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소속

  • 해부학교실

직위

  • 교수

연구실 위치

  • 의과대학 신관 146호

전화/팩스

  • 02) 2228-1646 /

학력사항

  • 연세대학교 생화학과 학사(1983)
    연세대학교 대학원 석사(생화학전공) (1985)
    연세대학교 대학원 박사(생화학전공) (1993)

교육 및 연구 경력

  • 1985.-1989. 연세대학교 의과대학 해부학교실 조교
    1989.-1994. 연세대학교 의과대학 해부학교실 연구강사
    1996.-1998. Stanford 대학(U.S.A.) Post Doc
    2002.1-2002.2 Stanford대학(USA) visiting Associate Professor
    1994.-현재 연세대학교 의과대학 해부학교실 전임강사, 조교수, 부교수, 교수

기타 학술 관련 경력

  • 미국 신경과학회 (Annual meeting for Neuroscience) 정회원
    국제통증학회 (International association for the study of pain) 정회원
    아시아-태평양지역 해부학회 (Asian Pacific International Congress of Anatomists) 정회원
    대한해부학회(Korean Association of Anatomy)정회원, 학술이사, 총무이사
    한국뇌신경과학회 정회원
    한국 분자세포생물학회 정회원
    한국 생화학분자생물학회 정회원

연구,관심분야

  • 뇌허혈(Cerebral Ischemia)
    저산소환경(Hypoxia)
    신경세포사멸(Neuronal cell death)
    별아교세포의 신경세포 보호작용(Neuroprotection of Astrocyte)
    열충격단백질(Heat shock protein)
    세포주기조절단백질(Cell Cycle Regulatory Proteins)
    내재성 신경보호물질(

