바로가기
메인메뉴로 바로가기
콘텐츠 바로가기
하단메뉴로 바로가기
패밀리사이트 바로가기


소속

  • 해부학교실

직위

  • 부교수

연구실 위치

  • 에비슨의생명연구센터(ABMRC) 204호

전화/팩스

  • 02-2228-0753 /

학력사항

  • 연세대학교 생명시스템대학 시스템생물학과 학사 (1992)
    연세대학교 생명시스템대학 시스템생물학과 석사 (1994)
    University of Iowa. Ph.D. (2002)

교육 및 연구 경력

  • 2002-2008, 미국 NIH 박사후 연구원
    2008-2009 연세대학교 의과대학 해부학교실 전임강사
    2009-현재 연세대학교 의과대학 해부학교실 조교수,부교수

기타 학술 관련 경력

  • Association for Research in Otolaryngology, member
    Society for Developmental Biology, member

연구,관심분야

  • Inner ear development and function
    Genetics and pathobiology of deafness
    Primary cilia and ciliopathies

논문

  • Multiple distinct signal pathways, including an autocrine neurotrophic mechanism, contribute to the survival-promoting effect of depolarization on spiral ganglion neurons in vitro
    JOURNAL OF NEUROSCIENCE 21/7 :2256-2267,2001
  • An extranuclear locus of cAMP-dependent protein kinase action is necessary and sufficient for promotion of spiral ganglion neuronal survival by cAMP
    JOURNAL OF NEUROSCIENCE 23/3 :777-787,2003
  • Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neurons
    JOURNAL OF NEUROSCIENCE RESEARCH 72/2 :169-184,2003
  • Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear
    DEVELOPMENT 132/9 :2115-2124,2005
  • CaMKII and CaMKIV mediate distinct prosurvival signaling pathways in response to depolarization in neurons
    MOLECULAR AND CELLULAR NEUROSCIENCE 36/1 :13-26,2007
  • Patterning and morphogenesis of the vertebrate inner ear
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 51/6-7 :521-533,2007
  • Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear
    DEVELOPMENT 134/9 :1713-1722,2007
  • Role of hindbrain in inner ear morphogenesis: Analysis of Noggin knockout mice
    DEVELOPMENTAL BIOLOGY 311/1 :69-78,2007
  • The third helix of the murine Hoxc8 homeodomain facilitates protein transduction in mammalian cells
    Biochemical And Biophysical Research Communications 377/ :161-164,2008
  • Different functional consequences of two missense mutations in the GJB2 gene associated with non-syndromic hearing loss
    Human Mutation 30/7 :716-727,2009
  • Clinical and molecular characterizations of novel POU3F4 mutations reveal that DFN3 is due to null function of POU3F4 protein
    Physiological Genomics 39/ :195-201,2009
  • Distinct contributions from the hindbrain and mesenchyme to inner ear morphogenesis
    Developmental Biology 337/2 :324-334,2010
  • Hoxc8 Represses BMP-Induced Expression of Smad6
    Molecules and Cells 29/1 :29-33,2010
  • Proliferating cell nuclear antigen (Pcna) as a direct downstream target gene of Hoxc8
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 392/4 :543-547,2010
  • Building the mammalian cochlea - an overview
    Genes And Genomics 32/1 :1-7,2010
  • Retinoic Acid Induces Abnormal Palate During Embryogenesis in Rat
    대한의생명과학회지(Journal of Experimental & Biomedical Science) 16/1 :1-9,2010
  • Clinical evaluation of DFN3 patients with deletions in the POU3F4 locus and detection of carrier female using MLPA
    Clinical Genetics 78/6 :524-532,2010
  • Pou3f4 deficiency causes defects in otic fibrocytes and stria vascularis by different mechanisms
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 404/1 :528-533,2011
  • Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108/1 :161-166,2011
  • Identification of genes concordantly expressed with Atoh1 during inner ear development
    Anatomy and Cell Biology 44/1 :69-78,2011
  • Functional Evaluation of GJB2 Variants in Nonsyndromic Hearing Loss
    MOLECULAR MEDICINE 17/5-6 :550-556,2011
  • Grp78 is a Novel Downstream Target Gene of Hoxc8 Homeoprotein
    Journal of experimental and biomedical sciences 17/1 :1-5,2011
  • CHD7 mutational analysis and clinical considerations for auditory rehabilitation in deaf patients with CHARGE syndrome
    PLOS ONE 6/9 :24511-24519,2011
  • Albumin-like protein is the major protein constituent of luminal fluid in the human endolymphatic Sac
    PLOS ONE 6/6 :1-13,2011
  • Albumin-Like Protein is the Major Protein Constituent of Luminal Fluid in the Human Endolymphatic Sac
    PLOS ONE 6/6 :e21656-,2011
  • Nonsyndromic X-linked hearing loss
    Frontiers in bioscience (Elite edition) 4 E/3 :924-933,2012
  • Developmental gene expression profiling along the tonotopic axis of the mouse cochlea
    PLOS ONE 7/7 :e40735-e40735,2012
  • A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development
    DEVELOPMENTAL DYNAMICS 242/3 :269-280,2013
  • Genetic analysis of the CHD7 gene in Korean patients with CHARGE syndrome
    GENE 517/2 :164-168,2013
  • Destabilization and Mislocalization of POU3F4 by C-Terminal Frameshift Truncation and Extension Mutation
    HUMAN MUTATION 34/2 :309-316,2013
  • Conditional Deletion of Pten Leads to Defects in Nerve Innervation and Neuronal Survival in Inner Ear Development
    PLOS ONE 8/2 :e55609-e55609,2013
  • Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110/34 :13869-13874,2013
  • Pax3 function is required specifically for inner ear structures with melanogenic fates
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 445/3 :608-614,2014
  • Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells
    HUMAN MOLECULAR GENETICS 23/6 :1591-1601,2014
  • Developmental Changes of ENaC Expression and Function in the Inner Ear of Pendrin Knock-Out Mice as a Perspective on the Development of Endolymphatic Hydrops
    PLOS ONE 9/4 :-,2014
  • Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111/23 :8541-8546,2014
  • The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss
    OPEN BIOLOGY 4/7 :140107-,2014
  • Correlation between genotype and phenotype in patients with bi-allelic SLC26A4 mutations
    CLINICAL GENETICS 86/ :270-275,2014
  • Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112/12 :3746-3751,2015
  • Pannexin 3 is required for normal progression of skeletal development in vertebrates
    FASEB JOURNAL 29/11 :4473-4484,2015
  • Identification of a nonsense mutation in the STRC gene in a Korean family with moderate hearing loss
    INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 80/1 :78-81,2016
  • Magnetic force nanoprobe for direct observation of audio frequency tonotopy of hair cells
    NANO LETTERS 16/6 :3885-3891,2016

복진웅

콘텐츠 처음으로 이동

네크워크 링크안내/사이트 정보