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소속

  • 생화학-분자생물학교실, 학장실

보직

  • 교학부학장

직위

  • 교수

연구실 위치

  • 에비슨의생명연구센터(ABMRC) 424호

전화/팩스

  • 02) 2228-0836 /

학력사항

  • 1988.연세대학교 의학과 학사
    1990.연세대학교 의학과 석사
    1997.연세대학교 의학과 박사

교육 및 연구 경력

  • 1997 ~ 1998 연세대학교 의과대학 생화학-분자생물학 교실 조교수
    1998 ~ 2006 관동대학교 의과대학 생화학교실 조교수
    2001 ~ 2004 University of Texas Southwestern Medical Center at Dallas, Department of Molecular Genetics, Post-doctoral fellow
    2007 ~ 현재 연세대학교 의과대학 생화학-분자생물학 교실 부교수
    2012. ~ 현재 연세대학교 의과대학 임상의학연구센터 실험동물부 부장

기타 학술 관련 경력

  • 1997 ~ 2010 대한생화학분자생물학회 정회원 (2009 대위원,운영위원)

    수상경력
    2008. Virtual Research Institute Research Grant Award 20. 보건산업진흥원/한국아스트라제네카 가상신약개발사업 수상
    2010. Virtual Research Institute Research Grant Award 20 . 보건산업진흥원/한국아스트라제네카 가상신약개발사업 수상

연구,관심분야

  • ㆍ Regulation of expression low density lipoprotein receptor (LDLR) by proprotein convertase subtilisin/kexin type 9 (PCSK9), and the eventual effects on cholesterol metabolism
    ㆍ Development of new therapeutic reagents from natural resources for diabetes, obesity, and dyslipidemia

강의분야

  • 세포 대사
    - Amino acid and protein chemistry
    - Nucleic acid chemistry and their metabolism
    - Nutrition and vitamin
    분자생물학
    - Transcription of the gene and its regulation

논문

  • Lagace, T.A., D.E. Curtis, R. Garuti, M.C. McNutt, S.W. Park, H.B. Prather, N.N. Anderson, Y.K. Ho, R.E. Hammer, and J.D. Horton. 2006. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest 116:2995-3005.
  • Park, S.W., Y.A. Moon, and J.D. Horton. 2004. Post-transcriptional Regulation of Low Density Lipoprotein Receptor Protein by Proprotein Convertase Subtilisin/Kexin Type 9a in Mouse Liver. J. Biol. Chem. 279:50630-50638.
  • Horton, J.D., N.A. Shah, J.A. Warrington, N.N. Anderson, S.W. Park, M.S. Brown, and J.L. Goldstein. 2003. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc. Natl. Acad. Sci. U. S. A. 100:12027-12032.
  • Oh, S.Y., S.K. Park, J.W. Kim, Y.H. Ahn, S.W. Park, and K.S. Kim. 2003. Acetyl-CoA Carboxylase-β Gene Is Regulated by Sterol Regulatory Element-binding Protein-1 in Liver. J. Biol. Chem. 278:28410-28417.
  • Moon, Y.A., J.J. Lee, S.W. Park, Y.H. Ahn, and K.S. Kim. 2000. The Roles of Sterol Regulatory Element-binding Proteins in the Transactivation of the Rat ATP Citrate-Lyase Promoter. J. Biol. Chem. 275:30280-30286.
  • Characterization of cis-acting elements in the rat ATP citrate-lyase gene promoter
    EXPERIMENTAL AND MOLECULAR MEDICINE 34/ :60-68,2002
  • Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100/21 :12027-12032,2003
  • Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver
    JOURNAL OF BIOLOGICAL CHEMISTRY 278/ :28410-28417,2003
  • Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
    JOURNAL OF BIOLOGICAL CHEMISTRY 279/48 :50630-50638,2004
  • Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
    JOURNAL OF CLINICAL INVESTIGATION 116/11 :2995-3005,2006
  • Up-regulation of acetyl-CoA carboxylase α and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
    JOURNAL OF BIOLOGICAL CHEMISTRY 282/36 :26122-26131,2007
  • Reversine stimulates adipocyte differentiation and downregulates Akt and p70
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 358/ :553-558,2007
  • Androgen-dependent activation of human cytomegalovirus major immediate-early promoter in prostate cancer cells
    Prostate 68/ :1450-1460,2008
  • Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2
    Journal of Lipid Research 49/ :399-409,2008
  • Resveratrol Downregulates Acetyl-CoA Carboxylase α and Fatty Acid Synthase by AMPK-mediated Downregulation of mTOR in Breast Cancer Cells
    Food Science and Biotechnology 17/5 :1047-1051,2008
  • KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells
    Biochemical Journal 417/ :313-322,2009
  • Hepatocyte Nuclear Factor 1 alpha Plays a Critical Role in PCSK9 Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine
    Journal of Biological Chemistry 284/42 :28885-28895,2009
  • Coculture with BJ fibroblast cells inhibits the adipogenesis and lipogenesis in 3T3-L1 cells
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 392/ :520-525,2010
  • Strong induction of PCSK9 gene expression through HNF1 alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters
    Journal Of Lipid Research 51/6 :1486-1495,2010
  • Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107/21 :9626-9631,2010
  • Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase 2 in prostate cancer cells
    BIOCHEMICAL JOURNAL 433/1 :225-233,2011
  • Kruppel-like Factor 4 (KLF4) Activates the Transcription of the Gene for the Platelet Isoform of Phosphofructokinase (PFKP) in Breast Cancer
    JOURNAL OF BIOLOGICAL CHEMISTRY 286/27 :23808-23816,2011
  • Role of surface charge in cytotoxicity of charged manganese ferrite nanoparticles towards macrophages
    NANOTECHNOLOGY 23/50 :505702-1-505702-8,2012
  • Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects.
    METABOLISM-CLINICAL AND EXPERIMENTAL 62/6 :845-850,2013
  • Lipin1 regulates PPARgamma transcriptional activity
    BIOCHEMICAL JOURNAL 453/1 :49-60,2013
  • Galactosylated manganese ferrite nanoparticles for targeted MR imaging of asialoglycoprotein receptor
    NANOTECHNOLOGY 24/47 :475103-,2013
  • G0/G1 switch gene 2 has a critical role in adipocyte differentiation
    CELL DEATH AND DIFFERENTIATION 21/7 :1071-1080,2014
  • Galactosylated magnetic nanovectors for regulation of lipid metabolism based on biomarker-specific RNAi and MR imaging
    NANOTECHNOLOGY 26/33 :335101-,2015
  • In silico Screening of Chemical Libraries to Develop Inhibitors That Hamper the Interaction of PCSK9 with the LDL Receptor
    YONSEI MEDICAL JOURNAL 56/5 :1251-1257,2015

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