강의분야

  • 조직학
    신경해부학
    신경생물학

논문

  • Overexpression of bcl-2, bcl-x or hsp70 in murine cortical astrocytes reduces injury of co-cultured neurons.
  • Neurosci Lett 277: 193-197, 1999
  • Transgenic mice which overexpress HSP70 are protected against some but not all central nervous system insults,
  • J Cereb Blood Flow Metab 19: S272, 1999
  • The effects of capsaicin on the ultrastructure of the hypothalamic neurosecretory cell in the adult rat.
  • Exp Neurobiol 8: 93-98, 1999
  • Differential effects of intraganglionic capsaicin and vehicle on substance P- and CGRP-immunoreactive neurons in the rat dorsal root ganglia.
  • Exp Neurobiol 8: 99-105, 1999
  • 흰쥐의 실험적 관절염 모델에서 Capsaicin이 척수의 c-fos 단백질 및 척수신경절의 substance P, CGRP에 미치는 영향.
  • 대한해부학회지 32: 761-772, 1999
  • 성숙 흰쥐에 capsaicin 투여가 시상하부의 항이뇨호르몬 분비세포와 자궁수축호르몬 분비세포에 미치는 영향.
  • 대한해부학회지 32: 779-788, 1999
  • The E6 and E7 genes of human papilloma virus-type 16 protect primary astrocyte cultures from injury.
  • Brain Res 795: 10-16, 1998
  • Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia.
  • Stroke 29:2171-2180, 1998
  • Capsaicin이 성숙흰쥐 Lissauer 신경로에 미치는 영향.
  • 대한해부학회지 31: 971-980, 1998
  • Expression and localization of brain glutamate dehydrogenase with its monoclonal antibody.
  • Korean J Biol Sci 2: 71-80, 1998
  • Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions.
  • Cencer Res 57: 4200-4204, 1997
  • Regulation of two soluble forms of brain glutamate dehydrogenase isoproteins by leucine.
  • J Biochem Mol Biol 30: 332-336, 1997
  • Distribution of succinic semialdehyde reductase in rat brain
  • Mol Cells 7: 13-20, 1997
  • 흰쥐 뇌에서 초기발현유전자 c-fos와 c-jun 유전자 발현에 미치는 capsaicin의 영향
  • 대한해부학회지 30: 351-359, 1997
  • 발생중인 흰쥐뇌에서 r-aminobutyric acid (GABA) 생성에 관여하는 효소의 발현.
  • 대한해부학회지 29: 369-386, 1996
  • Capsaicin 투여후 흰쥐 소장 장신경세포의 변화.
  • 대한해부학회지 29: 337-348, 1996
  • 흰쥐 소장 근육층신경얼기의 신경전달물질에 미치는 capsaicin의 영향.
  • 대한해부학회지 29: 315-325, 1996
  • Capsaicin이 동통억제효과를 나타내는 기전에 관한 연구.
  • 대한해부학회지 28: 507-520, 1995
  • 신생 흰쥐에 투여한 capsaicin이 장신경계의 calcitonin gene-related peptide(CGRP) 함유 신경에 미치는 영향.
  • 대한해부학회지 28: 333-343, 1995
  • Effect of capsaicin to the serotonergic neurons in the raphe nuclei of the rat midbrain.
  • Exp Neurobiol 4: 127-134, 1995
  • 신경교차연결후 흰쥐 골격근섬유의 마이오신 동질형의 변화.
  • 대한해부학회지 27: 321-332,, 1994
  • 흰쥐에서 척수신경 등쪽뿌리 절단후 척수등쪽뿔의 substance P 및calcitonin gene-related peptide 함유 신경섬유에 대한 면역조직화학적 연구.
  • 대한해부학회지 27: 306-320, 1994
  • 폴리아민이 흰쥐 복재신경 재생에 미치는 영향: I. 수초신경섬유의직경과수초두께의변화.
  • 대한해부학회지 27: 266-280, 1994
  • 면역조직화학적 방법을 이용한 흰쥐 골격근 근섬유형의 비교연구.
  • 대한해부학회지 27: 255-265, 1994
  • The morphometric study of the interstitial cells of Cajal in the rat intestine.
  • Exp Neurobiol 3: 75-85, 1994
  • Studies on the Active Site of the - Aminobutyraldehyde Dehydrogenase.
  • Korean Biochem J 26: 1-7, 1993
  • Distribution of calcitonine gene-related peptide(CGRP) immunoreactive first sacral primary afferent terminals in the dorsal horn of the rat.
  • Exp Neurobiol 2: 33-41, 1993
  • The Changes of the skeletal muscle fiber type after cross innervation of the rat by immunohistochemical study.
  • Exp Neurobiol 2: 25-32, 1993
  • Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandin E2 production and neurodegoneration in cortical and hippocampal cell cultures. Brain Research 908:1-9, 2001
  • Capsaicin에 의해 유도되는 마우스 해마신경세포의 아폽토시스에 미치는 agmatine의 영향. 대한해부학회지 33(6):723-742, 2000
  • Mild hypothermia reduces matrix metalloproteinases (MMPs) and increases tissue inhibitor of metalloprotainease-2 (TIMP-2) expression in experimental stroke. Accepted to J Neurosurg.
  • Reperfusion cellular injury in a animal model of transient ischemia. Am J neuroradiol 25:1342-2347, 2004
  • Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains. Molecular Brain Research 127:146-149, 2004
  • Stress proteins and ischemic tolerance. In: Cerebral ischemic tolerence(Editor: B.Schaller) Nova Science Publishers, Inc., 103-121, 2004
  • HSP70 supresses matirx metalloproteinases in experimental cerebral ischemia. Stroke 35(1):280, 2004
  • Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury. Experimental Neurology 189(1):122-130, 2004
  • Overexpression of the 70 kD heat shock protein suppresses matrix metalloproteinases in cultured astrocytes following ischemia-like insults. Neuroreport 15(3):499-502, 2004
  • 맥락얼기 뇌실막세포 이식이 척수손상 흰쥐의 신경재생에 미치는 영향. 대한해부학회지 37(5): 2004
