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소속

  • 생화학-분자생물학교실

직위

  • 교수

연구실 위치

  • 의과대학 신관 501호

전화/팩스

  • 02) 2228-1683 /

학력사항

  • 1994. 고려대학교 식품공학 학사
    1996. 고려대학교 생물공학 석사
    2000. 고려대학교 미생물공학 박사

교육 및 연구 경력

  • 2001 ~ 2003 Baylor College of Medicine. Postdoctoral Researcher
    2003 ~ 2005 Baylor college of Medicine. Instructor
    2005 ~ 2009 연세대학교 의과대학 생화학-분자생물학 교실 조교수
    2009 ~ 현재 연세대학교 의과대학 생화학-분자생물학 교실 부교수

기타 학술 관련 경력

  • 2005 ~ 현재 대한생화학·분자생물학회 평위원
    2005 ~ 현재 한국 생화학·분자생물학회 평위원
    2011 ~ 현재 한국식품영양과학회 (J Medicinal Food) 편집위원

    수상경력
    1998 신진연구자상 우수 박사학위 후보자에게 수여
    2004 New Investigator Research Award from PCRP (미국방부에서 공모한 신진 연구책임자 대상 국책연구비 수주 )
    2012 보원학술상 연구논문 학술상

연구,관심분야

  • Nuclear Hormone Receptor Signaling
    Transcripotional regulation
    Epigenetic Cancer Biology

