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소속

  • 생화학-분자생물학교실

보직

  • 주임교수

직위

  • 교수

연구실 위치

  • 의과대학 신관 501호

전화/팩스

  • 02) 2228-1680 /

학력사항

  • 1987.연세대학교 의학과 학사
    1989.연세대학교 의학과 석사
    1992.연세대학교 의학과 박사

교육 및 연구 경력

  • 1996 ~ 2002 연세대학교 의과대학 생화학-분자생물학 교실 조교수
    1998 ~ 2001 University of Pennsylvania School of Medicine Postdoctoral Researcher
    2002 ~ 2008 연세대학교 의과대학 생화학-분자생물학 교실 부교수
    2008 ~ 현재 연세대학교 의과대학 생화학-분자생물학 교실 교수 (주임교수 2012~)
    2009 ~ 2011 한국보건산업진흥원 중개연구단 단장

기타 학술 관련 경력

  • 1987 ~ 현재 대한생화학 분자생물학회 정회원
    1990 ~ 현재 암학회 일반회원
    1999 ~ 현재 American Association of Cancer Research. Active Member
    2001 ~ 현재 American Society for Cell Biology 일반회원

    수상경력
    2005. 의당학술상 (의당학술상 시상규정에 의거하여 우수한 연구업적자에 수여)
    2006. 연세학술상 (연구업적 우수자에게 수여하는 학술상)
    2009. 연세대학교 의과대학 올해의 교수상
    2012. 대통령표창 (보건산업 진흥 및 국민보건 향상에 공로한 자)

연구,관심분야

  • 암 (Cancer)
    전이 (Metastasis)
    세포사멸 (Apoptosis)
    신호전달 (Signal transduction)