  • Inactivation of human glutamate dehydrogenase by aluminum. Cellular & Molecular Life Sciences 60(11):2538-2546, 2003
  • UV-vulnerability of HPV-16 E7-expressing astrocytes is associated with mitochondrial membrane depolarization and caspase-3 activation. Mol Cells 14(2):288-294, 2002
  • An essential histidine residue in GTP binding domian of bovine brain glutamate dehydrogenase isoproteins. Mol Cells 12(1):121-126, 2001
  • In vitro and in vivo cerebral injury in transgenic mice which overexpress HSP70. Journal of Neurosurgery 90:217A, 1999
  • Transgenic mice which overexpress HSP70 are protected against some but not all central nervous system insults. Stroke 30:233, 1999
  • Effects of permanent focal cerebral ischemia in transgenic mice which overexpress HSP70. J of Neurosurgical Anesthesiology 10:258, 1998
  • Modification of brain glutamate dehydrogenase isoproteins with pyridoxal 5'-phosphage. Biochimie. 78:817-821, 1996
  • Expression of the r-Aminobutyraldehyde dehydrogenase in the bovine brain by immunohistochemistry and in situ hybridization methods. Molecules and Cells 5(2):161-166, 1995
  • Immunocytochemical and ultrastructural study of localization of the r-Aminobutyraldehyde Dehydrogenase in the bovine brain. Molecules and cells 5(2):167-170, 1995
  • Purification and characterization of bovine brain-r-aminobutyraldehyde dehydrogenase. Biochem Biophys Res Commun 189:450-454, 1992
  • 사상체질과 신체형태지수와의 연관성
    대한체질인류학회지(Korean Journal Of Physical Anthropology) 13/4 :389-396,2000
  • Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG.
    GENE 257/1 :45-55,2000
  • 신경성장인자 투여가 당뇨병성 신경병증시 슈반세포에 미치는 영향에 관한 형태학적 연구.
    대한해부학회지(Korean Journal Of Anatomy) 33/5 :723-731,2000
  • Capsaicin에 의해 유도되는 마우스 해마신경세포의 아폽토시스에 미치는 agmatin의 영향.
    대한해부학회지(Korean Journal Of Anatomy) 33/5 :733-742,2000
  • 납이 뇌줄기 청색반점핵의 norepinephrine 함유 신경세포에 미치는 영향.
    대한해부학회지(Korean Journal Of Anatomy) 33/4 :423-432,2000
  • Type I atelocollagen grafting onto ozone induced polyurethane films: cell attachment, proliferation and collagen synthesis
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH 52/4 :669-677,2000
  • 실험적으로 유발한 관절염 모델에서 COX 억제제, NMDA 수용체 길항체와 capsaicin이 척수후각의 c-fos 단백질과 척수신경절의 substance P, CGRP에 미치는 영향.
    대한해부학회지(Korean Journal Of Anatomy) 34/6 :653-666,2001
  • Human Papilloma Virus Type 16 E7 Genes Protect Astrocytes against Apoptotic and Necrotic Death Induced by Hydrogen Peroxide.
    YONSEI MEDICAL JOURNAL 42/5 :471-479,2001
  • 노화된 휜쥐 소장 장신경계의 형태계측학적 변화 및 미세구조 변화에 관한 연구.
    대한해부학회지(Korean Journal Of Anatomy) 34/2 :181-191,2001
  • Differential neuroprotection from human heat shock protein 70 overexpression in in vitro.
    EXPERIMENTAL NEUROLOGY 170/1 :129-139,2001
  • Studies on the changes of c-fos protein in spinal cord and neurotransmitter in dorsal root ganglion of the rat with an experimental peripheral neuropathy.
    YONSEI MEDICAL JOURNAL 42/1 :30-40,2001
  • 인체 각막표층의 MUC1의 생성 및 분포
    대한안과학회지(J Korean Ophthalmol Soc) 42/1 :145-151,2001
  • 인터넷을 이용한 신경해부학 교육과정 개발.
    대한해부학회지(Korean Journal Of Anatomy) 34/5 :525-534,2001
  • Mild hypothermia inhibits matrix metalloproteinase generation and blood-barin barrier disruption in experimental stroke
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 130/ :-,2001
  • 흰쥐에서 Capsaicin이 전립샘의 감각신경에 미치는 영향
    대한해부학회지(Korean Journal Of Anatomy) 34/5 :535-544,2001
  • An Essential Histidine Residue in GTP Binding Domain of Bovine Brain Glutamate.
    MOLECULES AND CELLS 12/1 :121-126,2001
  • Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandin E2 production and neurodegerneration in cortical and hippocampal cell cultures.
    BRAIN RESEARCH 908/1 :1-9,2001
  • Preparation of collagen modified hyaluronan microparticles for antibiotics carrier
    YONSEI MEDICAL JOURNAL 42/3 :291-298,2001
  • Characterization of UV-irradiated dense/porous collagen membranes : morphology, enzymatic degradation, and mechanical properties
    YONSEI MEDICAL JOURNAL 42/2 :172-179,2001
  • Warm ischemic time에 따른 냉동보존 돼지판막의 세포생존률
    대한흉부외과학회지(Korean Journal Of Thoracic And Cardiovascular Surgery) 34/4 :305-310,2001
  • Behaviors of osteoblasts on a type I atelocollagen grafted ozone oxidized poly L-lactic acid membrane
    INTERNATIONAL JOURNAL OF LEGAL MEDICINE 22/3 :219-230,2001
  • TAT-mediated delivery of human glutamate dehydrogenase into PC12 cells.
    NEUROCHEMISTRY INTERNATIONAL 41/1 :37-42,2002