강의분야

  • Molecular Biology
    Cell Biology

논문

  • Analysis of essential leucine residue for catalytic activity of novel thermostable chitosanase by site-directed mutagenesis
    JOURNAL OF PROTEIN CHEMISTRY 19/7 :621-630,2000
  • Thermostable chitosanase from Bacillus sp strain CK4: Its purification, characterization, and reaction patterns
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 65/4 :802-809,2001
  • Identification of essential amino acid residues for catalytic activity and thermostability of novel chitosanase by site-directed mutagenesis
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 56/ :173-180,2001
  • Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor
    MOLECULAR AND CELLULAR BIOLOGY 22/16 :5688-5697,2002
  • Gene cloning and biochemical analysis of thermostable chitosanase (TCH-2) from Bacillus coagulans CK108
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 66/5 :986-995,2002
  • N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso
    MOLECULAR CELL 12/3 :723-734,2003
  • Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1
    EUROPEAN MOLECULAR BIOLOGY ORGANIZATION JOURNAL 22/6 :1336-1346,2003
  • JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)
    MOLECULAR AND CELLULAR BIOLOGY 25/15 :6404-6414,2005
  • The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.
    MOLECULAR ENDOCRINOLOGY 20/5 :1048-1060,2006
  • Preparation of poly epsilon-caprolactone nanoparticles containing magnetite for magnetic drug carrier
    INTERNATIONAL JOURNAL OF PHARMACEUTICS 324/2 :185-190,2006
  • A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin
    MOLECULAR ENDOCRINOLOGY 20/4 :776-785,2006
  • Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer
    JOURNAL OF MATERIALS CHEMISTRY 17/26 :2695-2705,2007
  • Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid
    CHEMISTRY OF MATERIALS 19/ :3870-3876,2007
  • Motions of magnetic nanosphere under the magnetic field in the rectangular microchannel
    JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 317/1 :34-40,2007
  • Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
    NATURE MEDICINE 13/1 :95-99,2007
  • Regulation of P-TEFb elongation complex activity by CDK9 acetylation
    MOLECULAR AND CELLULAR BIOLOGY 27/13 :4641-4651,2007
  • Potent HAT inhibitory effect of aqueous extract from bellflower (Platycodon grandiflorum) roots on androgen receptor-mediated transcriptional regulation
    FOOD SCIENCE AND BIOTECHNOLOGY 16/3 :457-462,2007
  • The functional role of the CARM1-SNF5 complex and its associated HMT activity in transcriptional activation by thyroid hormone receptor
    EXPERIMENTAL AND MOLECULAR MEDICINE 39/4 :544-555,2007
  • Anti-Histone Acetyltransferase Activity from Allspice Extracts Inhibits Androgen Receptor-Dependent Prostate Cancer CellGrowth
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 71/ :70306-70314,2007
  • Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 46/46 :8836-8839,2007
  • Novel multifunctional PHDCA/PEI nano-drug carriers for simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging
    NANOTECHNOLOGY 18/47 :0-0,2007
  • Synthesis of water soluble PEGylated magnetic complexes using mPEG-fatty acid for biomedical applications
    Colloids And Surfaces B-Biointerfaces 64/1 :111-117,2008
  • Function of multiple Lis-homology domain/WD-40 repeat-containing proteins in feed-forward transcriptional repression by silencing mediator for retinoic and thyroid receptor/nuclear receptor corepressor complexes
    Molecular Endocrinology 22/5 :1093-1104,2008
  • Effect of anti-histone acetyltransferase activity from Rosa rugosa Thunb. (Rosaceae) extracts on androgen receptor-mediated transcriptional regulation
    Journal Of Ethnopharmacology 118/3 :412-417,2008
  • Zeatin supplement improves scopolamine-induced memory impairment in mice
    Bioscience Biotechnology And Biochemistry 72/ :577-581,2008
  • Proto-oncogene FBI-1 (Pokemon/ZBTB7A) Represses Transcription of the Tumor Suppressor Rb Gene via Binding Competition with Sp1 and Recruitment of Co-repressors
    Journal of Biological Chemistry 283/48 :33199-33210,2008
  • Effect of sodium hydroxide treatment of bacterial cellulose on cellulase activity
    Cellulose 15/ :465-471,2008
  • The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha
    Biochemical Journal 411/1 :19-26,2008
  • Multifunctional magnetic gold nanocomposites: Human epithelial cancer detection via magnetic resonance imaging and localized synchronous therapy
    Advanced Functional Materials 18/2 :258-264,2008
  • Enhancement of magnetic resonance contrast effect using ionic magnetic clusters
    JOURNAL OF COLLOID AND INTERFACE SCIENCE 319/2 :429-434,2008
  • Novel hyaluronic acid (HA) coated drug carriers (HCDCs) for human breast cancer treatment
    Biotechnology And Bioengineering 99/2 :442-454,2008
  • Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection
    Biomaterials 29/16 :2548-2555,2008
  • Magnetic sensitivity enhanced novel fluorescent magnetic silica nanoparticles for biomedical applications
    Nanotechnology 19/7 :075610-,2008
  • Hollow silica nanocontainers as drug delivery vehicles
    Langmuir 24/7 :3417-3421,2008
  • Enhancement of cellular binding efficiency and cytotoxicity using polyethylene glycol base triblock copolymeric nanoparticles for targeted drug delivery
    Journal of Biomedical Materials Research Part A 84A/1 :273-280,2008
  • Signal pathway of 17beta-estradiol-induced MUC5B expression in human airway epithelial cells.
    American Journal Of Respiratory Cell And Molecular Biology 40/2 :168-178,2009
  • Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of ReIA Acetylation
    Cancer Research 69/ :583-592,2009
  • Interrelationship between Liver X Receptor alpha, Sterol Regulatory Element-binding Protein-1c, Peroxisome Proliferator-activated Receptor gamma, and Small Heterodimer Partner in the Transcriptional Regulation of Glucokinase Gene Expression in Liver
    Journal of Biological Chemistry 284/ :15071-15083,2009
  • A Concise Synthesis of Licochalcone E and Its Regio-Isomer, Licochalcone F
    Chemical & Pharmaceutical Bulletin 57/ :607-609,2009
  • The histone methyltransferase, NSD2, enhances androgen receptor-mediated transcription
    Febs Letters 583/ :1880-1886,2009
  • Stimulatory effects of ferulic acid on endurance exercise capacity in mice
    Bioscience Biotechnology And Biochemistry 73/6 :1392-1397,2009
  • Gallic acid suppresses lipopolysaccharide-induced nuclear factor-kB signaling by preventing relA acetlylation in A549 lung cancer cells
    Molecular Cancer Research 7/12 :2011-2021,2009
  • Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression
