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소속

  • 해부학교실

직위

  • 교수

연구실 위치

  • 의과대학 신관 145호

전화/팩스

  • 02) 2228-1647 /

학력사항

  • 연세대학교 생물학과 학사 (1980)
    미국 Univ. or California, Los Angeles. Ph.D. (1985)

교육 및 연구 경력

  • 1986-1997 생명공학연구원, 선임, 책임연구원
    1990-1992 독일 Max Plank. Institute,Goettingen, Post-Doc.
    1997-현재 연세대학교 조교수, 부교수, 교수

기타 학술 관련 경력

  • 1985-현재: 한국생화학회, 회원
    1985-현재: 한국미생물학회, 회원
    1989-1989: 한국생화학회, 생화학뉴스 편집위원
    1992-1993: 한국생화학회, 평의원
    1993-현재: 한국분자생물학회, 종신회원
    1993-현재: 한국미생물학회, 평의원
    1997-1998: 한국유전학회, 국제협력 간사
    1997-현재: 대한해부학회, 회원
    2000-2007: 대한의생명과학회, 학술간사겸 상임이사
    2002-2007: 여성생명과학기술포럼, 이사
    2003-2004: 대한내분비학회, 학술위원
    2003-현재: Society of Developmental Biology, 회원
    2003-2005: 국립독성연구원, 생식독성분야 자문위원
    2005-2006: 한국생화 분자생물학회, SCI 등재가입추진위원회, 자문위원
    2006-2010: 한국생화분자생물학회, 평의원
    2006-현재: New York Academy of Sciences, 회원
    2006-현재: 인도발생생물학회, 평생회원
    2008-현재: 대한의생명과학회, 부회장, 회장, 이사장, 고문
    2008-2011 현재: 연세대학교 여자동창회 20대, 21대 이사, 임원
    2010-2010: 한국여성과학기술단체총연합회(여과총) 이사, 편집위원
    2010-2010: 한국생화분자생물학회 평의원
    2010-2012: 한국분자.세포생물학회 대의원(의약학),
    2010-2010: 한국유전학회 이사
    2010-현재: 대한해부학회 편집위원(ACB editor)
    2011-2013: 생화학분자생물학회 대의원

연구,관심분야

  • 척추동물 발생
    (vertebrate development)
    형태형성
    (pattern formation),
    Epigemomics & Chromatin conformation

