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소속

  • 생화학-분자생물학교실

보직

  • 연구부학장, 연구소 소장

직위

  • 교수

연구실 위치

  • 의과대학 신관 504호

전화/팩스

  • 02) 2228-1676 /

학력사항

  • 1984. 연세대학교 의학과 학사
    1986. 연세대학교 의학과 석사
    1989. 연세대학교 의학과 박사

교육 및 연구 경력

  • 1993~ 1999 연세대학교 의과대학 생화확-분자생물학 교실 조교수
    1995 ~ 1997 Purdue University 방문교수
    1999 ~ 2004 연세대학교 의과대학 생화확-분자생물학 교실 부교수
    2004 ~2012 연세대학교 의과대학 생화확-분자생물학 교실 주임교수
    2006 ~ 2011 만성대사성질환 연구센터 소장
    2011 ~ 현재. 대사조절유전체 통합연구센터 소장
    2012 ~ 현재. 연세대학교 의과대학 연구부 연구부학장

기타 학술 관련 경력

  • 2008 ~ 2011 대한의학협회지 운영위원
    2010 ~ 2011 생화학분자생물학회 학술위원장
    2011 ~ 2013 생화학분자생물학회 이사

    수상경력
    2001 최우수 연구업적상 (연세의대 연구업적 분야)