  • Caspase inhibitors reduce the apoptotic but not necrotic component of kainate injury in primary murine cortical neuronal cultures.
    NEUROLOGICAL RESEARCH 24/8 :796-800,2002
  • Effects of postnatally administered inorganic lead on the tyrosine hydroxylase immunoreactive norepinephrinergic neurons of the locus ceruleus of the rat.
    FOLIA MORPHOLOGICA 65/1 :45-53,2002
  • 일차배양된 신경세포에서 Capsaicin의 선택적 작용.
    대한해부학회지(Korean Journal Of Anatomy) 35/2 :161-171,2002
  • Laminin modified infection-preventing collagen membrane containing silver sulfardiazine-hyaluronan microparticles
    ARTIFICIAL ORGANS 26/6 :521-528,2002
  • An infection-preventing bilayered collagen membrane containing antibiotic-loaded hyaluronan microparticles : physical and biological properties
    ARTIFICIAL ORGANS 26/7 :636-646,2002
  • Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90
    MOLECULAR AND CELLULAR ENDOCRINOLOGY 188/ :47-54,2002
  • Effects of CETP gene polymorphisms on atherogenic lipoprotein phenotypes in Koreans
    NUTRITIONAL SCIENCES 6/2 :100-105,2003
  • 벤젠대사에 있어서 GST subfamily와 NQO1 유전자다형성의 영향
    대한해부학회지(Korean Journal Of Anatomy) 36/3 :264-273,2003
  • 뇌허혈 손상모델에서 HPLC를 이용한 Agmatine의 정량
    대한해부학회지(Korean Journal Of Anatomy) 36/3 :257-264,2003
  • 척수절단 후 후각망울조직의 이식이 하행신경섬유 재생에 미치는 영향
    대한해부학회지(Korean Journal Of Anatomy) 36/4 :247-255,2003
  • Stroke: Molecular Mechanisms and Potential Targets for Treatment
    CURRENT MOLECULAR MEDICINE 3/4 :361-372,2003
  • 맥락얼기 뇌실막세포이식이 척수 손상 흰쥐의 신경재생에 미치는 영향
    대한해부학회지(Korean Journal Of Anatomy) 37/6 :529-538,2004
  • Reperfusion cellular injury in an animal model of transient ischemia
    AMERICAN JOURNAL OF NEURORADIOLOGY 25/ :1342-1347,2004
  • The 70 kDa heat shock protein suppresses matrix metalloproteinases in astrocytes
    NEUROREPORT 15/3 :499-502,2004
  • Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury
    EXPERIMENTAL NEUROLOGY 189/1 :122-130,2004
  • Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains
    MOLECULAR BRAIN RESEARCH 127/1-2 :146-149,2004
  • 인체 U373 악성 교종 세포주의 세포 분열에 있어 Sept2의 역할
    대한소아신경외과학회지 2/1 :26-36,2005
  • 열처치에 의한 기질분해효소의 조절
    대한해부학회지(Korean Journal Of Anatomy) 38/5 :385-394,2005
  • Activation of monoamine oxidase isotypes by prolonged intake of aluminum in rat brain
    JOURNAL OF INORGANIC BIOCHEMISTRY 99/ :2088-2091,2005
  • Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1053/ :74-83,2005
  • Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke
    JOURNAL OF NEUROSURGERY 103/2 :289-297,2005
  • Mild hypothermia inhibits Fas expression and caspase-8 activation following experimental stroke
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 25/ :S486-,2005
  • HSP70 protects against experimental stroke through the inhibition of postischemic inflammatory reaction
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 25/ :S96-,2005
  • 당뇨성 신경병증에 미치는 α-lipoic acid의 보호효과
    대한해부학회지(Korean Journal Of Anatomy) 38/5 :-,2005
  • Induced expression of insulin-like growth factor-1 by amniotic membrane-conditioned medium in cultured human corneal epithelial cells
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 47/ :864-872,2006
  • The dopamine D
    JOURNAL OF NEUROSCIENCE 26/17 :4567-4576,2006
  • Stem Cell Impregnated Carbon Nanofibers/Nanotubes for Healing Damaged Neural Tissue
    MATERIALS RESEARCH SOCIETY SYMPOSIUM PROCEEDING 9/5 :17-22,2006
  • Recombinant human prothrombin kringle-2 inhibits B16F10 melanoma metastasis through inhibition of neovascularization and reduction of matrix metalloproteinase expression
    CLINICAL & EXPERIMENTAL METASTASIS 23/ :391-399,2006
  • Effects of Capsaicin on the c-fos in the spinal dorsal horn and substance P- and CGRP-like immunoreactivities in the dorsalroot ganglia of the experimental arthritic rat model
    Experimental Neurobiology 15/2 :71-79,2006
  • Protective effect of agmatine on a reperfusion model after transient cerebral ischemia: Temporal evolution on perfusion MR imaging and histopathologic findings
    AMERICAN JOURNAL OF NEURORADIOLOGY 27/ :780-785,2006
  • Chronic tibiofibular syndesmosis injury of ankle: Evaluation with contrast-enhanced fat-suppressed 3D fast spoiled gradient-recalled acquisition in the steady state MR imaging
    RADIOLOGY 242/1 :225-235,2007
  • Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability
    NATURE CELL BIOLOGY 9/3 :287-298,2007