    Febs Letters 584/11 :2225-2230,2010
  • AP2 alpha Is Essential for MUC8 Gene Expression in Human Airway Epithelial Cells
    Journal Of Cellular Biochemistry 110/6 :1386-1398,2010
  • HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells
    Cellular And Molecular Life Sciences 67/20 :3499-3510,2010
  • Chronic Effect of Ferulic Acid from Pseudosasa japonica Leaves on Enhancing Exercise Activity in Mice
    Phytotherapy Research 24/10 :1508-1513,2010
  • Functional Comparison of Esterified and Free Forms of Conjugated Linoleic Acid in High-Fat-Diet-Induced Obese C57BL/6J Mice
    Journal of Agricultural and Food Chemistry 58/21 :11441-11447,2010
  • Dietary Conjugated Linoleic Acid Increases Endurance Capacity of Mice During Treadmill Exercise
    JOURNAL OF MEDICINAL FOOD 13/5 :1057-1060,2010
  • The Potential Effects of Ethyl Acetate Fraction from Curcuma longa L. on Lipolysis in Differentiated 3T3-L1 Adipocytes
    JOURNAL OF MEDICINAL FOOD 13/2 :364-370,2010
  • In vitro and in vivo hepatoprotective effects of the aqueous extract from Taraxacum officinale (dandelion) root against alcohol-induced oxidative stress
    Food And Chemical Toxicology 48/6 :1632-1637,2010
  • Histone Acetyltransferase Inhibitory Activity of Bokbunja (Rubus coreanus Miq.) Ethanol Extract on Androgen Receptor-dependent Prostate Cancer Cell Growth
    Food Science and Biotechnology 19/6 :1503-1511,2010
  • Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor
    BIOCHEMICAL JOURNAL 433/ :235-244,2011
  • Neuroprotective effects of Eriobotrya japonica against β-amyloid-induced oxidative stress and memory impairment
    FOOD AND CHEMICAL TOXICOLOGY 49/4 :780-784,2011
  • Grape Seed Extract Regulates Androgen Receptor-Mediated Transcription in Prostate Cancer Cells Through Potent Anti?Histone Acetyltransferase Activity
    JOURNAL OF MEDICINAL FOOD 14/1 :9-16,2011
  • Reversible SUMOylation of TBL1-TBLR1 Regulates beta-Catenin-Mediated Wnt Signaling
    MOLECULAR CELL 43/2 :203-216,2011
  • Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-kappa B acetylation in fibroblast-like synoviocyte MH7A cells
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 410/3 :581-586,2011
  • The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling
    JOURNAL OF BIOLOGICAL CHEMISTRY 286/39 :34199-34214,2011
  • Inhibition of Premature Death by Isothiocyanates through Immune Restoration in LP-BM5 Leukemia Retrovirus-Infected C57BL/6 Mice
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 75/7 :1234-1239,2011
  • Fatigue-Alleviating Effect on Mice of an Ethanolic Extract from Rubus coreanus
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 75/2 :349-351,2011
  • Protective effects of a chalcone derivative against Aβ-induced oxidative stress and neuronal damage
    BMB REPORTS 44/11 :730-734,2011
  • Gallic acid, a histone acetyltransferase inhibitor, suppresses ss-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation
    MOLECULAR NUTRITION & FOOD RESEARCH 55/ :1798-1808,2011
  • Licochalcone E has an antidiabetic effect
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY 23/7 :759-767,2012
  • The chalcone derivative Chana 1 protects against amyloid beta peptide-induced oxidative stress and cognitive impairment
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 30/ :193-198,2012
  • EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 30/ :69-74,2012
  • Anti-obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes
    JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 92/ :1833-1840,2012
  • Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner
    MOLECULAR BIOLOGY OF THE CELL 23/15 :2943-2954,2012
  • p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells
    CELL CYCLE 12/10 :1578-1587,2013
  • PKA negatively regulates PP2Cb to activate NF-jB-mediated inflammatory signaling
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 436/3 :473-477,2013
  • Selective inhibition of PCAF suppresses microglial-mediated β-amyloid neurotoxicity.
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32/2 :469-475,2013
  • CK2-NCoR signaling cascade promotes prostate tumorigenesis
    Oncotarget 4/7 :972-983,2013
  • Reduction of the CD16(-)CD56(bright) NK Cell Subset Precedes NK Cell Dysfunction in Prostate Cancer
    PLOS ONE 8/11 :e78049-e78049,2013
  • Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice
    SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 73/8 :607-614,2013
  • High mobility group nucleosomal binding domain 2 (HMGN2) sumoylation by the SUMO E3 ligase PIAS1 decreases the binding affinity to nucleosome core particles
    JOURNAL OF BIOLOGICAL CHEMISTRY 289/29 :20000-20011,2014
  • Mig-6 suppresses endometrial cancer associated with pten deficiency and ERK activation
    CANCER RESEARCH 74/24 :7371-7382,2014
  • Metabolomic Signatures in Peripheral Blood Associated with Alzheimer's Disease Amyloid-beta-Induced Neuroinflammation
    JOURNAL OF ALZHEIMERS DISEASE 42/2 :421-433,2014
  • DNAJB1 destabilizes PDCD5 to suppress p53-mediated apoptosis
    CANCER LETTERS 357/1 :307-315,2015
  • Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress
    CANCER LETTERS 357/1 :419-427,2015
  • Pink1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death
    HUMAN MOLECULAR GENETICS 24/4 :1127-1141,2015
  • YAF2 promotes TP53-mediated genotoxic stress response via stabilization of PDCD5
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1853/5 :1060-1072,2015
  • Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation induced by Aβ in a model of Alzheimer's disease
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 35/4 :1109-1118,2015
  • Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage
    ONCOTARGET 6/12 :9970-9984,2015
  • Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response
    NATURE COMMUNICATIONS 6/7390 :1-17,2015
  • DNAJB1 negatively regulates MIG6 to promote epidermal growth factor receptor signaling
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1853/1853 :2722-2730,2015
  • Glucose Deprivation Triggers Protein Kinase C-dependent beta-Catenin Proteasomal Degradation
    JOURNAL OF BIOLOGICAL CHEMISTRY 290/15 :9863-9873,2015
  • Licochalcone F alleviates glucose tolerance and chronic inflammation in diet-induced obese mice through Akt and p38 MAPK
    CLINICAL NUTRITION 35/2 :414-421,2016
  • SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth
    ONCOTARGET 7/27 :41110-41122,2016
  • Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells.
    ONCOTARGET 7/35 :56,767-56,780,2016
  • Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5
    SCIENTIFIC REPORTS 7/39222 :1-11,2017

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