강의분야

  • 단백질 합성
    신호전달
    암의 분자생물학

논문

  • The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand
    CANCER RESEARCH 60/22 :6259-6265,2000
  • Molecular determinants of response to TRAIL in killing of normal and cancer cells
    CLINICAL CANCER RESEARCH 6/2 :335-346,2000
  • Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance.
    INTERNATIONAL JOURNAL OF ONCOLOGY 16/5 :917-925,2000
  • KILLER/DR5, a novel DNA-damage inducible death receptor gene, links the p53-tumor suppressor to caspase activation and apoptotic death
    ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 465/0 :143-151,2000
  • Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines.
    INTERNATIONAL JOURNAL OF ONCOLOGY 18/2 :241-247,2001
  • Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin
    EXPERIMENTAL AND MOLECULAR MEDICINE 34/2 :114-122,2002
  • 사람 유두종 바이러스 E6 단백질에 의한 death receptor 4의 발현및 세포사멸의 선택적 유도
    대부종콜포회지 13/2 :140-145,2002
  • 자궁경부 상피내종양 환자에서 외과적 절제술이인유두종 바이러스 감염 추이에 미치는 영향
    대한산부회지 47/3 :451-457,2004
  • Characteristics of the killing mechanism of human natural killer cells against hepatocellular carcinoma cell lines HepG2 and Hep3B
    CANCER IMMUNOLOGY IMMUNOTHERAPY 53/ :461-470,2004
  • Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells
    JOURNAL OF BIOLOGICAL CHEMISTRY 279/ :40044-40052,2004
  • Targeting Bcl-XL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9
    CELL DEATH AND DIFFERENTIATION 11/5 :583-587,2004
  • Cisplatin-induced apoptosis in Hep3B cells: Mitochondria-dependent and -independent pathways
    BIOCHEMICAL PHARMACOLOGY 67/ :1459-1468,2004
  • Caspase-2 primers cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
    EUROPEAN MOLECULAR BIOLOGY ORGANIZATION JOURNAL 24/ :3532-3542,2005
  • Silencing Bcl-X
    CANCER BIOLOGY & THERAPY 4/4 :398-399,2005
  • The combination of TRAIL treatment and cancer cell selective expression of TRAIL-death receptor DR4 induces cell death in TRAIL-resistant cancer cells
    YONSEI MEDICAL JOURNAL 47/1 :55-62,2006
  • Nuclear localization signals of the E-cadherin transcriptional repressor snail
    CELLS TISSUES ORGANS 185/ :66-72,2007
  • Separation of apoptotic cells using a microfluidic device
    BIOTECHNOLOGY LETTERS 29/ :1659-1663,2007
  • The functional role of the CARM1-SNF5 complex and its associated HMT activity in transcriptional activation by thyroid hormone receptor
    EXPERIMENTAL AND MOLECULAR MEDICINE 39/4 :544-555,2007
  • MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells
    American Journal Of Physiology-Renal Physiology 295/ :F749-F757,2008
  • Cilostazol protects rat chondrocytes against nitric oxide-induced apoptosis in vitro and prevents cartilage destruction in a rat model of osteoarthritis
    Arthritis & Rheumatism-Arthritis Care & Research 58/3 :790-800,2008
  • The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha
    Biochemical Journal 411/1 :19-26,2008
  • Inhibition of casein kinase 2 enhances the death ligand- and natural killer cell-induced hepatocellular carcinoma cell death
    Clinical And Experimental Immunology 152/ :336-344,2008
  • Distinguishing between apoptosis and necrosis using a capacitance sensor
    Biosensors & Bioelectronics 24/8 :2586-2591,2009
  • Impact of Grade, Hormone Receptor, and HER-2 Status in Women with Breast Cancer on Response to Specific Chemotherapeutic Agents by in vitro Adenosine Triphosphate-based Chemotherapy Response Assay
    Journal Of Korean Medical Science 24/6 :1150-1157,2009
  • Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex
    BIOMATERIALS 31/16 :4592-4599,2010
  • p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling
    SCIENCE SIGNALING 4/197 :ra71-,2011
  • Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner
    MOLECULAR BIOLOGY OF THE CELL 23/15 :2943-2954,2012
  • Protein Kinase Casein Kinase 2-Mediated Upregulation of N-Cadherin Confers Anoikis Resistance on Esophageal Carcinoma Cells
    MOLECULAR CANCER RESEARCH 10/8 :1032-1038,2012
  • Promyelocytic Leukemia Zinc Finger-Retinoic Acid Receptor alpha (PLZF-RAR alpha), an Oncogenic Transcriptional Repressor of Cyclin-dependent Kinase Inhibitor 1A (p21WAF/CDKN1A) and Tumor Protein p53 (TP53) Genes
    JOURNAL OF BIOLOGICAL CHEMISTRY 289/27 :18641-18656,2014
  • Role of Promyelocytic Leukemia Zinc Finger (PLZF) in Cell Proliferation and Cyclin-dependent Kinase Inhibitor 1A (p21WAF/CDKN1A) Gene Repression
    JOURNAL OF BIOLOGICAL CHEMISTRY 289/27 :18625-18640,2014
  • Ethyl 2-(benzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate analogues as a new scaffold for protein kinase casein kinase 2 inhibitor
    BIOORGANIC & MEDICINAL CHEMISTRY 22/17 :4553-4565,2014
  • ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65
    NUCLEIC ACIDS RESEARCH 43/3 :1609-1625,2015
  • Estrogen Upregulates Slug to Enhance the Migration of Keratinocytes
    JOURNAL OF INVESTIGATIVE DERMATOLOGY 135/2 :3200-3203,2015
  • Antiobesity and Antidiabetes Effects of a Cudrania tricuspidata Hydrophilic Extract Presenting PTP1B Inhibitory Potential.
    BIOMED RESEARCH INTERNATIONAL 2016/Arti :1-11,2016
  • Zbtb7c is a molecular ‘off’ and ‘on’ switch of Mmp gene transcription
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1859/11 :1,429-1,439,2016
  • The long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer.
    ONCOTARGET 7/50 :83,001-83,016,2016

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