  • Pyruvate Reduces the Necrotic but not Apoptotic Component of OGD/Reoxygenation Injury in Primary Murine CorticalNeuronal cult cultNeuronal cultures
    Experimental Neurobiology 16/1 :1226-2560,2007
  • Agmatine inhibits matrix metalloproteinase-9 via endothelial nitric oxide synthase in cerebral endothelial cells
    NEUROLOGICAL RESEARCH 29/ :749-754,2007
  • 방사선 조사 및 저산소환경 노출시 간암세포주 HepG2의 p53관여 작용기작과 세포사멸에 미치는 사람 유두종 바이러스 type 16 E6와 E7 단백질의 영향
    대한해부학회지(Korean Journal Of Anatomy) 40/2 :95-106,2007
  • MSX1 polymorphism associated with risk of oral cleft in Korea: Evidence from case-parent trio and case-control studies
    YONSEI MEDICAL JOURNAL 48/1 :101-108,2007
  • Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line
    BMC NEUROSCIENCE 8/1 :-,2007
  • The role of nerve growth factor in hyperosmolar stress induced apoptosis
    Journal Of Cellular Physiology 216/ :69-77,2008
  • 뇌허혈 손상시 아그마틴이 기질분해효소의발현에 미치는 영향
    대한해부학회지(Korean Journal Of Anatomy) 41/1 :97-104,2008
  • FasL shedding is reduced by hypothermia in experimental stroke
    Journal Of Neurochemistry 106/ :541-550,2008
  • Striatal-enriched protein tyrosine phosphatase regulates dopaminergic neuronal development via extracellular signal-regulated kinase signaling
    Experimental Neurology 214/ :69-77,2008
  • Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke
    Journal Of Cerebral Blood Flow And Metabolism 28/ :53-63,2008
  • Role of microglial IKK in kainic acid-induced hippocampal neuronal cell death
    Brain 131/ :3019-3033,2008
  • Neural induction with Neurogenin1 increases the therapeutic effects of mesenchymal stem cells in the ischemic brain
    Stem Cells 26/ :2217-2228,2008
  • Agmatine protects cultured retinal ganglion cells from tumor necrosis factor-alpha-induced apoptosis
    Life Sciences 84/1-2 :28-32,2009
  • Decreased macrophage density on carbon nanotube patterns on polycarbonate urethane
    Journal of Biomedical Materials Research Part A 88A/ :419-426,2009
  • Neuroprotective effects of agmatine on oxygen-glucose deprived primary-cultured astrocytes and nuclear translocation of nuclear factor-kappa B
    Brain Research 1281/0 :64-70,2009
  • Ex Vivo VEGF delivery by neural stem cells enhances proliferation of glial progenitors, angiogenesis, and tissue sparing after spinal cord injury
    PLoS One 4/3 :e987-e987,2009
  • Agmatine Attenuates Nitric Oxide Synthesis and Protects ER-structure from Global Cerebral Ischemia in Rats
    Korean Journal Of Anatomy(대한해부학회지) 42/3 :149-160,2009
  • 뇌혈관 질환에서 혈관장벽 유지 및 신경보호작용
    vascular neurology 1/ :16-23,2009
  • Effects of PDMS curing ratio and 3D micro-pyramid structure on the formation of an in vitro neuronal network
    Current Applied Physics 9/ :e294-e297,2009
  • Nerve growth factor and expression of its receptors in patients with diabetic neuropathy
    Diabetic Medicine 26/12 :1228-1234,2009
  • Stereological Analysis on Migration of Human Neural Stem Cells in the Brain of Rats Bearing Glioma
    NEUROSURGERY 66/2 :333-342,2010
  • Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia
    Journal Of Cerebral Blood Flow And Metabolism 30/5 :943-949,2010
  • Adsorption of mesenchymal stem cells and cortical neural stem cells on carbon nanotube/polycarbonate urethane
    Nanomedicine 5/3 :409-417,2010
  • Protective mechanism of agmatine pretreatment on RGC-5 cells injured by oxidative stress
    Brazilian Journal of Medical and Biological Research 43/4 :356-358,2010
  • Characterization, in vitro cytotoxicity assessment, and in vivo visualization of multimodal, RITC-labeled, silica-coated magnetic nanoparticles for labeling human cord blood-derived mesenchymal stem cells
    Nanomedicine-Nanotechnology Biology And Medicine 6/2 :263-276,2010
  • Recovered changes in the spleen by agmatine treatment after transient cerebral ischemia
    Anatomay and Cell biology 43/1 :44-53,2010
  • INDUCTION OF STRIATAL NEUROGENESIS ENHANCES FUNCTIONAL RECOVERY IN AN ADULT ANIMAL MODEL OF NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY
    NEUROSCIENCE 169/1 :259-268,2010
  • Endogenous Agmatine Inhibits Cerebral Vascular Matrix Metallopro-teinases Expression by Regulating Activating Transcription Factor 3 and Endothelial Nitric Oxide Synthesis
    Current Neurovascular Research 7/3 :201-212,2010
  • Regulation of endothelial nitric oxide synthase by agmatine after transient global cerebral ischemia in rat brain
