOS ONE 12/4 :e0175793-,2017

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