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소속

  • 생화학-분자생물학교실

직위

  • 부교수

연구실 위치

  • 의과대학 신관 501호

전화/팩스

  • 02) 2228-1699 /

학력사항

  • 1994. 덕성여자대학교 약학대 학사
    1995. 덕성여자대학교 약학대 석사
    2000. 동경대학교 약학대학원 약학 박사

교육 및 연구 경력

  • 2000 ~ 2003 University of Texas, MD Anderson Cancer Center. 박사후과정
    2003 ~ 2006 University of Texas, MD Anderson Cancer Center. 전임강사
    2006 ~ 2012 국립암센터 선임연구원
    2012 ~ 현재 연세대학교 의과대학 생화학-분자생물학 교실 조교수

기타 학술 관련 경력

  • 수상경력
    1996.Merck graduated student award (from CRS) 국제약물전달학회
    2011. The Blue Ribbon Lecturer 한국분자세포생물학회

연구,관심분야

  • 암 전이 및 항암 치료제 기전 연구 (Cancer metastasis & anti-cancer drug mechanism study)


논문

  • STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy
    CLINICAL & EXPERIMENTAL METASTASIS 29/4 :359-369,2012
  • Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression
    EXPERIMENTAL AND MOLECULAR MEDICINE 44/6 :387-393,2012
  • Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis
    NATURE COMMUNICATIONS 3/ :978-,2012
  • Acceleration of Gastric Tumorigenesis Through MKRN1-Mediated Posttranslational Regulation of p14ARF
    JOURNAL OF THE NATIONAL CANCER INSTITUTE 104/21 :1660-1672,2012
  • MicroRNA let-7a suppresses breast cancer cell migration and invasion through down-regulation of C-C chemokine receptor type 7
    BREAST CANCER RESEARCH 14/1 :R14-R14,2012
  • CK2-NCoR signaling cascade promotes prostate tumorigenesis
    Oncotarget 4/7 :972-983,2013
  • Galectin-7 is epigenetically-regulated tumor suppressor in gastric cancer
    Oncotarget 4/ :1461-1471,2013
  • The role of S100A14 in epithelial ovarian tumors
    ONCOTARGET 5/ :3482-3496,2014
  • Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer
    ONCOTARGET 5/10 :3386-3398,2014
  • Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress
    CELL DEATH AND DIFFERENTIATION 21/11 :1769-1779,2014
  • Targeting of miR34a-NOTCH1 Axis Reduced Breast Cancer Stemness and Chemoresistance
    CANCER RESEARCH 74/24 :7573-7582,2014
  • Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy
    BMB REPORTS 47/12 :697-702,2014
  • Galectin-3 Activates PPARg and Supports White Adipose Tissue Formation and High-Fat Diet-Induced Obesity
    ENDOCRINOLOGY 156/1 :147-156,2015
  • Cleaved CD44 intracellular domain supports activation of stemness factors and promotes tumorigenesis of breast cancer
    ONCOTARGET 6/11 :8709-8721,2015
  • Targeting Notch signaling by γ-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer
    CLINICAL & EXPERIMENTAL METASTASIS 32/6 :593-603,2015
  • PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis.
    NATURE COMMUNICATIONS 6/7769 :1-14,2015
  • Glucose Deprivation Triggers Protein Kinase C-dependent beta-Catenin Proteasomal Degradation
    JOURNAL OF BIOLOGICAL CHEMISTRY 290/15 :9863-9873,2015
  • A novel miR-34a target, protein kinase D1, stimulates cancer stemness and drug resistance through GSK3/β-catenin signaling in breast cancer
    ONCOTARGET 7/12 :14791-14802,2016
  • Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer
    ONCOGENE 35/2 :251-260,2016
  • Targeting the WEE1 kinase as a molecular targeted therapy for gastric cancer
    ONCOTARGET 7/31 :49902-49916,2016
  • Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1
    CANCER RESEARCH 76/16 :OF1-OF13,2016
  • The long non-coding RNA HOTAIR increases tumour growth and invasion in cervical cancer by targeting the Notch pathway
    ONCOTARGET 7/28 :44558-44571,2016
  • Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway
    SCIENTIFIC REPORTS 6/- :27391-,2016
  • Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma
    ONCOTARGET 7/34 :55678-55689,2016
  • Ablation of human telomerase reverse transcriptase (hTERT) induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism
    ONCOTARGET 7/35 :57117-57130,2016
  • Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain
    ONCOTARGET 7/42 :68,229-68,241,2016

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