    대한해부학회지 (anatomy and cell biology) 43/3 :230-240,2010
  • Recombinant hexahistidine arginine decarboxylase (hisADC) induced endogenous agmatine synthesis during stress
    MOLECULAR AND CELLULAR BIOCHEMISTRY 345/1-2 :53-60,2010
  • Soybeans Ameliolate Diabetic Nephropathy in Rats
    Evidence-Based Complementary And Alternative Medicine 7/4 :433-440,2010
  • Agmatine and Angiogenesis in Cerebral Ischemia: Therapeutic Approaches
    Vascular Neurology 2/ :7-13,2010
  • Agmatine reduces nitric oxide synthase expression and peroxynitrite formation in the cerebral cortex in a rat model of transient global cerebral ischemia
    Neural Regeneration Research 5/23 :1773-1781,2010
  • Effects of agmatine on hypoxic microglia and activity of nitric oxide synthase
    BRAIN RESEARCH 1373/ :48-54,2011
  • Effects of constraint-induced movement therapy on neurogenesis and functional recovery after early hypoxic-ischemic injury in mice
    DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY 53/4 :327-333,2011
  • Retroviral Expression of Arginine Decarboxylase Attenuates Oxidative Burden in Mouse Cortical Neural Stem Cells
    STEM CELLS AND DEVELOPMENT 20/3 :527-537,2011
  • Induction of Striatal Regeneration Delays Motor Deterioration in a Mouse Model of Huntington’s Disease
    TISSUE ENGINEERING AND REGENERATIVE MEDICINE 8/2 :164-172,2011
  • Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice
    INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 92/4 :251-259,2011
  • The expression of human papillomavirus type 16 (HPV16 E7) induces cell cycle arrest and apoptosis in radiation and hypoxia resistant glioblastoma cells
    MOLECULAR MEDICINE REPORTS 4/6 :1247-1253,2011
  • Agmatine enhances neurogenesis by increasing ERK1/2 expression, and suppresses astrogenesis by decreasing BMP 2,4 and SMAD 1,5,8 expression in subventricular zone neural stem cells
    LIFE SCIENCES 89/13-14 :439-449,2011
  • Experimental Models of Vascular Dementia and Vascular Cognitive Impairment
    Vascular Neurology 3/1 :30-35,2011
  • Brain 11: What's new in stroke research?
    Expert review of neurotherapeutics 11/9 :1235-1237,2011
  • Agmatine-Reduced Collagen Scar Area Accompanied With Surface Righting Reflex Recovery After Complete Transection Spinal Cord Injury
    SPINE 36/25 :2130-2138,2011
  • Toxicologic Screening Agmatine Using In Vitro and In Vivo Assays
    Vascular Neurology 3/1 :51-54,2011
  • The neuroprotective effect of agmatine after focal cerebral ischemia in diabetic rats.
    JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY 24/1 :39-50,2012
  • KLF10, transforming growth factor-beta-inducible early gene 1, acts as a tumor suppressor
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 419/2 :388-394,2012
  • Enhancement of anti-inflammatory and antinociceptive actions of red ginseng extract by fermentation
    JOURNAL OF PHARMACY AND PHARMACOLOGY 64/5 :756-762,2012
  • Anti-inflammatory, antinociceptive and anti-angiogenic activities of a phospholipid mixture purified from porcine lung tissues
    IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 34/3 :398-407,2012
  • Carbon nanotubes impregnated with subventricular zone neural progenitor cells promotes recovery from stroke
    INTERNATIONAL JOURNAL OF NANOMEDICINE 7/ :2751-2765,2012
  • Protective effects of agmatine on lipopolysaccharide-injured microglia and inducible nitric oxide synthase activity
    LIFE SCIENCES 91/25-26 :1345-1350,2012
  • Agmatine Produces Neuroprotection and Cognitive Improvement in Rat Treated with Streptozotocin.
    Vascular Neurology 4/1 :31-38,2012
  • Genetically Modifed Stem Cells and Their Applications in Central Nervous System Injury Models.
    Vascular Neurology 4/1 :15-19,2012
  • Mutifaceted effects of agmatine on functional recovery after compression spinal cord injury through modulations of BMP-2, 4, 7 expressions in neurons in Neurons and Glial Cells
    PLOS ONE 8/2 :e53911-e53911,2013
  • Agmatine promotes the migration of murine brain endothelial cells via multiple signaling pathways
    LIFE SCIENCES 92/1 :42-50,2013
  • Chaperone-like Activity of High-Mobility Group Box 1 Protein and Its Role in Reducing the Formation of Polyglutamine Aggregates
    JOURNAL OF IMMUNOLOGY 190/4 :1797-1806,2013
  • Overexpression of Human Arginine Decarboxylase Rescues Human Mesenchymal Stem Cells against H2O2 Toxicity through Cell Survival Protein Activation
