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소속

  • 생화학-분자생물학교실

직위

  • 교수

연구실 위치

  • 의과대학 신관 501호

전화/팩스

  • 02) 2228-1678 /

학력사항

  • 1981.성균관 대학교 약학과 학사(BS)
    1983.한국과학기술원KAIST 생물공학과 석사(MS)
    1993.미국 인디애나대학교 생화학 및 분자생물학
    이학박사 (Ph.D.)
    1995.Yale University 분자생물학 박사후연수

교육 및 연구 경력

  • 1983 ~ 1986 한국화학연구소 연구원
    1986 ~ 1993 Indiana University 조교
    1993 ~ 1995 미 예일대학교 분자 생물리학 및 생화학과 연구원(Post-Doc. Associate)
    1995 ~ 2001 연세대학교 의과대학 생화학-분자생물학 교실 조교수
    2001 ~ 2006 연세대학교 의과대학 생화학-분자생물학 교실 부교수
    2006 ~ 현재 연세대학교 의과대학 생화학-분자생물학 교실 교수
    2010 ~ 현재 연세대학교 의과대학 의생명과학부 겸임교수

기타 학술 관련 경력

  • 1993 ~ 현재 미국 생화학·분자생물학회(ASBMB) 평회원
    1995 ~ 현재 대한 생화학·분자생물학회 평회원
    1995 ~ 현재 대한 약학회 평회원 및 간사
    1995 ~ 2010 한국 유전학회 편집위원

    수상경력
    1993. Sigma Xi award (미국 Indiana University 대학원 우수 연구업적상 2위)
    2004. 우수연구업적교수상 (연세의대 연구업적 분야)
    2005. 우수연구업적교수상 (연세의대 연구업적 분야)
    2006. 최우수연구업적교수상(계연 학술상)
    2006. 우수연구업적교수상 (연세의대 연구업적 분야)

