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소속

  • 생화학-분자생물학교실

직위

  • 교수

연구실 위치

  • 에비슨의생명연구센터(ABMRC) 425호

전화/팩스

  • 02) 2228-0835 /

학력사항

  • 1979. 연세대학교 의학과 학사
    1981. 연세대학교 대학원 의학과 석사
    1984. 연세대학교 대학원 의학과 박사

교육 및 연구 경력

  • 1984 ~ 현재 연세대학교 의과대학 생화학-분자생물학교실 전임강사, 부교수, 교수
    2002 ~ 2006 만성대사성 질환 연구센터 소장
    2004 ~ 2006 연세대학교 의과대학 교학부학장
    2006 ~ 2008 한국보건산업진흥원 연구사업지원본부 본부장
    2009 ~ 2013 연세대학교 의과대학 도서관장

기타 학술 관련 경력

  • 2004 ~ 현재 대한생화학-분자생물학회 SCI학술지. 편집위원
    2005 ~ 현재 대한생화학-분자생물학회 용어심의 위원회. 위원장
    2005 ~ 현재 대한생화학-분자생물학회. 대의원
    2008 ~ 현재 Open Obesity Journal. Member of Advisory Editorial Board

    수상경력
    1996 Korean Medical Association, Kwang-hye Awards. 연구논문 학술상
    2001 Bowon Medical Award 연구논문 학술상

연구,관심분야

  • Metabolic Control of Gene Regualtion Insulin Resistance

강의분야

  • Metabolims,
    Enzyme,
    Gene Regulation

논문

  • Identification of transacting factors responsible for the tissue-specific expression of human glucose transporter type 2 isoform gene. Cooperative ro
    The journal of Biological Chemistry 275/24 :18358-18365,2000
  • Idenitification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter
    DIABETES 49/0 :1517-1524,2000
  • HNF1 and/or HNF3 may contribute to the tissue specific expression of glucokinase gene
    Experimental Molecular Medicine 33/0 :59-63,2001
  • Bcl-2 blocks cisplatin-induced apoptosis by suppression of ERK-mediated P53 accumulation in B104 cells
    Brain Res Mol Brain Res 93/0 :18-26,2001
  • Posttranscriptional regulation of human ADH5/FDH and Myf6 gene expression by upstream AUG codons.
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 386/2 :163-171,2001
  • Cloning of Human Acetyl-CoA Carboxylase β Promoter and Its Regulation by Muscle Regulatory Factors
    JOURNAL OF BIOLOGICAL CHEMISTRY 276/4 :2576-2585,2001
  • Isolation and characterization of Drosophila homologue of MKP-3 which has a high substrate specificity toward ERK
    INTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS 361/0 :143-151,2002
  • Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity
    ANNALS OF CLINICAL AND LABORATORY SCIENCE 32/2 :114-122,2002
  • Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver
    JOURNAL OF BIOLOGICAL CHEMISTRY 278/ :28410-28417,2003
  • Targeting of therapeutic gene expression to the liver by using liver-type pyruvate kinase proximal promoter and the SV40 viral enhancer active in multiple cell types
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 314/ :131-137,2004
  • Alternative usages of multiple promoters of the acetyl-CoA carboxylase β gene are related to differential transcriptional regulation in human and rodent tissues
    JOURNAL OF BIOLOGICAL CHEMISTRY 280/7 :5909-5916,2005
  • Glucose-stimulated upregulation of GLUT2 gene is mediated by sterol response element-binding protein-1c in the hepatocytes
    DIABETES 54/ :1684-1691,2005
  • Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter
    EXPERIMENTAL AND MOLECULAR MEDICINE 37/2 :101-110,2005
  • Different glucose uptake and glycolytic mechanisms between hepatocellular carcinoma and intrahepatic mass-forming cholangiocarcinoma with increased
    JOURNAL OF NUCLEAR MEDICINE 46/10 :1753-1759,2005
  • Stabilizing peptide fusion for solving the stability and solubility problems of therapeutic proteins
    PHARMACEUTICAL RESEARCH 22/ :1735-1746,2005
  • Regulation of GLUT4 gene expression by SREBP-1c in adipocytes
    BIOCHEMICAL JOURNAL 399/ :131-139,2006
  • Transcriptional regulation of glucose sensors in pancreatic β cells and liver
    Current Diabetes Reviews 2/1 :11-18,2006
  • Up-regulation of acetyl-CoA carboxylase α and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
    JOURNAL OF BIOLOGICAL CHEMISTRY 282/36 :26122-26131,2007
  • Transcriptional activation of SHP by PPAR-γ in liver
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 360/2 :301-306,2007
  • Regulation of glucose transporter type 4 isoform gene expression in muscle and adipocytes
    IUBMB LIFE 59/3 :134-145,2007
  • Lipin1 Is a Key Factor for the Maturation and Maintenance of Adipocytes in the Regulatory Network with CCAAT/Enhancer-binding Protein alpha and Peroxisome Proliferator-activated Receptor gamma(2)
    Journal of Biological Chemistry 283/ :34896-34906,2008
  • The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha
    Biochemical Journal 411/1 :19-26,2008
  • KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells
    Biochemical Journal 417/ :313-322,2009
  • Interrelationship between Liver X Receptor alpha, Sterol Regulatory Element-binding Protein-1c, Peroxisome Proliferator-activated Receptor gamma, and Small Heterodimer Partner in the Transcriptional Regulation of Glucokinase Gene Expression in Liver
    Journal of Biological Chemistry 284/ :15071-15083,2009
  • Transcriptional Regulation of Glucose Sensors in Pancreatic beta-Cells and Liver: An Update
    Sensors 10/ :5031-5053,2010
  • Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 403/3-4 :329-334,2010
  • Peroxisome Proliferator-activated Receptor alpha Is Responsible for the Up-regulation of Hepatic Glucose-6-phosphatase Gene Expression in Fasting and db/db Mice
    JOURNAL OF BIOLOGICAL CHEMISTRY 286/2 :1157-1164,2011
  • Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression
    PLOS ONE 6/7 :e22544-e22544,2011
  • Role of transcription factor modifications in the pathogenesis of insulin resistance
    EXPERIMENTAL DIABETES RESEARCH 2012/7164 :1-16,2012
  • Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liver
    DIABETOLOGIA 56/3 :635-643,2013
  • Modulation of the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor Gamma by Protein-Protein Interactions and Post-Translational Modifications
    YONSEI MEDICAL JOURNAL 54/3 :545-559,2013
  • Txnip contributes to impaired glucose tolerance by upregulating the expression of genes involved in hepatic gluconeogenesis in mice.
    DIABETOLOGIA 56/12 :2723-2732,2013
  • Identification of Creb3l4 as an essential negative regulator of adipogenesis
    CELL DEATH & DISEASE 5/e1527 :1-13,2014
  • Regulation of IGFBP-2 expression during fasting
    BIOCHEMICAL JOURNAL 467/3 :453-460,2015
  • Effects of low-fat diet and aging on metabolic profiles of Creb3l4 knockout mice
    NUTRITION & DIABETES 5/e179 :1-6,2015
  • Role of transcription factor acetylation in the regulation of metabolic homeostasis
    PROTEIN & CELL 6/11 :804-813,2015
  • Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity
    SCIENTIFIC REPORTS 5/17395 :1-13,2015
  • SMILE Is an Insulin-Inducible Transcriptional Corepressor of Hepatic Gluconeogenic Gene Programs
    DIABETES 65/1 :14-15,2016

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