강의분야

  • 분자발생,
    실험동물발생,
    유전자 발현조절

논문

  • Molecular Genetic analysis of DiGeorge syndrome among Korean patients with congenital heart disease. Mol. and Cells 9. 72-77, 1999
  • 캐치-22 증후군에 대한 표식 유전자 및 이를 이용한 캐치-22 증후군 진단용 키트. 특허 제236465호, 1999
  • Apoptosis induced by changes in the temperature during whole embryo culture of postimplantation rat embryos. Kor. J. Anatomy 31:761-770, 1998
  • Differential expression of the Hoxa-9 gene during mouse development. Kor. J. Genetics 20:91-101, 1998
  • Rapid analysis for the isolation of novel genes encoding putative effectros to the position-specific regulatory element of muring Hoxa-7. Mol. and Cells 7:220-225, 1997
  • Establishment of stable melanoma cell line expressing a novel gene jpk, using tetracycline-controlled gene expression system. Molecular Biotechnology 26:1-6, 2004
  • Calcyclin, a Ca2+ ion binding protein, contributes to the anabolic effects of simvastatin on bone. J Biol Chem 279:21239-21247, 2004
  • Cloning of TLR3 isoform. Yonsei Medical Journal 45:359-361, 2004
  • Dynamic expression pattern of Hoxc8 during mouse early embryogenesis anatomical record. 2004 (in Press)
  • Expression profile of jpk; Seeking for a possible diagnostic marker for the diabetes mellitus. Journal Experimental Biomedical Sciences, 2004 (in Press)
  • Analysis of plausible downstream target genes of Hoxc8 in F9 teratocarcinoma cells. Mol Biol Reports 30:141-148, 2003
  • Timetable for intestinal rotation in staged human embryos and fetuses. Birth Defects Research 67:941-945, 2003
  • A novel gene, Jpk induces apoptosis in F9 murine teratocarcinoma cell through ROS generation. Ann N. Y. Acad Sci 1010:433-436, 2003
  • Retinoic acid response element in HOXA7 regulatory region affects the rate not the formation of anterior boundary expression. Int J Dev Biol 46:325-328, 2002
  • Isolation and characaterization of novel gene, jpk from murine embryonic matchmaker cDNAlibrary. Korean J Genetics 24:197-203, 2002
  • Development of model system for radiation induced congenital malformation by whole embryo culture. Korean J Physical Anthropology 15:293-303, 2002
  • A novel factor associating with the upstream regulatory element of murine Hoxa-7 induces bacterial cell death. Mol Biol Reports 29:363-368, 2002
  • A plausible method for the diagnosis of genetic disorders using full length cDNA. Kor J Biomed Lab Sci 7:1-8, 2001
  • Intestinal rotation, luminal obstruction and recanalization in the human embryos and fetuses. Korean J Phys Anthropol 14:235-248, 2001
  • Transneuronal degeneration due to peripheral nerve injury in the rats. Korean J Phys Anthropol 14:259-271, 2001
  • Reporter transgene based on a human HOX regulatory element is expressed dynamically during mouse development. Kor J Genetics 23:385-392, 2001
  • Hypertherima effect on morphogenesis during mouse development. Kor. J Genetics 22:35-42, 2000
  • Isolation of novel genes expressed position-specifically in mouse embryo. Kor J Genetics 22:63-71, 2000
  • Clinical features and molecular diagnosis of CATCH-22 syndrome. Kor Cir. J 28:1077-1083, 1998
  • 307 bp fragment in HOXA7 upstream sequence is sufficient for anterior boundary formation. DNA and Cell Biol 17:293-299, 1998
  • Genomic structure and sequence analysis of human HOXA-9.DNA and Cell Biol 17:407-414, 1998
  • PAC and cosmid contig spanning the HOXA cluster on human chrmosome 7p15. Somatic Cell and Molecular Genetics 24:245-248, 1998
  • Sequence analysis of the 5'-flanking region of the gene encoding human HOXA7. Somatic Cell and Molecular Genetics 24:371-374, 1998
  • Development of nerves in the upper limb of human embyros. 대한성형외과학회지 24:926-934, 1997
  • Human genome project. J Kor Med Asso 40:1680-1686, 1997
  • Cloning and expression of human clotting factor 9 cDNA in Escherichia coli. Kor J Biomed Lab Sci 2:231-240, 1996
  • Sequence analysis of the 5'flanking region of the gene encoding human N-acetylglucosamyltransferase III. Gene 170:281-283, 1996
  • EcoRI variant N1991H has enhanced specific activity. Gene 171:129-130, 1996
  • Sequence and functional analysis of an upstream regulatory region of human HOXA gene. Gene 182:1-6, 1996
  • Chemical synthesis and cloning of Human β-endorphin gene in E.coli. Applied Biochem. and Biotech. 50 : 35-43, 1995
