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소속

  • 생화학-분자생물학교실

직위

  • 교수

연구실 위치

  • 에비슨의생명연구원(ABMRC) 423호

전화/팩스

  • 02) 2228-0837 /

학력사항

  • 1992.연세대학교 의학과 학사
    1995.연세대학교 의학과 석사
    1998.연세대학교 의학과 박사

교육 및 연구 경력

  • 1996 ~1998 연세대학교 의과대학 생화학-분자생물학교실 강사
    1998 ~ 2001 국군서울지구병원 연구실장
    2001 ~ 2003 연세대학교 의과대학 생화학-분자생물학교실 전임강사
    2003 ~ 2007 연세대학교 의과대학 생화학-분자생물학교실 조교수
    2004 ~2006 Johns Hopkins Univ. School of Medicine Post Doctoral
    2008 ~ 2010 연세대학교 의과대학 교무부장
    2008 ~ 2012 연세대학교 융합오믹스 의생명과학과 부교수 겸임
    2008 ~ 2012 연세대학교 의과대학 생화학-분자생물학 교실 부교수
    2010 ~ 2011 연세의료원 의과학연구처 연구지원부처장
    2013 ~ 현재 연세대학교 의과대학 생화학-분자생물학교실 교수
    2013 ~ 현재 연세대학교 융합오믹스 의생명과학과 교수 겸임


기타 학술 관련 경력

  • 2001 ~ 현재 한국세포분자생물학회 회원
    2001 ~ 현재 생화학·분자생물학회(대한, 통합) 회원
    2001 ~ 2004 대한유전학회 학술간사
    2007 ~ 2009 American Society of Cell Biology 회원
    2007 ~ 2010 대한내분비학회 학술간사
    2009 ~ 2010 생화학·분자생물학회(통합) 회원운영위원
    2010 ~ 현재 생화학·분자생물학회 BMB reports 편집위원
    2010 ~ 2011 생화학·분자생물학회(통합) 기획운영위원

    수상경력
    2009. 연세대학교 의과대학 우수교수상
    2010. 연세대학교 의과대학 올해의 교수상

연구,관심분야

  • Gene expression, transcriptional regulation, tissue-specific gene expression
    Cell differentiation, metabolic gene regulation, DNA-protein interaction