연구,관심분야

  • 유전자 발현조절,
    전사조절,
    유전자 특히 전사인자의 생체 내 기능 규명
    전사조절을 통한 신약개발

강의분야

  • 생화학
    분자생물학

논문

  • Inhibition of MAP kinase by a Drosophila dual-specific phosphatase.
    BIOCHEMICAL JOURNAL 349/3 :821-828,2000
  • Expression patterns of alpha-synuclein in human hematopoietic cells and in Drosophila at different developmental stages
    MOLECULES AND CELLS 10/1 :65-70,2000
  • Identification of a Clonorchis sinensis gene encoding a vitellaria antigenic protein containing repetitive sequences
    Mol Biochem Parasitol 111/0 :213-216,2000
  • Interleukin 6 gene promoter polymorphism is not associated with Kawasaki disease
    GENES AND IMMUNITY 2/7 :357-362,2001
  • Posttranscriptional regulation of human ADH5/FDH and Myf6 gene expression by upstream AUG codons.
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 386/2 :163-171,2001
  • In vivo에서 proximal promoter상의 cis-elements들의 공간적 배열이 유전자의 시간적, 공간적 발현조절에 미치는 영향
    Korean J Genetics 23/3 :287-293,2001
  • 형질전환 생쥐에서 인간 혹스 조절인자에의해 유도된 리포터 transgene의 역동적 패턴
    Korean J Genetics 23/4 :385-392,2001
  • Zeste maintains repression of Ubx transgenes: support for a new model of Polycomb repression
    DEVELOPMENT 129/6 :1339-1343,2002
  • Daunomycin binding to deoxypolynucleotides with alternating sequences: complete thermodynamic profiles of heterogeneous binding sites.
    Nucleosides Nucleotides Nucleic Acids 21/10 :637-649,2002
  • Comparative binding of antitumor drugs to DNA containing the telomere repeat sequence.
    EXPERIMENTAL AND MOLECULAR MEDICINE 34/5 :326-331,2002
  • Activation of dynamin I gene expression by Sp1 and Sp3 is required for neuronal differentiation of N1E-115 cells.
    JOURNAL OF BIOLOGICAL CHEMISTRY 277/14 :11904-11909,2002
  • Temporal and spatial regulation of a gene expression by the spatial arrangement of the cis-elements at proximal promoter region in vivo.
    KOREAN JOURNAL OF GENETICS 0/0 :287-293,2002
  • Reporter transgene based on a human HOX regulatory element is expressed dynamically during mouse development.
    KOREAN JOURNAL OF GENETICS 0/0 :385-392,2002
  • Involvement of two NF-κB binding sites in PMA-induced expression of the human leukotactin-1/CCL15 gene in U937 monocytoid cells
    MOLECULES AND CELLS 17/2 :316-321,2004
  • FBI-1 enhances transcription of the nuclear factor-κB (NF-κB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-κB
    JOURNAL OF BIOLOGICAL CHEMISTRY 280/30 :27783-27791,2005
  • Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK
    JOURNAL OF BIOLOGICAL CHEMISTRY 280/ :28061-28071,2005
  • Artificial zinc finger fusions targeting Sp1-binding sites and the trans-activator-responsive element potently repress transcription and replication of HIV-1
    JOURNAL OF BIOLOGICAL CHEMISTRY 280/22(1 :21545-21552,2005
  • Histone deacetylase-1 represses transcription by interacting with zinc-fingers and interfering with the DNA binding activity of Sp1
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 16/ :23-30,2005
  • Dose-linear pharmacokinetics, tissue distribution, and excretion of a recombinant fusion protein
    REGULATORY PEPTIDES 129/1 :25-30,2005
  • Regulation of GLUT4 gene expression by SREBP-1c in adipocytes
    BIOCHEMICAL JOURNAL 399/ :131-139,2006
  • Pharmacokinetics of GST-TatdMt, a recombinant fusion protein possessing potent anti-obesity activity, in mice
    ARCHIVES OF PHARMACAL RESEARCH 30/ :1162-1167,2007
  • New fast BiFC plasmid assay system for in vivo protein-protein interactions
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 20/ :703-714,2007
  • Regulation of Pokemon 1 activity by sumoylation
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 20/ :167-180,2007
  • Pharmacokinetics of 125I-GST-TatdMt, a recombinant fusion protein possessing potent anti-obesity activity, after intravenous, nasal, oral, and subcutaneous administration
    REGULATORY PEPTIDES 140/1-2 :74-80,2007
  • Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically active transcription of fatty-acid synthase gene (FASN)
    Journal of Biological Chemistry 283/43 :29341-29354,2008
  • Proto-oncogene FBI-1 (Pokemon/ZBTB7A) Represses Transcription of the Tumor Suppressor Rb Gene via Binding Competition with Sp1 and Recruitment of Co-repressors
    Journal of Biological Chemistry 283/48 :33199-33210,2008
  • Proto-oncogene FBI-1 Represses Transcription of p21CIP1 by Inhibition of Transcription Activation by p53 and Sp1
    Journal of Biological Chemistry 284/19 :12633-12644,2009
  • Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A)
    Cellular Physiology And Biochemistry 23/4-6 :359-370,2009
  • A novel POK family transcription factor, ZBTB5, represses transcription of p21CIP1 gene
    Journal of Biological Chemistry 284/30 :19856-19866,2009
  • ZBTB2, a novel master regulator of the p53 pathway
    Journal of Biological Chemistry 284/27 :17935-17946,2009
  • SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis
    Oncogene 28/35 :3145-3156,2009
  • NF-kappa B Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia
    The Journal of biological chemistry 285/13 :9706-9715,2010
  • The pleiohomeotic functions as a negative regulator of Drosophila even-skipped gene during embryogenesis
    Molecules and Cells 32/6 :549-554,2011
  • Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter
    JOURNAL OF LIPID RESEARCH 53/4 :755-766,2012
  • KR-POK Interacts with p53 and Represses Its Ability to Activate Transcription of p21WAF1/CDKN1A
    CANCER RESEARCH 72/5 :1137-1148,2012
  • The proto-oncoprotein KR-POK represses transcriptional activation of CDKN1A by MIZ-1 through competitive binding
    ONCOGENE 31/11 :1442-1458,2012
  • A unique histone deacetylase inhibitor alters microRNA expression and signal transduction in chemoresistant ovarian cancer cells
    CANCER BIOLOGY & THERAPY 13/8 :681-693,2012
  • Regulation of the Cyclin-dependent Kinase Inhibitor 1A Gene (CDKN1A) by the Repressor BOZF1 through Inhibition of p53 Acetylation and Transcription Factor Sp1 Binding
    JOURNAL OF BIOLOGICAL CHEMISTRY 288/10 :7053-7064,2013
  • The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation
    NUCLEIC ACIDS RESEARCH 41/13 :6403-6420,2013
  • Kaiso is a key regulator of spleen germinal center formation by repressing Bcl6 expression in splenocytes
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 442/3-4 :177-182,2013
  • CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation
    FASEB JOURNAL 28/2 :615-626,2014
  • Promyelocytic Leukemia Zinc Finger-Retinoic Acid Receptor alpha (PLZF-RAR alpha), an Oncogenic Transcriptional Repressor of Cyclin-dependent Kinase Inhibitor 1A (p21WAF/CDKN1A) and Tumor Protein p53 (TP53) Genes
    JOURNAL OF BIOLOGICAL CHEMISTRY 289/27 :18641-18656,2014
  • Role of Promyelocytic Leukemia Zinc Finger (PLZF) in Cell Proliferation and Cyclin-dependent Kinase Inhibitor 1A (p21WAF/CDKN1A) Gene Repression
    JOURNAL OF BIOLOGICAL CHEMISTRY 289/27 :18625-18640,2014
  • Human Kruppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene
    JOURNAL OF BIOLOGICAL CHEMISTRY 289/7 :4018-4031,2014
  • KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111/42 :15078-15083,2014
  • Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress
    NUCLEIC ACIDS RESEARCH 42/18 :11447-11461,2014
  • ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65
    NUCLEIC ACIDS RESEARCH 43/3 :1609-1625,2015
  • Transcriptional activation of APAF1 by KAISO (ZBTB33) and p53 isattenuated by RelA/p65
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1849/9 :1170-1178,2015
  • Zbtb7c is a molecular ‘off’ and ‘on’ switch of Mmp gene transcription
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1859/11 :1,429-1,439,2016
  • Role of MIZ-1 in AMELEX gene expression
    Biochemistry and Biophysics Reports 8/ :340-345,2016

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