  • A conserved enhancer of the human and murine Hoxa-7 gene specifies the anterior boundary of expression during embryonal development. Development 121 : 1077-1088, 1995
  • Cloning and expression of human clotting factor 9 cDNA in Escherichia coli. The Biopolymers and Bioproducts: Structure, Function and Applications (Svasti, J. et al. eds. ), pp. 133-138, 1995
  • A rapid and simple method for the isolation of mutant variants regulating tissue-specific expression of TnI gene through drug selection. Applied Biochem. and Biotech. 55 : 231-240, 1995
  • Analysis of human HOXA7 gene control region and its effects on anterior-posterior axiaal pattern formation using transgenic mouse embryo. Korean J. Vet. Res. 35 : 95-105, 1995
  • Isolation of 961E5 YAC DNA clone containing the plausible Human HOXA cluster. Kor. J. Biochem. 27 : 25-31, 1995
  • Position-specific control element of murine Hoxa-7 is conserved among several species. Kor. J. Genetics 17 : 123-132, 1995
  • Determination of genome size and a preliminary physical map of an extreme alkaliphile Micrococcus sp. Y-1, by pulsed-field gel electrophoresis. Microbiology 140 : 2247-2250, 1994
  • Allelic divergence in the human insulin gene providing evidence for intragenic recombination events of the non-coding regions: evidence for existance of new alleles. Molecular and General Genetics 245 : 146-151, 1994
  • Homeobox genes as regulators of vertebrate development. AgBiotech News and Information 5 : 189-194, 1993
  • 생쥐 발생이 고온이 형태형성에 미치는 영향
    The Korean Journal of Genetics 22/1 :35-42,2000
  • Sequence analysis and tissue specific expression of human HOXA7
    MOLECULAR BIOTECHNOLOGY 14/ :19-24,2000
  • 생쥐의 배자에서 위치 특징적 발현을 보이는 새로운 유전자의 분리
    The Korean Journal of Genetics 22/2 :175-183,2000
  • 사람 배자 및 태아에서 정상적으로 일어나는 창자의 회전, 관강 폐쇄 및 재형성
    대한체질인류학회지(Korean Journal Of Physical Anthropology) 14/3 :235-248,2001
  • Isolation of Novel cDNA encompassing the ADU balanced translocation break point in the DuGeorge critical region
    MOLECULAR BIOTECHNOLOGY 17/0 :213-217,2001
  • 형질전환 생쥐에서 인간 혹스 조절인자에의해 유도된 리포터 transgene의 역동적 패턴
    Korean J Genetics 23/4 :385-392,2001
  • A plausible method for the diagnosis of genetic disorders using full length cDNA
    대한의생명과학회지(JOURNAL OF EXPERIMENTAL & Biomedcal Science) 7/1 :1-8,2001
  • 흰쥐 말초신경 손상에의한 신경원통과성변성의 양상
    대한체질인류학회지(Korean Journal Of Physical Anthropology) 14/3 :259-271,2001
  • Retinoic acid responsive element in HoXA-7 regulatory region affects the rate, not the formation of anterior boundary expression.
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 46/ :325-328,2002
  • 생쥐 배자의 cDNA 라이브러리로부터 신규 유전자(Jpk)의 동정
    The Korean Journal of Genetics 24/2 :197-203,2002
  • Complete nucleotide sequence of KCNE1 in Korean genome
    대한의생명과학회지(JOURNAL OF EXPERIMENTAL & Biomedcal Science) 8/3 :185-188,2002
  • A novel factor associating with the upstream regulatory element of murine Hoxa-7 induces bacterial cell death
    MOLECULAR BIOLOGY REPORTS 29/ :363-368,2002
  • 배자배양법을 이용한 방사선 유도 선천성 기형 검사의 모델 시스템 개발
    대한체질인류학회지(Korean Journal Of Physical Anthropology) 15/4 :293-303,2002
  • Genome mapping of an extreme thermophile, Thermus caldophilus GK24
    GENOMICS & INFORMATICS 1/1 :50-54,2003
  • A novel gene, Jpk, induces apoptosis in F9 murine teratocarcinoma cell through ROS generation
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1010/ :433-436,2003
  • A study on Hox gene expression profile during murine liver regeneration.
    대한의생명과학회지(JOURNAL OF EXPERIMENTAL & Biomedcal Science) 9/1 :1-8,2003
  • Analysis of plausible downstream target genes of Hoxc8 in F9 teratocarcinoma cells - Putative downstream target genes of Hoxc8
    MOLECULAR BIOLOGY REPORTS 30/ :141-148,2003
  • Timetable for Intestinal Rotation in Staged Human Embryos and Fetuses
    BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY 67/11 :941-945,2003
  • Calcyclin, a Ca2+ ion-binding protein, contributes to the anabolic effects of simvastatin on bone
    JOURNAL OF BIOLOGICAL CHEMISTRY 279/20 :21239-21247,2004
  • Establishment of stable melanoma cell line expressing a novel gene, Jpk, using a tetracycline-control led gene expression system
    MOLECULAR BIOTECHNOLOGY 26/ :1-6,2004
  • Organ-Specific Expression Profile of JPK: Seeding for a Possible Diagnostic Marker for the Diabetes Mellitus
    대한의생명과학회지(JOURNAL OF EXPERIMENTAL & Biomedcal Science) 10/4 :385-389,2004