    JOURNAL OF KOREAN MEDICAL SCIENCE 28/3 :366-373,2013
  • TRPV1 Activation in Primary Cortical Neurons Induces Calcium-Dependent Programmed Cell Death
    Experimental Neurobiology 22/1 :51-57,2013
  • The 70 kDa heat shock protein protects against experimental traumatic brain injury
    NEUROBIOLOGY OF DISEASE 58/0 :281-288,2013
  • Agmatine: Clinical applications after 100 years in translation.
    DRUG DISCOVERY TODAY 18/17-18 :880-893,2013
  • Biocompatability of carbon nanotubes with stem cells to treat CNS injuries
    Anatomy and Cell Biology 46/2 :85-92,2013
  • Environmental Enrichment Synergistically Improves Functional Recovery by Transplanted Adipose Stem Cells in Chronic Hypoxic-Ischemic Brain Injury
    CELL TRANSPLANTATION 22/9 :1553-1568,2013
  • Cerebroprotective effects of red ginseng extract pretreatment against ischemia-induced oxidative stress and apoptosis
    INTERNATIONAL JOURNAL OF NEUROSCIENCE 123/4 :269-277,2013
  • Effect of Propofol Post-treatment on Blood-Brain Barrier Integrity and Cerebral Edema After Transient Cerebral Ischemia in Rats.
    NEUROCHEMICAL RESEARCH 38/11 :2276-2286,2013
  • Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury
    EXPERIMENTAL AND MOLECULAR MEDICINE (Korean journal of biochemistry) 45/e69 :1-7,2013
  • Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 441/2 :280-285,2013
  • Adiponectin as a new paradigm for approaching Alzheimer’s disease.
    Anatomy and Cell Biology 46/4 :229-234,2013
  • 다운증후군 환자에게서 발생한 구진성 탄력섬유파괴증.
    대한피부과학회지 51/9 :750-752,2013
  • The effect of agmatine on expression of IL-1β and TLX which promotes neuronal differentiation in lipopolysaccharide-treated neural progenitors.
    Experimental Neurobiology 22/4 :268-276,2013
  • Melatonin Improves Cognitive Impairment in Alzheimer’s Disease
    Vascular Neurology 5/- :7-11,2013
  • The Combinational Treatment of Antioxidants Protects Brain Endothelial Cells Against Oxygen-Glucose Deprivation Followed by Reperfusion Induced Injury
    Vascular Neurology 5/- :35-41,2013
  • The Therapeutic Potential of Apoptosis Signal-Regulating
    Vascular Neurology 5/- :3-6,2013
  • Time-dependent effect of combination therapy with erythropoietin and granulocyte colony-stimulating factor in a mouse model of hypoxic-ischemic brain injury
    NEUROSCIENCE BULLETIN 30/ :107-117,2014
  • Apoptosis signal regulating kinase 1 (ASK1): Potential as a therapeutic target for Alzheimer’s disease.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15/2 :2119-2129,2014
  • Glutathione rescues brain endothelial cells from hydrogen peroxide-induced oxidative stress by activating Nrf2 expression.
    Experimental Neurobiology 23/1 :93-103,2014
  • Agmatine improves cognitive dysfunction and prevents cell death in a streptozotocin-induced Alzheimer rat model
    YONSEI MEDICAL JOURNAL 55/3 :689-699,2014
  • Association between risk factors for vascular dementia and adiponectin
    BIOMED RESEARCH INTERNATIONAL 2014/Arti :1-13,2014
  • Receptor for Advanced Glycation End Products (RAGE) and Its Ligands: Focus on Spinal Cord Injury
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15/8 :13172-13191,2014
  • The Beneficial Effect of Melatonin in Brain Endothelial Cells against Oxygen-Glucose Deprivation Followed by Reperfusion-Induced Injury
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY /Article :1-14,2014
  • Retroviral Expression of Human Arginine Decarboxylase Reduces Oxidative Stress Injury in Mouse Cortical Astrocytes.
    BMC NEUROSCIENCE 15/99 :1-10,2014
  • Resveratrol promotes the expression of interleukin-10 and brain-derived neurotrophic factor in microglia under hypoxia.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15/ :15512-15529,2014
  • The Role and Regulatory Mechanism of 14-3-3 Sigma in Human Breast Cancer
    JOURNAL OF BREAST CANCER 17/3 :207-218,2014
  • Combination of a peroxisome proliferator-activated receptor-gamma agonist and an angiotensin II receptor blocker attenuates myocardial fibrosis and dysfunction in type 2 diabetic rats
    JOURNAL OF DIABETES INVESTIGATION 5/ :362-371,2014
  • Modulation of Stem Cell Differentiation by the Influence of Nanobiomaterials/Carriers.
    CURRENT STEM CELL RESEARCH & THERAPY 9/6 :458-468,2014
  • The effect of ASK1 on vascular permeability and edema formation in cerebral ischemia.