강의분야

  • 당질 대사, 유전사 전사 및 조절, Recombinant DNA technology, Gene cloning

논문

  • Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter
    DIABETES 49/0 :1517-1524,2000
  • Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells
    DIABETES 51/ :676-685,2002
  • C/EBP binding activity to site F of the rat GLUT2 glucose transporter gene promoter is attenuated by c-Jun in vitro
    EXPERIMENTAL AND MOLECULAR MEDICINE 34/5 :379-384,2002
  • Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity
    ANNALS OF CLINICAL AND LABORATORY SCIENCE 32/2 :114-122,2002
  • Staphylococcal enterotoxin B upregulates fas-mediated apoptosis of peripheral blood mononuclear cells in childhood atopic dermatitis.
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY 57/1 :62-67,2003
  • Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver
    JOURNAL OF BIOLOGICAL CHEMISTRY 278/ :28410-28417,2003
  • CCAAT/enhancer binding protein and nuclear factor-Y regulate adiponectin gene expression in adipose tissue
    DIABETES 53/ :2757-2766,2004
  • Adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element-binding protein 1c regulates mouse adiponectin expression
    JOURNAL OF BIOLOGICAL CHEMISTRY 279/ :22108-22117,2004
  • Glucose-stimulated upregulation of GLUT2 gene is mediated by sterol response element-binding protein-1c in the hepatocytes
    DIABETES 54/ :1684-1691,2005
  • Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter
    EXPERIMENTAL AND MOLECULAR MEDICINE 37/2 :101-110,2005
  • Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3 beta is required for adipogenesis
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102/28 :9766-9771,2005
  • Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: Role of the BMP-4 gene
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103/35 :13022-13027,2006
  • Regulation of German cockroach extract-induced IL-8 expression in human airway epithelial cells
    CLINICAL AND EXPERIMENTAL ALLERGY 37/ :1364-1373,2007
  • Upstream stimulatory factors regulate the C/EBPα gene during differentiation of 3T3-L1 preadipocytes
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 354/ :517-521,2007
  • Effect of phosphorylation and S-S bond-induced dimerization on DNA binding and transcriptional activation by C/EBPβ
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104/6 :1800-1804,2007
  • Role of cdk2 in the sequential phosphorylation/activation of C/EBPβ during adipocyte differentiation
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104/28 :11597-11602,2007
  • Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation
    Journal of Biological Chemistry 283/ :4200-4209,2008
  • Lipin1 Is a Key Factor for the Maturation and Maintenance of Adipocytes in the Regulatory Network with CCAAT/Enhancer-binding Protein alpha and Peroxisome Proliferator-activated Receptor gamma(2)
    Journal of Biological Chemistry 283/ :34896-34906,2008
  • The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma
    Journal Of Nuclear Medicine 50/8 :1222-1228,2009
  • Reactive Oxygen Species Facilitate Adipocyte Differentiation by Accelerating Mitotic Clonal Expansion
    Journal of Biological Chemistry 284/16 :10601-10609,2009
  • Temporal Profiling of the Adipocyte Proteome during Differentiation Using a Five-Plex SILAC Based Strategy
    JOURNAL OF PROTEOME RESEARCH 8/1 :48-58,2009
  • Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase 2 in prostate cancer cells
    BIOCHEMICAL JOURNAL 433/1 :225-233,2011
  • Peroxisome Proliferator-Activated Recepter Gamma/Signal Transducers and Activators of Transcription 5A Pathway Plays a Key Factor in Adipogenesis of Human Bone Marrow-Derived Stromal Cells and 3T3-L1 Preadipocytes
    STEM CELLS AND DEVELOPMENT 21/3 :465-475,2012
  • Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109/34 :13656-13661,2012
  • Regulation of Wnt/beta-Catenin Signaling by CCAT/Enhancer Binding Protein beta During Adipogenesis
    OBESITY 20/3 :482-487,2012
  • Kruppel-Like Factor KLF8 Plays a Critical Role in Adipocyte Differentiation
    PLOS ONE 7/12 :e52474-e52474,2012
  • High-dose resveratrol inhibits insulin signaling pathway in 3T3-L1 adipocytes
    Journal of Lifestyle Medicine 3/1 :41-47,2013
  • Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110/51 :20575-20580,2013
  • Transcription factor Snail is a novel regulator of adipocyte differentiation via inhibiting the expression of peroxisome proliferator?activated receptorγ
    Cellular and Molecular Life Sciences 70/20 :3959-3971,2013
  • New mechanisms contributing to hepatic steatosis: glucose, insulin, and lipid signaling
    ANIMAL CELLS AND SYSTEMS 18/2 :77-82,2014
  • G0/G1 switch gene 2 has a critical role in adipocyte differentiation
    CELL DEATH AND DIFFERENTIATION 21/7 :1071-1080,2014
  • Identification of Creb3l4 as an essential negative regulator of adipogenesis
    CELL DEATH & DISEASE 5/e1527 :1-13,2014
  • Regulation of retinoid X receptor gamma expression by fed state in mouse liver
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 458/1 :134-139,2015
  • Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor γ in human hepatocytes and increases lipid accumulation
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 460/3 :715-720,2015
  • O -GlcNAc modification is essential for the regulation of autophagy in Drosophila melanogaster
    CELLULAR AND MOLECULAR LIFE SCIENCES 72/16 :3173-3183,2015
  • O-GlcNAcylation of eIF2 alpha regulates the phospho-eIF2 alpha-mediated ER stress response
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1853/8 :1860-1869,2015
  • Protective effect of peroxisome proliferator-activated receptor α activation against cardiac ischemia-reperfusion injury is related to upregulation of uncoupling protein-3
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2016/Arti :1-11,2016
  • Caffeine inhibits adipogenesis through modulation of mitotic clonal expansion and the AKT/GSK3 pathway in 3T3-L1 adipocytes
    BMB REPORTS 49/2 :111-115,2016
  • Glucocorticoid-mediated anti-inflammatory effect through NFκB is preserved in the absence of Dexras1
    ANIMAL CELLS AND SYSTEMS 20/1 :1-6,2016
  • Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis
    SCIENTIFIC REPORTS 6/ :28648-,2016
  • Suppression of PPAR γ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis
    SCIENTIFIC REPORTS 6/ :29352-,2016
  • How to Begin Molecular Research of Metabolic Diseases
    대한내분비학회지 31/4 :505-509,2016

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