  • Cloning of TLR3 isoform
    YONSEI MEDICAL JOURNAL 45/ :359-361,2004
  • ER Stress-Induced Jpk Expression and the Concomitant Cell Death
    대한의생명과학회지(JOURNAL OF EXPERIMENTAL & Biomedcal Science) 11/2 :135-141,2005
  • Spatio-Temporal Expression Pattern of Grp78, a Putative Hoxc8 Downstream Target Gene, During Murine Embryogenesis
    대한의생명과학회지(JOURNAL OF EXPERIMENTAL & Biomedcal Science) 11/3 :311-318,2005
  • Membraneous localization of Jpk is not essential to exert cytotoxicity in F9 teratocarcinoma cells
    JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-COMPARATIVE EXPERIMENTAL BIOLOGY 303/A :422-429,2005
  • Dynamic expression pattern of Hoxc8 during mouse early embryogenesis
    ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY 283A/ :187-192,2005
  • Efficient cellular uptake of recombinant murine Hoxc8 homeoprotein in COS-7 cells
    LIFE SCIENCES 79/ :2345-2348,2006
  • Jpk, a novel cell death inducer, regulates the expression of Hoxa7 in F9 teratocarcinoma cells, but not during apoptosis
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1090/ :182-187,2006
  • Development of a Unidirectional Expression Vector: in a Search of Suppressor against a Cell Death-Inducing Protein, Jpk
    대한의생명과학회지(JOURNAL OF EXPERIMENTAL & BIOMEDCAL SCIENCE) 12/ :139-143,2006
  • 흰쥐에서 임신 중 레티노산이 입천장 형태발생에 미치는 영향
    대한해부학회지(Korean Journal Of Anatomy) 39/4 :331-341,2006
  • A Homeotic Gene, Hoxc8, Regulates the Expression of Proliferating Cell Nuclear Antigen in NIH3T3 Cell
    대한의생명과학회지(JOURNAL OF EXPERIMENTAL & Biomedcal Science) 13/3 :239-244,2007
  • Differentially expressed genes and morphological changes during lengthened immobilization in rat soleus muscle
    DIFFERENTIATION 75/ :147-157,2007
  • Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts.
    JOURNAL OF BONE AND MINERAL RESEARCH 22/6 :889-896,2007
  • ER stress induces the expression of Jpk, which inhibits cell cycle progression in F9 teratocarcinoma cell
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1095/ :76-81,2007
  • Differential expression of Hox genes during murine liver regeneration
    KOREAN JOURNAL OF GENETICS 29/4 :513-519,2007
  • Membrane transducing activity of recombinant Hoxc8 protein and its possible application as a gene delivery vector
    Experimental And Molecular Medicine 40/ :151-160,2008
  • Overexpression of Hoxc8, a homeobox gene, in B16F10 melanoma inhibits the growth of tumor cells
    Genes And Genomics 30/ :141-149,2008
  • Isolation of Putative in vivo Hoxc8 Downstream Target Genes Using ChIP-Cloning Method
    대한의생명과학회지(Journal Of Experimental & Biomedcal Science) 14/1 :47-53,2008
  • The third helix of the murine Hoxc8 homeodomain facilitates protein transduction in mammalian cells
    Biochemical And Biophysical Research Communications 377/ :161-164,2008
  • The Third Helix of the Hoxc8 Homeodomain Peptide Enhances the Efficiency of Gene Transfer in Combination with Lipofectamine
    Molecular Biotechnology 42/ :41-48,2009
  • Hypoxia-enhanced wound-healing function of adipose-derived stem cells: Increase in stem cell proliferation and up-regulation of VEGF and bFGF
    Wound Repair And Regeneration 17/4 :540-547,2009
  • Synthetic Maternal Stress Hormone Can Modulate the Expression of Hox Genes
    대한의생명과학회지(Journal Of Experimental & Biomedcal Science) 15/3 :249-255,2009
  • In Vitro Osteoblast Differentiation is Negatively Regulated by Hoxc8
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 160/3 :891-900,2010
  • Hoxc8 Represses BMP-Induced Expression of Smad6
    Molecules and Cells 29/1 :29-33,2010
  • Proliferating cell nuclear antigen (Pcna) as a direct downstream target gene of Hoxc8
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 392/4 :543-547,2010
  • Chromatin organization and transcriptional activation of Hox genes
    대한해부학회지 (anatomy and cell biology) 43/1 :78-85,2010
  • Retinoic Acid Induces Abnormal Palate During Embryogenesis in Rat
    대한의생명과학회지(Journal of Experimental & Biomedical Science) 16/1 :1-9,2010
  • Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8
    Journal Of Biomedicine And Biotechnology 2010/Art :1-7,2010
  • Identification of genes concordantly expressed with Atoh1 during inner ear development
    Anatomy and Cell Biology 44/1 :69-78,2011
  • Grp78 is a Novel Downstream Target Gene of Hoxc8 Homeoprotein