    BRAIN RESEARCH 1595/Jan :143-155,2015
  • Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation.
    NEUROSCIENCE 286C/- :272-280,2015
  • Restorative benefits of transplanting human mesenchymal stem cells overexpressing arginine decarboxylase genes following spinal cord injury.
    CYTOTHERAPY 17/1 :25-37,2015
  • The Protective Effect of Melatonin on Neural Stem Cell against LPS-Induced Inflammation
    BIOMED RESEARCH INTERNATIONAL 2015/Arti :1-13,2015
  • Glutathione suppresses cerebral infarct volume and cell death after ischemic injury: involvement of FOXO3 inactivation and Bcl2 expression.
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2015/Arti :1-11,2015
  • Dehydroascorbic acid attenuates ischemic brain edema and neurotoxicity in cerebral ischemia: An in vivo study.
    Experimental Neurobiology 24/1 :41-54,2015
  • The role of orexin in post-stroke inflammation, cognitive decline, and depression
    MOLECULAR BRAIN 8/ :16-,2015
  • Effects of Agmatine on Blood-Brain Barrier Stabilization Assessed by Permeability MRI in a Rat Model of Transient Cerebral Ischemia
    AMERICAN JOURNAL OF NEURORADIOLOGY 36/2 :283-288,2015
  • miR-155 is involved in Alzheimer’s disease by regulating T lymphocyte function.
    FRONTIERS IN AGING NEUROSCIENCE 7/4 :1-8,2015
  • ASK1 modulates the expression of microRNA Let7A in microglia under high glucose in vitro condition
    FRONTIERS IN CELLULAR NEUROSCIENCE 9/Article :1-13,2015
  • Let7a involves in neural stem cell differentiation relating with TLX level.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 462/- :396-401,2015
  • Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death
    NEUROSCIENCE 301/- :26-38,2015
  • Agmatine attenuates brain edema formation and apoptotic cell death after traumatic brain injury.
    JOURNAL OF KOREAN MEDICAL SCIENCE 30/7 :943-952,2015
  • miR-Let7A Modulates Autophagy Induction in LPS-Activated Microglia
    Experimental Neurobiology 24/2 :117-125,2015
  • PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury
    NEURAL PLASTICITY 2015/Arti :1-13,2015
  • MicroRNA-Let-7a regulates the function of microglia in inflammation.
    MOLECULAR AND CELLULAR NEUROSCIENCE 68/ :167-176,2015
  • Adiponectin receptor 1-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study.
    CELL DEATH & DISEASE 6/- :e1844-,2015
  • Permeability Parameters Measured with Dynamic Contrast-Enhanced MRI: Correlation with the Extravasation of Evans Blue in a Rat Model of Transient Cerebral Ischemia
    KOREAN JOURNAL OF RADIOLOGY 16/4 :791-797,2015
  • Environmental enrichment enhances synaptic plasticity by internalization of striatal dopamine transporters
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 36/12 :2122-2133,2016
  • Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling
    Experimental Neurobiology 25/1 :24-32,2016
  • Blunted response of hippocampal AMPK associated with reduced neurogenesis in older versus younger mice
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 71/ :57-65,2016
  • 70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
    STROKE 47/8 :2103-2111,2016
  • Transfection of arginine decarboxylase gene increases the neuronal differentiation of neural progenitor cells
    STEM CELL RESEARCH 17/2 :256-265,2016
  • Suppression of let-7a microRNA expression by agmatine induces neuronal differentiation
    YONSEI MEDICAL JOURNAL 57/6 :1461-1467,2016
  • The Anti-inflammatory Effects of Agmatine on Transient Focal Cerebral Ischemia in Diabetic Rats
    JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY 28/3 :203-213,2016
  • Blockade of Apoptosis Signal-Regulating Kinase 1 Attenuates Matrix Metalloproteinase 9 Activity in Brain Endothelial Cells and the Subsequent Apoptosis in Neurons after Ischemic Injury
    FRONTIERS IN CELLULAR NEUROSCIENCE 10/Articl :1-12,2016
  • Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells
    Experimental Neurobiology 25/5 :241-251,2016
  • Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling
    NEUROPHARMACOLOGY 113/Pt A :467-479,2017
  • Metabolism-centric overview of the pathogenesis of Alzheimer’s disease.
    YONSEI MEDICAL JOURNAL 58/3 :479-488,2017
  • M2 phenotype microglia-derived cytokine stimulates proliferation and neural differentiation of endogenous stem cells in ischemic brain.
    Experimental Neurobiology 26/1 :33-41,2017

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