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소속

  • 생화학-분자생물학교실

직위

  • 기초연구조교수

연구실 위치

  • 에비슨의생명연구센터 (ABMRC) 418호

전화/팩스

  • 02) 2228-0627 /

논문

  • Substrate-Induced Up-Regulation of Aldose Reductase by Methylglyoxal, a Reactive Oxoaldehyde Elevated in Diabetes
  • Mol Pharmacol 61:1184~1191, 2002
  • Suppression of tumor necrosis factor-α and inducible nitric oxide synthase gene expression by THI 52, a new synthetic naphtyl-benzyliosquinoline alkaloid
  • Biochemical pharmacology 65:457~464, 2003
  • Induction of Manganese-Superoxide Dismutase by YS 51, a Synthetic 1-(ß-Naphtylmethyl)6,7-Dihydroxy-1,2,3,4-Tetrahydroisoquinoline Alkaloid
  • Pharmacology 71:57~65, 2004
  • Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation
  • Cell. Mol. Life Sci. 62:1146~1155, 2005
  • Involvement of nuclear factor ꠑB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells
  • The International Journal of Biochemistry & Cell Biology 37:2297~2309, 2005
  • Identification of a truncated alternative splicing variant of human PPARγ1 that exhibits dominant negative activity
  • Biochemical and Biophysical Research Communications 347:698~706, 2006
  • Phorbol ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARγ in A549 cells
  • Biochemical and Biophysical Research Communications 349:660~667, 2006
  • Expression of a Peroxisome Proliferator-Activated Receptor 1SpliceVariant that Was Identified in Human Lung Cancers Suppresses Cell Death Induced by Cisplatin and Oxidative Stress
  • Clin Cancer Res 13:2577~2583, 2007
  • Up-regulation of aldose reductase expression mediated by PI3K/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage
  • Free Radical Biology & Medicine 43:535~545, 2007
  • Akt-dependent heme oxygenase-1 induction by NS-398 in C6 glial cells
  • Neuro Pharmacology 53:542~551, 2007
  • Ran suppresses paclitaxel-induced apoptosis in human glioblastoma cells
  • Apoptosis 13:1223~1231, 2008
  • Transforming growth factor- beta1 is a molecular target for the peroxisome proliferator- activated receptor delta.
  • Circulation Research 102:193~200,2008
  • Down-regulation of aldose reductase renders J774A.1 cells more susceptible to acrolein- or hydrogen peroxide-induced cell death.
  • Free radical research 42:930-938, 2008
  • Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear factor –kB
  • Pharmacological Research 58:15~21, 2008
  • Peroxisome proliferator-activated receptor {delta} regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta}1 /Smad3.
  • Circulation Research 105:16~24, 2009
  • ACtivation of PPARγ by carbon monoxide from CORM-2 leads to the inhibition of iNOS but not COX-2 expression in LPS-stimulated macrophage
  • Inflammation 32:364~371, 2009
  • PPARδ promotes wound healing by up-regulating TGF-β1-dependent or-independent expression of extracellular matrix proteins
  • J. Cell. Mol. Med. 14:1~14,2009
  • PPARdelta inhibits IL-1beta- stimulated proliferation and migration of vascular smooth muscle cells via up-regulation of IL-1Ra.
  • Cell. Mol. Life Sci. 67:2119~2130, 2010
  • Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells
  • Neuroscience letters 474:115~120, 2010
  • Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells.
  • Biochemical and Biophysical Research Communications 406:564~569, 2011
  • PPARδ coordinates Angiotensin II-induce senescence in vascular smooth muscle cells through PTEN-mediated inhibition of superoxide generation.
  • J Biol. Chem. 286: 44585~44593, 2011
  • Activation of PPARδ counteracts angiotensin II-induced ROS generation by inhibiting rac1 translocation in vascular smooth muscle cells.
  • Free Radical Research, 467:912~919, 2012
  • Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109/34 :13656-13661,2012
  • Kruppel-Like Factor KLF8 Plays a Critical Role in Adipocyte Differentiation
    PLOS ONE 7/12 :e52474-e52474,2012
  • Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110/51 :20575-20580,2013
  • PPARδ reduces abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice by regulating extracellular matrix homeostasis and inflammatory responses
    INTERNATIONAL JOURNAL OF CARDIOLOGY 174/1 :43-50,2014
  • G0/G1 switch gene 2 has a critical role in adipocyte differentiation
    CELL DEATH AND DIFFERENTIATION 21/7 :1071-1080,2014
  • Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor γ in human hepatocytes and increases lipid accumulation
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 460/3 :715-720,2015
  • Protective effect of peroxisome proliferator-activated receptor α activation against cardiac ischemia-reperfusion injury is related to upregulation of uncoupling protein-3
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2016/Arti :1-11,2016
  • Caffeine inhibits adipogenesis through modulation of mitotic clonal expansion and the AKT/GSK3 pathway in 3T3-L1 adipocytes
    BMB REPORTS 49/2 :111-115,2016
  • Glucocorticoid-mediated anti-inflammatory effect through NFκB is preserved in the absence of Dexras1
    ANIMAL CELLS AND SYSTEMS 20/1 :1-6,2016
  • Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis
    SCIENTIFIC REPORTS 6/ :28648-,2016
  • Suppression of PPAR γ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis
    SCIENTIFIC REPORTS 6/ :29352-,2016

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