    Journal of experimental and biomedical sciences 17/1 :1-5,2011
  • Effects of Dexamethasone on Embryo Development and Hox Gene Expression Patterns in Mice
    Journal of experimental and biomedical sciences 17/3 :231-238,2011
  • Hoxc8 Downregulates Mgl1 Tumor Suppressor Gene Expression and Reduces Its Concomitant Function on Cell Adhesion
    Molecules and Cells 32/3 :273-279,2011
  • Identification and characterization of a noncoding RNA at the mouse Pcna locus
    Molecules and Cells 33/2 :111-116,2012
  • Structural Dynamics and Epigenetic Modifications of Hoxc Loci along the Anteroposterior Body Axis in Developing Mouse Embryos
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 8/6 :802-810,2012
  • A novel protein Jpk induces bacterial cell death through reactive oxygen species
    GENE 504/2 :274-278,2012
  • Post-transcriptional Regulation of Gcn5, a Putative Regulator of Hox in Mouse Embryonic Fibroblast Cells
    Journal of Experimental and Biomedical Sciences 18/2 :1-4,2012
  • Hox Genes are Differentially Expressed during Mouse Placentation
    Journal of Experimental and Biomedical Sciences 18/2 :1-6,2012
  • Prenatal administration of dexamethasone during early pregnancy negatively affects placental development and function in mice
    JOURNAL OF ANIMAL SCIENCE 90/13 :4846-4856,2012
  • Akt1 as a putative regulator of Hox genes
    GENE 513/2 :287-291,2013
  • Hoxc Gene Collinear Expression and Epigenetic Modifications Established during Embryogenesis Are Maintained until after Birth
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 9/9 :960-965,2013
  • Direct Interaction Between Akt1 and Gcn5 and its Plausible Function on Hox Gene Expression in Mouse Embryonic Fibroblast Cells
    대한의생명과학회지 19/3 :266-269,2013
  • Analysis of HOX Gene Expression Patterns in Human Breast Cancer
    MOLECULAR BIOTECHNOLOGY 56/1 :64-71,2014
  • Pax3 function is required specifically for inner ear structures with melanogenic fates
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 445/3 :608-614,2014
  • Effect of Prenatal Dexamethasone on Sex-specific Changes in Embryonic and Placental Growth
    대한의생명과학회지 20/1 :43-47,2014
  • Akt1 mediates the posterior Hoxc gene expression through epigenetic modifications in mouse embryonic fibroblasts
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1839/9 :793-799,2014
  • PI3K/Akt pathway regulates retinoic acid-induced Hox gene expression in F9 cells
    DEVELOPMENT GROWTH & DIFFERENTIATION 56/7 :518-525,2014
  • Prenatal Stress Induces Skeletal Malformations in Mouse Embryos
    대한의생명과학회지 21/1 :15-22,2015
  • HOXB5 Promotes the Proliferation and Invasion of Breast Cancer Cells
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 11/6 :701-711,2015
  • F9 EC 세포에서 레티노산에 의해 유도되는 Hoxc 유전자의 발현에 히스톤 메틸화가 미치는 영향
    생명과학회지 25/6 :703-708,2015
  • CTCF negatively regulates HOXA10 expression in breast cancer cells
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 467/4 :828-834,2015
  • Prenatal exposure to dexamethasone disturbs sex-determining gene expression and fetal testosterone production in male embryos
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 471/1 :149-155,2016
  • HOXC9 induces phenotypic switching between proliferation and invasion in breast cancer cells.
    JOURNAL OF CANCER 7/7 :768-773,2016
  • Genes Frequently Coexpressed with Hoxc8 Provide Insight into the Discovery of Target Genes
    MOLECULES AND CELLS 39/5 :395-402,2016
  • CTCF-mediated Chromatin Loop for the Posterior Hoxc Gene Expression in MEF Cells
    IUBMB LIFE 68/6 :436-444,2016
  • The mitotic checkpoint regulator RAE1 induces aggressive breast cancer cell phenotypes by mediating epithelial-mesenchymal transition.
    SCIENTIFIC REPORTS 7/42256 :1-9,2017
  • The histone acetylation mediated by Gcn5 regulates the Hoxc11 gene expression in MEFs.
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA 49/7 :643-648,2017
  • Depletion of CTCF in Breast Cancer Cells Selectively Induces Cancer Cell Death via p53
    JOURNAL OF CANCER 8/11 :2,124-2,131,2017
  • Prenatal exposure to dexamethasone in the mouse induces sex-specific differences in placental gene expression
    DEVELOPMENT GROWTH & DIFFERENTIATION 59/6 :515-525,2017
  • HOXB5 Directly Regulates the Expression of IL-6 in MCF7 Breast Cancer Cells
    대한의생명과학회지 23/3 :272-276,2017

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