연구,관심분야

  • 지질대사 조절에 관여하는 효소 유전자들의 전사조절

강의분야

  • 유전자 전사조절,
    지질대사 조절

논문

  • Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter
    DIABETES 49/0 :1517-1524,2000
  • Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
    NATURE 23/408 :483-488,2000
  • Identification of a Clonorchis sinensis gene encoding a vitellaria antigenic protein containing repetitive sequences
    Mol Biochem Parasitol 111/0 :213-216,2000
  • Cloning of Human Acetyl-CoA Carboxylase β Promoter and Its Regulation by Muscle Regulatory Factors
    JOURNAL OF BIOLOGICAL CHEMISTRY 276/4 :2576-2585,2001
  • Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts
    ACTA DERMATO-VENEREOLOGICA 82/ :174-178,2002
  • Characterization of cis-acting elements in the rat ATP citrate-lyase gene promoter
    EXPERIMENTAL AND MOLECULAR MEDICINE 34/ :60-68,2002
  • Acetyl-CoA carboxylase β expression mediated by MyoD and muscle regulatory factor 4 is differentially affected by retinoic acid receptor and retinoid X receptor
    EXPERIMENTAL AND MOLECULAR MEDICINE 35/1 :23-29,2003
  • Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model
    WORLD JOURNAL OF GASTROENTEROLOGY 10/8 :1191-1197,2004
  • Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1
    JOURNAL OF BIOLOGICAL CHEMISTRY 279/ :28122-28131,2004
  • Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells
    CELLULAR SIGNALLING 16/11 :1309-1317,2004
  • SREBP-1c mediates the insulin-dependent hepatic glucokinase expression
    JOURNAL OF BIOLOGICAL CHEMISTRY 279/ :30823-30829,2004
  • CCAAT/enhancer binding protein and nuclear factor-Y regulate adiponectin gene expression in adipose tissue
    DIABETES 53/ :2757-2766,2004
  • Targeting of therapeutic gene expression to the liver by using liver-type pyruvate kinase proximal promoter and the SV40 viral enhancer active in multiple cell types
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 314/ :131-137,2004
  • Controlled transcriptional regulation in eukaryotes by a novel transcription factor derived from Escherichia coli purine repressor
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 319/ :334-341,2004
  • Nanoscale size effect of magnetic nanocrystals and their utilisation for cancer diagnosis via magnetic resonance imaging
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 127/16 :5732-5733,2005
  • Alternative usages of multiple promoters of the acetyl-CoA carboxylase β gene are related to differential transcriptional regulation in human and rodent tissues
    JOURNAL OF BIOLOGICAL CHEMISTRY 280/7 :5909-5916,2005
  • Glucose-stimulated upregulation of GLUT2 gene is mediated by sterol response element-binding protein-1c in the hepatocytes
    DIABETES 54/ :1684-1691,2005
  • Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas
    LABORATORY INVESTIGATION 85/ :1130-1138,2005
  • In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 127/ :12387-12391,2005
  • Safety and efficacy of adeno-associated viral vector-mediated insulin gene transfer via portal vein to the livers of streptozotocin-induced diabetic Sprague-Dawley rats
    JOURNAL OF GENE MEDICINE 7/ :621-629,2005
  • Regulation of GLUT4 gene expression by SREBP-1c in adipocytes
    BIOCHEMICAL JOURNAL 399/ :131-139,2006
  • Development of ligand-dependent regulatory system and its application to gene therapy of insulin-dependent diabetes mellitus
    EXPERIMENTAL AND MOLECULAR MEDICINE 38/4 :385-392,2006
  • Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
    NATURE NEUROSCIENCE 9/7 :901-906,2006
  • Up-regulation of acetyl-CoA carboxylase α and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
    JOURNAL OF BIOLOGICAL CHEMISTRY 282/36 :26122-26131,2007
  • Transcriptional activation of SHP by PPAR-γ in liver
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 360/2 :301-306,2007
  • Glucocorticoid receptor mediated repression of human insulin gene expression is regulated by PGC-1α
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 352/ :716-721,2007
  • Androgen-dependent activation of human cytomegalovirus major immediate-early promoter in prostate cancer cells
    Prostate 68/ :1450-1460,2008
  • LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients
    Molecular Genetics And Metabolism 95/1-2 :96-100,2008
  • Adenoviral vector-mediated glucagon-like peptide 1 gene therapy improves glucose homeostasis in Zucker diabetic fatty rats
    Journal Of Gene Medicine 10/ :260-268,2008
  • Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically active transcription of fatty-acid synthase gene (FASN)
    Journal of Biological Chemistry 283/43 :29341-29354,2008
  • Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2
    Journal of Lipid Research 49/ :399-409,2008
  • Resveratrol Downregulates Acetyl-CoA Carboxylase α and Fatty Acid Synthase by AMPK-mediated Downregulation of mTOR in Breast Cancer Cells
    Food Science and Biotechnology 17/5 :1047-1051,2008
  • Lipin1 Is a Key Factor for the Maturation and Maintenance of Adipocytes in the Regulatory Network with CCAAT/Enhancer-binding Protein alpha and Peroxisome Proliferator-activated Receptor gamma(2)
    Journal of Biological Chemistry 283/ :34896-34906,2008
  • The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha
    Biochemical Journal 411/1 :19-26,2008
  • KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells
    Biochemical Journal 417/ :313-322,2009
  • Interrelationship between Liver X Receptor alpha, Sterol Regulatory Element-binding Protein-1c, Peroxisome Proliferator-activated Receptor gamma, and Small Heterodimer Partner in the Transcriptional Regulation of Glucokinase Gene Expression in Liver
    Journal of Biological Chemistry 284/ :15071-15083,2009
  • Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats
    Metabolism-Clinical and Experimental 58/8 :1170-1177,2009
  • The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma
    Journal Of Nuclear Medicine 50/8 :1222-1228,2009
  • Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 403/3-4 :329-334,2010
  • Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase 2 in prostate cancer cells
    BIOCHEMICAL JOURNAL 433/1 :225-233,2011
  • Kruppel-like Factor 4 (KLF4) Activates the Transcription of the Gene for the Platelet Isoform of Phosphofructokinase (PFKP) in Breast Cancer
    JOURNAL OF BIOLOGICAL CHEMISTRY 286/27 :23808-23816,2011
  • Peroxisome Proliferator-activated Receptor alpha Is Responsible for the Up-regulation of Hepatic Glucose-6-phosphatase Gene Expression in Fasting and db/db Mice
    JOURNAL OF BIOLOGICAL CHEMISTRY 286/2 :1157-1164,2011
  • KR-POK Interacts with p53 and Represses Its Ability to Activate Transcription of p21WAF1/CDKN1A
    CANCER RESEARCH 72/5 :1137-1148,2012
  • Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109/34 :13656-13661,2012
  • Snail, a transcriptional regulator, represses adiponectin expression by directly binding to an E-box motif in the promoter
    METABOLISM-CLINICAL AND EXPERIMENTAL 61/ :1622-1632,2012
  • Regulation of the Cyclin-dependent Kinase Inhibitor 1A Gene (CDKN1A) by the Repressor BOZF1 through Inhibition of p53 Acetylation and Transcription Factor Sp1 Binding
    JOURNAL OF BIOLOGICAL CHEMISTRY 288/10 :7053-7064,2013
  • Lipin1 regulates PPARgamma transcriptional activity
    BIOCHEMICAL JOURNAL 453/1 :49-60,2013
  • The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation
    NUCLEIC ACIDS RESEARCH 41/13 :6403-6420,2013
  • G0/G1 switch gene 2 has a critical role in adipocyte differentiation
    CELL DEATH AND DIFFERENTIATION 21/7 :1071-1080,2014
  • Human Kruppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene
    JOURNAL OF BIOLOGICAL CHEMISTRY 289/7 :4018-4031,2014
  • Phosphoglucomutase1 is necessary for sustained cell growth under repetitive glucose depletion
    FEBS LETTERS 588/17 :3074-3080,2014
  • A comparative study of the effects of inhibitory cytokines on human natural killer cells and the mechanistic features of transforming growth factor-beta
    CELLULAR IMMUNOLOGY 290/1 :52-61,2014
  • DNAJB1 destabilizes PDCD5 to suppress p53-mediated apoptosis
    CANCER LETTERS 357/1 :307-315,2015
  • ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65
    NUCLEIC ACIDS RESEARCH 43/3 :1609-1625,2015
  • The regulation of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase by autophagy in low-glycolytic hepatocellular carcinoma cells
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 463/2015 :440-446,2015
  • Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 474/ :547-553,2016
  • Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer
    MOLECULAR AND CELLULAR ENDOCRINOLOGY 431/ :36-45,2016
  • Zbtb7c is a molecular ‘off’ and ‘on’ switch of Mmp gene transcription
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1859/11 :1,429-1,439,2016
  • Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin
    NEURO-ONCOLOGY 19/2 :197-207,2017

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